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Umeå universitet
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Personalbild Sun Nyunt Wai

Sun Nyunt Wai

Sun Nyunt Wai, professor i medicinsk mikrobiell patogenes, bedriver forskning om sjukdomsframkallande bakteriers egenskaper på molekylär nivå.  

Vetenskaplig meritering: Docent

Kontakt

E-post
sun.nyunt.wai@umu.se
Telefon
090-785 67 04

Verksam vid

Anknytning
Professor vid Institutionen för molekylärbiologi Enhet: Grupp Sun Nyunt Wai
Plats
6K och 6L, Sjukhusområdet Umeå universitet, 901 87 Umeå
Anknytning
Anknuten som professor till Molekylär Infektionsmedicin, Sverige (MIMS)
Plats
6L, Institutionen för molekylärbiologi Institutionen för molekylärbiologi, 90187 Umeå

Forskningen syftar till att reda ut mekanismer i samspelet mellan mikrober och värdceller för att bättre förstå orsakerna till infektionssjukdomar, och för att hitta nya möjligheter att förhindra och bota dem. Min forskargrupp har bland annat visat hur små membranblåsor som frisläpps från bakterier påverkar värdceller då de innehåller specifika proteiner och andra makromolekyler som kan ha effekt på värdens immunsystem och även de cellulära signalmekanismer som spelar stor roll bland annat vid tumörbildning och cancersjukdom.

Jag är medlem i forskarkonsortiet Umeå Centre for Microbial Research (UCMR) som utgör den vetenskapliga miljön där The Laboratory for Molecular Infection Medicine Sweden (MIMS) etablerades. Jag har som representant för MIMS deltagit vid internationella rekryteringar som genomförs inom ramen för The Nordic EMBL Partnership for Molecular Medicine när nya gruppledare knutits till de olika noderna i Danmark, Finland, Norge och Sverige. Inom MIMS har jag bedrivit forskningsamarbeten som resulterat i sampubliceringar av vetenskapliga artiklar med flera av de unga gruppledarna Jörgen Johansson, Richard Lundmark, Emmanuelle Charpentier och Andrea Puhar.

MakC and MakD are two proteins associated with a tripartite toxin of Vibrio cholerae
Frontiers in Microbiology, Frontiers Media S.A. 2024, Vol. 15
Bodra, Nandita; Toh, Eric; Nadeem, Aftab; et al.
Parvimonas micra forms a distinct bacterial network with oral pathobionts in colorectal cancer patients
Journal of Translational Medicine, BioMed Central (BMC) 2024, Vol. 22, (1)
Löwenmark, Thyra; Köhn, Linda; Kellgren, Therese; et al.
Colony phase variation switch modulates antimicrobial tolerance and biofilm formation in Acinetobacter baumannii
Microbiology Spectrum, American Society for Microbiology 2024, Vol. 12, (2)
Mushtaq, Fizza; Nadeem, Aftab; Yabrag, Abdelbasset; et al.
Bacterial symbionts in oral niche use type VI secretion nanomachinery for fitness increase against pathobionts
iScience
Oscarsson, Jan; Bao, Kai; Shiratsuchi, Akiko; et al.
Protocol for analyzing the function of the type VI secretion system of the oral symbiont Aggregatibacter aphrophilus in targeting pathobionts
STAR Protocols, Cell Press 2024, Vol. 5, (4)
Oscarsson, Jan; Bao, Kai; Shiratsuchi, Akiko; et al.
Csu pili dependent biofilm formation and virulence of Acinetobacter baumannii
npj Biofilms and Microbiomes, Springer Nature 2023, Vol. 9, (1)
Ahmad, Irfan; Nadeem, Aftab; Mushtaq, Fizza; et al.
Macrophage innate immune responses delineate between defective translocon assemblies produced by Yersinia pseudotuberculosis YopD mutants
Virulence, London: Taylor & Francis Group 2023, Vol. 14, (1)
Farag, Salah; Francis, Monika K.; Gurung, Jyoti M.; et al.
Dissecting the genetic landscape of GPCR signaling through phenotypic profiling in  C. elegans
Nature Communications, Springer Nature 2023, Vol. 14
Pu, Longjun; Wang, Jing; Lu, Qiongxuan; et al.
The gut microbiota prime systemic antiviral immunity via the cGAS-STING-IFN-I axis
Immunity, Cell Press 2022, Vol. 55, (5) : 847-861
Erttmann, Saskia F.; Swacha, Patrycja; Aung, Kyaw Min; et al.
FcγRIIIa receptor interacts with androgen receptor and PIP5K1α to promote growth and metastasis of prostate cancer
Molecular Oncology
Flodbring Larsson, Per; Karlsson, Richard; Sarwar, Martuza; et al.
Cpx-signalling facilitates Hms-dependent biofilm formation by Yersinia pseudotuberculosis
npj Biofilms and Microbiomes, London: Nature Publishing Group 2022, Vol. 8, (1)
Kumar Gahlot, Dharmender; Wai, Sun Nyunt; Erickson, David L.; et al.
Bone mineral: A trojan horse for bone cancers. Efficient mitochondria targeted delivery and tumor eradication with nano hydroxyapatite containing doxorubicin
Materials Today Bio, Elsevier 2022, Vol. 14
Liu, Yang; Nadeem, Aftab; Sebastian, Sujeesh; et al.
Parvimonas micra is associated with tumour immune profiles in molecular subtypes of colorectal cancer
Cancer Immunology and Immunotherapy, Springer 2022, Vol. 71 : 2565-2575
Löwenmark, Thyra; Li, Xingru; Löfgren Burström, Anna; et al.
Protein-lipid interaction at low pH induces oligomerization of the MakA cytotoxin from Vibrio cholerae
eLIFE, eLife Sciences Publications, Ltd 2022, Vol. 11
Nadeem, Aftab; Berg, Alexandra; Pace, Hudson; et al.
Bacterial protein MakA causes suppression of tumour cell proliferation via inhibition of PIP5K1α/Akt signalling
Cell Death and Disease, Springer Nature 2022, Vol. 13, (12)
Toh, Eric; Baryalai, Palwasha; Nadeem, Aftab; et al.
The composition and function of Enterococcus faecalis membrane vesicles
MicroLife, Oxford University Press 2021, Vol. 2
Afonina, Irina; Tien, Brenda; Nair, Zeus; et al.
Vibrio cholerae cytotoxin MakA induces noncanonical autophagy resulting in the spatial inhibition of canonical autophagy
Journal of Cell Science, The Company of Biologists 2021, Vol. 134, (5)
Corkery, Dale; Nadeem, Aftab; Aung, Kyaw Min; et al.
Transcriptome Profiling of Staphylococcus aureus Associated Extracellular Vesicles Reveals Presence of Small RNA-Cargo
Frontiers in Molecular Biosciences, Frontiers Media S.A. 2021, Vol. 7
Joshi, Bishnu; Singh, Bhupender; Nadeem, Aftab; et al.
CRISPR-based subtyping to track the evolutionary history of a global clone of Acinetobacter baumannii
Infection, Genetics and Evolution, Elsevier 2021, Vol. 90
Karah, Nabil; Wai, Sun Nyunt; Uhlin, Bernt Eric
Ecotin and LamB in Escherichia coli influence the susceptibility to Type VI secretion-mediated interbacterial competition and killing by Vibrio cholerae
Biochimica et Biophysica Acta - General Subjects, Elsevier 2021, Vol. 1865, (7)
Myint, Si Lhyam; Zlatkov, Nikola; Aung, Kyaw Min; et al.
Phosphatidic acid-mediated binding and mammalian cell internalization of the Vibrio cholerae cytotoxin MakA
PLoS Pathogens, Public Library of Science 2021, Vol. 17, (3)
Nadeem, Aftab; Alam, Athar; Toh, Eric; et al.
Suppression of β-catenin signaling in colon carcinoma cells by a bacterial protein
International Journal of Cancer, John Wiley & Sons 2021, Vol. 149, (2) : 442-459
Nadeem, Aftab; Aung, Kyaw Min; Ray, Tanusree; et al.
A tripartite cytolytic toxin formed by Vibrio cholerae proteins with flagellum-facilitated secretion
Proceedings of the National Academy of Sciences of the United States of America, Vol. 118, (47)
Nadeem, Aftab; Nagampalli, Raghavendra; Toh, Eric; et al.
Eco-evolutionary feedbacks mediated by bacterial membrane vesicles
FEMS Microbiology Reviews, Oxford University Press 2021, Vol. 45, (2)
Zlatkov, Nikola; Nadeem, Aftab; Uhlin, Bernt Eric; et al.
Molecular epidemiology and antimicrobial resistance features of Acinetobacter baumannii clinical isolates from Pakistan
Annals of Clinical Microbiology and Antimicrobials, Springer 2020, Vol. 19
Karah, Nabil; Khalid, Fizza; Wai, Sun Nyunt; et al.
The functional interlink between AR and MMP9/VEGF signaling axis is mediated through PIP5K1α/pAKT in prostate cancer
International Journal of Cancer, John Wiley & Sons 2020, Vol. 146, (6) : 1686-1699
Larsson, Per; Khaja, Azharuddin Sajid Syed; Semenas, Julius; et al.
Parvimonas micra as a putative non-invasive faecal biomarker for colorectal cancer
Scientific Reports, Nature Publishing Group 2020, Vol. 10, (1)
Löwenmark, Thyra; Löfgren Burström, Anna; Zingmark, Carl; et al.
Delivery of virulence factors by bacterial membrane vesicles to mammalian host cells
Bacterial membrane vesicles: biogenesis, functions and applications, Springer 2020 : 131-158
Nadeem, Aftab; Oscarsson, Jan; Wai, Sun Nyunt
Elevated levels of VCA0117 in response to external signals activates type VI secretion in Vibrio cholerae A1552
Environmental Microbiology, John Wiley & Sons 2020, Vol. 22, (10) : 4409-4423
Seibt, Henrik; Aung, Kyaw Min; Ishikawa, Takahiko; et al.
Analysis of colony phase variation switch in Acinetobacter baumannii clinical isolates
PLOS ONE, Public Library Science 2019, Vol. 14, (1)
Ahmad, Irfan; Karah, Nabil; Nadeem, Aftab; et al.
Vibrio cholerae derived outer membrane vesicles modulate the inflammatory response of human intestinal epithelial cells by inducing microRNA-146a
Scientific Reports, Nature Publishing Group 2019, Vol. 9
Bitar, Aziz; Aung, Kyaw Min; Wai, Sun Nyunt; et al.
Proteome profiling of secreted and membrane vesicle associated proteins of an invasive and a commensal Staphylococcus haemolyticus isolate
Data in Brief, Elsevier 2019, Vol. 22 : 914-919
Cavanagh, Jorunn Pauline; Askarian, Fatemeh; Pain, Maria; et al.
Comparative exoproteome profiling of an invasive and a commensal Staphylococcus haemolyticus isolate
Journal of Proteomics, Elsevier 2019, Vol. 197 : 106-114
Cavanagh, Jorunn Pauline; Pain, Maria; Askarian, Fatemeh; et al.
Role of OmpA1 and OmpA2 in Aggregatibacter actinomycetemcomitans and Aggregatibacter aphrophilus serum resistance
Journal of Oral Microbiology, Taylor & Francis 2019, Vol. 11, (1)
Lindholm, Mark; Aung, Kyaw Min; Wai, Sun Nyunt; et al.
Accumulation of virulence-associated proteins in Campylobacter jejuni Outer Membrane Vesicles at human body temperature
Journal of Proteomics, Vol. 195 : 33-40
Taheri, Nayyer; Fällman, Maria; Wai, Sun Nyunt; et al.
Staphylococcus aureus Membrane-Derived Vesicles Promote Bacterial Virulence and Confer Protective Immunity in Murine Infection Models
Frontiers in Microbiology, Vol. 9
Askarian, Fatemeh; Lapek, John D., Jr.; Dongre, Mitesh; et al.
Immunomodulatory Effects of Pneumococcal Extracellular Vesicles on Cellular and Humoral Host Defenses
mBio, American Society for Microbiology 2018, Vol. 9, (2)
Codemo, Mario; Muschiol, Sandra; Iovino, Federico; et al.
Flagella-mediated secretion of a novel Vibrio cholerae cytotoxin affecting both vertebrate and invertebrate hosts
Communications Biology, Springer Nature Publishing AG 2018, Vol. 1
Dongre, Mitesh; Singh, Bhupender; Aung, Kyaw Min; et al.
The Global Acetylome of the Human Pathogen Vibrio cholerae V52 Reveals Lysine Acetylation of Major Transcriptional Regulators
Frontiers in Cellular and Infection Microbiology, FRONTIERS MEDIA SA 2018, Vol. 7
Jers, Carsten; Ravikumar, Vaishnavi; Lezyk, Mateusz; et al.
Enhanced Biofilm Formation and Membrane Vesicle Release by Escherichia coli Expressing a Commonly Occurring Plasmid Gene, kil
Frontiers in Microbiology, Frontiers Media S.A. 2018, Vol. 9
Nakao, Ryoma; Myint, Si Lhyam; Wai, Sun Nyunt; et al.
Campylobacter jejuni bile exposure influences outer membrane vesicles protein content and bacterial interaction with epithelial cells
Scientific Reports, Nature Publishing Group 2018, Vol. 8
Taheri, Nayyer; Mahmud, A K M Firoj; Sandblad, Linda; et al.
Modulation of gene transcription and epigenetics of colon carcinoma cells by bacterial membrane vesicles
Scientific Reports, Nature Publishing Group 2018, Vol. 8
Vdovikova, Svitlana; Gilfillan, Siv; Wang, Shixiong; et al.
Reversible senescence of human colon cancer cells after blockage of mitosis/cytokinesis caused by the CNF1 cyclomodulin from Escherichia coli
Scientific Reports, Nature Publishing Group 2018, Vol. 8
Zhang, Zhen; Aung, Kyaw Min; Uhlin, Bernt Eric; et al.
Induction of immunomodulatory miR-146a and miR-155 in small intestinal epithelium of Vibrio cholerae infected patients at acute stage of cholera
PLOS ONE, Vol. 12, (3)
Bitar, Aziz; De, Rituparna; Melgar, Silvia; et al.
Surface expression of Helicobacter pylori HpaA adhesion antigen on Vibrio cholerae, enhanced by co-expressed enterotoxigenic Escherichia coli fimbrial antigens
Microbial Pathogenesis, Vol. 105 : 177-184
Tobias, Joshua; Lebens, Michael; Wai, Sun Nyunt; et al.
A Novel Role of Listeria monocytogenes Membrane Vesicles in Inhibition of Autophagy and Cell Death
Frontiers in Cellular and Infection Microbiology, Frontiers Media S.A. 2017, Vol. 7
Vdovikova, Svitlana; Luhr, Morten; Szalai, Paula; et al.
Naturally Occurring IgG Antibodies Provide Innate Protection against Vibrio cholerae Bacteremia by Recognition of the Outer Membrane Protein U
Journal of Innate Immunity, Vol. 8, (3) : 269-283
Aung, Kyaw Min; Sjöström, Annika E; von Pawel-Rammingen, Ulrich; et al.
Novel Aminoglycoside Resistance Transposons and Transposon-Derived Circular Forms Detected in Carbapenem-Resistant Acinetobacter baumannii Clinical Isolates
Antimicrobial Agents and Chemotherapy, Vol. 60, (3) : 1801-1818
Karah, Nabil; Dwibedi, Chinmay Kumar; Sjöström, Karin; et al.
Cytotoxic and Inflammatory Responses Induced by Outer Membrane Vesicle-Associated Biologically Active Proteases from Vibrio cholerae
Infection and Immunity, Vol. 84, (5) : 1478-1490
Mondal, Ayan; Tapader, Rima; Chatterjee, Nabendu Sekhar; et al.
A Two-Component Regulatory System Impacts Extracellular Membrane-Derived Vesicle Production in Group A Streptococcus
mBio, Vol. 7, (6)
Resch, Ulrike; Tsatsaronis, James Anthony; Le Rhun, Anais; et al.
Visa publikationer i DiVA

Forskargrupper

Forskningsledare
Sun Nyunt Wai Lab

Forskningsprojekt

1 januari 2023 till 31 december 2025
Molekylära mekanismer vid bakterie-värd-interaktioner
Sun Nyunt Wai Lab

Klargöra mekanismer och vägar modulerade av bakterier i värdceller genom frisättning av protein.

Kolerabakterien i centrum för forskningen

Sun Nyunt Wai bedriver forskning om sjukdomsframkallande bakteriers egenskaper på molekylär nivå.