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Personalbild Sofie Degerman

Sofie Degerman

Professor i Biomedicinsk Laboratorievetenskap.

Vetenskaplig meritering: Docent

0000-0002-2783-0712

Kontakt

sofie.degerman@umu.se

090-785 28 73

Verksam som

Professor vid Institutionen för klinisk mikrobiologi Enhet: Biomedicinsk laboratorievetenskap, Avdelningen för infektion och immunologi

6F och 6M, Universitetssjukhuset by 6 o 24 Umeå universitet, 901 85 Umeå

Anknuten som forskare till Institutionen för medicinsk biovetenskap Enhet: Patologi

By 6M, vån 2, Sjukhusområdet Umeå universitet, 901 85 Umeå

CpG island methylator phenotype classification improves risk assessment in pediatric T-cell acute lymphoblastic leukemia

Blood

Schäfer Hackenhaar, Fernanda; Refhagen, Nina; Hagleitner, Melanie; et al.

Semimethylation is a feature of diffuse large B-cell lymphoma, and subgroups with poor prognosis are characterized by global hypomethylation and short telomere length

Clinical Epigenetics, BioMed Central (BMC) 2024, Vol. 16, (1)

Carlund, Olivia; Thörn, Elina; Osterman, Pia; et al.

DNA methylation variations and epigenetic aging in telomere biology disorders

Scientific Reports, Springer Nature 2023, Vol. 13, (1)

Carlund, Olivia; Norberg, Anna; Osterman, Pia; et al.

Pre-clinical evaluation of the hypomethylating agent decitabine for the treatment of t-cell lymphoblastic lymphoma

Cancers, MDPI 2023, Vol. 15, (3)

Provez, Lien; Putteman, Tom; Landfors, Mattias; et al.

Sixteen-year longitudinal evaluation of blood-based DNA methylation biomarkers for early prediction of Alzheimer’s disease

Journal of Alzheimer's Disease, IOS Press 2023, Vol. 94, (4) : 1443-1464

Schäfer Hackenhaar, Fernanda; Josefsson, Maria; Nordin Adolfsson, Annelie; et al.

DNA methylation changes and increased mRNA expression of coagulation proteins, factor V and thrombomodulin in Fuchs endothelial corneal dystrophy

Cellular and Molecular Life Sciences (CMLS), Springer 2023, Vol. 80, (3)

Westin, Ida Maria; Landfors, Mattias; Giannopoulos, Antonios; et al.

Long-Term Follow-Up of Newborns with 22q11 Deletion Syndrome and Low TRECs

Journal of Clinical Immunology, Springer 2022, Vol. 42 : 618-633

Framme, Jenny Lingman; Lundqvist, Christina; Lundell, Anna-Carin; et al.

A novel DNA methylation signature is associated with androgen receptor activity and patient prognosis in bone metastatic prostate cancer

Clinical Epigenetics, BioMed Central 2021, Vol. 13, (1)

Bovinder Ylitalo, Erik; Thysell, Elin; Landfors, Mattias; et al.

A novel association between ykl-40, a marker of structural lung disease, and short telomere length in 10-year-old children with bronchopulmonary dysplasia

Children, MDPI 2021, Vol. 8, (2)

Henckel, Ewa; James, Anna; Konradsen, Jon R.; et al.

Short leukocyte telomeres, but not telomere attrition rates, predict memory decline in the 20-year longitudinal Betula study

The journals of gerontology. Series A, Biological sciences and medical sciences, Oxford University Press 2021, Vol. 76, (6) : 955-963

Pudas, Sara; Josefsson, Maria; Nordin Adolfsson, Annelie; et al.

Short leukocyte telomeres predict 25-year Alzheimer's disease incidence in non-APOE ε4-carriers

Alzheimer's Research & Therapy, BioMed Central (BMC) 2021, Vol. 13

Schäfer Hackenhaar, Fernanda; Josefsson, Maria; Nordin Adolfsson, Annelie; et al.

Cell-of-origin determined by both gene expression profiling and immunohistochemistry is the strongest predictor of survival in patients with diffuse large B-cell lymphoma

American Journal of Hematology, Wiley-Blackwell 2020, Vol. 95, (1) : 57-67

Abdulla, Maysaa; Hollander, Peter; Pandzic, Tatjana; et al.

Combining epigenetic and clinicopathological variables improves specificity in prognostic prediction in clear cell renal cell carcinoma

Journal of Translational Medicine, Vol. 18, (1)

Andersson-Evelönn, Emma; Vidman, Linda; Källberg, David; et al.

DNA methylation and copy number variation profiling of T-cell lymphoblastic leukemia and lymphoma

Blood Cancer Journal, Nature Publishing Group 2020, Vol. 10, (4)

Haider, Zahra; Landfors, Mattias; Golovleva, Irina; et al.

Hematopoietic cellular aging is not accelerated during the first 2 years of life in children born preterm

Pediatric Research, Nature Publishing Group 2020, Vol. 88

Henckel, Ewa; Landfors, Mattias; Haider, Zahra; et al.

SIX6 is a TAL1-regulated transcription factor in T-ALL and associated with inferior outcome

Leukemia and Lymphoma, Taylor & Francis 2020, Vol. 61, (13) : 3089-3100

Laukkanen, Saara; Oksa, Laura; Nikkilä, Atte; et al.

Aging of preleukemic thymocytes drives CpG island hypermethylation in T-cell acute lymphoblastic leukemia

Blood cancer discovery, American Association for Cancer Research 2020, Vol. 1, (3) : 274-289

Roels, Juliette; Thénoz, Morgan; Szarzyńska, Bronisława; et al.

DNA methylation associates with survival in non-metastatic clear cell renal cell carcinoma

BMC Cancer, BioMed Central 2019, Vol. 19

Andersson Evelönn, Emma; Landfors, Mattias; Haider, Zahra; et al.

The association between longer relative leukocyte telomere length and risk of glioma is independent of the potentially confounding factors allergy, BMI, and smoking

Cancer Causes and Control, Springer 2019, Vol. 30, (2) : 177-185

Andersson, Ulrika; Degerman, Sofie; Dahlin, Anna M.; et al.

An integrated transcriptome analysis in T-cell acute lymphoblastic leukemia links DNA methylation subgroups to dysregulated TAL1 and ANTP homeobox gene expression

Cancer Medicine, John Wiley & Sons 2019, Vol. 8, (1) : 311-324

Haider, Zahra; Larsson, Pär; Landfors, Mattias; et al.

Characterization of an X-chromosome-linked telomere biology disorder in females with DKC1 mutation

Leukemia, Nature Publishing Group 2019, Vol. 33, (1) : 275-278

Hirvonen, Elina A. M.; Peuhkuri, Saara; Norberg, Anna; et al.

Growth-inhibition of cell lines derived from B cell lymphomas through antagonism of serotonin receptor signaling

Scientific Reports, Nature Publishing Group 2019, Vol. 9

Kolan, Shrikant S; Lidström, Tommy; Mediavilla, Tomás; et al.

DNA methylation holds prognostic information in relapsed precursor B-cell acute lymphoblastic leukemia

Clinical Epigenetics, BioMed Central 2018, Vol. 10

Borssén, Magnus; Nordlund, Jessica; Haider, Zahra; et al.

Telomere length was similar in school-age children with bronchopulmonary dysplasia and allergic asthma

Acta Paediatrica, John Wiley & Sons 2018, Vol. 107, (8) : 1395-1401

Henckel, E.; Svenson, Ulrika; Nordlund, B.; et al.

Novel variants in Nordic patients referred for genetic testing of telomere-related disorders

European Journal of Human Genetics, Nature Publishing Group 2018, Vol. 26, (6) : 858-867

Norberg, Anna; Rosén, Anna; Raaschou-Jensen, Klas; et al.

Diagnostics of rare disorders: whole-exome sequencing deciphering locus heterogeneity in telomere biology disorders

Orphanet Journal of Rare Diseases, BioMed Central (BMC) 2018, Vol. 13

Trotta, Luca; Norberg, Anna; Taskinen, Mervi; et al.

Telomere length, allergies and risk of Glioma

Neuro-Oncology, Oxford University Press 2017, Vol. 19, (S3) : 23-23

Andersson, Ulrika; Degerman, Sofie; Dahlin, Anna; et al.

Maintained memory in aging is associated with young epigenetic age

Neurobiology of Aging, Elsevier 2017, Vol. 55 : 167-171

Degerman, Sofie; Josefsson, Maria; Nordin Adolfsson, Annelie; et al.

Short telomere length is associated with impaired cognitive performance in European ancestry cohorts

Translational Psychiatry, Vol. 7

Hagg, S.; Zhan, Y.; Karlsson, R.; et al.

Decreased telomere length in children with cartilage-hair hypoplasia

Journal of Medical Genetics, BMJ PUBLISHING GROUP 2017, Vol. 54, (5) : 365-370

Kostjukovits, Svetlana; Degerman, Sofie; Pekkinen, Minna; et al.

DNA methylation status defines clinicopathological parameters including survival for patients with clear cell renal cell carcinoma (ccRCC)

Tumor Biology, Vol. 37, (8) : 10219-10228

Andersson Evelönn, Emma; Degerman, Sofie; Köhn, Linda; et al.

DNA Methylation Adds Prognostic Value to Minimal Residual Disease Status in Pediatric T-Cell Acute Lymphoblastic Leukemia

Pediatric Blood & Cancer, Vol. 63, (7) : 1185-1192

Borssén, Magnus; Haider, Zahra; Landfors, Mattias; et al.

Long telomeres are associated with clonality in wild populations of the fissiparous starfish Coscinasterias tenuispina

Heredity, Vol. 115, (5) : 437-443

Garcia-Cisneros, A.; Perez-Portela, R.; Almroth, B. C.; et al.

Long Leukocyte Telomere Length at Diagnosis Is a Risk Factor for Dementia Progression in Idiopathic Parkinsonism

PLOS ONE, Vol. 9, (12)

Degerman, Sofie; Domellöf, Magdalena; Landfors, Mattias; et al.

Immortalization of T-Cells Is Accompanied by Gradual Changes in CpG Methylation Resulting in a Profile Resembling a Subset of T-Cell Leukemias

Neoplasia, Vol. 16, (7) : 606-615

Degerman, Sofie; Landfors, Mattias; Siwicki, Jan Konrad; et al.

Prognostic Implications of Mutations in NOTCH1 and FBXW7 in Childhood T-ALL Treated According to the NOPHO ALL-1992 and ALL-2000 Protocols

Pediatric Blood & Cancer, Wiley-Blackwell 2014, Vol. 61, (3) : 424-430

Fogelstrand, Linda; Staffas, Anna; Wasslavik, Carina; et al.

Promoter DNA methylation pattern identifies prognostic subgroups in childhood T-cell acute lymphoblastic leukemia

PLOS ONE, Vol. 8, (6) : e65373-

Borssen, Magnus; Palmqvist, Lars; Karrman, Kristina; et al.

Short telomere length is associated with NOTCH1/SF3B1/TP53 aberrations and poor outcome in newly diagnosed chronic lymphocytic leukemia patients

American Journal of Hematology, Vol. 88, (8) : 647-651

Mansouri, Larry; Grabowski, Pawel; Degerman, Sofie; et al.

Telomerase upregulation is a postcrisis event during senescence bypass and immortalization of two Nijmegen breakage syndrome T cell cultures

Aging Cell, John Wiley & Sons 2010, Vol. 9 : 220-235

Degerman, Sofie; Siwicki, Jan Konrad; Osterman, Pia; et al.

Wilms' tumour 1 can suppress hTERT gene expression and telomerase activity in clear cell renal cell carcinoma via multiple pathways

British Journal of Cancer, Vol. 103, (8) : 1255-1262

Sitaram, Raviprakash T; Degerman, Sofie; Ljungberg, Börje; et al.

Spontaneously immortalized human T lymphocytes develop gain of chromosomal region 2p13-24 as an early and common genetic event

Genes, Chromosomes and Cancer, Vol. 41, (2) : 133-144

Siwicki, Jan Konrad; Berglund, Mattias; Rygier, Jolanta; et al.

Telomere maintenance and cell cycle regulation in spontaneously immortalized T-cell lines from Nijmegen breakage syndrome patients

Experimental Cell Research, Vol. 287, (1) : 178-189

Siwicki, Jan Konrad; Degerman, Sofie; Chrzanowska, Krystyna H; et al.

Combining epigenetic and clinicopathological variables improves prognostic prediction in clear cell Renal Cell Carcinoma

Andersson-Evelönn, Emma; Vidman, Linda; Källberg, David; et al.

Integrated DNA methylation and gene expression analysis of molecular heterogeneity in prostate cancer bone metastasis

Bovinder Ylitalo, Erik; Thysell, Elin; Landfors, Mattias; et al.

Functional analysis of telomerase activity in T-lymphocytes as a diagnostic tool for pathogenicity assessment of novel genetic variants in telomere biology disorders

Carlund, Olivia; Norberg, Anna; Osterman, Pia; et al.

Senescence bypass and immortalization of T cell cultures are linked to stepwise DNA methylation changes

Degerman, Sofie; Borssen, Magnus; Andersson, Emma; et al.

The NBS1 gene is overexpressed and regulated by DJ-1 in clear cell renal cell carcinoma

Degerman, Sofie; Tumkur Sitaram, Raviprakash; Ljungberg, Börje; et al.

Epigenetic and genetic distinctions between T-cell acute lymphoblastic leukemia and lymphoma

Haider, Zahra; Landfors, Mattias; Golovleva, Irina; et al.

Telomere length is a robust prognostic marker in early chronic lymphocytic leukemia

Mansouri, Larry; Grabowski, Pawel; Degerman, Sofie; et al.

Visa publikationer i DiVA

Forskargrupper

Forskningsledare

Sofie Degermans labb

Forskningsprojekt

1 januari 2022 till 1 januari 2025

Epigenetiska klockor: modellering av biomarkörer för att mäta och förutsäga biologiskt åldrande

Publicerad: 08 nov, 2024

Nya Cancerfondsmiljoner till UMU-forskning

Publicerad: 16 jan, 2024

Cancerforskningsfonden i Norrland delar ut 75 miljoner kronor

Publicerad: 12 nov, 2020

Nya Cancerfondsmiljoner till forskning vid Umeå universitet

Publicerad: 14 feb, 2020

Risk för spridd njurcancer bedöms med DNA-markör

Publicerad: 08 mar, 2019

Epigenetisk markör kan förutsäga överlevnad vid barnleukemi

Sofie Degerman: DNA-mönster avslöjar risk för återfall vid barnleukemi

Idag överlever drygt 8 av 10 barn som drabbas av leukemi, och forskarna försöker öka överlevnaden och minska b...