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Umeå universitet
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Huvudmenyn dold.
Personalbild Richard Lundmark

Richard Lundmark

Professor i histologi med cellbiologi. Föreståndare för Biochemical Imaging Centre Umeå (BICU)

Jag studerar transport av molekyler i celler. Mer om vår forskning se: www.lundmark-lab.se

Kontakt

E-post
richard.lundmark@umu.se
Telefon
090-786 93 01, 070-620 24 64

Verksam vid

Anknytning
Professor vid Institutionen för medicinsk och translationell biologi Enhet: Grupp Richard Lundmark
Plats
hus H, Johan Bures väg 12, Biologihuset Umeå universitet, 901 87 Umeå
Anknytning
Anknuten som universitetslektor till Molekylär Infektionsmedicin, Sverige (MIMS)
Plats
6L, Institutionen för molekylärbiologi Institutionen för molekylärbiologi, 90187 Umeå

Vi studerar de proteiner och mekanismer som krävs för att skulptera cellulära membran till vesikulära strukturer, vilket är nödvändigt för trafikering och sortering av proteiner och lipider i cellen. Skulptering av membraner är grundläggande för många cellulära processer och fel kan leda till ett brett spektrum av sjukdomar. Vår grupp fokuserar på att förstå de underliggande mekanismerna och vikten av membranskulptering vid infektion, cancer, fetma och lipiddystrofier.

Vi använder en rad olika tekniker som sträcker sig från protein och lipidbiokemi, och strukturell analys till avancerad höghastighetsavbildning av molekyler i levande celler och korrelativa imaging-metoder för ultrastrukturell upplösning. För visualisering har vi etablerat Biochemical Imaging Centre Umeå (BICU), som är en öppen facilitet för mikroskopitekniker och som tillsammans med Umeå Centre for Electron Microscopy (UCEM) bildar en nationell nod för korrelativ imaging.

 

För mer information kring vår forskning se: www.lundmark-lab.se

 

Forskargrupp:

Elin Larsson, PhD, labmanager

Ankita Shukla, PhD, post doc

Kang Cheng Liu, PhD, post doc

Wai Lok Yau, PhD, post doc

Sebastian Rönfeldt, PhD, post doc

Albin Jakobsson, Forskaraspirant vid läkarprogrammet

 

The adaptable caveola coat generates a plasma membrane sensory system
Current Opinion in Cell Biology, Elsevier 2024, Vol. 88
Lundmark, Richard; Larsson, Elin; Pulkkinen, I. A. Lauri
Is endocytosis by caveolae dependent on dynamin?
Nature reviews. Molecular cell biology, Springer Nature 2024, Vol. 25, (7) : 511-512
Parton, Robert G.; Taraska, Justin W.; Lundmark, Richard
Dynamin2 functions as an accessory protein to reduce the rate of caveola internalization
Journal of Cell Biology, Rockefeller University Press 2023, Vol. 222, (4)
Larsson, Elin; Morén, Björn; McMahon, Kerrie-Ann; et al.
Simultaneous membrane and RNA binding by tick-borne encephalitis virus capsid protein
PLoS Pathogens, Public Library of Science 2023, Vol. 19, (2)
Pulkkinen, Lauri Ilmari Aurelius; Barrass, Sarah Victoria; Lindgren, Marie; et al.
Expansion of the Inguinal Adipose Tissue Depot Correlates With Systemic Insulin Resistance in C57BL/6J Mice
Frontiers in Cell and Developmental Biology, Frontiers Media S.A. 2022, Vol. 10
Fryklund, Claes; Neuhaus, Mathis; Morén, Björn; et al.
Caveolae biogenesis and lipid sorting at the plasma membrane
Plasma membrane shaping, Academic Press 2022 : 219-228
Hubert, Madlen; Larsson, Elin; Liu, Kang Cheng; et al.
Membrane insertion mechanism of the caveola coat protein Cavin1
Proceedings of the National Academy of Sciences of the United States of America, Proceedings of the National Academy of Sciences 2022, Vol. 119, (25)
Liu, Kang-Cheng; Pace, Hudson; Larsson, Elin; et al.
PIP5K1α is Required for Promoting Tumor Progression in Castration-Resistant Prostate Cancer
Frontiers in Cell and Developmental Biology, Frontiers Media S.A. 2022, Vol. 10
Wang, Tianyan; Sarwar, Martuza; Whitchurch, Jonathan B.; et al.
Induction of Epithelial-mesenchymal Transition in MDCK II Cells
Bio-protocol, Bio-protocol 2021, Vol. 11, (3)
Pastula, Agnieszka; Lundmark, Richard
A Comparison of Chitosan, Mesoporous Silica and Poly(lactic-co-glycolic) Acid Nanocarriers for Optimising Intestinal Uptake of Oral Protein Therapeutics
Journal of Pharmaceutical Sciences, Elsevier 2021, Vol. 110, (1) : 217-227
Wright, Leah; Joyce, Paul; Barnes, Timothy J.; et al.
Keeping in touch with the membrane; protein- and lipid-mediated confinement of caveolae to the cell surface
Biochemical Society Transactions, PORTLAND PRESS LTD 2020, Vol. 48 : 155-163
Hubert, Madlen; Larsson, Elin; Lundmark, Richard
Lipid accumulation controls the balance between surface connection and scission of caveolae
eLIFE, eLife Sciences Publications Ltd 2020, Vol. 9
Hubert, Madlen; Larsson, Elin; Vegesna, Naga Venkata Gayathri; et al.
Analysis of protein and lipid interactions using liposome co-sedimentation assays
Caveolae: methods and protocols, Humana Press 2020 : 119-127
Larsson, Elin; Hubert, Madlen; Lundmark, Richard
EHD2-mediated restriction of caveolar dynamics regulates cellular fatty acid uptake
Proceedings of the National Academy of Sciences of the United States of America, NATL ACAD SCIENCES 2020, Vol. 117, (13) : 7471-7481
Matthaeus, Claudia; Lahmann, Ines; Kunz, Severine; et al.
Caveolae: The FAQs
Traffic: the International Journal of Intracellular Transport, John Wiley & Sons 2020, Vol. 21, (1) : 181-185
Parton, Robert G.; del Pozo, Miguel A.; Vassilopoulos, Stephane; et al.
Role of Membrane Tension Sensitive Endocytosis and Rho GTPases in the Uptake of the Alzheimer’s Disease Peptide Aβ(1-42)
ACS Chemical Neuroscience, American Chemical Society (ACS) 2020, Vol. 11, (13) : 1925-1936
Wesen, Emelie; Lundmark, Richard; Esbjörner, Elin K.
Photoactivated Colibactin Probes Induce Cellular DNA Damage
Angewandte Chemie International Edition, Vol. 58, (5) : 1417-1421
Moodie, Lindon W. K.; Hubert, Madlen; Zhou, Xin; et al.
EHD2 regulates adipocyte function and is enriched at cell surface-associated lipid droplets in primary human adipocytes
Molecular Biology of the Cell, AMER SOC CELL BIOLOGY 2019, Vol. 30, (10) : 1147-1159
Moren, Bjorn; Hansson, Bjorn; Negoita, Florentina; et al.
Cellular uptake of self-assembled phytantriol-based hexosomes is independent of major endocytic machineries
Journal of Colloid and Interface Science, Elsevier 2019, Vol. 553 : 820-833
Rodrigues, Leticia; Schneider, Fabian; Zhang, Xiaohan; et al.
Model System for the Formation of Tick-Borne Encephalitis Virus Replication Compartments without Viral RNA Replication
Journal of Virology, AMER SOC MICROBIOLOGY 2019, Vol. 93, (18)
Yau, Wai-Lok; Nguyen-Dinh, Van; Larsson, Elin; et al.
Simultaneous determination of ribonucleoside and deoxyribonucleoside triphosphates in biological samples by hydrophilic interaction liquid chromatography coupled with tandem mass spectrometry
Nucleic Acids Research, Oxford University Press 2018, Vol. 46, (11)
Kong, Ziqing; Jia, Shaodong; Chabes, Anna Lena; et al.
Plasma membrane damage caused by listeriolysin O is not repaired through endocytosis of the membrane pore
Biology Open, The Company of Biologists 2018, Vol. 7, (10)
Nygård Skalman, Lars; Holst, Mikkel R.; Larsson, Elin; et al.
Viperin targets flavivirus virulence by inducing assembly of non-infectious capsid particles
Journal of Virology, American Society of Microbiology 2018, Vol. 92, (1)
Vonderstein, Kirstin; Nilsson, Emma; Hubel, Philipp; et al.
Cooperative but distinct early co-signaling events originate from ERBB2 and ERBB1 receptors upon trastuzumab treatment in breast cancer cells
Oncotarget, IMPACT JOURNALS LLC 2017, Vol. 8, (36) : 60109-60122
Bagnato, Paola; Castagnino, Alessia; Cortese, Katia; et al.
Control of actin polymerization via the coincidence of phosphoinositides and high membrane curvature
Journal of Cell Biology, ROCKEFELLER UNIV PRESS 2017, Vol. 216, (11) : 3745-3765
Daste, Frederic; Walrant, Astrid; Holst, Mikkel R.; et al.
Determining membrane bound protein structures by infrared reflection-absorption spectroscopy
European Biophysics Journal, Springer 2017, Vol. 46 : S161-S161
Hoernke, M.; Mohan, J.; Larsson, Elin; et al.
EHD2 restrains dynamics of caveolae by an ATP-dependent, membrane-bound, open conformation
Proceedings of the National Academy of Sciences of the United States of America, Vol. 114, (22) : E4360-E4369
Hoernke, Maria; Mohan, Jagan; Larsson, Elin; et al.
Clathrin-Independent Endocytosis Suppresses Cancer Cell Blebbing and Invasion
Cell Reports, Cell Press 2017, Vol. 20, (8) : 1893-1905
Holst, Mikkel Roland; Vidal-Quadras, Maite; Larsson, Elin; et al.
Caveolae dynamics is strongly influenced by the lipid composition of the plasma membrane
European Biophysics Journal, Springer 2017, Vol. 46 : S121-S121
Hubert, Madlen; Larsson, Elin; Lundmark, Richard
CCL11, a novel mediator of inflammatory bone resorption
Scientific Reports, Nature Publishing Group 2017, Vol. 7, (1)
Kindstedt, Elin; Koskinen Holm, Cecilia; Sulniute, Rima; et al.
Structural insights into the activation mechanism of dynamin-like EHD ATPases
Proceedings of the National Academy of Sciences of the United States of America, Vol. 114, (22) : 5629-5634
Melo, Arthur Alves; Hegde, Balachandra G.; Shah, Claudio; et al.
Human Adenovirus Type 37 Uses αVβ1 and α3β1 Integrins for Infection of Human Corneal Cells
Journal of Virology, Vol. 91, (5)
Storm, Rickard J; Persson, David B; Skalman, Lars Nygård; et al.
A Novel Role of Listeria monocytogenes Membrane Vesicles in Inhibition of Autophagy and Cell Death
Frontiers in Cellular and Infection Microbiology, Frontiers Media S.A. 2017, Vol. 7
Vdovikova, Svitlana; Luhr, Morten; Szalai, Paula; et al.
Endocytic turnover of Rab8 controls cell polarization
Journal of Cell Science, Vol. 130, (6) : 1147-1157
Vidal-Quadras, Maite; Holst, Mikkel R.; Francis, Monika K.; et al.
Structural Mechanism in a Membrane Remodelling ATP-ASE
Biophysical Journal, Vol. 110, (3) : 578A-578A
Hoernke, Maria; Larsson, Elin; Mohan, Jagan; et al.
Endocytic membrane turnover at the leading edge is driven by a transient interaction between Cdc42 and GRAF1
Journal of Cell Science, Vol. 128, (22) : 4183-4195
Francis, Monika K.; Holst, Mikkel R.; Vidal-Quadras, Maite; et al.
Cavin3 interacts with cavin1 and caveolin1 to increase surface dynamics of caveolae
Journal of Cell Science, Vol. 128, (5) : 979-991
Mohan, Jagan; Morén, Björn; Larsson, Elin; et al.
Outer Membrane Vesicle-Mediated Export of Processed PrtV Protease from Vibrio cholerae
PLOS ONE, Vol. 10, (7)
Rompikuntal, Pramod K.; Vdovikova, Svitlana; Duperthuy, Marylise; et al.
Uptake of Helicobacter pylori vesicles is facilitated by clathrin-dependent and clathrin-independent endocytic pathways
mBio, Vol. 5, (3) : e00979-14-
Olofsson, Annelie; Nygård Skalman, Lars; Obi, Ikenna; et al.
Structural insights into membrane interaction and caveolar targeting of dynamin-like EHD2
Structure, Vol. 22, (3) : 409-420
Shah, Claudio; Hegde, Balachandra G; Morén, Björn; et al.
The HSP90 inhibitor geldanamycin perturbs endosomal structure and drives recycling ErbB2 and transferrin to modified MVBs/lysosomal compartments
Molecular Biology of the Cell, The American Society for Cell Biology 2013, Vol. 24, (2) : 129-144
Cortese, Katia; Howes, Mark T.; Lundmark, Richard; et al.
EHD2 regulates caveolar dynamics via ATP-driven targeting and oligomerization
Molecular Biology of the Cell, American society for cell biology 2012, Vol. 23, (7) : 1316-1329
Morén, Björn; Shah, Claudio; Howes, Mark T; et al.
The endocytic protein GRAF1 is directed to cell-matrix adhesion sites and regulates cell spreading
Molecular Biology of the Cell, Bethesda: American Society for Cell Biology 2011, Vol. 22, (22) : 4380-4389
Doherty, Gary J.; Åhlund, Monika K.; Howes, Mark T.; et al.
Clathrin-independent carriers form a high capacity endocytic sorting system at the leading edge of migrating cells
Journal of Cell Biology, Rockefeller University Press 2010, Vol. 190, (4) : 675-691
Howes, Mark T; Kirkham, Matthew; Riches, James; et al.
Driving membrane curvature in clathrin-dependent and clathrin-independent endocytosis.
Seminars in Cell and Developmental Biology, Vol. 21, (4) : 363-70
Lundmark, Richard; Carlsson, Sven R
GRAF1-dependent endocytosis
Biochemical Society Transactions, London: Portland Press 2009, Vol. 37, (5) : 1061-1065
Doherty, Gary J; Lundmark, Richard
A BAR domain-mediated autoinhibitory mechanism for RhoGAPs of the GRAF family
Biochemical Journal, Vol. 417, (1) : 371-377
Eberth, Alexander; Lundmark, Richard; Gremer, Lothar; et al.
SNX9 - a prelude to vesicle release
Journal of Cell Science, Vol. 122, (1) : 5-11
Lundmark, Richard; Carlsson, Sven R
SNX18 is an SNX9 paralog that acts as a membrane tubulator in AP-1-positive endosomal trafficking.
Journal of Cell Science, Vol. 121, (Pt 9) : 1495-505
Håberg, Karin; Lundmark, Richard; Carlsson, Sven
The GTPase-activating protein GRAF1 regulates the CLIC/GEEC endocytic pathway
Current Biology, Vol. 18, (22) : 1802-1808
Lundmark, Richard; Doherty, Gary J; Howes, Mark T; et al.
Visa publikationer i DiVA

Forskargrupper

Forskningsledare
Richard Lundmark Lab

Forskningsprojekt

1 januari 2023 till 31 december 2026
Ultrasnabb mid-infraröd fototermisk avbildning av fettsyror och lipiddroppar i levande celler
1 januari 2022 till 31 december 2025
Drivkrafter för bildandet av stabila membranvesiklar i celler

Jag undervisar inom biokemi, cellbiologi, histologi och mikroskopi vid läkarprogrammet, tandläkarprogrammet och biomedicinprogrammet vid UmU.

Film: Richard Lundmark, professor i histologi med cellbiologi
Richard Lundmark, professor i histologi med cellbiologi

Richard Lundmark forskar om hur proteiner och lipider påverkar mebranen runt celler. Målet är att designa läkemedel som kan motverka fetma och virusinfektioner.

Cellens väggar nyckeln i kampen mot många sjukdomar

Virus skapar egna rum i cellens väggar, där de i hemlighet kan kopiera sin arvsmassa och göra stor skada.

Skulptering av cellens membran

Målet med Richard Lundmarks forskning är kunna designa läkemedel som kan motverka fetma och virusinfektioner.

Richard Lundmark: Cellens nanoarkitektur – viktig roll vid infektion och fetma

I cellernas väggar kan det bildas små strukturer som har en viktig roll bland annat när våra celler blir infek...

Film: Forskning på ett ögonblick med Richard Lundmark
Forskning på ett ögonblick med Richard Lundmark

Fokus ligger på att förstå underliggande mekanismer vid infektion, cancer och fetma.