Pressbild

Patrik Danielson

Professor i anatomi

Överläkare i ögonsjukdomar

Dekan för Medicinska fakulteten

Kontakt

patrik.danielson@umu.se

Besöksadress, se karta

090-786 58 93, 070-336 80 30

Verksam som

Professor, överläkare vid Institutionen för medicinsk och translationell biologi Enhet: Lärare A-flygeln, Grupp Patrik Danielson

Anknuten som professor till Kansliet för medicin

Dekans sekreterare: Anna Olson

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Professor i anatomi vid Umeå universitet och överläkare i ögonsjukdomar vid Norrlands universitetssjukhus,
samt Dekan för Medicinska fakulteten.

Publikationslista:
Google Scholar-profil för Patrik Danielson

Forskningsprojekt:
Mekanismer för ärrbildning och vävnadsnedbrytning i kollagenrik vävnad

____________________________

CV | Curriculum Vitae | PATRIK DANIELSON

Personligt

Född 1980, uppvuxen i Kramfors, Ångermanland.

Akademiska meriter och anställningar

2016 | Professor/Överläkare, anatomi/specialist i ögonsjukdomar
2014 | Professor i anatomi
2012 | Docent i anatomi
2009 | Universitetslektor i anatomi
2007 | Medicine doktor (Med.dr), anatomi
2007 | Leg. läkare
2005 | Läkarexamen

Förtroendeuppdrag (urval)

Dekan, Medicinska fakulteten, Umeå universitet, 2017-
Ledamot, Regeringskansliets rådgivande grupp för life science, 2024-
Vice ordförande, Svenska Läkaresällskapet, 2024-07-01--
Styrelseledamot, Svenska Sällskapet för Medicinsk Forskning (SSMF), 2019-
Ordförande, Nationella styrgruppen för ALF-avtalet, 2021
Ledamot (regeringsutsedd), Nationella styrgruppen för ALF-avtalet, 2015-18; 2019-2022 (adjungerad från 2023)
Ledamot (regeringsutsedd), Kommittén för kliniska studier, Vetenskapsrådet, 2018-2020
Ledamot, Svenska Läkaresällskapets nämnd, 2015-18
Prodekan, Medicinska fakulteten, Umeå universitet, 2014-17
Ledamot (lärarrepresentant), medicinska fakultetsnämnden, Umeå universitet, 2011-14
Ledamot (studeranderepresentant), universitetsstyrelsen, Umeå universitet, 2002-04
Ledamot (studeranderepresentant), medicinska fakultetsnämnden, Umeå universitet, 2001-04
Kårordförande, Umeå Medicinska Studentkår (tidigare Corpus), 2002-04

Nationella forskningsanslag (som huvudsökande; urval)

2018-21 | Vetenskapsrådet: 4 800 tkr
2014-17 | Vetenskapsrådet: 5 044 tkr
2010-12 | Vetenskapsrådet: 2 100 tkr
2017-23 | Ögonfonden: 1 160 tkr
2011-15 | Svenska Läkaresällskapet: 1 200 tkr
2011-17 | Cronqvists stiftelse: 900 tkr

Vetenskapliga publikationer

Länk till Google Scholar-profil

Priser och utmärkelser

European Society of Ophthalmology (SOE) Speaker of the Year på Svenska Ögonläkarföreningens Årsmöte 2017
Svenska Läkaresällskapets pris för bästa translationella forskning 2013
Umeå universitets karriärbidrag 2011
Kungl. Skytteanska Samfundets pris till yngre forskare vid Medicinska fakulteten 2010
Hedersmedlem på livstid i Umeå Medicinska Studentkår, 2007

Corneal strain influences keratocyte proliferation and migration through upregulation of ALDH3A1 expression

The FASEB Journal, John Wiley & Sons 2024, Vol. 38, (23)

Zhang, Qian; Zhou, Xin; Zhang, Wei; et al.

Keratocyte Differentiation Is Regulated by NF-κB and TGFβ Signaling Crosstalk

International Journal of Molecular Sciences, MDPI 2022, Vol. 23, (19)

Zhou, Xin; Li, Junhong; Backman, Ludvig J.; et al.

Microstructured collagen films for 3D corneal stroma modelling

Connective Tissue Research, Taylor & Francis Group 2022, Vol. 63, (5) : 443-452

Prittinen, Juha; Zhou, Xin; Bano, Fouzia; et al.

Activation of NF-κB signaling via cytosolic mitochondrial RNA sensing in kerotocytes with mitochondrial DNA common deletion

Scientific Reports, Nature Publishing Group 2021, Vol. 11, (1)

Zhou, Xin; Backman, Ludvig J.; Danielson, Patrik

Acetylcholine decreases formation of myofibroblasts and excessive extracellular matrix production in an in vitro human corneal fibrosis model

Journal of Cellular and Molecular Medicine, John Wiley & Sons 2020, Vol. 24, (8) : 4850-4862

Sloniecka, Marta; Danielson, Patrik

Regulation of Keratocyte Phenotype and Cell Behavior by Substrate Stiffness

ACS Biomaterials Science & Engineering, American Chemical Society (ACS) 2020, Vol. 6, (9) : 5162-5171

Chen, Jialin; Backman, Ludvig J.; Zhang, Wei; et al.

Sustained Release of TPCA-1 from Silk Fibroin Hydrogels Preserves Keratocyte Phenotype and Promotes Corneal Regeneration by Inhibiting Interleukin-1β Signaling

Advanced Healthcare Materials, Wiley-VCH Verlagsgesellschaft 2020, Vol. 9, (17)

Zhang, Wei; Chen, Jialin; Qu, Mingli; et al.

Induction of Fibroblast Senescence During Mouse Corneal Wound Healing

Investigative Ophthalmology and Visual Science, ASSOC RESEARCH VISION OPHTHALMOLOGY INC 2019, Vol. 60, (10) : 3669-3679

Wang, Xiaolei; Qu, Mingli; Li, Jing; et al.

Substance P induces fibrotic changes through activation of the RhoA/ROCK pathway in an in vitro human corneal fibrosis model

Journal of Molecular Medicine, Springer Berlin/Heidelberg 2019, Vol. 97, (10) : 1477-1489

Sloniecka, Marta; Danielson, Patrik

Mechanical stress potentiates the differentiation of periodontal ligament stem cells into keratocytes

British Journal of Ophthalmology, BMJ Publishing Group Ltd 2018, Vol. 102, (4) : 562-569

Chen, Jialin; Zhang, Wei; Backman, Ludvig J.; et al.

Ascorbic Acid Promotes the Stemness of Corneal Epithelial Stem/Progenitor Cells and Accelerates Epithelial Wound Healing in the Cornea

Stem Cells Translational Medicine, WILEY 2017, Vol. 6, (5) : 1356-1365

Chen, Jialin; Lan, Jie; Liu, Dongle; et al.

Corneal Epithelium-Derived Neurotrophic Factors Promote Nerve Regeneration

Investigative Ophthalmology and Visual Science, ASSOC RESEARCH VISION OPHTHALMOLOGY INC 2017, Vol. 58, (11) : 4695-4702

Di, Guohu; Qi, Xia; Zhao, Xiaowen; et al.

Glutamate signaling through the NMDA receptor reduces the expression of scleraxis in plantaris tendon derived cells

BMC Musculoskeletal Disorders, Vol. 18

Spang, Christoph; Backman, Ludvig J.; Le Roux, Sandrine; et al.

Substance P and patterned silk biomaterial stimulate periodontal ligament stem cells to form corneal stroma in a bioengineered three-dimensional model

Stem Cell Research & Therapy, BIOMED CENTRAL LTD 2017, Vol. 8

Chen, Jialin; Zhang, Wei; Kelk, Peyman; et al.

Surface Topography and Mechanical Strain Promote Keratocyte Phenotype and Extracellular Matrix Formation in a Biomimetic 3D Corneal Model

Advanced Healthcare Materials, Wiley-VCH Verlagsgesellschaft 2017, Vol. 6, (5)

Zhang, Wei; Chen, Jialin; Backman, Ludvig J.; et al.

Antiapoptotic Effect of Acetylcholine in Fas-Induced Apoptosis in Human Keratocytes

Investigative Ophthalmology and Visual Science, Vol. 57, (14) : 5892-5902

Sloniecka, Marta; Backman, Ludvig J.; Danielson, Patrik

Ciliary Neurotrophic Factor Promotes the Migration of Corneal Epithelial Stem/progenitor Cells by Up-regulation of MMPs through the Phosphorylation of Akt

Scientific Reports, Vol. 6

Chen, Jialin; Chen, Peng; Backman, Ludvig J.; et al.

Substance P Enhances Keratocyte Migration and Neutrophil Recruitment through Interleukin-8

Molecular Pharmacology, Vol. 89, (2) : 215-225

Sloniecka, Marta; Le Roux, Sandrine; Zhou, Qingjun; et al.

Acetylcholine enhances keratocyte proliferation through muscarinic receptor activation.

International Immunopharmacology, Vol. 29, (1) : 57-62

Słoniecka, Marta; Backman, Ludvig J; Danielson, Patrik

Expression Profiles of Neuropeptides, Neurotransmitters, and Their Receptors in Human Keratocytes In Vitro and In Situ

PLOS ONE, Public library science 2015, Vol. 10, (7)

Sloniecka, Marta; Le Roux, Sandrine; Boman, Peter; et al.

Mutations in Collagen, Type XVII, Alpha 1 (COL17A1) Cause Epithelial Recurrent Erosion Dystrophy (ERED)

Human Mutation, John Wiley & Sons 2015, Vol. 36, (4) : 463-473

Jonsson, Frida; Byström, Berit; Davidson, Alice E.; et al.

Substance P promotes diabetic corneal epithelial wound healing through molecular mechanisms mediated via the neurokinin-1 receptor.

Diabetes, Vol. 63, (12) : 4262-4274

Yang, Lingling; Di, Guohu; Qi, Xia; et al.

Substance P reduces TNF-α-induced apoptosis in human tenocytes through NK-1 receptor stimulation

British Journal of Sports Medicine, BMJ Publishing Group Ltd 2014, Vol. 48, (19) : 1414-1420

Backman, Ludvig J.; Eriksson, Daniella E.; Danielson, Patrik

Akt-mediated anti-apoptotic effects of substance P in Anti-Fas-induced apoptosis of human tenocytes

Journal of Cellular and Molecular Medicine, Wiley-Blackwell 2013, Vol. 17, (6) : 723-733

Backman, Ludvig J; Danielson, Patrik

Alpha-2 adrenergic stimulation triggers Achilles tenocyte hypercellularity: comparison between two model systems

Scandinavian Journal of Medicine and Science in Sports, John Wiley & Sons 2013, Vol. 23, (6) : 687-696

Backman, Ludvig J; Andersson, Gustav; Fong, Gloria; et al.

Human tenocytes are stimulated to proliferate by acetylcholine through an EGFR signalling pathway

Cell and Tissue Research, Springer-Verlag New York 2013, Vol. 351, (3) : 465-475

Fong, Gloria; Backman, Ludvig; Andersson, Gustav; et al.

Sports and exercise-related tendinopathies: a review of selected topical issues by participants of the second International Scientific Tendinopathy Symposium (ISTS) Vancouver 2012

British Journal of Sports Medicine, London, England: BMJ Publishing Group 2013, Vol. 47, (9) : 536-+

Scott, Alex; Docking, Sean; Vicenzino, Bill; et al.

Substance P enhances collagen remodeling and MMP-3 expression by human tenocytes

Journal of Orthopaedic Research, HOBOKEN, NJ, USA: Wiley-Blackwell 2013, Vol. 31, (1) : 91-98

Fong, Gloria; Backman, Ludvig J.; Hart, David A.; et al.

In situ hybridization studies favouring the occurrence of a local production of BDNF in the human Achilles tendon

Histology and Histopathology, Vol. 27, (9) : 1239-1246

Bagge, Johan; Danielson, Patrik; Forsgren, Sture

Endogenous substance P production in the Achilles tendon increases with loading in an in vivo model of tendinopathy: peptidergic elevation preceding tendinosis-like tissue changes

Journal of Musculoskeletal and Neuronal Interactions - JMNI, International Society of Musculoskeletal and Neuronal Interactions 2011, Vol. 11, (2) : 133-140

Backman, Ludvig; Andersson, Gustav; Wennstig, Gabriel; et al.

Low range of ankle dorsiflexion predisposes for patellar tendinopathy in junior elite basketball players: a 1-year prospective study

American Journal of Sports Medicine, Vol. 39, (12) : 2626-2633

Backman, Ludvig J; Danielson, Patrik

Mechanical force modulates scleraxis expression in bioartificial tendons

Journal of Musculoskeletal and Neuronal Interactions - JMNI, International Society of Musculoskeletal and Neuronal Interactions 2011, Vol. 11, (2) : 124-132

Scott, A; Danielson, Patrik; Abraham, T; et al.

Physical activity level in Achilles tendinosis is associated with blood levels of pain-related factors: a pilot study

Scandinavian Journal of Medicine and Science in Sports, Vol. 21, (6) : E430-E438

Bagge, Johan; Gaida, JE; Danielson, Patrik; et al.

Substance P accelerates hypercellularity and angiogenesis in tendon tissue and enhances paratendinitis in response to Achilles tendon overuse in a tendinopathy model

British Journal of Sports Medicine, Loughborough: British Assoc. of Sport and Medicine 2011, Vol. 45, (13) : 1017-1022

Andersson, Gustav; Backman, Ludvig; Scott, Alexander; et al.

Substance P is a mechanoresponsive, autocrine regulator of human tenocyte proliferation

PLOS ONE, San Francisco, USA: Public Library of Science 2011, Vol. 6, (11) : e27209-

Backman, Ludvig; Fong, Gloria; Andersson, Gustav; et al.

Immunohistochemical evidence of local production of catecholamines in cells of the muscle origins at the lateral and medial humeral epicondyles: of importance for the development of tennis and golfer's elbow?

British Journal of Sports Medicine, Vol. 43, (4) : 269-275

Zeisig, Eva; Ljung, B-O; Alfredson, Håkan; et al.

Novel information on the non-neuronal cholinergic system in orthopedics provides new possible treatment strategies for inflammatory and degenerative diseases

Orthopedic Reviews, Vol. 1, (1) : 39-46

Forsgren, Sture; Alfredson, Håkan; Bjur, Dennis; et al.

Reviving the "biochemical" hypothesis for tendinopathy: new findings suggest the involvement of locally produced signal substances

British Journal of Sports Medicine, BMJ Publishing Group 2009, Vol. 43, (4) : 265-268

Danielson, Patrik

Immunohistochemical and in situ hybridization observations favor a local catecholamine production in the human Achilles tendon

Histology and Histopathology, Vol. 23, (2) : 197-208

Bjur, Dennis; Danielson, Patrik; Alfredson, Håkan; et al.

Marked sympathetic component in the perivascular innervation of the dorsal paratendinous tissue of the patellar tendon in arthroscopically treated tendinosis patients.

Knee Surgery, Sports Traumatology, Arthroscopy, Vol. 16, (6) : 621-6

Danielson, Patrik; Andersson, Gustav; Alfredson, Håkan; et al.

Presence of a non-neuronal cholinergic system and occurrence of up- and down-regulation in expression of M2 muscarinic acetylcholine receptors: new aspects of importance regarding Achilles tendon tendinosis (tendinopathy)

Cell and Tissue Research, Vol. 331, (2) : 385-400

Bjur, Dennis; Danielson, Patrik; Alfredson, Håkan; et al.

Presence of substance P and the neurokinin-1 receptor in tenocytes of the human Achilles tendon

Regulatory Peptides, Vol. 150, (1-3) : 81-87

Andersson, Gustav; Danielson, Patrik; Alfredson, Håkan; et al.

Den kroniskt smärtande senan - histopatologi.

Idrottsskador - frontlinjen inom behandling och rehablitering, Laholm: Centrum för idrottsforskning 2007 : 267-274

Forsgren, Sture; Bjur, Dennis; Danielson, Patrik; et al.

Extensive expression of markers for acetylcholine synthesis and of M2 receptors in tenocytes in therapy-resistant chronic painful patellar tendon tendinosis - a pilot study.

Life Sciences, Vol. 80, (24-25) : 2235-2238

Danielson, Patrik; Andersson, Gustav; Alfredson, Håkan; et al.

In situ hybridization studies confirming recent findings of the existence of a local nonneuronal catecholamine production in human patellar tendinosis.

Microscopy research and technique (Print), Vol. 70, (10) : 908-911

Danielson, Patrik; Alfredson, Håkan; Forsgren, Sture

Visa publikationer i DiVA

Forskargrupper

Gruppledare

Forskargrupp Danielson/Backman

Forskningsprojekt

1 juli 2009

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