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Personalbild Ludmilla Morozova-Roche

Ludmilla Morozova-Roche

Vetenskaplig meritering: Docent

Kontakt

ludmilla.morozova-roche@umu.se

090-786 52 83, 073-620 52 83

Verksam som

Professor vid Institutionen för medicinsk kemi och biofysik

KB. H6, Campus, Umeå Umeå universitet, 901 87 Umeå

Differential expression of neurodegeneration-related genes in SH-SY5Y neuroblastoma cells under the influence of Cyclophilin A: could the enzyme be a likely trigger and therapeutic target for Alzheimer's disease?

Neurochemical Research, Springer Nature 2025, Vol. 50, (1)

Pashaei, Somayeh; Shabani, Sasan; Mohammadi, Soheila; et al.

ApoE isoforms inhibit amyloid aggregation of proinflammatory protein S100a9

International Journal of Molecular Sciences, MDPI 2024, Vol. 25, (4)

Ghosh, Shamasree; Tamilselvi, Shanmugam; Williams, Chloe; et al.

Pro-inflammatory protein S100A9 targeted by a natural molecule to prevent neurodegeneration onset

International Journal of Biological Macromolecules, Elsevier 2024, Vol. 276, (Part 2)

Leri, Manuela; Sun, Dan; Svedružic, Željko M.; et al.

The surprising nonlinear effects of S100A9 proteins in the retina

ACS Chemical Neuroscience, American Chemical Society (ACS) 2024, Vol. 15, (4) : 735-744

Naaman, Efrat; Qarawani, Amanda; Ben-Zvi Elimelech, Rony; et al.

Effect of proinflammatory S100A9 protein on migration and proliferation of microglial cells

Journal of Molecular Neuroscience, Springer Nature 2023, Vol. 73, (11-12) : 983-995

Bai, Qiao; Sun, Dan; Zeng, Yang; et al.

Residue-specific binding of Ni(II) ions influences the structure and aggregation of amyloid beta (Aβ) peptides

Scientific Reports, Nature Publishing Group 2023, Vol. 13, (1)

Berntsson, Elina; Vosough, Faraz; Svantesson, Teodor; et al.

Spider silk protein forms amyloid-like nanofibrils through a non-nucleation-dependent polymerization mechanism

Small, John Wiley & Sons 2023, Vol. 18, (46)

Qi, Xingmei; Wang, Yu; Yu, Hairui; et al.

The stabilization of S100A9 structure by calcium inhibits the formation of amyloid fibrils

International Journal of Molecular Sciences, MDPI 2023, Vol. 24, (17)

Sanders, Ella; Csondor, Rebecca; Šulskis, Darius; et al.

Common mechanisms underlying α-synuclein-induced mitochondrial dysfunction in Parkinson's disease

Journal of Molecular Biology, Elsevier 2023, Vol. 435, (12)

Sohrabi, Tahereh; Mirzaei-Behbahani, Behnaz; Zadali, Ramin; et al.

Proinflammatory S100A9 stimulates TLR4/NF-κB signaling pathways causing enhanced phagocytic capacity of microglial cells

Immunology Letters, Elsevier 2023, Vol. 255 : 54-61

Zhang, Xiaoyin; Sun, Dan; Zhou, Xin; et al.

S100A9 amyloid growth and S100A9 fibril-induced impairment of gamma oscillations in area CA3 of mouse hippocampus ex vivo is prevented by Bri2 BRICHOS

Progress in Neurobiology, Elsevier 2022, Vol. 219

Andrade-Talavera, Yuniesky; Chen, Gefei; Pansieri, Jonathan; et al.

Chaperones mainly suppress primary nucleation during formation of functional amyloid required for bacterial biofilm formation

Chemical Science, Vol. 13, (2) : 536-553

Nagaraj, Madhu; Najarzadeh, Zahra; Pansieri, Jonathan; et al.

Co-aggregation of S100A9 with DOPA and cyclen-based compounds manifested in amyloid fibril thickening without altering rates of self-assembly

International Journal of Molecular Sciences, MDPI 2021, Vol. 22, (16)

Arabuli, Lili; Iashchishyn, Igor; Romanova, Nina; et al.

Polyoxometalates as Effective Nano-inhibitors of Amyloid Aggregation of Pro-inflammatory S100A9 Protein Involved in Neurodegenerative Diseases

ACS Applied Materials and Interfaces, American Chemical Society (ACS) 2021, Vol. 13, (23) : 26721-26734

Chaudhary, Himanshu; Iashchishyn, Igor A.; Romanova, Nina V.; et al.

Cholesterol-containing lipid nanodiscs promote an α-synuclein binding mode that accelerates oligomerization

The FEBS Journal, John Wiley & Sons 2021, Vol. 288, (6) : 1887-1905

Jakubec, Martin; Barias, Espen; Furse, Samuel; et al.

Human polymerase δ-interacting protein 2 (Poldip2) inhibits the formation of human tau oligomers and fibrils

International Journal of Molecular Sciences, MDPI 2021, Vol. 22, (11)

Kasho, Kazutoshi; Krasauskas, Lukas; Smirnovas, Vytautas; et al.

Natural Compound from Olive Oil Inhibits S100A9 Amyloid Formation and Cytotoxicity: Implications for Preventing Alzheimer's Disease

ACS Chemical Neuroscience, American Chemical Society (ACS) 2021, Vol. 12, (11) : 1905-1918

Leri, Manuela; Chaudhary, Himanshu; Iashchishyn, Igor; et al.

Elongation of wood fibers combines features of diffuse and tip growth

New Phytologist, John Wiley & Sons 2021, Vol. 232, (2) : 673-691

Majda, Mateusz; Kozlova, Liudmila; Banasiak, Alicja; et al.

Surface-Directed Structural Transition of Amyloidogenic Aggregates and the Resulting Neurotoxicity

ACS Omega, American Chemical Society (ACS) 2020, Vol. 5, (6) : 2856-2864

Chen, Hao; Sun, Dan; Tian, Yin; et al.

Templating S100A9 amyloids on Aβ fibrillar surfaces revealed by charge detection mass spectrometry, microscopy, kinetic and microfluidic analyses

Chemical Science, Royal Society of Chemistry 2020, Vol. 11, (27) : 7031-7039

Pansieri, Jonathan; Iashchishyn, Igor A.; Fakhouri, Hussein; et al.

Proinflammatory S100A9 Regulates Differentiation and Aggregation of Neural Stem Cells

ACS Chemical Neuroscience, American Chemical Society (ACS) 2020, Vol. 11, (21) : 3549-3556

Tian, Yin; Cao, Rui; Che, Bingchen; et al.

HEWL interacts with dissipated oleic acid micelles, and decreases oleic acid cytotoxicity

PLOS ONE, PUBLIC LIBRARY SCIENCE 2019, Vol. 14, (2)

Huang, Qin; Sun, Dan; Hussain, Muhammad Zubair; et al.

Pro-Inflammatory S100A9 Protein Aggregation Promoted by NCAM1 Peptide Constructs

ACS Chemical Biology, AMER CHEMICAL SOC 2019, Vol. 14, (7) : 1410-1417

Pansieri, Jonathan; Ostojic, Lucija; Iashchishyn, Igor; et al.

Proinflammatory and amyloidogenic S100A9 induced by traumatic brain injury in mouse model

Neuroscience Letters, ELSEVIER IRELAND LTD 2019, Vol. 699 : 199-205

Wang, Chao; Iashchishyn, Igor; Kara, John; et al.

Unravelling the Role of S100A9 in the Development of Neurodegenerative Disease

Biophysical Journal, CELL PRESS 2019, Vol. 116, (3) : 338A-338A

Williamson, Philip T. F.; Horrocks, Jack; Maheswaran, Luckshi; et al.

S100A9 Protein Aggregates Boost Hippocampal Glutamate Modifying Monoaminergic Neurochemistry: A Glutamate Antibody Sensitive Outcome on Alzheimer-like Memory Decline

ACS Chemical Neuroscience, American Chemical Society (ACS) 2018, Vol. 9, (3) : 568-577

Gruden, Marina A.; Davydova, Tatiana V.; Kudrin, Vladimir S.; et al.

Co-aggregation of pro-inflammatory S100A9 with alpha-synuclein in Parkinson's disease: ex vivo and in vitro studies

Journal of Neuroinflammation, BioMed Central 2018, Vol. 15

Horvath, Istvan; Iashchishyn, Igor; Moskalenko, Roman A.; et al.

Intranasally Administered S100A9 Amyloids Induced Cellular Stress, Amyloid Seeding, and Behavioral Impairment in Aged Mice

ACS Chemical Neuroscience, American Chemical Society (ACS) 2018, Vol. 9, (6) : 1338-1348

Iashchishyn, Igor A.; Gruden, Marina A.; Moskalenko, Roman A.; et al.

S100A9-Driven Amyloid-Neuroinflammatory Cascade in Traumatic Brain Injury as a Precursor State for Alzheimer's Disease

Scientific Reports, Nature Publishing Group 2018, Vol. 8

Wang, Chao; Iashchishyn, Igor; Pansieri, Jonathan; et al.

Amyloid beta-peptides 1-40 and 1-42 form oligomers with mixed beta-sheets

Chemical Science, ROYAL SOC CHEMISTRY 2017, Vol. 8, (12) : 8247-8254

Baldassarre, Maurizio; Baronio, Cesare M.; Morozova-Roche, Ludmilla A.; et al.

Helicobacter pylori Adapts to Chronic Infection and Gastric Disease via pH-Responsive BabA-Mediated Adherence

Cell Host and Microbe, CELL PRESS 2017, Vol. 21, (3) : 376-389

Bugaytsova, Jeanna A.; Björnham, Oscar; Chernov, Yevgen A.; et al.

beta-Hydroxybutyrate deactivates Neutrophil NLRP3 inflammasome to relieve gout flares

Cell Reports, Vol. 18, (9) : 2077-2087

Goldberg, Emily L.; Asher, Jennifer L.; Molony, Ryan D.; et al.

Antibodies to Glutamate Reversed the Amnesic Effects of Proinflammatory S100A9 Protein Fibrils in Aged C57Bl/6 Mice

Bulletin of experimental biology and medicine, SPRINGER 2017, Vol. 162, (4) : 430-432

Gruden, M. A.; Davydova, T. V.; Fomina, V. G.; et al.

Immunochemical Detection of alpha-Synuclein Autoantibodies in Parkinson's Disease: Correlation between Plasma and Cerebrospinal Fluid Levels

ACS Chemical Neuroscience, American Chemical Society (ACS) 2017, Vol. 8, (6) : 1170-1176

Horvath, Istvan; Iashchishyn, Igor A.; Forsgren, Lars; et al.

Finke-Watzky Two-Step Nucleation-Autocatalysis Model of S100A9 Amyloid Formation: Protein Misfolding as "Nucleation" Event

ACS Chemical Neuroscience, American Chemical Society (ACS) 2017, Vol. 8, (10) : 2152-2158

Iashchishyn, Igor A.; Sulskis, Darius; Ngoc, Mai Nguyen; et al.

Pro-inflammatory S100a9 protein involved in the amyloid-neuroinflammatory cascade in Alzheimer's disease serves as a robust biomarker differentiating early stages of dementia

John Wiley & Sons 2017

Morozova-Roche, Ludmilla

Involvement of proinflammatory S100A9/A8 in the atherocalcinosis of aortic valves

Pathologia, Zaporizʹkyĭ derz͡havnyĭ medychnyĭ universytet 2017, (1) : 49-56

Moskalenko, R. A.; Romaniuk, A. M.; Iashchishyn, Igor; et al.

Tyrosine Hydroxylase Binding to Phospholipid Membranes Prompts Its Amyloid Aggregation and Compromises Bilayer Integrity

Scientific Reports, Vol. 6

Baumann, Anne; Jorge-Finnigan, Ana; Jung-KC, Kunwar; et al.

The misfolded pro-inflammatory protein S100A9 disrupts memory via neurochemical remodelling instigating an Alzheimer's disease-like cognitive deficit

Behavioural Brain Research, Vol. 306 : 106-116

Gruden, Marina A.; Davydova, Tatiana V.; Wang, Chao; et al.

Pro-inflammatory S100A9 Protein as a Robust Biomarker Differentiating Early Stages of Cognitive Impairment in Alzheimer's Disease

ACS Chemical Neuroscience, Vol. 7, (1) : 34-39

Horvath, Istvan; Jia, Xueen; Johansson, Per; et al.

Abnormal pigment epithelium-derived factor processing in progressive myopia

Experimental Eye Research, Vol. 152 : 1-9

Minkevich, Natalya I.; Morozova-Roche, Ludmilla A.; Iomdina, Elena N.; et al.

Proinflammatory S100A8/A9 in amyloid formation in the aging prostate: risk factor for cancer

International Journal of Molecular Medicine, Spandidos 2016, Vol. 38 : S28-S28

Morozova-Roche, Ludmilla

Noradrenergic and serotonergic neurochemistry arising from intranasal inoculation with α-synuclein aggregates which incite parkinsonian-like symptoms

Behavioural Brain Research, Vol. 279 : 191-201

Gruden, Marina A; Davydova, Tatiana V; Narkevich, Victor B; et al.

A Generic Method for Design of Oligomer-Specific Antibodies

PLOS ONE, Vol. 9, (3) : e90857-

Brännström, Kristoffer; Lindhagen-Persson, Malin; Gharibyan, Anna L.; et al.

Structural heterogeneity and bioimaging of S100 amyloid assemblies

Bio-nanoimaging: protein misfolding and aggregation, Academic Press 2014 : 197-212

Carvalho, Sofia B.; Cardoso, Isabel; Botelho, Hugo M.; et al.

Observation of the Early Structural Changes Leading to the Formation of Protein Superstructures

The Journal of Physical Chemistry Letters, Vol. 5, (18) : 3254-3258

Fodera, Vito; Vetri, Valeria; Wind, Thea S.; et al.

Intranasal administration of alpha-synuclein aggregates: a Parkinson's disease model with behavioral and neurochemical correlates

Behavioural Brain Research, Elsevier 2014, Vol. 263 : 158-168

Gruden, Marina A; Davydova, Tatiana V; Narkevich, Victor B; et al.

Generic structures of cytotoxic liprotides: nano-sized complexes with oleic acid cores and shells of disordered proteins

ChemBioChem, Wiley-VCH Verlagsgesellschaft 2014, Vol. 15, (18) : 2693-2702

Kaspersen, Jørn D.; Pedersen, Jannik N.; Hansted, Jon G.; et al.

ELOA - equine lysozyme complexes with oleic acid. structure and cytotoxicity studied by bio-imaging techniques

Bio-nanoimaging: protein misfolding and aggregation, Academic Press 2014 : 453-462

Vukojević, Vladana; Klechikov, Alexey; Morozova-Roche, Ludmilla

The role of pro-inflammatory S100A9 in Alzheimer's disease amyloid-neuroinflammatory cascade

Acta Neuropathologica, Vol. 127, (4) : 507-522

Wang, Chao; Klechikov, Alexey G.; Gharibyan, Anna L.; et al.

Visa publikationer i DiVA

Forskargrupper

Forskningsledare

Ludmilla Morozova-Roche

Forskningsprojekt

26 november 2003 till 31 december 2008

Felveckning av proteiner på molekylnivå

Publicerad: 01 jul, 2021

Nanopartikel upptäckt som kan motverka Alzheimer och Parkinson

Publicerad: 26 jun, 2020

Templerande S100A9-amyloider på Aβ-fibrillarytor avslöjade

Publicerad: 28 okt, 2019

Vetenskapsmiljoner till medicinsk forskning i Umeå