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Umeå universitet
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Personalbild Ludmilla Morozova-Roche

Ludmilla Morozova-Roche

Vetenskaplig meritering: Docent

Kontakt

E-post
ludmilla.morozova-roche@umu.se
Telefon
090-786 52 83, 073-620 52 83

Verksam vid

Anknytning
Professor vid Institutionen för medicinsk kemi och biofysik
Plats
KB. H6, Campus, Umeå Umeå universitet, 901 87 Umeå
ApoE isoforms inhibit amyloid aggregation of proinflammatory protein S100a9
International Journal of Molecular Sciences, MDPI 2024, Vol. 25, (4)
Ghosh, Shamasree; Tamilselvi, Shanmugam; Williams, Chloe; et al.
Pro-inflammatory protein S100A9 targeted by a natural molecule to prevent neurodegeneration onset
International Journal of Biological Macromolecules, Elsevier 2024, Vol. 276, (Part 2)
Leri, Manuela; Sun, Dan; Svedružic, Željko M.; et al.
The surprising nonlinear effects of S100A9 proteins in the retina
ACS Chemical Neuroscience, American Chemical Society (ACS) 2024, Vol. 15, (4) : 735-744
Naaman, Efrat; Qarawani, Amanda; Ben-Zvi Elimelech, Rony; et al.
Effect of proinflammatory S100A9 protein on migration and proliferation of microglial cells
Journal of Molecular Neuroscience, Springer Nature 2023, Vol. 73, (11-12) : 983-995
Bai, Qiao; Sun, Dan; Zeng, Yang; et al.
Residue-specific binding of Ni(II) ions influences the structure and aggregation of amyloid beta (Aβ) peptides
Scientific Reports, Nature Publishing Group 2023, Vol. 13, (1)
Berntsson, Elina; Vosough, Faraz; Svantesson, Teodor; et al.
Spider silk protein forms amyloid-like nanofibrils through a non-nucleation-dependent polymerization mechanism
Small, John Wiley & Sons 2023, Vol. 18, (46)
Qi, Xingmei; Wang, Yu; Yu, Hairui; et al.
The stabilization of S100A9 structure by calcium inhibits the formation of amyloid fibrils
International Journal of Molecular Sciences, MDPI 2023, Vol. 24, (17)
Sanders, Ella; Csondor, Rebecca; Šulskis, Darius; et al.
Common mechanisms underlying α-synuclein-induced mitochondrial dysfunction in Parkinson's disease
Journal of Molecular Biology, Elsevier 2023, Vol. 435, (12)
Sohrabi, Tahereh; Mirzaei-Behbahani, Behnaz; Zadali, Ramin; et al.
Proinflammatory S100A9 stimulates TLR4/NF-κB signaling pathways causing enhanced phagocytic capacity of microglial cells
Immunology Letters, Elsevier 2023, Vol. 255 : 54-61
Zhang, Xiaoyin; Sun, Dan; Zhou, Xin; et al.
S100A9 amyloid growth and S100A9 fibril-induced impairment of gamma oscillations in area CA3 of mouse hippocampus ex vivo is prevented by Bri2 BRICHOS
Progress in Neurobiology, Elsevier 2022, Vol. 219
Andrade-Talavera, Yuniesky; Chen, Gefei; Pansieri, Jonathan; et al.
Chaperones mainly suppress primary nucleation during formation of functional amyloid required for bacterial biofilm formation
Chemical Science, Vol. 13, (2) : 536-553
Nagaraj, Madhu; Najarzadeh, Zahra; Pansieri, Jonathan; et al.
Co-aggregation of S100A9 with DOPA and cyclen-based compounds manifested in amyloid fibril thickening without altering rates of self-assembly
International Journal of Molecular Sciences, MDPI 2021, Vol. 22, (16)
Arabuli, Lili; Iashchishyn, Igor; Romanova, Nina; et al.
Polyoxometalates as Effective Nano-inhibitors of Amyloid Aggregation of Pro-inflammatory S100A9 Protein Involved in Neurodegenerative Diseases
ACS Applied Materials and Interfaces, American Chemical Society (ACS) 2021, Vol. 13, (23) : 26721-26734
Chaudhary, Himanshu; Iashchishyn, Igor A.; Romanova, Nina V.; et al.
Cholesterol-containing lipid nanodiscs promote an α-synuclein binding mode that accelerates oligomerization
The FEBS Journal, John Wiley & Sons 2021, Vol. 288, (6) : 1887-1905
Jakubec, Martin; Barias, Espen; Furse, Samuel; et al.
Human polymerase δ-interacting protein 2 (Poldip2) inhibits the formation of human tau oligomers and fibrils
International Journal of Molecular Sciences, MDPI 2021, Vol. 22, (11)
Kasho, Kazutoshi; Krasauskas, Lukas; Smirnovas, Vytautas; et al.
Natural Compound from Olive Oil Inhibits S100A9 Amyloid Formation and Cytotoxicity: Implications for Preventing Alzheimer's Disease
ACS Chemical Neuroscience, American Chemical Society (ACS) 2021, Vol. 12, (11) : 1905-1918
Leri, Manuela; Chaudhary, Himanshu; Iashchishyn, Igor; et al.
Elongation of wood fibers combines features of diffuse and tip growth
New Phytologist, John Wiley & Sons 2021, Vol. 232, (2) : 673-691
Majda, Mateusz; Kozlova, Liudmila; Banasiak, Alicja; et al.
Surface-Directed Structural Transition of Amyloidogenic Aggregates and the Resulting Neurotoxicity
ACS Omega, American Chemical Society (ACS) 2020, Vol. 5, (6) : 2856-2864
Chen, Hao; Sun, Dan; Tian, Yin; et al.
Templating S100A9 amyloids on Aβ fibrillar surfaces revealed by charge detection mass spectrometry, microscopy, kinetic and microfluidic analyses
Chemical Science, Royal Society of Chemistry 2020, Vol. 11, (27) : 7031-7039
Pansieri, Jonathan; Iashchishyn, Igor A.; Fakhouri, Hussein; et al.
Proinflammatory S100A9 Regulates Differentiation and Aggregation of Neural Stem Cells
ACS Chemical Neuroscience, American Chemical Society (ACS) 2020, Vol. 11, (21) : 3549-3556
Tian, Yin; Cao, Rui; Che, Bingchen; et al.
HEWL interacts with dissipated oleic acid micelles, and decreases oleic acid cytotoxicity
PLOS ONE, PUBLIC LIBRARY SCIENCE 2019, Vol. 14, (2)
Huang, Qin; Sun, Dan; Hussain, Muhammad Zubair; et al.
Pro-Inflammatory S100A9 Protein Aggregation Promoted by NCAM1 Peptide Constructs
ACS Chemical Biology, AMER CHEMICAL SOC 2019, Vol. 14, (7) : 1410-1417
Pansieri, Jonathan; Ostojic, Lucija; Iashchishyn, Igor; et al.
Proinflammatory and amyloidogenic S100A9 induced by traumatic brain injury in mouse model
Neuroscience Letters, ELSEVIER IRELAND LTD 2019, Vol. 699 : 199-205
Wang, Chao; Iashchishyn, Igor; Kara, John; et al.
Unravelling the Role of S100A9 in the Development of Neurodegenerative Disease
Biophysical Journal, CELL PRESS 2019, Vol. 116, (3) : 338A-338A
Williamson, Philip T. F.; Horrocks, Jack; Maheswaran, Luckshi; et al.
S100A9 Protein Aggregates Boost Hippocampal Glutamate Modifying Monoaminergic Neurochemistry: A Glutamate Antibody Sensitive Outcome on Alzheimer-like Memory Decline
ACS Chemical Neuroscience, American Chemical Society (ACS) 2018, Vol. 9, (3) : 568-577
Gruden, Marina A.; Davydova, Tatiana V.; Kudrin, Vladimir S.; et al.
Co-aggregation of pro-inflammatory S100A9 with alpha-synuclein in Parkinson's disease: ex vivo and in vitro studies
Journal of Neuroinflammation, BioMed Central 2018, Vol. 15
Horvath, Istvan; Iashchishyn, Igor; Moskalenko, Roman A.; et al.
Intranasally Administered S100A9 Amyloids Induced Cellular Stress, Amyloid Seeding, and Behavioral Impairment in Aged Mice
ACS Chemical Neuroscience, American Chemical Society (ACS) 2018, Vol. 9, (6) : 1338-1348
Iashchishyn, Igor A.; Gruden, Marina A.; Moskalenko, Roman A.; et al.
S100A9-Driven Amyloid-Neuroinflammatory Cascade in Traumatic Brain Injury as a Precursor State for Alzheimer's Disease
Scientific Reports, Nature Publishing Group 2018, Vol. 8
Wang, Chao; Iashchishyn, Igor; Pansieri, Jonathan; et al.
Amyloid beta-peptides 1-40 and 1-42 form oligomers with mixed beta-sheets
Chemical Science, ROYAL SOC CHEMISTRY 2017, Vol. 8, (12) : 8247-8254
Baldassarre, Maurizio; Baronio, Cesare M.; Morozova-Roche, Ludmilla A.; et al.
Helicobacter pylori Adapts to Chronic Infection and Gastric Disease via pH-Responsive BabA-Mediated Adherence
Cell Host and Microbe, CELL PRESS 2017, Vol. 21, (3) : 376-389
Bugaytsova, Jeanna A.; Björnham, Oscar; Chernov, Yevgen A.; et al.
beta-Hydroxybutyrate deactivates Neutrophil NLRP3 inflammasome to relieve gout flares
Cell Reports, Vol. 18, (9) : 2077-2087
Goldberg, Emily L.; Asher, Jennifer L.; Molony, Ryan D.; et al.
Antibodies to Glutamate Reversed the Amnesic Effects of Proinflammatory S100A9 Protein Fibrils in Aged C57Bl/6 Mice
Bulletin of experimental biology and medicine, SPRINGER 2017, Vol. 162, (4) : 430-432
Gruden, M. A.; Davydova, T. V.; Fomina, V. G.; et al.
Immunochemical Detection of alpha-Synuclein Autoantibodies in Parkinson's Disease: Correlation between Plasma and Cerebrospinal Fluid Levels
ACS Chemical Neuroscience, American Chemical Society (ACS) 2017, Vol. 8, (6) : 1170-1176
Horvath, Istvan; Iashchishyn, Igor A.; Forsgren, Lars; et al.
Finke-Watzky Two-Step Nucleation-Autocatalysis Model of S100A9 Amyloid Formation: Protein Misfolding as "Nucleation" Event
ACS Chemical Neuroscience, American Chemical Society (ACS) 2017, Vol. 8, (10) : 2152-2158
Iashchishyn, Igor A.; Sulskis, Darius; Ngoc, Mai Nguyen; et al.
Pro-inflammatory S100a9 protein involved in the amyloid-neuroinflammatory cascade in Alzheimer's disease serves as a robust biomarker differentiating early stages of dementia
John Wiley & Sons 2017
Morozova-Roche, Ludmilla
Involvement of proinflammatory S100A9/A8 in the atherocalcinosis of aortic valves
Pathologia, Zaporizʹkyĭ derz͡havnyĭ medychnyĭ universytet 2017, (1) : 49-56
Moskalenko, R. A.; Romaniuk, A. M.; Iashchishyn, Igor; et al.
Tyrosine Hydroxylase Binding to Phospholipid Membranes Prompts Its Amyloid Aggregation and Compromises Bilayer Integrity
Scientific Reports, Vol. 6
Baumann, Anne; Jorge-Finnigan, Ana; Jung-KC, Kunwar; et al.
The misfolded pro-inflammatory protein S100A9 disrupts memory via neurochemical remodelling instigating an Alzheimer's disease-like cognitive deficit
Behavioural Brain Research, Vol. 306 : 106-116
Gruden, Marina A.; Davydova, Tatiana V.; Wang, Chao; et al.
Pro-inflammatory S100A9 Protein as a Robust Biomarker Differentiating Early Stages of Cognitive Impairment in Alzheimer's Disease
ACS Chemical Neuroscience, Vol. 7, (1) : 34-39
Horvath, Istvan; Jia, Xueen; Johansson, Per; et al.
Abnormal pigment epithelium-derived factor processing in progressive myopia
Experimental Eye Research, Vol. 152 : 1-9
Minkevich, Natalya I.; Morozova-Roche, Ludmilla A.; Iomdina, Elena N.; et al.
Proinflammatory S100A8/A9 in amyloid formation in the aging prostate: risk factor for cancer
International Journal of Molecular Medicine, Spandidos 2016, Vol. 38 : S28-S28
Morozova-Roche, Ludmilla
Noradrenergic and serotonergic neurochemistry arising from intranasal inoculation with α-synuclein aggregates which incite parkinsonian-like symptoms
Behavioural Brain Research, Vol. 279 : 191-201
Gruden, Marina A; Davydova, Tatiana V; Narkevich, Victor B; et al.
A Generic Method for Design of Oligomer-Specific Antibodies
PLOS ONE, Vol. 9, (3) : e90857-
Brännström, Kristoffer; Lindhagen-Persson, Malin; Gharibyan, Anna L.; et al.
Structural heterogeneity and bioimaging of S100 amyloid assemblies
Bio-nanoimaging: protein misfolding and aggregation, Academic Press 2014 : 197-212
Carvalho, Sofia B.; Cardoso, Isabel; Botelho, Hugo M.; et al.
Observation of the Early Structural Changes Leading to the Formation of Protein Superstructures
The Journal of Physical Chemistry Letters, Vol. 5, (18) : 3254-3258
Fodera, Vito; Vetri, Valeria; Wind, Thea S.; et al.
Intranasal administration of alpha-synuclein aggregates: a Parkinson's disease model with behavioral and neurochemical correlates
Behavioural Brain Research, Elsevier 2014, Vol. 263 : 158-168
Gruden, Marina A; Davydova, Tatiana V; Narkevich, Victor B; et al.
Generic structures of cytotoxic liprotides: nano-sized complexes with oleic acid cores and shells of disordered proteins
ChemBioChem, Wiley-VCH Verlagsgesellschaft 2014, Vol. 15, (18) : 2693-2702
Kaspersen, Jørn D.; Pedersen, Jannik N.; Hansted, Jon G.; et al.
ELOA - equine lysozyme complexes with oleic acid. structure and cytotoxicity studied by bio-imaging techniques
Bio-nanoimaging: protein misfolding and aggregation, Academic Press 2014 : 453-462
Vukojević, Vladana; Klechikov, Alexey; Morozova-Roche, Ludmilla
The role of pro-inflammatory S100A9 in Alzheimer's disease amyloid-neuroinflammatory cascade
Acta Neuropathologica, Vol. 127, (4) : 507-522
Wang, Chao; Klechikov, Alexey G.; Gharibyan, Anna L.; et al.
A Complex of Equine Lysozyme and Oleic Acid with Bactericidal Activity against Streptococcus pneumoniae
PLOS ONE, Public Library of Science 2013, Vol. 8, (11) : Article Number: UNSP e80649-
Clementi, Emily A.; Wilhelm, Kristina R.; Schleucher, Juergen; et al.
Visa publikationer i DiVA

Forskargrupper

Forskningsledare
Ludmilla Morozova-Roche

Forskningsprojekt

26 november 2003 till 31 december 2008
Felveckning av proteiner på molekylnivå