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Umeå universitet
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Personalbild Jan Oscarsson

Jan Oscarsson

Bakterien A. actinomycetemcomitans i samband med parodontala sjukdomar.

Vetenskaplig meritering: Docent

Kontakt

E-post
jan.oscarsson@umu.se
Telefon
090-785 60 97

Verksam vid

Anknytning
Forskare vid Institutionen för odontologi Enhet: Tandläkarutbildningen, Oral mikrobiologi
Plats
1A, våning 5, Norrlands universitetssjukhus Umeå universitet, 901 85 Umeå

Jag forskar om mekanismer hos bakterien A. actinomycetemcomitans i samband med parodontala sjukdomar. Min grupp använder cell- och molekylärbiologiska metoder för att hur bakterien kan orsaka skador och överleva inom värden.  Med ny kunskap hoppas vi kunna bidra till nya sätt att avväpna bakteriens virulens snarare än att döda den.

Prevalence of the oral pathogen Filifactor alocis and its FtxA toxin related to clinical parameters and presence of Aggregatibacter actinomycetemcomitans
Frontiers in Cellular and Infection Microbiology, Lausanne: Frontiers Media S.A. 2025, Vol. 14
Razooqi, Zeinab; Khzam, Nabil; L’Hostis, Mahina; et al.
Prevalence of subgingival Aggregatibacter actinomycetemcomitans: descriptive cross-sectional study
Pathogens, Basel: MDPI 2024, Vol. 13, (7)
Khzam, Nabil; Kujan, Omar; Haubek, Dorte; et al.
The effectiveness of salivary sampling for the detection and quantification of Aggregatibacter actinomycetemcomitans in periodontitis patients
Pathogens, Basel: MDPI 2024, Vol. 13, (12)
Khzam, Nabil; Kujan, Omar; Haubek, Dorte; et al.
Zebrafish larvae as a model for studying the impact of oral bacterial vesicles on tumor cell growth and metastasis
Human Cell
Metsäniitty, Marjut; Hasnat, Saika; Öhman, Carina; et al.
Extracellular vesicles from Aggregatibacter actinomycetemcomitans exhibit potential antitumorigenic effects in oral cancer: a comparative in vitro study
Archives of Microbiology, Springer Nature 2024, Vol. 206, (6)
Metsäniitty, Marjut; Hasnat, Shrabon; Öhman, Carina; et al.
Bacterial symbionts in oral niche use type VI secretion nanomachinery for fitness increase against pathobionts
iScience
Oscarsson, Jan; Bao, Kai; Shiratsuchi, Akiko; et al.
Protocol for analyzing the function of the type VI secretion system of the oral symbiont Aggregatibacter aphrophilus in targeting pathobionts
STAR Protocols, Cell Press 2024, Vol. 5, (4)
Oscarsson, Jan; Bao, Kai; Shiratsuchi, Akiko; et al.
Association of Filifactor alocis and its RTX toxin gene ftxA with periodontal attachment loss, and in synergy with Aggregatibacter actinomycetemcomitans
Frontiers in Cellular and Infection Microbiology, Frontiers Media S.A. 2024, Vol. 14
Razooqi, Zeinab; Tjellström, Ingeborg; Höglund-Åberg, Carola; et al.
Radiographic and clinical signs of periodontitis and associated bacterial species in a Swedish adolescent population
Journal of Periodontology, John Wiley & Sons 2023, Vol. 94, (5) : 630-640
Lindholm, Mark; Claesson, Rolf; Löf, Hanna; et al.
Extracellular Vesicle Subproteome Differences among Filifactor alocis Clinical Isolates
Microorganisms, MDPI 2022, Vol. 10, (9)
Bao, Kai; Claesson, Rolf; Belibasakis, Georgios N.; et al.
Proteomic Characterization of the Oral Pathogen Filifactor alocis Reveals Key Inter-Protein Interactions of Its RTX Toxin: FtxA
Pathogens, MDPI AG 2022, Vol. 11, (5)
Bao, Kai; Claesson, Rolf; Gehrig, Peter; et al.
Carriage of the JP2 genotype of Aggregatibacter actinomycetemcomitans by periodontitis patients of various geographic origin, living in Sweden
Pathogens, MDPI 2022, Vol. 11, (11)
Claesson, Rolf; Oscarsson, Jan; Johansson, Anders
Aggregatibacter actinomycetemcomitans and Filifactor alocis: two exotoxin-producing oral pathogens
Frontiers in Oral Health, Frontiers Media S.A. 2022, Vol. 3
Ozuna, Hazel; Snider, Ian; Belibasakis, Georgios N.; et al.
Aggregatibacter actinomycetemcomitans and Filifactor alocis as associated with periodontal attachment loss in a cohort of ghanaian adolescents
Microorganisms, MDPI 2022, Vol. 10, (12)
Razooqi, Zeinab; Höglund-Åberg, Carola; Kwamin, Francis; et al.
Multilocus Sequence Typing of Non-JP2 Serotype b Aggregatibacter actinomycetemcomitans Strains of Ghanaian and Swedish Origin
Frontiers in Cellular and Infection Microbiology, Frontiers Media S.A. 2021, Vol. 11
Claesson, Rolf; Johansson, Anders; Höglund-Åberg, Carola; et al.
Aggregatibacter actinomycetemcomitans and Aggregatibacter aphrophilus in a Kenyan Maasai Adolescent Population and Inhibition of Leukotoxic Activity by Herbal Plants Used as Part of Oral Hygiene Procedures
Journal of Clinical Medicine, Basel: MDPI 2021, Vol. 10, (22)
Lindholm, Mark; Claesson, Rolf; Kemoli, Arthur; et al.
Characterization of Aggregatibacter actinomycetemcomitans Serotype b Strains with Five Different, Including Two Novel, Leukotoxin Promoter Structures
Vaccines, Basel, Switzerland: MDPI 2020, Vol. 8, (3)
Claesson, Rolf; Chiang, Huei-Min; Lindholm, Mark; et al.
Outer membrane vesicle-mediated serum protection in Aggregatibacter actinomycetemcomitans
Journal of Oral Microbiology, Taylor & Francis 2020, Vol. 12, (1)
Lindholm, Mark; Metsäniitty, Marjut; Granström, Elisabeth; et al.
Delivery of virulence factors by bacterial membrane vesicles to mammalian host cells
Bacterial membrane vesicles: biogenesis, functions and applications, Springer 2020 : 131-158
Nadeem, Aftab; Oscarsson, Jan; Wai, Sun Nyunt
Phylogenetic Analysis of Filifactor alocis Strains Isolated from Several Oral Infections Identified a Novel RTX Toxin, FtxA
Toxins, MDPI 2020, Vol. 12, (11)
Oscarsson, Jan; Claesson, Rolf; Bao, Kai; et al.
Editorial Comments to the Special Issue: "Aggregaterbacter actinomycetemcomitans—Gram-Negative Bacterial Pathogen"
Pathogens, Basel: MDPI 2020, Vol. 9, (6)
Oscarsson, Jan; DiRienzo, Joseph; Johansson, Anders
Aggregatibacter actinomycetemcomitans LPS binds human interleukin-8
Journal of Oral Microbiology, TAYLOR & FRANCIS LTD 2019, Vol. 11, (1)
Ahlstrand, Tuuli; Kovesjoki, Laura; Maula, Terhi; et al.
Virulence and Pathogenicity Properties of Aggregatibacter actinomycetemcomitans
Pathogens, Basel: MDPI 2019, Vol. 8, (4)
Belibasakis, Georgios N; Maula, Terhi; Bao, Kai; et al.
Genetic Profiling of Aggregatibacter actinomycetemcomitans Serotype B Isolated from Periodontitis Patients Living in Sweden
Pathogens, Basel, Switzerland: MDPI 2019, Vol. 8, (3) : 1-13
Johansson, Anders; Claesson, Rolf; Höglund-Åberg, Carola; et al.
Role of OmpA1 and OmpA2 in Aggregatibacter actinomycetemcomitans and Aggregatibacter aphrophilus serum resistance
Journal of Oral Microbiology, Taylor & Francis 2019, Vol. 11, (1)
Lindholm, Mark; Aung, Kyaw Min; Wai, Sun Nyunt; et al.
Tools of Aggregatibacter actinomycetemcomitans to Evade the Host Response
Journal of Clinical Medicine, Basel: MDPI 2019, Vol. 8, (7)
Oscarsson, Jan; Claesson, Rolf; Lindholm, Mark; et al.
Comment from the Editor to the Special Issue: “Periodontitis: From Dysbiotic Microbial Immune Response to Systemic Inflammation”
Journal of Clinical Medicine, Basel, Switzerland: MDPI 2019, Vol. 8, (10)
Oscarsson, Jan; Johansson, Anders
Aggregatibacter actinomycetemcomitans H-NS promotes biofilm formation and alters protein dynamics of other species within a polymicrobial oral biofilm
npj Biofilms and Microbiomes, Springer 2018, Vol. 4, (12) : 1-11
Bao, Kai; Bostanci, Nagihan; Thurnheer, Thomas; et al.
A novel intrinsically disordered outer membrane lipoprotein of Aggregatibacter actinomycetemcomitans binds various cytokines and plays a role in biofilm response to interleukin-1β and interleukin-8
Virulence, Vol. 8, (2) : 115-134
Ahlstrand, Tuuli; Tuominen, Heidi; Beklen, Arzu; et al.
The cagE gene sequence as a diagnostic marker to identify JP2 and non-JP2 highly leukotoxic Aggregatibacter actinomycetemcomitans serotype b strains.
Journal of Periodontal Research, John Wiley & Sons 2017, Vol. 52, (5) : 903-912
Johansson, Anders; Claesson, Rolf; Höglund Åberg, Carola; et al.
Dataset of the proteome of purified outer membrane vesicles from the human pathogen Aggregatibacter actinomycetemcomintans
Data in Brief, Elsevier 2017, Vol. 10 : 426-431
Kieselbach, Thomas; Oscarsson, Jan
Proteomics of Aggregatibacter actinomycetemcomitans Outer Membrane Vesicles
PLOS ONE, Vol. 10, (9)
Kieselbach, Thomas; Zijnge, Vincent; Granström, Elisabeth; et al.
Outer Membrane Vesicle-Mediated Export of Processed PrtV Protease from Vibrio cholerae
PLOS ONE, Vol. 10, (7)
Rompikuntal, Pramod K.; Vdovikova, Svitlana; Duperthuy, Marylise; et al.
Elevated recombinant clyA gene expression in the uropathogenic Escherichia coli strain 536, a clue to explain pathoadaptive mutations in a subset of extraintestinal E. coli strains
BMC Microbiology, BioMed Central 2014, Vol. 14 : 216-
Enow Oben Ayuk, Constance; Oscarsson, Jan; Zlatkov, Nikola; et al.
Aggregatibacter actinomycetemcomitans Outer Membrane Vesicles are internalized in human host cells and trigger NOD1- and NOD2-dependent NF-κB activation
Infection and Immunity, American Society for Microbiology Press 2014, Vol. 82, (10) : 4034-4046
Thay, Bernard; Damm, Anna; Kufer, Thomas; et al.
Staphylococcus aureus alpha-toxin-dependent induction of host cell death by membrane-derived vesicles
PLOS ONE, Vol. 8, (1)
Thay, Bernard; Wai, Sun Nyunt; Oscarsson, Jan
Perinuclear localization of internalized outer membrane vesicles carrying active cytolethal distending toxin (CDT) from aggregatibacter actinomycetemcomitans
Infection and Immunity, American Society for Microbiology 2012, Vol. 80, (1) : 31-42
Rompikuntal, Pramod Kumar; Thay, Bernard; Khan, Muhammad Khanzeb; et al.
Proteomics of protein secretion by aggregatibacter actinomycetemcomitans
PLOS ONE, Vol. 7, (7) : e41662-
Zijnge, Vincent; Kieselbach, Thomas; Oscarsson, Jan
Specified species in gingival crevicular fluid predict bacterial diversity
PloS one, Vol. 5, (10) : e13589-
Asikainen, Sirkka; Doğan, Başak; Turgut, Zeynep; et al.
Lack of Serotype Antigen in A. actinomycetemcomitans
Journal of Dental Research, Vol. 89, (3) : 292-6
Kanasi, E; Dogan, B; Karched, M; et al.
Mathematical modelling of the regulation of spa (protein A) transcription in Staphylococcus aureus.
International journal of medical microbiology : IJMM, Vol. 299, (1) : 65-74
Gustafsson, Erik; Karlsson, Stefan; Oscarsson, Jan; et al.
Maximal transcription of aur (aureolysin) and sspA (serine protease) in Staphylococcus aureus requires staphylococcal accessory regulator R (sarR) activity.
FEMS Microbiology Letters, Vol. 284, (2) : 158-64
Gustafsson, Erik; Oscarsson, Jan
Vesicle-independent extracellular release of a proinflammatory outer membrane lipoprotein in free-soluble form
BMC Microbiology, Vol. 28, (8:18)
Karched, Maribasappa; Ihalin, Rikka; Eneslätt, Kjell; et al.
Proinflammatory effect in whole blood by free soluble bacterial components released from planktonic and biofilm cells
BMC Microbiology, London: BioMed Central 2008, Vol. 8, (206) : 13-
Oscarsson, Jan; Karched, Maribasappa; Thay, Bernard; et al.
Vesicle-mediated export and assembly of pore-forming oligomers of the enterobacterial ClyA cytotoxin.
Cell, Vol. 115, (1) : 25-35
Wai, Sun Nyunt; Lindmark, Barbro; Söderblom, Tomas; et al.
Localization and structure of the ClyA protein in Escherichia coli before secretion and pore-formation
Enow, Constance; Oscarsson, Jan; Mizunoe, Yoshimitsu; et al.
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