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Umeå universitet
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Personalbild Emmanuelle Charpentier
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Emmanuelle Charpentier

År 2009-2017 forskningsledare vid MIMS och gästforskare vid UCMR. Tilldelas 2020 års Nobelpris i kemi tillsammans med Jennifer A. Doudna för upptäckten av gensaxen CRISPR-Cas9.

 

Vetenskaplig meritering: Docent

Kontakt

E-post
contact@emmanuelle-charpentier.org
Telefon

Verksam vid

Anknytning
Anknuten som övrig/annan befattning till Institutionen för molekylärbiologi
Plats
6K och 6L, Sjukhusområdet Umeå universitet, 901 87 Umeå

Emmanuelle Charpentier är Nobelpristagare i kemi 2020. Hon är världsledande expert inom de mekanismer som styr processer i bakteriella patogener som rör infektion och immunitet. Hon är i dag professor, vetenskaplig ledare och chef för Max Planck Unit for the Science of Pathogens i Berlin, ett institut hon grundat tillsammans med Max Plancksällskapet.

Vid Årshögtiden 2017 promoverades hon till hedersdoktor vid Umeå universitet.

 

Bridge helix arginines play a critical role in Cas9 sensitivity to mismatches
Nature Chemical Biology, Nature Publishing Group 2020, Vol. 16, (5) : 587-595
Bratovic, Majda; Fonfara, Ines; Chylinski, Krzysztof; et al.
An RNA-seq based comparative approach reveals the transcriptome-wide interplay between 3 '-to-5 ' exoRNases and RNase Y
Nature Communications, Nature Publishing Group 2020, Vol. 11, (1)
Broglia, Laura; Lécrivain, Anne-Laure; Renault, Thibaud T.; et al.
Characterization of a transcriptional TPP riboswitch in the human pathogen Neisseria meningitidis
RNA Biology, Taylor & Francis Group 2020, Vol. 17, (5) : 718-730
Righetti, Francesco; Materne, Solange Lise; Boss, John; et al.
RNase Y-mediated regulation of the streptococcal pyrogenic exotoxin B
RNA Biology, Taylor & Francis 2018, Vol. 15, (10) : 1336-1347
Broglia, Laura; Materne, Solange; Lecrivain, Anne-Laure; et al.
Spotlight on... Emmanuelle Charpentier
FEMS Microbiology Letters, Oxford University Press 2018, Vol. 365, (4)
Charpentier, Emmanuelle
The Biology of CRISPR-Cas: Backward and Forward
Cell, Elsevier 2018, Vol. 172, (6) : 1239-1259
Hille, Frank; Richter, Hagen; Wong, Shi Pey; et al.
Refined sgRNA efficacy prediction improves large- and small-scale CRISPR-Cas9 applications
Nucleic Acids Research, Vol. 46, (3) : 1375-1385
Labuhn, Maurice; Adams, Felix F.; Ng, Michelle; et al.
Interplay between 3′-to-5′ exoRNases and RNase Y in Streptococcus pyogenes
Lécrivain, Anne-Laure; Broglia, Laura; Renault, Thibaud; et al.
In vivo 3′-to-5′ exoribonuclease targetomes of Streptococcus pyogenes
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences 2018, Vol. 115, (46) : 11814-11819
Lécrivain, Anne-Laure; Le Rhun, Anaïs; Renault, Thibaud T.; et al.
Extracellular Vesicle RNA: A Universal Mediator of Microbial Communication?
Trends in Microbiology, ELSEVIER SCI LTD 2018, Vol. 26, (5) : 401-410
Tsatsaronis, James A.; Franch-Arroyo, Sandra; Resch, Ulrike; et al.
Functional Diversity of AAA plus Protease Complexes in Bacillus subtilis
Frontiers in Molecular Biosciences, Frontiers Media S.A. 2017, Vol. 4
Elsholz, Alexander K. W.; Birk, Marlene S.; Charpentier, Emmanuelle; et al.
Hypothesis: RNA and DNA Viral Sequence Integration into the Mammalian Host Genome Supports Long-Term B Cell and T Cell Adaptive Immunity
Viral immunology, MARY ANN LIEBERT, INC 2017, Vol. 30, (9) : 628-632
Hurwitz, Julia L.; Jones, Bart G.; Charpentier, Emmanuelle; et al.
Identification of endoribonuclease specific cleavage positions reveals novel targets of RNase III in Streptococcus pyogenes
Nucleic Acids Research, Vol. 45, (5) : 2329-2340
Le Rhun, Anais; Lecrivain, Anne-Laure; Reimegard, Johan; et al.
CRISPR-Cas9-induced t(11;19)/MLL-ENL translocations initiate leukemia in human hematopoietic progenitor cells in vivo
Haematologica, Vol. 102, (9) : 1558-1566
Reimer, Jana; Knoess, Sabine; Labuhn, Maurice; et al.
Switchable Cas9
Current Opinion in Biotechnology, CURRENT BIOLOGY LTD 2017, Vol. 48 : 119-126
Richter, Florian; Fonfara, Ines; Gelfert, Renate; et al.
Improved bi-allelic modification of a transcriptionally silent locus in patient-derived iPSC by Cas9 nickase
Scientific Reports, Nature Publishing Group 2016, Vol. 6
Eggenschwiler, Reto; Moslem, Mohsen; Fráguas, Mariane Serra; et al.
The CRISPR-associated DNA-cleaving enzyme Cpf1 also processes precursor CRISPR RNA
Nature, Vol. 532, (7600) : 517-520
Fonfara, Ines; Richter, Hagen; Bratovic, Majda; et al.
CRISPR-Cas: biology, mechanisms and relevance
Philosophical Transactions of the Royal Society of London. Biological Sciences, Vol. 371, (1707)
Hille, Frank; Charpentier, Emmanuelle
Alpharetroviral self-inactivating vectors produced by a superinfection-resistant stable packaging cell line allow genetic modification of primary human T lymphocytes.
Biomaterials, Elsevier 2016, Vol. 97 : 97-109
Labenski, Verena; Suerth, Julia D; Barczak, Elke; et al.
RNA sequencing uncovers antisense RNAs and novel small RNAs in Streptococcus pyogenes
RNA Biology, Vol. 13, (2) : 177-195
Le Rhun, Anaïs; Beer, Yan Yan; Reimegård, Johan; et al.
A Two-Component Regulatory System Impacts Extracellular Membrane-Derived Vesicle Production in Group A Streptococcus
mBio, Vol. 7, (6)
Resch, Ulrike; Tsatsaronis, James Anthony; Le Rhun, Anais; et al.
Engineering of temperature- and light-switchable Cas9 variants
Nucleic Acids Research, Oxford University Press 2016, Vol. 44, (20) : 10003-10014
Richter, Florian; Fonfara, Ines; Bouazza, Boris; et al.
Adaptation in CRISPR-Cas Systems
Molecular Cell, Vol. 61, (6) : 797-808
Sternberg, Samuel H; Richter, Hagen; Charpentier, Emmanuelle; et al.
CRISPR germline engineering: the community speaks
Nature Biotechnology, Vol. 33, (5) : 478-486
Bosley, Katrine S; Botchan, Michael; Bredenoord, Annelien L; et al.
CRISPR-Cas9: how research on a bacterial RNA-guided mechanism opened new perspectives in biotechnology and biomedicine
EMBO Molecular Medicine, Vol. 7, (4) : 363-365
Charpentier, Emmanuelle
RNA in bacteria: biogenesis, regulatory mechanisms and functions
FEMS Microbiology Reviews, Vol. 39, (3) : 277-279
Charpentier, Emmanuelle; Hess, Wolfgang R
Biogenesis pathways of RNA guides in archaeal and bacterial CRISPR-Cas adaptive immunity
FEMS Microbiology Reviews, Vol. 39, (3) : 428-441
Charpentier, Emmanuelle; Richter, Hagen; van der Oost, John; et al.
Toward whole-transcriptome editing with CRISPR-Cas9
Molecular Cell, Cell Press 2015, Vol. 58, (4) : 560-562
Heckl, Dirk; Charpentier, Emmanuelle
CRISPR: methods and protocols
Methods in molecular biology, 1311
Lundgren, Magnus; Charpentier, Emmanuelle; Fineran, Peter C.
An updated evolutionary classification of CRISPR-Cas systems
Nature Reviews Microbiology, Vol. 13, (11) : 722-736
Makarova, Kira S; Wolf, Yuri I; Alkhnbashi, Omer S; et al.
DNA and RNA interference mechanisms by CRISPR-Cas surveillance complexes
FEMS Microbiology Reviews, Vol. 39, (3) : 442-463
Plagens, Andre; Richter, Hagen; Charpentier, Emmanuelle; et al.
Programmable RNA-guided Cas9 endonuclease: a novel tool for genome engineering
Transgenic research, Vol. 23, (1) : 188-189
Charpentier, Emmanuelle
Editorial overview: Novel technologies in microbiology: Recent advances in techniques in microbiology
Current Opinion in Microbiology, Vol. 19 : VIII-X
Charpentier, Emmanuelle; Marraffini, Luciano A.
Harnessing CRISPR-Cas9 immunity for genetic engineering
Current Opinion in Microbiology, Vol. 19 : 114-119
Charpentier, Emmanuelle; Marraffini, Luciano A.
Classification and evolution of type II CRISPR-Cas systems
Nucleic Acids Research, Oxford University Press 2014, Vol. 42, (10) : 6091-6105
Chylinski, Krzysztof; Makarova, Kira S.; Charpentier, Emmanuelle; et al.
The new frontier of genome engineering with CRISPR-Cas9
Science, Vol. 346, (6213) : 1077-+
Doudna, Jennifer A.; Charpentier, Emmanuelle
Phylogeny of Cas9 determines functional exchangeability of dual-RNA and Cas9 among orthologous type II CRISPR-Cas systems
Nucleic Acids Research, Vol. 42, (4) : 2577-2590
Fonfara, Ines; Le Rhun, Anaïs; Chylinski, Krzysztof; et al.
Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation
Science, Vol. 343, (6176) : 1215-
Jinek, Martin; Jiang, Fuguo; Taylor, David W.; et al.
Dynamin inhibition interferes with inflammasome activation and cytokine gene expression in Streptococcus pyogenes-infected human macrophages
Clinical and Experimental Immunology, Vol. 178, (2) : 320-333
Latvala, S.; Makela, S. M.; Miettinen, M.; et al.
Biotechnology: rewriting a genome
Nature, Nature Publishing Group 2013, Vol. 495, (7439) : 50-51
Charpentier, Emmanuelle; Doudna, Jennifer A.
CrRNA biogenesis
CRISPR-cas systems: RNA-mediated adaptive immunity in bacteria and archaea, Springer Berlin/Heidelberg 2013 : 115-144
Charpentier, Emmanuelle; Van Der Oost, John; White, Malcolm F.
The tracrRNA and Cas9 families of type II CRISPR-Cas immunity systems
RNA Biology, Landes Bioscience 2013, Vol. 10, (5) : 726-737
Chylinski, Krzysztof; Le Rhun, Anaïs; Charpentier, Emmanuelle
Structural Basis for Recognizing Phosphoarginine and Evolving Residue-Specific Protein Phosphatases in Gram-Positive Bacteria
Cell Reports, Vol. 3, (6) : 1832-1839
Fuhrmann, Jakob; Mierzwa, Beata; Trentini, Debora B.; et al.
Memory of viral infections by CRISPR-Cas adaptive immune systems: acquisition of new information
Virology, Vol. 434, (2) : 202-209
Fineran, Peter C.; Charpentier, Emmanuelle
A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity
Science, Vol. 337, (6096) : 816-821
Jinek, Martin; Chylinski, Krzysztof; Fonfara, Ines; et al.
Small RNAs in streptococci
RNA Biology, Vol. 9, (4) : 414-426
Le Rhun, Anaïs; Charpentier, Emmanuelle
CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III
Nature, Vol. 471, (7340) : 602-607
Deltcheva, Elitza; Chylinski, Krzysztof; Sharma, Cynthia M; et al.
Evolution and classification of the CRISPR-Cas systems
Nature Reviews Microbiology, Nature Publishing Group 2011, Vol. 9, (6) : 467-477
Makarova, Kira S; Haft, Daniel H; Barrangou, Rodolphe; et al.
An overview of RNAs with regulatory functions in gram-positive bacteria.
Cellular and Molecular Life Sciences (CMLS), Basel: Birkhäuser Vlg 2010, Vol. 67, (2) : 217-237
Romby, Pascale; Charpentier, Emmanuelle
McsB is a protein arginine kinase that phosphorylates and inhibits the heat-shock regulator CtsR
Science, American Association for the Advancement of Science 2009, Vol. 324, (5932) : 1323-1327
Fuhrmann, Jakob; Schmidt, Andreas; Spiess, Silvia; et al.
Visa publikationer i DiVA
Nobelpris till upptäckt vid Umeå universitet

Emmanuelle Charpentier prisas för upptäckten av gensaxen CRISPR-Cas9.

Läs mer om Emmanuelles forskning
Läs mer om Emmanuelles forskning

Hon är vetenskaplig ledare och chef för Max Planck Unit for the Science of Pathogens i Berlin.

Nobelpriset i kemi

Här upptäcktes gensaxen CRISPR-Cas9 av Emmanuelle Charpentier, som tilldelades Nobelpriset i kemi 2020.

CRISPR-Cas9 – Genteknik för framtiden

Porträtt av Emmanuelle Charpentier och hennes väg fram till den banbrytande upptäckten och vidare.

Expertlista CRISPR-Cas9

Expertlista med kontaktuppgifter på våra experter inom CRISPR-Cas9 vid Umeå universitet.