Elin Chorell

Min forskning syftar till att identifiera mekanismer som är involverade i utveckling och remission av typ 2 diabetes.

Vetenskaplig meritering: Docent

Kontakt

elin.chorell@umu.se

090-785 13 26

Verksam som

Universitetslektor vid Institutionen för folkhälsa och klinisk medicin Enhet: Endokrinologi och diabetes

Besöksadress, se karta

Forskningen syftar till att identifiera processer och mekanismer som är involverade i utveckling av typ 2 diabetes. Ett stort fokus ligger på att identifiera sjukdomsmekanismer som kan leda till utvecklande av nya behandlingsmetoder och biomarkörer för att tidigt kunna upptäcka och förebygga sjukdomen.

Mitt forskningsfokus är att på molekylnivå hitta vilka lipidprocesser som är involverade i sjukdomsutveckling och tillfriskande. I ett forskningsprojekt kommer en del av fosfolipidmetabolismen att studeras. Denna del av metabolismen kan skapa obalans i fettinnehållet i vävnaderna, främst bukspottskörteln, levern och skelettmuskulaturen och kan driva sjukdomsutvecklingen.

Lipoproteins and lipoprotein lipid composition are associated with stages of dysglycemia and subclinical coronary atherosclerosis

International Journal of Cardiology, Elsevier 2025, Vol. 419

Gigante, Bruna; Chen, Qiaosen; Björkbacka, Harry; et al.

Myofiber-specific lipidomics unveil differential contributions to insulin sensitivity in individuals of African and European ancestry

Heliyon, Elsevier 2024, Vol. 10, (12)

Eurén, Tova; Gower, Barbara; Steneberg, Pär; et al.

Drug-target Mendelian randomization analysis supports lowering plasma ANGPTL3, ANGPTL4, and APOC3 levels as strategies for reducing cardiovascular disease risk

European Heart Journal Open, Oxford University Press 2024, Vol. 4, (3)

Landfors, Fredrik; Henneman, Peter; Chorell, Elin; et al.

Genetic mimicry analysis reveals the specific lipases targeted by the ANGPTL3-ANGPTL8 complex and ANGPTL4

Journal of Lipid Research, Elsevier 2023, Vol. 64, (1)

Landfors, Fredrik; Chorell, Elin; Kersten, Sander

Leukotriene A4 Hydrolase and Hepatocyte Growth Factor Are Risk Factors of Sudden Cardiac Death Due to First-Ever Myocardial Infarction

International Journal of Molecular Sciences, MDPI 2022, Vol. 23, (18)

Landfors, Fredrik; Vikström, Simon; Wennberg, Patrik; et al.

Lysophospholipids as Predictive Markers of ST-Elevation Myocardial Infarction (STEMI) and Non-ST-Elevation Myocardial Infarction (NSTEMI)

Metabolites, MDPI 2021, Vol. 11, (1)

Chorell, Elin; Olsson, Tommy; Jansson, Jan-Håkan; et al.

Improved peripheral and hepatic insulin sensitivity after lifestyle interventions in type 2 diabetes is associated with specific metabolomic and lipidomic signatures in skeletal muscle and plasma

Metabolites, MDPI 2021, Vol. 11, (12)

Chorell, Elin; Otten, Julia; Stomby, Andreas; et al.

Fatty Acid Metabolism and Associations with Insulin Sensitivity Differs Between Black and White South African Women

Journal of Clinical Endocrinology and Metabolism, Endocrine Society 2021, Vol. 106, (1) : E140-E151

Goedecke, Julia H.; Chorell, Elin; van Jaarsveld, Paul J.; et al.

Exercise training improves mitochondrial respiration and is associated with an altered intramuscular phospholipid signature in women with obesity

Diabetologia, Springer 2021, Vol. 64, (7) : 1642-1659

Mendham, Amy E.; Goedecke, Julia H.; Zeng, Yingxu; et al.

The liver-alpha-cell axis after a mixed meal and during weight loss in type 2 diabetes

Endocrine Connections, Bioscientifica 2021, Vol. 10, (9) : 1101-1110

Otten, Julia; Stomby, Andreas; Waling, Maria; et al.

Branched-chain amino acid metabolism is regulated by ERRα in primary human myotubes and is further impaired by glucose loading in type 2 diabetes

Diabetologia, Springer 2021, Vol. 64, (9) : 2077-2091

Sjögren, Rasmus J. O.; Rizo-Roca, David; Chibalin, Alexander V.; et al.

Metabolic Profiling of Plasma in Patients with Irritable Bowel Syndrome after a 4-Week Starch- and Sucrose-Reduced Diet

Metabolites, MDPI 2021, Vol. 11, (7)

Stenlund, Hans; Nilholm, Clara; Chorell, Elin; et al.

Walking Time Is associated With Hippocampal Volume in Overweight and Obese Office Workers

Frontiers in Human Neuroscience, Frontiers Media S.A. 2020, Vol. 14

Bergman, Frida; Matsson-Frost, Tove; Jonasson, Lars S.; et al.

Circulating and Adipose Tissue Fatty Acid Composition in Black South African Women with Obesity: A Cross-Sectional Study

Nutrients, MDPI 2020, Vol. 12, (6)

Nankam, Pamela A. Nono; van Jaarsveld, Paul J.; Chorell, Elin; et al.

Fat redistribution and accumulation of visceral adipose tissue predicts type 2 diabetes risk in middle-aged black South African women: a 13-year longitudinal study

Nutrition & Diabetes, Nature Publishing Group 2019, Vol. 9

Mtintsilana, Asanda; Micklesfield, Lisa K.; Chorell, Elin; et al.

Adiposity Mediates the Association between the Dietary Inflammatory Index and Markers of Type 2 Diabetes Risk in Middle-Aged Black South African Women

Nutrients, MDPI 2019, Vol. 11, (6)

Mtintsilana, Asanda; Micklesfield, Lisa K.; Chorell, Elin; et al.

Postprandial levels of GLP-1, GIP, and glucagon after two years of weight loss with a Paleolithic diet: a randomized controlled trial in healthy obese women

European Journal of Endocrinology, Bioscientifica 2019, Vol. 180, (6) : 417-427

Otten, Julia; Ryberg, Mats; Mellberg, Caroline; et al.

Alterations in the metabolism of phospholipids, bile acids and branched-chain amino acids predicts development of type 2 diabetes in black South African women: a prospective cohort study

Metabolism: Clinical and Experimental, Elsevier 2019, Vol. 95 : 57-64

Zeng, Yingxu; Mtintsilana, Asanda; Goedecke, Julia H.; et al.

Decreased lipogenesis-promoting factors in adipose tissue in postmenopausal women with overweight on a Paleolithic-type diet

European Journal of Nutrition, Springer 2018, Vol. 57, (8) : 2877-2886

Blomquist, Caroline; Chorell, Elin; Ryberg, Mats; et al.

An Exercise Intervention to Unravel the Mechanisms Underlying Insulin Resistance in a Cohort of Black South African Women: Protocol for a Randomized Controlled Trial and Baseline Characteristics of Participants

JMIR Research Protocols, JMIR PUBLICATIONS, INC 2018, Vol. 7, (4)

Goedecke, Julia H.; Mendham, Amy E.; Clamp, Louise; et al.

Attenuated Low-Grade Inflammation Following Long-Term Dietary Intervention in Postmenopausal Women with Obesity

Obesity, Vol. 25, (5) : 892-900

Blomquist, Caroline; Alvehus, Malin; Burén, Jonas; et al.

Pregnancy to postpartum transition of serum metabolites in women with gestational diabetes

Metabolism: Clinical and Experimental, Saunders Elsevier 2017, Vol. 72 : 27-36

Chorell, Elin; Hall, Ulrika Andersson; Gustavsson, Carolina; et al.

Plasma metabolomic response to postmenopausal weight loss induced by different diets

Metabolomics, Springer 2016, Vol. 12, (5)

Chorell, Elin; Ryberg, Mats; Larsson, Christel; et al.

Metabolomics, New York: Springer-Verlag New York 2016, Vol. 12, (3)

Dugas, Lara R.; Chorell, Elin; Plange-Rhule, Jacob; et al.

Glucocorticoid receptor gene expression in adipose tissue and associated metabolic risk in black and white South African women

International Journal of Obesity, Vol. 39, (2) : 303-311

Goedecke, J H; Chorell, Elin; Livingstone, D E W; et al.

Constrained randomization and multivariate effect projections improve information extraction and biomarker pattern discovery in metabolomics studies involving dependent samples

Metabolomics, Springer 2015, Vol. 11, (6) : 1667-1678

Jonsson, Pär; Wuolikainen, Anna; Thysell, Elin; et al.

Development and optimization of simple one-step methods for the synthesis of 4-amino-substituted 1,8-naphthalimides

European Journal of Organic Chemistry, (28) : 6175-6182

Kindahl, Tomas; Chorell, Elin; Chorell, Erik

Ökat omvårdnadsbehov främsta orsak till lång vårdtid på medicinklinik: Retrospektiv journalstudie styrker att tidig vårdplanering skulle kunna ge bättre platstillgång

Läkartidningen, Vol. 111, (6) : 219-222

Skärby, Rut; Chorell, Elin; Karling, Pontus

Impact of probiotic feeding during weaning on the serum lipid profile and plasma metabolome in infants

British Journal of Nutrition, Cambridge University Press 2013, Vol. 110, (1) : 116-126

Chorell, Elin; Videhult, Frida Karlsson; Hernell, Olle; et al.

Efficient Synthesis of 2-Substituted Phthalimides from Phthalic Acids in One Step

European Journal of Organic Chemistry, Wiley-VCH Verlagsgesellschaft 2013, Vol. 2013, (33) : 7512-7516

Chorell, Erik; Chorell, Elin

Physical fitness level is reflected by alterations in the human plasma metabolome

Molecular BioSystems, Royal Society of Chemistry 2012, Vol. 8, (4) : 1187-1196

Chorell, Elin; Svensson, Michael; Moritz, Thomas; et al.

Validated and Predictive Processing of Gas Chromatography-Mass Spectrometry Based Metabolomics Data for Large Scale Screening Studies, Diagnostics and Metabolite Pattern Verification

Metabolites, Basel: MDPI 2012, Vol. 2 : 796-817

Thysell, Elin; Chorell, Elin; Svensson, Michael B; et al.

Validated and predictive processing of gas chromatography-mass spectra screening studies, diagnostics and metabolite pattern verification

Metabolites, M D P I AG 2012, Vol. 2, (4) : 796-817

Thysell, Elin; Chorell, Elin; Svensson, Michael; et al.

Mapping the consequenses of physical exercise and nutrition on human health: A predictive metabolomics approach

Umeå: Print och Media 2011

Chorell, Elin

A predictive metabolomics evaluation of nutrition-modulated metabolic stress responses in human blood serum during the early recovery phase of strenuous physical exercise

Journal of Proteome Research, Washington: American Chemical Society 2009, Vol. 8, (6) : 2966-77

Chorell, Elin; Moritz, Thomas; Branth, Stefan; et al.

A Multivariate Screening Strategy for Investigating Metabolic Effects of Strenuous Physical Exercise in Human Serum

Journal of Proteome Research, American Chemical Society 2007, Vol. 6, (6) : 2113-2120

Chorell, Elin; Thysell, Elin; Jonsson, Pär; et al.

Reliable Profile Detection in Comparative Metabolomics

Omics, Mary Ann Liebert 2007, Vol. 11, (2) : 209-224

Thysell, Elin; Pohjanen, Elin; Lindberg, Johan; et al.

Statistical multivariate metabolite profiling for aiding biomarker pattern detection and mechanistic interpretations in GC/MS based metabolomics

Metabolomics, Vol. 2, (4) : 257-68

Chorell, Elin; Thysell, Elin; Lindberg, Johan; et al.

Installing treadmill workstations in offices does little for cognitive performance and brain structure, despite a baseline association between sitting time and hippocampus volume

Bergman, Frida; Mattson-Frost, Tove; Jonasson, Lars; et al.

Long-term effects of a Paleolithic diet on plasma fatty acid composition in postmenopausal women with obesity: a randomized trial

Blomquist, Caroline; Chorell, Elin; Ryberg, Mats; et al.

The impact of feeding Lactobacillus F19 during weaning: a study of the plasma metabolome

Chorell, Elin; Antti, Henrik; Karlsson, Frida; et al.

A metabolomic evaluation of short and long term effects of different macronutrient intake in overweight and obese postmenopausal women

Chorell, Elin; Rydberg, Mats; Larsson, Christel; et al.

Processing of mass spectrometry based metabolomics data for large scale screening studies and diagnostics

Thysell, Elin; Chorell, Elin; Svensson, Michael B.; et al.

Visa publikationer i DiVA

Forskargrupper

Forskningsledare

Chorell Research Lab

Forskningsprojekt

1 maj 2023 till 1 maj 2033

Hur kan vi förebygga utveckling av typ 2-diabetes i olika populationer?

31 augusti 2022 till 31 december 2028

Remission av typ 2-diabetes blir möjligt genom e-hälsa

1 januari 2015

Vad händer i kroppen när man äter LCHF? - en randomiserad kontrollerad studie

29 april 2013 till 31 december 2027

VIPVIZA

Publicerad: 24 feb, 2025

SciLifeLab Umeå välkomnar 16 nya gruppledare

Publicerad: 03 maj, 2022

Vill hitta och bromsa diabetes typ 2

Publicerad: 28 okt, 2021

VR-miljoner till medicinsk forskning i Umeå

Elin Chorell: Hur kan kost och träning förhindra och bota typ 2 diabetes?

Orsaken till diabetes är en kombination av våra gener och vår livsstil.

Vill hitta och bromsa diabetes typ 2

Elin Chorells mål är att det ska gå bromsa diabetes typ 2 och anpassa behandling efter varje enskild individ.