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Umeå universitet
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Huvudmenyn dold.
Personalbild Elin Chorell

Elin Chorell

Min forskning syftar till att identifiera mekanismer som är involverade i utveckling och remission av typ 2 diabetes. 

Vetenskaplig meritering: Docent

Kontakt

E-post
elin.chorell@umu.se
Telefon
090-785 13 26

Verksam vid

Anknytning
Universitetslektor vid Institutionen för folkhälsa och klinisk medicin Enhet: Endokrinologi och diabetes
Plats
Besöksadress, se karta

Forskningen syftar till att identifiera processer och mekanismer som är involverade i utveckling av typ 2 diabetes. Ett stort fokus ligger på att identifiera sjukdomsmekanismer som kan leda till utvecklande av nya behandlingsmetoder och biomarkörer för att tidigt kunna upptäcka och förebygga sjukdomen.

Mitt forskningsfokus är att på molekylnivå hitta vilka lipidprocesser som är involverade i sjukdomsutveckling och tillfriskande. I ett forskningsprojekt kommer en del av fosfolipidmetabolismen att studeras. Denna del av metabolismen kan skapa obalans i fettinnehållet i vävnaderna, främst bukspottskörteln, levern och skelettmuskulaturen och kan driva sjukdomsutvecklingen.

Myofiber-specific lipidomics unveil differential contributions to insulin sensitivity in individuals of African and European ancestry
Heliyon, Elsevier 2024, Vol. 10, (12)
Eurén, Tova; Gower, Barbara; Steneberg, Pär; et al.
Genetic mimicry analysis reveals the specific lipases targeted by the ANGPTL3-ANGPTL8 complex and ANGPTL4
Journal of Lipid Research, Elsevier 2023, Vol. 64, (1)
Landfors, Fredrik; Chorell, Elin; Kersten, Sander
Leukotriene A4 Hydrolase and Hepatocyte Growth Factor Are Risk Factors of Sudden Cardiac Death Due to First-Ever Myocardial Infarction
International Journal of Molecular Sciences, MDPI 2022, Vol. 23, (18)
Landfors, Fredrik; Vikström, Simon; Wennberg, Patrik; et al.
Lysophospholipids as Predictive Markers of ST-Elevation Myocardial Infarction (STEMI) and Non-ST-Elevation Myocardial Infarction (NSTEMI)
Metabolites, MDPI 2021, Vol. 11, (1)
Chorell, Elin; Olsson, Tommy; Jansson, Jan-Håkan; et al.
Improved peripheral and hepatic insulin sensitivity after lifestyle interventions in type 2 diabetes is associated with specific metabolomic and lipidomic signatures in skeletal muscle and plasma
Metabolites, MDPI 2021, Vol. 11, (12)
Chorell, Elin; Otten, Julia; Stomby, Andreas; et al.
Fatty Acid Metabolism and Associations with Insulin Sensitivity Differs Between Black and White South African Women
Journal of Clinical Endocrinology and Metabolism, Endocrine Society 2021, Vol. 106, (1) : E140-E151
Goedecke, Julia H.; Chorell, Elin; van Jaarsveld, Paul J.; et al.
Exercise training improves mitochondrial respiration and is associated with an altered intramuscular phospholipid signature in women with obesity
Diabetologia, Springer 2021, Vol. 64, (7) : 1642-1659
Mendham, Amy E.; Goedecke, Julia H.; Zeng, Yingxu; et al.
The liver-alpha-cell axis after a mixed meal and during weight loss in type 2 diabetes
Endocrine Connections, Bioscientifica 2021, Vol. 10, (9) : 1101-1110
Otten, Julia; Stomby, Andreas; Waling, Maria; et al.
Branched-chain amino acid metabolism is regulated by ERRα in primary human myotubes and is further impaired by glucose loading in type 2 diabetes
Diabetologia, Springer 2021, Vol. 64, (9) : 2077-2091
Sjögren, Rasmus J. O.; Rizo-Roca, David; Chibalin, Alexander V.; et al.
Metabolic Profiling of Plasma in Patients with Irritable Bowel Syndrome after a 4-Week Starch- and Sucrose-Reduced Diet
Metabolites, MDPI 2021, Vol. 11, (7)
Stenlund, Hans; Nilholm, Clara; Chorell, Elin; et al.
Walking Time Is associated With Hippocampal Volume in Overweight and Obese Office Workers
Frontiers in Human Neuroscience, Frontiers Media S.A. 2020, Vol. 14
Bergman, Frida; Matsson-Frost, Tove; Jonasson, Lars S.; et al.
Circulating and Adipose Tissue Fatty Acid Composition in Black South African Women with Obesity: A Cross-Sectional Study
Nutrients, MDPI 2020, Vol. 12, (6)
Nankam, Pamela A. Nono; van Jaarsveld, Paul J.; Chorell, Elin; et al.
Fat redistribution and accumulation of visceral adipose tissue predicts type 2 diabetes risk in middle-aged black South African women: a 13-year longitudinal study
Nutrition & Diabetes, Nature Publishing Group 2019, Vol. 9
Mtintsilana, Asanda; Micklesfield, Lisa K.; Chorell, Elin; et al.
Adiposity Mediates the Association between the Dietary Inflammatory Index and Markers of Type 2 Diabetes Risk in Middle-Aged Black South African Women
Nutrients, MDPI 2019, Vol. 11, (6)
Mtintsilana, Asanda; Micklesfield, Lisa K.; Chorell, Elin; et al.
Postprandial levels of GLP-1, GIP, and glucagon after two years of weight loss with a Paleolithic diet: a randomized controlled trial in healthy obese women
European Journal of Endocrinology, Bioscientifica 2019, Vol. 180, (6) : 417-427
Otten, Julia; Ryberg, Mats; Mellberg, Caroline; et al.
Alterations in the metabolism of phospholipids, bile acids and branched-chain amino acids predicts development of type 2 diabetes in black South African women: a prospective cohort study
Metabolism: Clinical and Experimental, Elsevier 2019, Vol. 95 : 57-64
Zeng, Yingxu; Mtintsilana, Asanda; Goedecke, Julia H.; et al.
Decreased lipogenesis-promoting factors in adipose tissue in postmenopausal women with overweight on a Paleolithic-type diet
European Journal of Nutrition, Springer 2018, Vol. 57, (8) : 2877-2886
Blomquist, Caroline; Chorell, Elin; Ryberg, Mats; et al.
An Exercise Intervention to Unravel the Mechanisms Underlying Insulin Resistance in a Cohort of Black South African Women: Protocol for a Randomized Controlled Trial and Baseline Characteristics of Participants
JMIR Research Protocols, JMIR PUBLICATIONS, INC 2018, Vol. 7, (4)
Goedecke, Julia H.; Mendham, Amy E.; Clamp, Louise; et al.
Attenuated Low-Grade Inflammation Following Long-Term Dietary Intervention in Postmenopausal Women with Obesity
Obesity, Vol. 25, (5) : 892-900
Blomquist, Caroline; Alvehus, Malin; Burén, Jonas; et al.
Pregnancy to postpartum transition of serum metabolites in women with gestational diabetes
Metabolism: Clinical and Experimental, Saunders Elsevier 2017, Vol. 72 : 27-36
Chorell, Elin; Hall, Ulrika Andersson; Gustavsson, Carolina; et al.
Plasma metabolomic response to postmenopausal weight loss induced by different diets
Metabolomics, Springer 2016, Vol. 12, (5)
Chorell, Elin; Ryberg, Mats; Larsson, Christel; et al.
Obesity-related metabolite profiles of black women spanning the epidemiologic transition
Metabolomics, New York: Springer-Verlag New York 2016, Vol. 12, (3)
Dugas, Lara R.; Chorell, Elin; Plange-Rhule, Jacob; et al.
Glucocorticoid receptor gene expression in adipose tissue and associated metabolic risk in black and white South African women
International Journal of Obesity, Vol. 39, (2) : 303-311
Goedecke, J H; Chorell, Elin; Livingstone, D E W; et al.
Constrained randomization and multivariate effect projections improve information extraction and biomarker pattern discovery in metabolomics studies involving dependent samples
Metabolomics, Springer 2015, Vol. 11, (6) : 1667-1678
Jonsson, Pär; Wuolikainen, Anna; Thysell, Elin; et al.
Development and optimization of simple one-step methods for the synthesis of 4-amino-substituted 1,8-naphthalimides
European Journal of Organic Chemistry, (28) : 6175-6182
Kindahl, Tomas; Chorell, Elin; Chorell, Erik
Ökat om­vårdnadsbehov främsta orsak till lång vårdtid på medicinklinik: Retrospektiv journalstudie styrker att tidig vårdplanering skulle kunna ge bättre platstillgång
Läkartidningen, Vol. 111, (6) : 219-222
Skärby, Rut; Chorell, Elin; Karling, Pontus
Impact of probiotic feeding during weaning on the serum lipid profile and plasma metabolome in infants
British Journal of Nutrition, Cambridge University Press 2013, Vol. 110, (1) : 116-126
Chorell, Elin; Videhult, Frida Karlsson; Hernell, Olle; et al.
Efficient Synthesis of 2-Substituted Phthalimides from Phthalic Acids in One Step
European Journal of Organic Chemistry, Wiley-VCH Verlagsgesellschaft 2013, Vol. 2013, (33) : 7512-7516
Chorell, Erik; Chorell, Elin
Physical fitness level is reflected by alterations in the human plasma metabolome
Molecular BioSystems, Royal Society of Chemistry 2012, Vol. 8, (4) : 1187-1196
Chorell, Elin; Svensson, Michael; Moritz, Thomas; et al.
Validated and Predictive Processing of Gas Chromatography-Mass Spectrometry Based Metabolomics Data for Large Scale Screening Studies, Diagnostics and Metabolite Pattern Verification
Metabolites, Basel: MDPI 2012, Vol. 2 : 796-817
Thysell, Elin; Chorell, Elin; Svensson, Michael B; et al.
Validated and predictive processing of gas chromatography-mass spectra screening studies, diagnostics and metabolite pattern verification
Metabolites, M D P I AG 2012, Vol. 2, (4) : 796-817
Thysell, Elin; Chorell, Elin; Svensson, Michael; et al.
Mapping the consequenses of physical exercise and nutrition on human health: A predictive metabolomics approach
Umeå: Print och Media 2011
Chorell, Elin
A predictive metabolomics evaluation of nutrition-modulated metabolic stress responses in human blood serum during the early recovery phase of strenuous physical exercise
Journal of Proteome Research, Washington: American Chemical Society 2009, Vol. 8, (6) : 2966-77
Chorell, Elin; Moritz, Thomas; Branth, Stefan; et al.
A Multivariate Screening Strategy for Investigating Metabolic Effects of Strenuous Physical Exercise in Human Serum
Journal of Proteome Research, American Chemical Society 2007, Vol. 6, (6) : 2113-2120
Chorell, Elin; Thysell, Elin; Jonsson, Pär; et al.
Reliable Profile Detection in Comparative Metabolomics
Omics, Mary Ann Liebert 2007, Vol. 11, (2) : 209-224
Thysell, Elin; Pohjanen, Elin; Lindberg, Johan; et al.
Statistical multivariate metabolite profiling for aiding biomarker pattern detection and mechanistic interpretations in GC/MS based metabolomics
Metabolomics, Vol. 2, (4) : 257-68
Chorell, Elin; Thysell, Elin; Lindberg, Johan; et al.
Installing treadmill workstations in offices does little for cognitive performance and brain structure, despite a baseline association between sitting time and hippocampus volume
Bergman, Frida; Mattson-Frost, Tove; Jonasson, Lars; et al.
Long-term effects of a Paleolithic diet on plasma fatty acid composition in postmenopausal women with obesity: a randomized trial
Blomquist, Caroline; Chorell, Elin; Ryberg, Mats; et al.
The impact of feeding Lactobacillus F19 during weaning: a study of the plasma metabolome
Chorell, Elin; Antti, Henrik; Karlsson, Frida; et al.
A metabolomic evaluation of short and long term effects of different macronutrient intake in overweight and obese postmenopausal women
Chorell, Elin; Rydberg, Mats; Larsson, Christel; et al.
Processing of mass spectrometry based metabolomics data for large scale screening studies and diagnostics
Thysell, Elin; Chorell, Elin; Svensson, Michael B.; et al.
Visa publikationer i DiVA

Forskargrupper

Forskningsledare
Chorell Research Lab

Forskningsprojekt

1 maj 2023 till 1 maj 2033
Hur kan vi förebygga utveckling av typ 2-diabetes i olika populationer?
31 augusti 2022 till 31 december 2028
Remission av typ 2-diabetes blir möjligt genom e-hälsa
1 januari 2015
Vad händer i kroppen när man äter LCHF? - en randomiserad kontrollerad studie
29 april 2013 till 31 december 2027
VIPVIZA

Min huvudsakliga undervisning bedrivs inom molekylär metabolism, lipid metabolism och mutlivariat bioinformatik.

Elin Chorell: Hur kan kost och träning förhindra och bota typ 2 diabetes?

Orsaken till diabetes är en kombination av våra gener och vår livsstil.

Vill hitta och bromsa diabetes typ 2

Elin Chorells mål är att det ska gå bromsa diabetes typ 2 och anpassa behandling efter varje enskild individ.