Anders Olofsson

Vetenskaplig meritering: Docent

Kontakt

anders.olofsson@umu.se

Verksam vid

Universitetslektor vid Institutionen för klinisk mikrobiologi Enhet: Biomedicinsk laboratorievetenskap

KBC huset, Linneus väg 6 , Biomedicinsk analytikerprogrammet BML Umeå universitet, 901 85 Umeå

ApoE isoforms inhibit amyloid aggregation of proinflammatory protein S100a9

International Journal of Molecular Sciences, MDPI 2024, Vol. 25, (4)

Ghosh, Shamasree; Tamilselvi, Shanmugam; Williams, Chloe; et al.

Plasma IAPP-autoantibody levels in Alzheimer’s disease patients are affected by APOE4 status

International Journal of Molecular Sciences, MDPI 2023, Vol. 24, (4)

Pocevičiūtė, Dovilė; Roth, Bodil; Schultz, Nina; et al.

Endogenous Human Proteins Interfering with Amyloid Formation

Biomolecules, MDPI 2022, Vol. 12, (3)

Gharibyan, Anna; Jayaweera, Sanduni Wasana; Lehmann, Manuela; et al.

K₂S₂O₈-mediated coupling of 6-amino-7-aminomethyl-thiazolino-pyridones with aldehydes to construct amyloid affecting pyrimidine-fused thiazolino-2-pyridones

Organic and biomolecular chemistry, The Royal Society of Chemistry 2021, Vol. 19, (44) : 9758-9772

Bharate, Jaideep B.; Ådén, Jörgen; Gharibyan, Anna; et al.

Mechanisms of Transthyretin Inhibition of IAPP Amyloid Formation

Biomolecules, MDPI 2021, Vol. 11, (3)

Jayaweera, Sanduni Wasana; Surano, Solmaz; Pettersson, Nina; et al.

Tandem Ring Opening/Intramolecular [2 + 2] Cycloaddition Reaction for the Synthesis of Cyclobutane Fused Thiazolino-2-Pyridones

Journal of Organic Chemistry, American Chemical Society (ACS) 2021, Vol. 86, (23) : 16582-16592

Tyagi, Mohit; Adolfsson, Dan E.; Singh, Pardeep; et al.

Intramolecular Povarov Reactions for the Synthesis of Chromenopyridine fused 2-Pyridone Polyheterocycles Binding to α-Synuclein and Amyloid-β fibrils

Journal of Organic Chemistry, American Chemical Society (ACS) 2020, Vol. 85, (21) : 14174-14189

Adolfsson, Dan E.; Tyagi, Mohit; Singh, Pardeep; et al.

Apolipoprotein E Interferes with IAPP Aggregation and Protects Pericytes from IAPP-Induced Toxicity

Biomolecules, MDPI 2020, Vol. 10, (1)

Gharibyan, Anna; Islam, Tohidul; Pettersson, Nina; et al.

Apolipoprotein E impairs amyloid-β fibril elongation and maturation

The FEBS Journal, Wiley-Blackwell 2020, Vol. 287, (6) : 1208-1219

Islam, Tohidul; Gharibyan, Anna L.; Golchin, Solmaz A.; et al.

Morphological analysis of Apolipoprotein E binding to A beta Amyloid using a combination of Surface Plasmon Resonance, Immunogold Labeling and Scanning Electron Microscopy

BMC Biotechnology, BMC 2019, Vol. 19, (1)

Islam, Tohidul; Gharibyan, Anna L.; Lee, Cheng Choo; et al.

Pyridine-Fused 2-Pyridones via Povarov and A³ Reactions: Rapid Generation of Highly Functionalized Tricyclic Heterocycles Capable of Amyloid Fibril Binding

Journal of Organic Chemistry, American Chemical Society (ACS) 2019, Vol. 84, (7) : 3887-3903

Singh, Pardeep; Adolfsson, Dan E.; Ådén, Jörgen; et al.

Scanning electron microscopy as a tool for evaluating morphology of amyloid structures formed on surface plasmon resonance chips

Data in Brief, Elsevier 2018, Vol. 19 : 1166-1170

Brännström, Kristoffer; Gharibyan, Anna L.; Islam, Tohidul; et al.

The Properties of Amyloid-β Fibrils Are Determined by their Path of Formation

Journal of Molecular Biology, Elsevier 2018, Vol. 430, (13) : 1940-1949

Brännström, Kristoffer; Islam, Tohidul; Gharibyan, Anna L.; et al.

Transthyretin Interferes with Aβ Amyloid Formation by Redirecting Oligomeric Nuclei into Non-Amyloid Aggregates

Journal of Molecular Biology, Elsevier 2018, Vol. 430, (17) : 2722-2733

Nilsson, Lina; Pamrén, Annelie; Islam, Tohidul; et al.

Amyloid-beta 1-40 is associated with alterations in NG2+ pericyte population ex vivo and in vitro

Aging Cell, John Wiley & Sons 2018, Vol. 17, (3)

Schultz, Nina; Brännström, Kristoffer; Byman, Elin; et al.

Interspecies variation between fish and human transthyretins in their binding of thyroid-disrupting chemicals

Environmental Science and Technology, American Chemical Society (ACS) 2018, Vol. 52, (20) : 11865-11874

Zhang, Jin; Grundström, Christin; Brännström, Kristoffer; et al.

The role of histidines in amyloid β fibril assembly

FEBS Letters, Vol. 591, (8) : 1167-1175

Brännström, Kristoffer; Islam, Tohidul; Sandblad, Linda; et al.

Helicobacter pylori Adapts to Chronic Infection and Gastric Disease via pH-Responsive BabA-Mediated Adherence

Cell Host and Microbe, CELL PRESS 2017, Vol. 21, (3) : 376-389

Bugaytsova, Jeanna A.; Björnham, Oscar; Chernov, Yevgen A.; et al.

Tetrabromobisphenol A Is an Efficient Stabilizer of the Transthyretin Tetramer

PLOS ONE, Public Library Science 2016, Vol. 11, (4)

Iakovleva, Irina; Begum, Afshan; Brännström, Kristoffer; et al.

Modifications of the 7-Hydroxyl Group of the Transthyretin Ligand Luteolin Provide Mechanistic Insights into Its Binding Properties and High Plasma Specificity

PLOS ONE, Public Library Science 2016, Vol. 11, (4)

Nilsson, Lina; Larsson, Andreas; Begum, Afshan; et al.

Structure-based Virtual Screening Protocol for in silico Identification of Potential Thyroid Disrupting Chemicals Targeting Transthyretin

Environmental Science and Technology, Vol. 50, (21) : 11984-11993

Zhang, Jin; Begum, Afshan; Brännström, Kristoffer; et al.

The flavonoid luteolin, but not luteolin-7-o-glucoside, prevents a transthyretin mediated toxic response

PLOS ONE, Public Library Science 2015, Vol. 10, (5)

Iakovleva, Irina; Begum, Afshan; Pokrzywa, Malgorzata; et al.

Enthalpic Forces Correlate with Selectivity of Transthyretin-Stabilizing Ligands in Human Plasma

Journal of Medicinal Chemistry, Vol. 58, (16) : 6507-6515

Iakovleva, Irina; Brännström, Kristoffer; Nilsson, Lina; et al.

Interaction Studies of the Human and Arabidopsis thaliana Med25-ACID Proteins with the Herpes Simplex Virus VP16-and Plant-Specific Dreb2a Transcription Factors

PLOS ONE, Vol. 9, (5) : e98575-

Aguilar, Ximena; Blomberg, Jeanette; Brännström, Kristoffer; et al.

A Generic Method for Design of Oligomer-Specific Antibodies

PLOS ONE, Vol. 9, (3) : e90857-

Brännström, Kristoffer; Lindhagen-Persson, Malin; Gharibyan, Anna L.; et al.

The N-terminal Region of Amyloid β Controls the Aggregation Rate and Fibril Stability at Low pH Through a Gain of Function Mechanism

Journal of the American Chemical Society, American Chemical Society (ACS) 2014, Vol. 136, (31) : 10956-10964

Brännström, Kristoffer; Öhman, Anders; Nilsson, Lina; et al.

The role of pro-inflammatory S100A9 in Alzheimer's disease amyloid-neuroinflammatory cascade

Acta Neuropathologica, Vol. 127, (4) : 507-522

Wang, Chao; Klechikov, Alexey G.; Gharibyan, Anna L.; et al.

Ca2+ enhances Aβ polymerization rate and fibrillar stability in a dynamic manner

Biochemical Journal, Portland Press 2013, Vol. 450 : 189-197

Brännström, Kristoffer; Öhman, Anders; Lindhagen-Persson, Malin; et al.

Modulation of α-synuclein fibrillization by ring-fused 2-pyridones: templation and inhibition involve oligomers with different structure

Archives of Biochemistry and Biophysics, Elsevier 2013, Vol. 532, (2) : 84-90

Horvath, Istvan; Sellstedt, Magnus; Weise, Christoph; et al.

Transthyretin is dysregulated in preeclampsia, and its native form prevents the onset of disease in a preclinical mouse model

American Journal of Pathology, Elsevier 2013, Vol. 183, (5) : 1425-1436

Kalkunte, Satyan S.; Neubeck, Stefan; Norris, Wendy E.; et al.

Structural topology and activation of an initial adenylate kinase-substrate complex

Biochemistry, Vol. 52, (6) : 1055-1061

Ådén, Jörgen; Weise, Christoph; Brännström, Kristoffer; et al.

Interactions between DNA, transcriptional regulator Dreb2a and the Med25 mediator subunit from Arabidopsis thaliana involve conformational changes

Nucleic Acids Research, Oxford: Oxford University Press 2012, Vol. 40, (13) : 5938-5950

Blomberg, Jeanette; Aguilar, Ximena; Brännström, Kristoffer; et al.

Characterization of SPINK9, a KLK5-specific inhibitor expressed in palmo-plantar epidermis

Biological chemistry (Print), Walter de Gruyter 2012, Vol. 393, (5) : 369-377

Brännström, Kristoffer; Öhman, Anders; von Pawel-Rammingen, Ulrich; et al.

The C-terminal repeating units of CsgB direct bacterial functional amyloid nucleation

Journal of Molecular Biology, Elsevier 2012, Vol. 422, (3) : 376-389

Hammer, Neal D; McGuffie, Bryan A; Zhou, Yizhou; et al.

Mechanisms of Protein Oligomerization: Inhibitor of Functional Amyloids Templates α-Synuclein Fibrillation

Journal of the American Chemical Society, American Chemical Society (ACS) 2012, Vol. 134, (7) : 3439-3444

Horvath, Istvan; Weise, Christoph F; Andersson, Emma K; et al.

Aβ peptide fibrillar architectures controlled by conformational constraints of the monomer

PLOS ONE, San Francisco, CA: Public Library of Science 2011, Vol. 6, (9) : e25157-

Brännström, Kristoffer; Öhman, Anders; Olofsson, Anders

Neuroprotective and nootropic drug noopept rescues α-synuclein amyloid cytotoxicity

Journal of Molecular Biology, Vol. 414, (5) : 699-712

Jia, Xueen; Gharibyan, Anna; Öhman, Anders; et al.

Clicked tacrine conjugates as acetylcholinesterase and β-amyloid directed compounds

Organic and biomolecular chemistry, The Royal Society of Chemistry 2011, Vol. 9, (4) : 1140-1147

Ouberai, Myriam; Brännström, Kristoffer; Vestling, Monika; et al.

Functional links between Aβ toxicity, endocytic trafficking, and Alzheimer's disease risk factors in yeast

Science, Washington: American association of advancement in science 2011, Vol. 334, (6060) : 1241-1245

Treusch, Sebastian; Hamamichi, Shusei; Goodman, Jessica L; et al.

Amyloid-β oligomer specificity mediated by the IgM isotype: implications for a specific protective mechanism exerted by endogenous auto-antibodies

PLOS ONE, Public Library of Science 2010, Vol. 5, (11) : e13928-

Lindhagen-Persson, Malin; Brännström, Kristoffer; Vestling, Monika; et al.

Designed fluorescent probes reveal interactions between Amyloid-β(1-40) Peptides and G_M1 Gangliosides in Micelles and Lipid Vesicles

Biophysical Journal, Vol. 99, (5) : 1510-1519

Mikhalyov, I; Olofsson, Anders; Gröbner, Gerhard; et al.

Stability and fibril formation properties of human and fish transthyretin, and of the Escherichia coli transthyretin-related protein

The FEBS Journal, Wiley InterScience 2009, Vol. 276, (7) : 1999-2011

Lundberg, Erik; Olofsson, Anders; Westermark, Gunilla T; et al.

Quenched hydrogen/deuterium exchange NMR characterization of amyloid-β peptide aggregates formed in the presence of Cu²⁺ or Zn²⁺

The FEBS Journal, Wiley InterScience 2009, Vol. 276, (15) : 4051-4060

Olofsson, Anders; Lindhagen Persson, Malin; Vestling, Monika; et al.

Amyloid fibril dynamics revealed by combined hydrogen/deuterium exchange and nuclear magnetic resonance

Analytical Biochemistry, Elsevier 2009, Vol. 385, (2) : 374-376

Olofsson, Anders; Sauer-Eriksson, A Elisabeth; Öhman, Anders

Disordered proteins: Biological membranes as two-dimensional aggregation matrices

Cell Biochemistry and Biophysics, Vol. 52, (3) : 175-189

Byström, Roberth; Aisenbrey, Christopher; Borowik, Tomasz; et al.

Formation of cytotoxic transthyretin is not dependent on inter-molecular disulphide bridges commonly found within the amyloid form

Amyloid: Journal of Protein Folding Disorders, Vol. 15, (4) : 240-245

Lindhagen-Persson, Malin; Vestling, M; Reixach, N; et al.

Negatively Charged Phospholipid Membranes Induce Amyloid Formation of Medin via an alpha-Helical Intermediate

Journal of Molecular Biology, Vol. 374, (1) : 186-94

Olofsson, Anders; Borowik, Tomasz; Gröbner, Gerhard; et al.

Amide solvent protection analysis demonstrates that amyloid-beta(1-40) and amyloid-beta(1-42) form different fibrillar structures under identical conditions.

Biochem J, Vol. 404, (1) : 63-70

Olofsson, Anders; Lindhagen-Persson, Malin; Sauer-Eriksson, Elisabeth; et al.

The solvent protection of alzheimer amyloid-beta-(1-42) fibrils as determined by solution NMR spectroscopy.

Journal of Biological Chemistry, Vol. 281, (1) : 477-83

Olofsson, Anders; Sauer-Eriksson, Elisabeth; Öhman, Anders

The effect of iodide and chloride on transthyretin structure and stability

Biochemistry, Vol. 44, (26) : 9290-9299

Hörnberg, Andreas; Wikström Hultdin, Ulrika; Olofsson, Anders; et al.

Visa publikationer i DiVA

Forskargrupper

Forskningsledare

Anders Olofsson

Publicerad: 06 nov, 2023

Friska miljoner från Vetenskapsrådet till medicinsk forskning

Publicerad: 05 dec, 2022

Söderberg-anslag till Umeåforskare

Publicerad: 14 jun, 2022

Umeåforskare prisas för sin forskning om Skelleftesjukan

Publicerad: 07 feb, 2019

WCMM beviljar postdoktorresurser

Anders Olofsson: Går det att stoppa Alzheimers sjukdom?

Antalet som drabbas av Alzheimers ökar med stigande ålder. Det finns ännu inget botemedel men detta är en livs...