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Umeå universitet
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Huvudmenyn dold.
Personalbild Anders Hofer

Anders Hofer

Universitetslektor och docent i Medicinsk kemi

 

Vetenskaplig meritering: Docent
Pedagogisk meritering: Meriterad lärare

Kontakt

E-post
anders.hofer@umu.se
Telefon
070-297 40 96

Verksam vid

Anknytning
Universitetslektor vid Institutionen för medicinsk kemi och biofysik Roll: Studierektor
Plats
KB.H6, Campus, Umeå, A6.50.15 Umeå universitet, 901 87 Umeå

Jag forskar om nukleotidmetabolism – enzymer, reglering och läkemedelsutveckling.

Nukleotider har en central roll i cellens funktion genom att vara energibärare och beståndsdelar i DNA och RNA. I min forskargrupp studerar vi hur de enzymer som ingår i nukleotidmetabolismen är reglerade med fokus på nukleosidkinaser och ribonukleotidreduktas.

Forskningen inkluderar studier av nukleotidmetabolismen hos flertalet patogener där vi försöker utnyttja skillnader i nukleotidmetabolismen mellan dem och mammala celler för att selektivt kunna slå ut patogenerna med så få biverkningar som möjligt.

How tumors hijack macrophages for immune evasion
Nature Cancer, Springer Nature 2024, Vol. 5, (8) : 1134-1135
Hofer, Anders
Quantification of all 12 canonical ribonucleotides by real-time fluorogenic in vitro transcription
Nucleic Acids Research, Oxford University Press 2024, Vol. 52, (1)
Purhonen, Janne; Hofer, Anders; Kallijärvi, Jukka
NUDT6 and NUDT9, two mitochondrial members of the NUDIX family, have distinct hydrolysis activities
Mitochondrion (Amsterdam. Print), Elsevier 2023, Vol. 71 : 93-103
Debar, Louis; Ishak, Layal; Moretton, Amandine; et al.
Targeting the nucleotide metabolism of Trypanosoma brucei and other trypanosomatids
FEMS Microbiology Reviews, Oxford University Press 2023, Vol. 47, (3)
Hofer, Anders
14-3-3 activated bacterial exotoxins AexT and ExoT share actin and the SH2 domains of CRK proteins as targets for ADP-ribosylation
Pathogens, MDPI 2022, Vol. 11, (12)
Ebenwaldner, Carmen; Hornyak, Peter; García-Saura, Antonio Ginés; et al.
HUG Domain Is Responsible for Active Dimer Stabilization in an NrdJd Ribonucleotide Reductase
Biochemistry, American Chemical Society (ACS) 2022, Vol. 61, (15) : 1633-1641
Fietze, Tobias; Wilk, Piotr; Kabinger, Florian; et al.
Giardia intestinalis thymidine kinase is a high-affinity enzyme crucial for DNA synthesis and an exploitable target for drug discovery
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology 2022, Vol. 298, (6)
Krakovka, Sascha; Ranjbarian, Farahnaz; Luján, Lucas A.; et al.
Zinc(II) Complex with Pyrazolone-Based Hydrazones is Strongly Effective against Trypanosoma brucei Which Causes African Sleeping Sickness
Inorganic Chemistry, American Chemical Society (ACS) 2022, Vol. 61, (34) : 13561-13575
Marchetti, Fabio; Tombesi, Alessia; Di Nicola, Corrado; et al.
Isocratic HPLC analysis for the simultaneous determination of dNTPs, rNTPs and ADP in biological samples
Nucleic Acids Research, Oxford University Press 2022, Vol. 50, (3)
Ranjbarian, Farahnaz; Sharma, Sushma; Falappa, Giulia; et al.
Structural and Biochemical Investigation of Class i Ribonucleotide Reductase from the Hyperthermophile Aquifex aeolicus
Biochemistry, Vol. 61, (2) : 92-106
Rehling, Daniel; Scaletti, Emma Rose; Rozman Grinberg, Inna; et al.
Antitrypanosomal Activity of Anthriscus Nemorosa Essential Oils and Combinations of Their Main Constituents
Antibiotics, MDPI 2021, Vol. 10, (11)
Baldassarri, Cecilia; Falappa, Giulia; Mazzara, Eugenia; et al.
Phytochemical Analysis and Trypanocidal Activity of Marrubium incanum Desr.
Molecules, MDPI 2020, Vol. 25, (14)
Frezza, Claudio; Venditti, Alessandro; Bianco, Armandodoriano; et al.
A ribonucleotide reductase from Clostridium botulinum reveals distinct evolutionary pathways to regulation via the overall activity site
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology 2020, Vol. 295, (46) : 15576-15587
Martinez-Carranza, Markel; Jonna, Venkateswara Rao; Lundin, Daniel; et al.
The maturase HydF enables [FeFe] hydrogenase assembly via transient, cofactor-dependent interactions
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology 2020, Vol. 295, (33) : 11891-11901
Nemeth, Brigitta; Land, Henrik; Magnuson, Ann; et al.
Inactivation of folylpolyglutamate synthetase Met7 results in genome instability driven by an increased dUTP/dTTP ratio
Nucleic Acids Research, Oxford University Press 2020, Vol. 48, (1) : 264-277
Schmidt, Tobias T; Sharma, Sushma; Reyes, Gloria X; et al.
Combining tubercidin and cordycepin scaffolds results in highly active candidates to treat late-stage sleeping sickness
Nature Communications, Nature Publishing Group 2019, Vol. 10
Hulpia, Fabian; Mabille, Dorien; Campagnaro, Gustavo D.; et al.
Mosquito control with green nanopesticides: towards the One Health approach? A review of non-target effects
Environmental Science and Pollution Research, Vol. 25, (11) : 10184-10206
Benelli, Giovanni; Maggi, Filippo; Pavela, Roman; et al.
Novel ATP-Cone-Driven Allosteric Regulation of Ribonucleotide Reductase Via the Radical-Generating Subunit
Protein Science, Wiley-Blackwell 2018, Vol. 27 : 87-88
Grinberg, Inna; McGann, Matthew; Lundin, Daniel; et al.
Formation of a Secretion-Competent Protein Complex by a Dynamic Wrap-around Binding Mechanism
Journal of Molecular Biology, Elsevier 2018, Vol. 430, (18, Part B) : 3157-3169
Gupta, Arun A.; Reinartz, Ines; Karunanithy, Gogulan; et al.
Identification of highly effective antitrypanosomal compounds in essential oils from the Apiaceae family
Ecotoxicology and Environmental Safety, Elsevier 2018, Vol. 156 : 154-165
Kamte, Stephane L. Ngahang; Ranjbarian, Farahnaz; Cianfaglione, Kevin; et al.
Novel ATP-cone-driven allosteric regulation of ribonucleotide reductase via the radical-generating subunit
eLIFE, ELIFE SCIENCES PUBLICATIONS LTD 2018, Vol. 7
Rozman Grinberg, Inna; Lundin, Daniel; Hasan, Mahmudul; et al.
A glutaredoxin domain fused to the radical-generating subunit of ribonucleotide reductase (RNR) functions as an efficient RNR reductant
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology 2018, Vol. 293, (41) : 15889-15900
Rozman Grinberg, Inna; Lundin, Daniel; Sahlin, Margareta; et al.
PrgB promotes aggregation, biofilm formation, and conjugation through DNA binding and compaction
Molecular Microbiology, John Wiley & Sons 2018, Vol. 109, (3) : 291-305
Schmitt, Andreas; Jiang, Kai; Camacho, Martha I.; et al.
Identification of tagitinin C from Tithonia diversifolia as antitrypanosomal compound using bioactivity-guided fractionation
Fitoterapia (Milano), Elsevier 2018, Vol. 124 : 145-151
Sut, Stefania; Dall'Acqua, Stefano; Baldan, Valeria; et al.
Helicobacter pylori Adapts to Chronic Infection and Gastric Disease via pH-Responsive BabA-Mediated Adherence
Cell Host and Microbe, CELL PRESS 2017, Vol. 21, (3) : 376-389
Bugaytsova, Jeanna A.; Björnham, Oscar; Chernov, Yevgen A.; et al.
Global Disordering in Stereo-Specific Protein Association
Biophysical Journal, CELL PRESS 2017, Vol. 112, (3) : 33A-33A
Gupta, Arun; Reinartz, Ines; Spilotros, Alessandro; et al.
Trypanosoma brucei Inhibition by Essential Oils from Medicinal and Aromatic Plants Traditionally Used in Cameroon (Azadirachta indica, Aframomum melegueta, Aframomum daniellii, Clausena anisata, Dichrostachys cinerea and Echinops giganteus)
International Journal of Environmental Research and Public Health, MDPI AG 2017, Vol. 14, (7)
Kamte, Stephane L. Ngahang; Ranjbarian, Farahnaz; Campagnaro, Gustavo Daniel; et al.
A unique cysteine-rich zinc finger domain present in a majority of class II ribonucleotide reductases mediates catalytic turnover
Journal of Biological Chemistry, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC 2017, Vol. 292, (46) : 19044-19054
Loderer, Christoph; Jonna, Venkateswara Rao; Crona, Mikael; et al.
An overlooked horticultural crop, Smyrnium olusatrum, as a potential source of compounds effective against African trypanosomiasis
Parasitology international, Vol. 66, (2) : 146-151
Petrelli, Riccardo; Ranjbarian, Farahnaz; Dall'Acqua, Stefano; et al.
9-(2 '-Deoxy-2 '-Fluoro-beta-D-Arabinofuranosyl) Adenine Is a Potent Antitrypanosomal Adenosine Analogue That Circumvents Transport-Related Drug Resistance
Antimicrobial Agents and Chemotherapy, American Society for Microbiology 2017, Vol. 61, (6)
Ranjbarian, Farahnaz; Vodnala, Munender; Alzahrani, Khalid J. H.; et al.
Biochemical Characterization of Kat1: a Domesticated hAT-Transposase that Induces DNA Hairpin Formation and MAT-Switching
Scientific Reports, Nature Publishing Group 2016, Vol. 6
Chiruvella, Kishore K; Rajaei, Naghmeh; Jonna, Venkateswara Rao; et al.
A ribonucleotide reductase inhibitor with deoxyribonucleoside-reversible cytotoxicity
Molecular Oncology, Vol. 10, (9) : 1375-1386
Crona, Mikael; Codo, Paula; Jonna, Venkateswara Rao; et al.
Structural Mechanism of Allosteric Activity Regulation in a Ribonucleotide Reductase with Double ATP Cones
Structure, Vol. 24, (6) : 906-917
Johansson, Renzo; Jonna, Venkateswara Rao; Kumar, Rohit; et al.
Biological Activities of the Essential Oil from Erigeron floribundus
Molecules, Vol. 21, (8)
Petrelli, Riccardo; Orsomando, Giuseppe; Sorci, Leonardo; et al.
VP3 is crucial for the stability of Nora virus virions
Virus Research, Elsevier 2016, Vol. 223 : 20-27
Sadanandan, Sajna Anand; Ekström, Jens-Ola; Jonna, Venkateswara Rao; et al.
Trypanosoma brucei Methylthioadenosine Phosphorylase Protects the Parasite from the Antitrypanosomal Effect of Deoxyadenosine: IMPLICATIONS FOR THE PHARMACOLOGY OF ADENOSINE ANTIMETABOLITES
Journal of Biological Chemistry, Vol. 291, (22) : 11717-11726
Vodnala, Munender; Ranjbarian, Farahnaz; Pavlova, Anna; et al.
Biochemical Characterization of the Split Class II Ribonucleotide Reductase from Pseudomonas aeruginosa
PLOS ONE, Vol. 10, (7)
Crona, Mikael; Hofer, Anders; Astorga-Wells, Juan; et al.
Diversity in Overall Activity Regulation of Ribonucleotide Reductase
Journal of Biological Chemistry, Vol. 290, (28) : 17339-17348
Jonna, Venkateswara Rao; Crona, Mikael; Rofougaran, Reza; et al.
From the covalent linkage of drugs to novel inhibitors of ribonucleotide reductase: Synthesis and biological evaluation of valproic esters of 3'-C-methyladenosine
Bioorganic & Medicinal Chemistry Letters, Vol. 24, (22) : 5304-5309
Petrelli, Riccardo; Meli, Maria; Vita, Patrizia; et al.
Nucleoside-catabolizing Enzymes in Mycoplasma-infected Tumor Cell Cultures Compromise the Cytostatic Activity of the Anticancer Drug Gemcitabine
Journal of Biological Chemistry, Vol. 289, (19) : 13054-13065
Vande Voorde, Johan; Sabuncuoglu, Suna; Noppen, Sam; et al.
Transmitting the allosteric signal in methylglyoxal synthase
Protein Engineering Design & Selection, Oxford University Press 2013, Vol. 26, (7) : 445-452
Falahati, Hanieh; Pazhang, Mohammad; Zareian, Shekufeh; et al.
Substrate kinetics and substrate effects on the quaternary structure of barley UDP-glucose pyrophosphorylase
Phytochemistry, Vol. 79 : 39-45
Decker, Daniel; Meng, Meng; Gornicka, Agnieszka; et al.
DNA building blocks: keeping control of manufacture
Critical reviews in biochemistry and molecular biology, London: Informa Healthcare 2012, Vol. 47, (1) : 50-63
Hofer, Anders; Crona, Mikael; Logan, Derek T; et al.
Trypanosoma brucei thymidine kinase is tandem protein consisting of two homologous parts, which together enable efficient substrate binding
Journal of Biological Chemistry, Vol. 287, (21) : 17628-17636
Ranjbarian, Farahnaz; Vodnala, Munender; Vodnala, Sharvani Munender; et al.
Assembly of a fragmented ribonucleotide reductase by protein interaction domains derived from a mobile genetic element.
Nucleic Acids Research, Oxford Journals 2011, Vol. 39, (4) : 1381-9
Crona, Mikael; Moffatt, Connor; Friedrich, Nancy C; et al.
NrdH-Redoxin Protein Mediates High Enzyme Activity in Manganese-reconstituted Ribonucleotide Reductase from Bacillus anthracis
Journal of Biological Chemistry, Bethesda, Md.: American Society for Biochemistry and Molecular Biology 2011, Vol. 286, (38) : 33053-33060
Crona, Mikael; Torrents, Eduard; Rohr, Asmund K.; et al.
Ribosylurea accumulates in yeast urc4 mutants
Nucleosides, Nucleotides & Nucleic Acids, Vol. 29, (4-6) : 433-437
Björnberg, O; Vodnala, Munender; Domkin, Vladimir; et al.
Cryo-EM reveals promoter DNA binding and conformational flexibility of the general transcription factor TFIID
Structure, Vol. 17, (11) : 1442-1452
Elmlund, Hans; Baraznenok, Vera; Linder, Tomas; et al.
A second pathway to degrade pyrimidine nucleic acid precursors in eukaryotes.
Journal of Molecular Biology, Vol. 380, (4) : 656-66
Andersen, Gorm; Björnberg, Olof; Polakova, Silvia; et al.
The N-terminal domain of TWINKLE contributes to single-stranded DNA binding and DNA helicase activities.
Nucleic Acids Research, Vol. 36, (2) : 393-403
Farge, Géraldine; Holmlund, Teresa; Khvorostova, Julia; et al.
Visa publikationer i DiVA

Forskargrupper

Forskningsledare
Anders Hofer Lab

Forskningsprojekt

1 januari 2020 till 31 december 2025
Läkemedelsutveckling mot humanpatogener beroende av nukleotider från värdorganismen
21 juli 2016 till 1 januari 2020
Nukleotider - enzymer, syntesvägar och läkemedelsutveckling

Jag undervisar på termin 1-3 på läkarprogrammet och på första terminen på tandläkarprogrammet. Jag är även ansvarig för den första terminen på läkarprogrammet och medlem i programrådet för läkarprogrammet (PRL).