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Staff photo Praveen Mathews Varghese

Praveen Mathews Varghese

How respiratory viruses, such as hantaviruses, parainfluenza, and RSV, interact with the lung microenvironment. ALI models are used to identify host susceptibility factors and antiviral strategies.

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Affiliation
Affiliated as postdoctoral position at Department of Clinical Microbiology
Location
6F och 6M, Universitetssjukhuset by 6 o 24 Umeå universitet, 901 85 Umeå

During my master’s degree in biotechnology, I developed a strong interest in virology and immunology. I studied how Annexin A6 regulates NFκB signalling during Influenza A virus infection in lung epithelial cells, highlighting how viruses manipulate host cell signalling pathways and deepening my interest in host-pathogen interactions. To further expand my expertise, I pursued a PhD investigating how innate immune proteins influence viral infections, focusing on Influenza A virus, coronaviruses, and HIV. My research revealed that complement regulators modulate IAV infection in a subtype-dependent, but complement activation-independent, manner.

Currently, I am postdoctoral researcher in the Annasara Lenman lab at Umeå University. I study host factors that influence susceptibility to respiratory pathogens, including Respiratory Syncytial Virus, Hantavirus, and Parainfluenza viruses. Using air-liquid interface (ALI) models of primary lung epithelial cells, I aim to uncover key genes and pathways driving variability in infection outcomes. This research contributes to the development of personalized therapies and diagnostics, improving patient care and strengthening preparedness for emerging viral threats.

Additionally, I explore bacteria-virus interactions in the gut to understand how coinfections shape host immune responses.

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