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Umeå University
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Staff photo Maria Fällman

Maria Fällman

Our research aims at understanding molecular mechanisms behind the ability of bacteria to adapt to different environments.

Research qualifications: Docent
0000-0001-6874-6384

Contact

E-mail
maria.fallman@umu.se
Phone
+46 90 786 73 41

Works at

Affiliation
Professor at Department of Molecular Biology Section: Research group Maria Fällman Role: Deputy head of department
Location
6K och 6L, Sjukhusområdet Umeå universitet, 901 87 Umeå
Affiliation
Affiliated as research fellow at Molecular Infection Medicine Sweden (MIMS)
Location
6L, Institutionen för molekylärbiologi Institutionen för molekylärbiologi, 90187 Umeå
Co-PATHOgenex web application for assessing complex stress responses in pathogenic bacteria
Microbiology Spectrum, American Society for Microbiology 2024, Vol. 12, (1)
Fernández, Leyden; Rosvall, Martin; Normark, Johan; et al.
A two-step activation mechanism enables mast cells to differentiate their response between extracellular and invasive enterobacterial infection
Nature Communications, Springer Nature 2024, Vol. 15, (1)
von Beek, Christopher; Fahlgren, Anna; Geiser, Petra; et al.
RNA atlas of human bacterial pathogens uncovers stress dynamics linked to infection
Nature Communications, Springer Nature 2021, Vol. 12, (1)
Avican, Kemal; Aldahdooh, Jehad; Togninalli, Matteo; et al.
ProkSeq for complete analysis of RNA-Seq data from prokaryotes
Bioinformatics, UK: Oxford University Press 2021, Vol. 37, (1) : 126-128
Mahmud, A. K. M. Firoj; Delhomme, Nicolas; Nandi, Soumyadeep; et al.
Antimicrobial Resistance Profiling and Molecular Epidemiological Analysis of Extended Spectrum β-Lactamases Produced by Extraintestinal Invasive Escherichia coli Isolates From Ethiopia: The Presence of International High-Risk Clones ST131 and ST410 Revealed
Frontiers in Microbiology, Frontiers Media S.A. 2021, Vol. 12
Negeri, Abebe Aseffa; Mamo, Hassen; Gurung, Jyoti M.; et al.
Spatiotemporal Variations in Growth Rate and Virulence Plasmid Copy Number during Yersinia pseudotuberculosis Infection
Infection and Immunity, American Society for Microbiology 2021, Vol. 89, (4)
Schneiders, Stephan; Hechard, Tifaine; Edgren, Tomas; et al.
Targeted inhibition of ERα signaling and PIP5K1α/Akt pathways in castration‐resistant prostate cancer
Molecular Oncology, John Wiley & Sons 2021, Vol. 15, (4) : 968-986
Semenas, Julius; Wang, Tianyan; Khaja, Azharuddin Sajid Syed; et al.
Genome-Scale Mapping Reveals Complex Regulatory Activities of RpoN in Yersinia pseudotuberculosis
mSystem, Vol. 5, (6)
Mahmud, A. K. M. Firoj; Nilsson, Kristina; Fahlgren, Anna; et al.
Accumulation of virulence-associated proteins in Campylobacter jejuni Outer Membrane Vesicles at human body temperature
Journal of Proteomics, Vol. 195 : 33-40
Taheri, Nayyer; Fällman, Maria; Wai, Sun Nyunt; et al.
Campylobacter jejuni bile exposure influences outer membrane vesicles protein content and bacterial interaction with epithelial cells
Scientific Reports, Nature Publishing Group 2018, Vol. 8
Taheri, Nayyer; Mahmud, A K M Firoj; Sandblad, Linda; et al.
The amino-terminal part of the needle-tip translocator LcrV of Yersinia pseudotuberculosis is required for early targeting of YopH and in vivo virulence
Frontiers in Cellular and Infection Microbiology, Vol. 6
Ekestubbe, Sofie; Bröms, Jeanette E.; Edgren, Tomas; et al.
Yersinia pseudotuberculosis Blocks Neutrophil Degranulation
Infection and Immunity, Vol. 84, (12) : 3369-3378
Taheri, Nayyer; Fahlgren, Anna; Fällman, Maria
Increased plasmid copy number is essential for Yersinia T3SS function and virulence
Science, Vol. 353, (6298) : 492-495
Wang, He; Avican, Kemal; Fahlgren, Anna; et al.
Reprogramming of Yersinia from Virulent to Persistent Mode Revealed by Complex In Vivo RNA-seq Analysis
PLoS Pathogens, Vol. 11, (1)
Avican, Kemal; Fahlgren, Anna; Huss, Mikael; et al.
Pathogenic Yersinia Promotes Its Survival by Creating an Acidic Fluid-Accessible Compartment on the Macrophage Surface
PLOS ONE, Vol. 10, (8)
Bahnan, Wael; Boettner, Douglas R.; Westermark, Linda; et al.
Bacteria Induce Prolonged PMN Survival via a Phosphatidylcholine-Specific Phospholipase C- and Protein Kinase C-Dependent Mechanism
PLOS ONE, Vol. 9, (1) : e87859-
Erttmann, Saskia F.; Gekara, Nelson O.; Fällman, Maria
Colonization of cecum is important for development of persistent infection by Yersinia pseudotuberculosis
Infection and Immunity, American Society for Microbiology 2014, Vol. 82, (8) : 3471-3482
Fahlgren, Anna; Avican, Kemal; Westermark, Linda; et al.
Yersinia pseudotuberculosis Efficiently Escapes Polymorphonuclear Neutrophils during Early Infection
Infection and Immunity, Vol. 82, (3) : 1181-1191
Westermark, Linda; Fahlgren, Anna; Fällman, Maria
Metabolic profiling for detection of staphylococcus aureus infection and antibiotic resistance
PLOS ONE, Vol. 8, (2)
Antti, Henrik; Fahlgren, Anna; Näsström, Elin; et al.
Type III secretion translocon assemblies that attenuate Yersinia virulence
Cellular Microbiology, Wiley-Blackwell 2013, Vol. 15, (7) : 1088-1110
Costa, Tiago; Amer, Ayad; Farag, Salah; et al.
Role of YopK in Yersinia pseudotuberculosis Resistance Against Polymorphonuclear Leukocyte Defense
Infection and Immunity, Vol. 81, (1) : 11-22
Thorslund, Sara E; Ermert, David; Fahlgren, Anna; et al.
Coiled-coils in the YopD translocator family: A predicted structure unique to the YopD N-terminus contributes to full virulence of Yersinia pseudotuberculosis
Infection, Genetics and Evolution, Elsevier 2012, Vol. 12, (8) : 1729-1742
Costa, Tiago R. D.; Amer, Ayad A. A.; Fällman, Maria; et al.
Lipopolysaccharide O-Antigen Prevents Phagocytosis of Vibrio anguillarum by Rainbow Trout (Oncorhynchus mykiss) Skin Epithelial Cells
PLOS ONE, San Francisco: Public Library of Science 2012, Vol. 7, (5) : e37678-
Lindell, Kristoffer; Fahlgren, Anna; Hjerde, Erik; et al.
Immune response to diphtheria toxin-mediated depletion complicates the use of the CD11c-DTRtg model for studies of bacterial gastrointestinal infections
Immunology, Vol. 137, (S1) : 271-271
Westermark, Linda; Fahlgren, Anna; Fällman, Maria
Immune response to diphtheria toxin-mediated depletion complicates the use of the CD11c-DTR(tg) model for studies of bacterial gastrointestinal infections
Microbial Pathogenesis, Vol. 53, (3-4) : 154-161
Westermark, Linda; Fahlgren, Anna; Fällman, Maria
Translocation of surface-localized effectors in type III secretion
Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, (4) : 1639-1644
Akopyan, Karen; Edgren, Tomas; Wang-Edgren, Helen; et al.
The RACK1 signaling scaffold protein selectively interacts with Yersinia pseudotuberculosis virulence function
PLOS ONE, San Francisco: Public Library of Science 2011, Vol. 6, (2) : e16784-
Thorslund, Sara E; Edgren, Tomas; Pettersson, Jonas; et al.
Cell type-specific effects of Yersinia pseudotuberculosis virulence effectors
Cellular Microbiology, Vol. 11, (12) : 1750-1767
Fahlgren, Anna; Westermark, Linda; Akopyan, Karen; et al.
Yersinia inhibition of phagocytosis
Phagocytosis of bacteria and Bacterial Pathogenicity, Cambridge: Cambridge University Press 2006 : 181-218
Fällman, Maria; Gustavsson, Anna
Active cytotoxic necrotizing factor 1 associated with outer membrane vesicles from uropathogenic Escherichia coli.
Infection and Immunity, Vol. 74, (4) : 2022-2030
Kouokam, J Clavin; Wai, Sun Nyunt; Fällman, Maria; et al.
Cellular mechanisms of bacterial internalization counteracted by Yersinia
International Review of Cytology: a survey of cell biology, Elsevier 2005 : 135-188
Fällman, Maria; Gustavsson, Anna
Disruption of target cell adhesion structures by the Yersinia effector YopH requires interaction with the substrate domain of p130Cas.
European Journal of Cell Biology, Vol. 84, (4) : 477-489
Mogemark, Lena; McGee, Karen; Yuan, Ming; et al.
Interaction between the Yersinia tyrosine phosphatase YopH and its macrophage substrate, Fyn-binding protein, Fyb
Journal of Molecular Biology and Biotechnology, Wymondham, Norfolk: Horizon Scientific Press 2005, Vol. 9, (3-4) : 214-223
Yuan, Ming; Deleuil, Fabienne; Fällman, Maria
Fyn binding protein, Fyb, interacts with mammalian actin binding protein, mAbp1.
FEBS Letters, Vol. 579, (11) : 2339-2347
Yuan, Ming; Mogemark, Lena; Fällman, Maria
Temporal dissection of beta1-integrin signaling indicates a role for p130Cas-Crk in filopodia formation.
Journal of Biological Chemistry, Vol. 279, (22) : 22893-22901
Gustavsson, Anna; Yuan, Ming; Fällman, Maria
Streptococcal M5 protein prevents neutrophil phagocytosis by interfering with CD11b/CD18 receptor-mediated association and signaling.
J Immunol, Vol. 172, (6) : 3798-807
Weineisen, Maria; Sjöbring, Ulf; Fällman, Maria; et al.
Interaction between the Yersinia protein tyrosine phosphatase YopH and eukaryotic Cas/Fyb is an important virulence mechanism
Cellular Microbiology, Blackwell Publishing 2003, Vol. 5, (1) : 53-64
Deleuil, Fabienne; Mogemark, Lena; Francis, Matthew S; et al.
Microtubule-dependent regulation of Rho GTPases during internalisation of Yersinia pseudotuberculosis
FEBS Letters, Vol. 533, (1-3) : 35-41
McGee, Karen; Holmfeldt, Per; Fällman, Maria
Resistance to phagocytosis by Yersinia
International Journal of Medical Microbiology, Urban & Fischer 2002, Vol. 291, (6-7) : 501-509
Fällman, Maria; Deleuil, Fabienne; McGee, Karen
Role of the β1-integrin cytoplasmic tail in mediating invasin-promoted internalization of Yersinia
Journal of Cell Science, The Company of Biologists Ltd 2002, Vol. 115, (13) : 2669-2678
Gustavsson, Anna; Armulik, Annika; Brakebusch, Cord; et al.
YopH dephosphorylates Cas and Fyn-binding protein in macrophages
Microbial Pathogenesis, Academic Press 1999, Vol. 27, (4) : 231-242
Hamid, Nivia; Gustavsson, Anna; Andersson, Kerstin; et al.
Localization of the Yersinia PTPase to focal complexes is an important virulence mechanism
Molecular Microbiology, Wiley-Blackwell Publishing Inc. 1999, Vol. 33, (4) : 828-838
Persson, Cathrine; Nordfelth, Roland; Andersson, Kerstin; et al.
Bidirectional signaling between Yersinia and its target cell
Folia microbiologica (Prague), Vol. 43, (3) : 263-273
Fällman, Maria; Persson, Cathrine; Schesser, K.; et al.
Yersinia proteins that target host cell signaling pathways
Journal of Clinical Investigation, Vol. 99, (6) : 1153-1157
Fällman, Maria; Persson, Cathrine; Wolf-Watz, Hans
YopK of Yersinia pseudotuberculosis controls translocation of Yop effectors across the eukaryotic cell membrane.
Molecular Microbiology, John Wiley & Sons 1997, Vol. 24, (1) : 73-91
Holmström, Anna; Petterson, Jonas; Rosqvist, Roland; et al.
The PTPase YopH inhibits uptake of Yersinia, tyrosine phosphorylation of p130Cas and FAK, and the associated accumulation of these proteins in peripheral focal adhesions
EMBO Journal, Oxford University Press 1997, Vol. 16, (9) : 2307-2318
Persson, Cathrine; Carballeira, Nivia; Wolf-Watz, Hans; et al.
YopH of Yersinia pseudotuberculosis interrupts early phosphotyrosine signalling associated with phagocytosis.
Molecular Microbiology, Vol. 20, (5) : 1057-69
Andersson, K; Carballeira Suarez, N; Magnusson, K E; et al.
Transcriptomic characterization of RfaH linked to persistent infection of Yersinia pseudotuberculosis
Avican, Kemal; Nilsson, K; Fällman, Maria
Transcriptomic and phenotypic analysis of sufI and tatC mutants of Yersinia pseudotuberculosis
Avican, Ummehan; Avican, Kemal; Fällman, Maria; et al.
RpoN is required for a functional type III secretion system in Yersinia pseudotuberculosis
Mahmud, A. K. M. Firoj; Navais, Roberto; Nilsson, Kristina; et al.
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