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Umeå University
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Staff photo Lucia Mincheva-Nilsson

Lucia Mincheva-Nilsson

Pregnancy and cancer share common aims – to escape attack by the immune system.

Research qualifications: Docent

Contact

E-mail
lucia.mincheva-nilsson@umu.se
Phone
+46 90 785 22 37

Works at

Affiliation
Affiliated as professor emerita at Department of Clinical Microbiology Section: Clinical Immunology
Location
6B, Universitetssjukhuset, Klinisk immunologi, plan 1 Umeå universitet, 901 85 Umeå

In a collaborative translational clinical and basic research project we study:

  • normal pregnancy and related disorders such as pre-eclampsia, and
  • high-grade serous carcinoma of the ovary (HGSC) and severe endometriosis that can impair fertility and booster the risk for HGSC.
Endometriotic tissue-derived exosomes downregulate NKg2D-mediated cytotoxicity and promote apoptosis: mechanisms for survival of ectopic endometrial tissue in endometriosis
Journal of Immunology, The American Association of Immunologists 2024, Vol. 213, (5) : 567-576
Björk, Emma; Israelsson, Pernilla; Nagaev, Ivan; et al.
NKG2D-mediated cytotoxicity improves after primary surgery for high-grade serous ovarian cancer
American Journal of Reproductive Immunology, John Wiley & Sons 2023, Vol. 89, (1)
Israelsson, Pernilla; Björk, Emma; Nagaev, Ivan; et al.
Immunosuppressive Protein Signatures Carried by Syncytiotrophoblast-Derived Exosomes and Their Role in Human Pregnancy
Frontiers in Immunology, Frontiers Media S.A. 2021, Vol. 12
Mincheva-Nilsson, Lucia
Rift valley fever virus propagates in human villous trophoblast cell lines and induces cytokine mrna responses known to provoke miscarriage
Viruses, MDPI 2021, Vol. 13, (11)
Yong-Dae, Gwon; Mahani, Seyed Alireza Nematollahi; Nagaev, Ivan; et al.
Enhanced local and systemic inflammatory cytokine mRNA expression in women with endometriosis evokes compensatory adaptive regulatory mRNA response that mediates immune suppression and impairs cytotoxicity
American Journal of Reproductive Immunology, John Wiley & Sons 2020, Vol. 84, (4)
Björk, Emma; Vinnars, Marie-Therese; Nagaev, Ivan; et al.
The chimera-type galectin-3 is a positive modulator of trophoblast functions with dysregulated expression in gestational diabetes mellitus
American Journal of Reproductive Immunology, John Wiley & Sons 2020, Vol. 84, (6)
Freitag, Nancy; Tirado-Gonzalez, Irene; Barrientos, Gabriela; et al.
Cytokine mRNA and protein expression by cell cultures of epithelial ovarian cancer: Methodological considerations on the choice of analytical method for cytokine analyses
American Journal of Reproductive Immunology, John Wiley & Sons 2020, Vol. 84, (1)
Israelsson, Pernilla; Dehlin, Eva; Nagaev, Ivan; et al.
Assessment of cytokine mRNA expression profiles in tumor microenvironment and peripheral blood mononuclear cells of patients with high-grade serous carcinoma of the ovary
International Journal of Gynecological Cancer, BMJ Publishing Group Ltd 2019, Vol. 29 : A138-A138
Israelsson, Pernilla; Labani-Motlagh, Alireza; Nagaev, Ivan; et al.
Enhanced Th1 and inflammatory mRNA responses upregulate NK cell cytotoxicity and NKG2D ligand expression in human pre-eclamptic placenta and target it for NK cell attack
American Journal of Reproductive Immunology, John Wiley & Sons 2018, Vol. 80, (1)
Vinnars, Marie-Therese; Björk, Emma; Nagaev, Ivan; et al.
Melanocortin 2, 3 and 4 Receptor Gene Expressions are Downregulated in CD8(+) T Cytotoxic Lymphocytes and CD19(+) B Lymphocytes in Rheumatoid Arthritis Responding to TNF- Inhibition
Scandinavian Journal of Immunology, John Wiley & Sons 2017, Vol. 86, (1) : 31-39
Andersen, M.; Nagaev, Ivan; Meyer, M. K.; et al.
Lymphocyte profile and cytokine mRNA expression in peripheral blood mononuclear cells of patients with recurrent respiratory papillomatosis suggest dysregulated cytokine mRNA response and impaired cytotoxic capacity
Immunity, Inflammation and Disease, Wiley-Blackwell 2017, Vol. 5, (4) : 541-550
Holm, Anna; Nagaeva, Olga; Nagaev, Ivan; et al.
Assessment of cytokine mRNA expression profiles in tumor microenvironment and peripheral blood mononuclear cells of patients with high-grade serous carcinoma of the ovary
Journal of Cancer Science & Therapy, Vol. 9, (5) : 422-429
Israelsson, Pernilla; Labani-Motlagh, Alireza; Nagaev, Ivan; et al.
Mood and oxytocin blood levels in physically active women with and without oral contraceptive use in relation to seasonal daylight variation
International Journal of Sports and Exercise Medicine, Vol. 3, (3)
Wikström-Frisén, Lisbeth; Larsson, Peter; Mincheva Nilsson, Lucia; et al.
Differential expression of ligands for NKG2D and DNAM-1 receptors by epithelial ovarian cancer-derived exosomes and its influence on NK cell cytotoxicity
Tumor Biology, Vol. 37, (4) : 5455-5466
Labani-Motlagh, Alireza; Israelsson, Pernilla; Ottander, Ulrika; et al.
Isolation and characterization of exosomes from cultures of tissue explants and cell lines
Current Protocols in Immunology, Wiley-Blackwell 2016, Vol. 2016 : 14.42.1-14.42.21
Mincheva-Nilsson, Lucia; Baranov, Vladimir; Nagaeva, Olga; et al.
Impact of Season and Oral Contraceptive use on Cortisol Levelsin Physically Active Women
Journal of Exercise, Sports & Orthopedics, Vol. 3, (2)
Wikström-Frisén, Lisbeth; Nordström, Anna; Mincheva-Nilsson, Lucia; et al.
Dynamics of cytokine mRNA expression and fecal biomarkers in school-children undergoing a double-blind placebo-controlled food challenge series
Cytokine, Vol. 88 : 259-266
Winberg, Anna; Nagaeva, Olga; Nagaev, Ivan; et al.
Adalimumab (Humira (R)) normalizes melanocortin receptor subtype 2, 3, and 4 expression in CD8+, CD14+, and CD19+leucocyte subsets in rheumatoid arthritis
Scandinavian Journal of Rheumatology, Informa Healthcare 2014, Vol. 43, (Suppl. 127) : 25-26 Meeting Abstr. PP119
Andersen, M.; Olesen, M. K.; Nagaev, Ivan; et al.
Prostate Tumor-Derived Exosomes Down-Regulate NKG2D Expression on Natural Killer Cells and CD8(+) T Cells: Mechanism of Immune Evasion
PLOS ONE, Vol. 9, (9) : e108925-
Lundholm, Marie; Schröder, Mona; Nagaeva, Olga; et al.
Cancer exosomes and NKG2D receptor-ligand interactions: impairing NKG2D-mediated cytotoxicity and anti-tumour immune surveillance
Seminars in Cancer Biology, Vol. 28 : 24-30
Mincheva-Nilsson, Lucia; Baranov, Vladimir
Placenta-derived exosomes and syncytiotrophoblast microparticles and their role in human reproduction: immune modulation for pregnancy success
American Journal of Reproductive Immunology, Wiley-Blackwell 2014, Vol. 72, (5) : 440-457
Mincheva-Nilsson, Lucia; Baranov, Vladimir
Serological assessment for celiac disease in IgA deficient adults
PLOS ONE, PLoS one 2014, Vol. 9, (4) : e93180-
Wang, Ning; Truedsson, Lennart; Elvin, Kerstin; et al.
Exosomen: intercellulär signalbärare med framtidspotential. Kan ge nya diagnostiska och terapeutiska möjligheter.
Läkartidningen, Läkartidningen förlag AB 2013, Vol. 110, (46) : 2050-2052
Ronquist, Gunnar; Lötvall, Jan; Gabrielsson, Susanne; et al.
Characterization of human thymic exosomes
PLOS ONE, Vol. 8, (7) : e67554-
Skogberg, Gabriel; Gudmundsdottir, Judith; van der Post, Sjoerd; et al.
Exosomes secreted by human placenta carry functional Fas ligand and TRAIL molecules and convey apoptosis in activated immune cells, suggesting exosome-mediated immune privilege of the fetus
Journal of Immunology, The American Association of Immunologists 2013, Vol. 191, (11) : 5515-5523
Stenqvist, Ann-Christin; Nagaeva, Olga; Baranov, Vladimir; et al.
Galectin-1 influences trophoblast immune evasion and emerges as a predictive factor for the outcome of pregnancy
Molecular human reproduction, Vol. 19, (1) : 43-53
Tirado-Gonzalez, Irene; Freitag, Nancy; Barrientos, Gabriela; et al.
Dermal Melanocortin Receptor Rebound in Diffuse Systemic Sclerosis after Anti-TGF ss 1 Antibody Therapy
Scandinavian Journal of Immunology, Hoboken: Wiley-Blackwell 2012, Vol. 76, (5) : 478-482
Andersen, G. Neumann; Andersen, M.; Nagaeva, Olga; et al.
Vesiclepedia: a compendium for extracellular vesicles with continuous community annotation
PLoS biology, Public library of science 2012, Vol. 10, (12) : e1001450-
Kalra, Hina; Simpson, Richard J; Ji, Hong; et al.
Microvesicle-associated AAV Vector as a Novel Gene Delivery System
Molecular Therapy, New York: Nature Publishing Group 2012, Vol. 20, (5) : 960-971
Maguire, Casey A.; Balaj, Leonora; Sivaraman, Sarada; et al.
The Melanocortin System: A New and Important Actor on the Scene of Systemic Sclerosis
Arthritis and Rheumatism, Malden: Wiley-Blackwell 2011, Vol. 63, (10) : S908-S908
Andersen, Grethe N.; Nagaeva, Olga; Mincheva-Nilsson, Lucia; et al.
Cytokine mRNA profile of alveolar T lymphocytes and macrophages in patients with systemic sclerosis suggests a local Tr1 response
Scandinavian Journal of Immunology, Oslo: Univ.forl. 2011, Vol. 74, (3) : 272-81
Andersen, Grethe N.; Nilsson, Kenneth; Nagaeva, O; et al.
Maternal Foxp3 expressing CD4+ CD25+ and CD4+ CD25- regulatory T-cell populations are enriched in human early normal pregnancy decidua: a phenotypic study of paired decidual and peripheral blood samples.
American Journal of Reproductive Immunology and Microbiology, John Wiley & Sons 2011, Vol. 66, (Suppl 1) : 44-56
Dimova, Tanya; Nagaeva, Olga; Stenqvist, Ann-Christin; et al.
Thermal- and oxidative stress causes enhanced release of NKG2D ligand-bearing immunosuppressive exosomes in leukemia/lymphoma T and B cells
PLOS ONE, Vol. 6, (2) : e16899-
Hedlund, Malin; Nagaeva, Olga; Kargl, Dominic; et al.
Thermal- and oxidative stress causes enhanced release of NKG2D ligand-bearing immunosuppressive exosomes in leukemia/lymphoma T and B cells
PLOS ONE, Public Library of Science 2011, Vol. 6, (2)
Hedlund, Malin; Nagaeva, Olga; Kargl, Dominic; et al.
Studie av larynxpapillom i norra Sverige: två fall av onkogena HPV bland 26 patienter: [A study of laryngeal papilloma in northern Sweden: Two cases of oncogenic HPV among 26 patients]
Läkartidningen, Svergies läkarförbund 2011, Vol. 108, (21) : 1187-1189
Olofsson, Katarina; Loizou, Christos; Evander, Magnus; et al.
Placental exosome-mediated immune protection of the fetus: feeling groovy in a cloud of exosomes
Expert Review of Obstetrics & Gynecology, Expert Reviews LTD 2010, Vol. 5, (5) : 619-634
Mincheva-Nilsson, Lucia
The role of placental exosomes in reproduction
American Journal of Reproductive Immunology and Microbiology, Vol. 63, (6) : 520-533
Mincheva-Nilsson, Lucia; Baranov, Vladimir
Low agreement between radio binding assays in analyzing glutamic acid decarboxylase (GAD65Ab) autoantibodies in patients classified with type 2 diabetes.
Autoimmunity, Informa Healthcare 2009, Vol. 42, (6) : 507-514
Daka, Bledar; Svensson, Maria K; Lernmark, Åke; et al.
Human placenta expresses and secretes NKG2D ligands via exosomes that down-modulate the cognate receptor expression: evidence for immunosuppressive function
Journal of Immunology, Vol. 183, (1) : 340-351
Hedlund, Malin; Stenqvist, Ann-Christin; Nagaeva, Olga; et al.
Prostate cancer-derived urine exosomes: a novel approach to biomarkers for prostate cancer.
British journal of cancer, Vol. 100, (10) : 1603-1607
Nilsson, Jonas; Skog, Johan; Nordstrand, Annika; et al.
Suppressed signal transduction in the bronchial epithelium of patients with systemic sclerosis
Respiratory Medicine, Vol. 103, (2) : 301-308
Sehlstedt, Maria; Andersen, Grethe Neumann; Nilsson, Kenneth; et al.
An efficient optimized method for isolation of villous trophoblast cells from human early pregnancy placenta suitable for functional and molecular studies
American Journal of Reproductive Immunology and Microbiology, Vol. 60, (1) : 33-42
Stenqvist, Ann-Christin; Chen, Ting; Hedlund, Malin; et al.
Bronchoalveolar matrix metalloproteinase 9 relates to restrictive lung function impairment in systemic sclerosis.
Respiratory Medicine, Vol. 101, (10) : 2199-2206
Andersen, Grethe Neumann; Nilsson, Kenneth; Pourazar, Jamshid; et al.
Immune cells and molecules in pregnancy: friends or foes to the fetus?
Expert Review of Clinical Immunology, Future Drugs LTD 2006, Vol. 2, (3) : 457-470
Mincheva-Nilsson, Lucia
Placenta-derived soluble MHC class I chain-related molecules down-regulate NKG2D receptor on peripheral blood mononuclear cells during human pregnancy: a possible novel immune escape mechanism for fetal survival
Journal of Immunology, Vol. 176, (6) : 3585-3592
Mincheva-Nilsson, Lucia; Nagaeva, Olga; Chen, Ting; et al.
Quantitative measurement of the levels of melanocortin receptor subtype 1, 2, 3 and 5 and pro-opio-melanocortin peptide gene expression in subsets of human peripheral blood leucocytes
Scandinavian Journal of Immunology, Oxford: Blackwell Publishing 2005, Vol. 61, (3) : 279-284
Andersen, Grethe; Hägglund, M; Nagaeva, Olga; et al.
Assessment of vascular function in systemic sclerosis: indications of the development of nitrate tolerance as a result of enhanced endothelial nitric oxide production
Arthritis and Rheumatism, Vol. 46, (5) : 1324-1332
Andersen, Grethe Neumann; Mincheva-Nilsson, Lucia; Kazzam, Elsadig; et al.
Correlation between increased nitric oxide production and markers of endothelial activation in systemic sclerosis: findings with the soluble adhesion molecules E-selectin, intercellular adhesion molecule 1, and vascular adhesion molecule 1
Arthritis and Rheumatism, Vol. 43, (5) : 1085-1093
Andersen, Grethe Neumann; Caidahl, Kenneth; Kazzam, Elsadig; et al.
Lipids are a constitutive component of cytolytic granules.
Histochemistry and Cell Biology, Vol. 114, (2) : 167-71
Baranov, Vladimir; Nagaeva, Olga; Hammarström, Sten; et al.
Activated human gamma delta T lymphocytes express functional lactoferrin receptors.
Scandinavian Journal of Immunology, Vol. 46, (6) : 609-18
Mincheva-Nilsson, Lucia; Hammarström, Sten; Hammarström, Marie-Louise
View publications in DiVA

Research groups

Head of research
Lucia Mincheva-Nilsson