KBC Postdoc working in joint with Lars-Anders Carlson’s group Yaowen Wu’s group. The research work focuses on understanding the role of autophagy pathway in positive-sense RNA virus infection.
I am a postdoc in Lars-Ander's Carlson lab and Yaowen Wu's lab at Umeå University in Sweden. My current research focuses on autophagy in positive-sense RNA virus infection. Positive-sense RNA viruses are a large group of human pathogens including coronaviruses, picornaviruses and arthropod-borne flaviviruses and alphaviruses. Autophagy is an evolutionarily conserved catabolic process that maintains cellular homeostasis by eliminating or recycling dysfunctional cellular organelles or unused proteins.
In my project, using novel cell biology methods combined with high-end proteomics and cryo-electron tomography we are trying to understand how the autophagy machinery is used for the replication or restriction of a diverse set of positive-sense RNA viruses with an ultimate goal to discover novel therapeutic targets.
Before joining Umeå University, I worked as a postdoctoral fellow in an antiviral development programme at Regional Centre for Biotechnology (RCB), Faridabad, India. In this programme, we constructed reporter viruses for the development of high content antiviral screening assays against Chikungunya and Japanese encephalitis virus infection and elucidated the potential and mechanism of action of hit anti-viral drug candidates in vivo and cell culture model systems.
I obtained a doctoral degree in molecular virology from Translational Health Science and Technology Institute (THSTI), Faridabad, India. During my PhD, I studied the interactions between cellular autophagy machinery and innate immune responses during Japanese Encephalitis Virus infection.
ORCID 0000-0002-2575-4525