Jan Oscarsson

The bacterium A. actinomycetemcomitans in relation to periodontal diseases.

Research qualifications: Docent

Contact

jan.oscarsson@umu.se

+46 90 785 60 97

Works at

Research fellow at Department of Odontology Section: School of Dentistry, Oral Microbiology

1A, våning 5, Norrlands universitetssjukhus Umeå universitet, 901 85 Umeå

I am researching the mechanisms of the bacterium A. actinomycetemcomitans in relation to periodontal diseases. My group uses cell and molecular biological methods to understand how the bacterium can cause damage and survive within the host. With new knowledge, we hope to contribute to new ways to disarm the virulence of the bacterium rather than killing it.

Prevalence of the oral pathogen Filifactor alocis and its FtxA toxin related to clinical parameters and presence of Aggregatibacter actinomycetemcomitans

Frontiers in Cellular and Infection Microbiology, Lausanne: Frontiers Media S.A. 2025, Vol. 14

Razooqi, Zeinab; Khzam, Nabil; L’Hostis, Mahina; et al.

Prevalence of subgingival Aggregatibacter actinomycetemcomitans: descriptive cross-sectional study

Pathogens, Basel: MDPI 2024, Vol. 13, (7)

Khzam, Nabil; Kujan, Omar; Haubek, Dorte; et al.

The effectiveness of salivary sampling for the detection and quantification of Aggregatibacter actinomycetemcomitans in periodontitis patients

Pathogens, Basel: MDPI 2024, Vol. 13, (12)

Khzam, Nabil; Kujan, Omar; Haubek, Dorte; et al.

Zebrafish larvae as a model for studying the impact of oral bacterial vesicles on tumor cell growth and metastasis

Human Cell

Metsäniitty, Marjut; Hasnat, Saika; Öhman, Carina; et al.

Extracellular vesicles from Aggregatibacter actinomycetemcomitans exhibit potential antitumorigenic effects in oral cancer: a comparative in vitro study

Archives of Microbiology, Springer Nature 2024, Vol. 206, (6)

Metsäniitty, Marjut; Hasnat, Shrabon; Öhman, Carina; et al.

Bacterial symbionts in oral niche use type VI secretion nanomachinery for fitness increase against pathobionts

iScience

Oscarsson, Jan; Bao, Kai; Shiratsuchi, Akiko; et al.

Protocol for analyzing the function of the type VI secretion system of the oral symbiont Aggregatibacter aphrophilus in targeting pathobionts

STAR Protocols, Cell Press 2024, Vol. 5, (4)

Oscarsson, Jan; Bao, Kai; Shiratsuchi, Akiko; et al.

Association of Filifactor alocis and its RTX toxin gene ftxA with periodontal attachment loss, and in synergy with Aggregatibacter actinomycetemcomitans

Frontiers in Cellular and Infection Microbiology, Frontiers Media S.A. 2024, Vol. 14

Razooqi, Zeinab; Tjellström, Ingeborg; Höglund-Åberg, Carola; et al.

Radiographic and clinical signs of periodontitis and associated bacterial species in a Swedish adolescent population

Journal of Periodontology, John Wiley & Sons 2023, Vol. 94, (5) : 630-640

Lindholm, Mark; Claesson, Rolf; Löf, Hanna; et al.

Extracellular Vesicle Subproteome Differences among Filifactor alocis Clinical Isolates

Microorganisms, MDPI 2022, Vol. 10, (9)

Bao, Kai; Claesson, Rolf; Belibasakis, Georgios N.; et al.

Proteomic Characterization of the Oral Pathogen Filifactor alocis Reveals Key Inter-Protein Interactions of Its RTX Toxin: FtxA

Pathogens, MDPI AG 2022, Vol. 11, (5)

Bao, Kai; Claesson, Rolf; Gehrig, Peter; et al.

Carriage of the JP2 genotype of Aggregatibacter actinomycetemcomitans by periodontitis patients of various geographic origin, living in Sweden

Pathogens, MDPI 2022, Vol. 11, (11)

Claesson, Rolf; Oscarsson, Jan; Johansson, Anders

Aggregatibacter actinomycetemcomitans and Filifactor alocis: two exotoxin-producing oral pathogens

Frontiers in Oral Health, Frontiers Media S.A. 2022, Vol. 3

Ozuna, Hazel; Snider, Ian; Belibasakis, Georgios N.; et al.

Aggregatibacter actinomycetemcomitans and Filifactor alocis as associated with periodontal attachment loss in a cohort of ghanaian adolescents

Microorganisms, MDPI 2022, Vol. 10, (12)

Razooqi, Zeinab; Höglund-Åberg, Carola; Kwamin, Francis; et al.

Multilocus Sequence Typing of Non-JP2 Serotype b Aggregatibacter actinomycetemcomitans Strains of Ghanaian and Swedish Origin

Frontiers in Cellular and Infection Microbiology, Frontiers Media S.A. 2021, Vol. 11

Claesson, Rolf; Johansson, Anders; Höglund-Åberg, Carola; et al.

Aggregatibacter actinomycetemcomitans and Aggregatibacter aphrophilus in a Kenyan Maasai Adolescent Population and Inhibition of Leukotoxic Activity by Herbal Plants Used as Part of Oral Hygiene Procedures

Journal of Clinical Medicine, Basel: MDPI 2021, Vol. 10, (22)

Lindholm, Mark; Claesson, Rolf; Kemoli, Arthur; et al.

Characterization of Aggregatibacter actinomycetemcomitans Serotype b Strains with Five Different, Including Two Novel, Leukotoxin Promoter Structures

Vaccines, Basel, Switzerland: MDPI 2020, Vol. 8, (3)

Claesson, Rolf; Chiang, Huei-Min; Lindholm, Mark; et al.

Outer membrane vesicle-mediated serum protection in Aggregatibacter actinomycetemcomitans

Journal of Oral Microbiology, Taylor & Francis 2020, Vol. 12, (1)

Lindholm, Mark; Metsäniitty, Marjut; Granström, Elisabeth; et al.

Delivery of virulence factors by bacterial membrane vesicles to mammalian host cells

Bacterial membrane vesicles: biogenesis, functions and applications, Springer 2020 : 131-158

Nadeem, Aftab; Oscarsson, Jan; Wai, Sun Nyunt

Phylogenetic Analysis of Filifactor alocis Strains Isolated from Several Oral Infections Identified a Novel RTX Toxin, FtxA

Toxins, MDPI 2020, Vol. 12, (11)

Oscarsson, Jan; Claesson, Rolf; Bao, Kai; et al.

Editorial Comments to the Special Issue: "Aggregaterbacter actinomycetemcomitans—Gram-Negative Bacterial Pathogen"

Pathogens, Basel: MDPI 2020, Vol. 9, (6)

Oscarsson, Jan; DiRienzo, Joseph; Johansson, Anders

Aggregatibacter actinomycetemcomitans LPS binds human interleukin-8

Journal of Oral Microbiology, TAYLOR & FRANCIS LTD 2019, Vol. 11, (1)

Ahlstrand, Tuuli; Kovesjoki, Laura; Maula, Terhi; et al.

Virulence and Pathogenicity Properties of Aggregatibacter actinomycetemcomitans

Pathogens, Basel: MDPI 2019, Vol. 8, (4)

Belibasakis, Georgios N; Maula, Terhi; Bao, Kai; et al.

Genetic Profiling of Aggregatibacter actinomycetemcomitans Serotype B Isolated from Periodontitis Patients Living in Sweden

Pathogens, Basel, Switzerland: MDPI 2019, Vol. 8, (3) : 1-13

Johansson, Anders; Claesson, Rolf; Höglund-Åberg, Carola; et al.

Role of OmpA1 and OmpA2 in Aggregatibacter actinomycetemcomitans and Aggregatibacter aphrophilus serum resistance

Journal of Oral Microbiology, Taylor & Francis 2019, Vol. 11, (1)

Lindholm, Mark; Aung, Kyaw Min; Wai, Sun Nyunt; et al.

Tools of Aggregatibacter actinomycetemcomitans to Evade the Host Response

Journal of Clinical Medicine, Basel: MDPI 2019, Vol. 8, (7)

Oscarsson, Jan; Claesson, Rolf; Lindholm, Mark; et al.

Comment from the Editor to the Special Issue: “Periodontitis: From Dysbiotic Microbial Immune Response to Systemic Inflammation”

Journal of Clinical Medicine, Basel, Switzerland: MDPI 2019, Vol. 8, (10)

Oscarsson, Jan; Johansson, Anders

Aggregatibacter actinomycetemcomitans H-NS promotes biofilm formation and alters protein dynamics of other species within a polymicrobial oral biofilm

npj Biofilms and Microbiomes, Springer 2018, Vol. 4, (12) : 1-11

Bao, Kai; Bostanci, Nagihan; Thurnheer, Thomas; et al.

A novel intrinsically disordered outer membrane lipoprotein of Aggregatibacter actinomycetemcomitans binds various cytokines and plays a role in biofilm response to interleukin-1β and interleukin-8

Virulence, Vol. 8, (2) : 115-134

Ahlstrand, Tuuli; Tuominen, Heidi; Beklen, Arzu; et al.

The cagE gene sequence as a diagnostic marker to identify JP2 and non-JP2 highly leukotoxic Aggregatibacter actinomycetemcomitans serotype b strains.

Journal of Periodontal Research, John Wiley & Sons 2017, Vol. 52, (5) : 903-912

Johansson, Anders; Claesson, Rolf; Höglund Åberg, Carola; et al.

Dataset of the proteome of purified outer membrane vesicles from the human pathogen Aggregatibacter actinomycetemcomintans

Data in Brief, Elsevier 2017, Vol. 10 : 426-431

Kieselbach, Thomas; Oscarsson, Jan

Proteomics of Aggregatibacter actinomycetemcomitans Outer Membrane Vesicles

PLOS ONE, Vol. 10, (9)

Kieselbach, Thomas; Zijnge, Vincent; Granström, Elisabeth; et al.

Outer Membrane Vesicle-Mediated Export of Processed PrtV Protease from Vibrio cholerae

PLOS ONE, Vol. 10, (7)

Rompikuntal, Pramod K.; Vdovikova, Svitlana; Duperthuy, Marylise; et al.

Elevated recombinant clyA gene expression in the uropathogenic Escherichia coli strain 536, a clue to explain pathoadaptive mutations in a subset of extraintestinal E. coli strains

BMC Microbiology, BioMed Central 2014, Vol. 14 : 216-

Enow Oben Ayuk, Constance; Oscarsson, Jan; Zlatkov, Nikola; et al.

Aggregatibacter actinomycetemcomitans Outer Membrane Vesicles are internalized in human host cells and trigger NOD1- and NOD2-dependent NF-κB activation

Infection and Immunity, American Society for Microbiology Press 2014, Vol. 82, (10) : 4034-4046

Thay, Bernard; Damm, Anna; Kufer, Thomas; et al.

Staphylococcus aureus alpha-toxin-dependent induction of host cell death by membrane-derived vesicles

PLOS ONE, Vol. 8, (1)

Thay, Bernard; Wai, Sun Nyunt; Oscarsson, Jan

Perinuclear localization of internalized outer membrane vesicles carrying active cytolethal distending toxin (CDT) from aggregatibacter actinomycetemcomitans

Infection and Immunity, American Society for Microbiology 2012, Vol. 80, (1) : 31-42

Rompikuntal, Pramod Kumar; Thay, Bernard; Khan, Muhammad Khanzeb; et al.

Proteomics of protein secretion by aggregatibacter actinomycetemcomitans

PLOS ONE, Vol. 7, (7) : e41662-

Zijnge, Vincent; Kieselbach, Thomas; Oscarsson, Jan

Specified species in gingival crevicular fluid predict bacterial diversity

PloS one, Vol. 5, (10) : e13589-

Asikainen, Sirkka; Doğan, Başak; Turgut, Zeynep; et al.

Lack of Serotype Antigen in A. actinomycetemcomitans

Journal of Dental Research, Vol. 89, (3) : 292-6

Kanasi, E; Dogan, B; Karched, M; et al.

Mathematical modelling of the regulation of spa (protein A) transcription in Staphylococcus aureus.

International journal of medical microbiology : IJMM, Vol. 299, (1) : 65-74

Gustafsson, Erik; Karlsson, Stefan; Oscarsson, Jan; et al.

Maximal transcription of aur (aureolysin) and sspA (serine protease) in Staphylococcus aureus requires staphylococcal accessory regulator R (sarR) activity.

FEMS Microbiology Letters, Vol. 284, (2) : 158-64

Gustafsson, Erik; Oscarsson, Jan

Vesicle-independent extracellular release of a proinflammatory outer membrane lipoprotein in free-soluble form

BMC Microbiology, Vol. 28, (8:18)

Karched, Maribasappa; Ihalin, Rikka; Eneslätt, Kjell; et al.

Proinflammatory effect in whole blood by free soluble bacterial components released from planktonic and biofilm cells

BMC Microbiology, London: BioMed Central 2008, Vol. 8, (206) : 13-

Oscarsson, Jan; Karched, Maribasappa; Thay, Bernard; et al.

Vesicle-mediated export and assembly of pore-forming oligomers of the enterobacterial ClyA cytotoxin.

Cell, Vol. 115, (1) : 25-35

Wai, Sun Nyunt; Lindmark, Barbro; Söderblom, Tomas; et al.

Localization and structure of the ClyA protein in Escherichia coli before secretion and pore-formation

Enow, Constance; Oscarsson, Jan; Mizunoe, Yoshimitsu; et al.

View publications in DiVA

Research groups

Head of research

Jan Oscarsson Lab

Research projects

1 January 2017 until 31 December 2020

Aggregatibacter actinomycetemcomitans – a periopathogen with capacity to cause dysregulation in the host response

1 January 2011

How does Aggregatibacter actinomycetemcomitans contribute to periodontitis - molecular mechanisms and characterization of virulent genotypes

Published: 28 Jun, 2023

Odontological research is financed with TUA funds