Postdoctor in Lena Svensson’s group. Her research focuses on immune cell function mechanisms and how LFA-1 are reorganized and reused in fast moving cells like leukocytes.
Fariba completed her Ph.D. degree from the University of Tehran, Iran. Her area of research interest was related to cancer cell biology and nanobiotechnology. Her main goal was to target apoptotic pathways in different cancer cell lines to reduce chemotherapy resistance in cancer cells. For addressing such a complex question in cancer cell signalling, she has applied a wide variety of techniques at biological, biochemical, and molecular levels, such as ELISA and microscopy techniques, flow cytometric analysis, DNA and RNA extraction, western blotting techniques, and so on.
In addition to the good result she found, she faced some challenges about the nanoparticles developing. In this regard, she connected with the MBC Laboratory at the University of Turin in Italy. She had a successful collaboration with MBC. Her project involved cell assays, nanoparticle preparation and characterization, data analysis, and the use of nano chemistry laboratory equipment such as HPLC, FPLC, and Zeta sizers. From a technical point of view, she could develop new skills in protein-based innovative nanotechnology to address complex biological limitations in cancer treatment.
Fariba is currently working as a postdoc in Lena Svensson lab, and her main motivation to join this group is to fill her knowledge gap about immune cell function mechanisms in tumor microenvironment which is a critical regulator of immune escape, progression, and distant metastasis of cancer. She is using state-of-the-art technology to visualise LFA-1 trafficking in T cells migrating within tumour contexts, to fully comprehend both how the endocytic trafficking of these compelling cargoes controls T cell motility and explore the mechanisms behind LFA-1 impairment recycling in the tumour microenvironment.