My research focuses on unraveling the molecular mechanisms governing lipoprotein trafficking in Gram-negative pathogens.
By integrating structural, biochemical, and biophysical techniques, I aim to understand bacterial lipoprotein transport systems and explore how targeting these pathways could lead to novel antimicrobial strategies.
During my doctoral studies in Karina Persson lab, I specialized in protein biochemistry and structural biology, with a focus on the localization and function of the lipoprotein (Lol) machinery in various Gram-negative pathogens. My research involved protein expression, purification, and structural determination using X-ray crystallography and cryo-EM, along with biophysical binding assays (BLI, ITC, and QCM-D) to characterize protein-protein, protein-membrane interactions and antibiotic binding modalities.
Before my Ph.D., I pursued my M.Tech. research at IIT Kanpur, where I developed a cryogel chromatographic platform for exosome purification from mammalian and stem cell cultures. During my M.Sc. At TERI school of advanced studies, New Delhi India, I worked on Helicobacter pylori restriction-modification systems, which sparked my interest in bacterial pathogenesis.