Annelie Behndig

MD PhD

Associate Professor in Pulmonary Medicine

Research qualifications: Docent

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Associate professor, senior consultant (attending) physician at Department of Public Health and Clinical Medicine Section: Pulmonary Medicine Role: Assistant head of department

Byggnad 1A, plan 4, målpunkt B41, Norrlands universitetssjukhus

I am Associate Professor in Pulmonary Medicine and work as a Senior Physician at the Pulmonary section with pulmonary medicine and lung cancer.

I am University Lecturer and Assistant Head of Department at the Department of Public Health and Clinical Medicine.

In my research, I have studied respiratory effects of air pollutants such as diesel exhaust and ozone with a focus on inflammatory changes and antioxidants. I have also studied COPD with a focus on inflammatory changes and epigenetic changes in the airways.

My continued research is focused on lung cancer, new diagnostic methods and the possibility of detecting lung cancer at an earlier stage. A good national network with both pulmonologists and oncologists forms the basis for these studies.

The challenges of recruiting never-smokers with chronic obstructive pulmonary disease from the large population-based Swedish cardiopulmonary bioimage study (SCAPIS) cohort

European Clinical Respiratory Journal, Taylor & Francis 2024, Vol. 11, (1)

Sönnerfors, Pernilla; Jacobson, Petra Kristina; Andersson, Anders; et al.

Impact of individual level uncertainty of lung cancer polygenic risk score (PRS) on risk stratification

Genome Medicine, BioMed Central (BMC) 2024, Vol. 16, (1)

Wang, Xinan; Zhang, Ziwei; Ding, Yi; et al.

Human exposure to diesel exhaust induces CYP1A1 expression and AhR activation without a coordinated antioxidant response

Particle and Fibre Toxicology, BioMed Central (BMC) 2023, Vol. 20, (1)

Friberg, Maria; Behndig, Annelie F.; Bosson, J.A.; et al.

Reduced bronchoalveolar macrophage phagocytosis and cytotoxic effects after controlled short-term exposure to wood smoke in healthy humans

Particle and Fibre Toxicology, BioMed Central (BMC) 2023, Vol. 20, (1)

Hansson, Alva; Rankin, Gregory; Uski, O.; et al.

A cross-sectional study of inflammatory markers as determinants of circulating kynurenines in the Lung Cancer Cohort Consortium

Scientific Reports, Springer Nature 2023, Vol. 13, (1)

Midttun, Øivind; Ulvik, Arve; Meyer, Klaus; et al.

Low levels of endogenous anabolic androgenic steroids in females with severe asthma taking corticosteroids

ERJ Open Research, European Respiratory Society 2023, Vol. 9, (5)

Yasinska, Valentyna; Gómez, Cristina; Kolmert, Johan; et al.

Mapping atopic dermatitis and anti–IL-22 response signatures to type 2–low severe neutrophilic asthma

Journal of Allergy and Clinical Immunology, Elsevier 2022, Vol. 149, (1) : 89-101

Badi, Yusef Eamon; Pavel, Ana B.; Pavlidis, Stelios; et al.

Birch pollen, air pollution and their interactive effects on airway symptoms and peak expiratory flow in allergic asthma during pollen season: a panel study in Northern and Southern Sweden

Environmental Health, BioMed Central (BMC) 2022, Vol. 21, (1)

Carlsen, Hanne Krage; Haga, Susanna Lohman; Olsson, David; et al.

Chronic obstructive pulmonary disease is associated with epigenome-wide differential methylation in BAL lung cells

American Journal of Respiratory Cell and Molecular Biology, American Thoracic Society 2022, Vol. 66, (6) : 638-647

Eriksson Ström, Jonas; Kebede Merid, Simon; Pourazar, Jamshid; et al.

Urinary metabotype of severe asthma evidences decreased carnitine metabolism independent of oral corticosteroid treatment in the U-BIOPRED study

European Respiratory Journal, NLM 2022, Vol. 59, (6)

Reinke, Stacey N.; Naz, Shama; Chaleckis, Romanas; et al.

A Large-Scale Genome-Wide Gene-Gene Interaction Study of Lung Cancer Susceptibility in Europeans With a Trans-Ethnic Validation in Asians

Journal of Thoracic Oncology, Elsevier 2022, Vol. 17, (8) : 974-990

Zhang, Ruyang; Shen, Sipeng; Wei, Yongyue; et al.

Urinary Leukotriene E-4 and Prostaglandin D-2 Metabolites Increase in Adult and Childhood Severe Asthma Characterized by Type 2 Inflammation A Clinical Observational Study

American Journal of Respiratory and Critical Care Medicine, AMER THORACIC SOC 2021, Vol. 203, (1) : 37-53

Kolmert, Johan; Gomez, Cristina; Balgoma, David; et al.

A gene expression-based single sample predictor of lung adenocarcinoma molecular subtype and prognosis

International Journal of Cancer, Wiley-Blackwell 2021, Vol. 148, (1) : 238-251

Liljedahl, Helena; Karlsson, Anna; Oskarsdottir, Gudrun N.; et al.

The ratio FEV1/FVC and its association to respiratory symptoms-A Swedish general population study

Clinical Physiology and Functional Imaging, John Wiley & Sons 2021, Vol. 41, (2) : 181-191

Torén, Kjell; Schiöler, Linus; Lindberg, Anne; et al.

In allergic individuals, FENO50 is associated with O₃ and PM10 during pollen season

European Respiratory Journal, European Respiratory Society 2020, Vol. 56

Carlsen, Hanne Krage; Koca, Hatice; Lohman-Haga, Susanna; et al.

Airway regulatory T cells are decreased in COPD with a rapid decline in lung function

Respiratory Research, BioMed Central 2020, Vol. 21, (1)

Eriksson Ström, Jonas; Pourazar, Jamshid; Linder, Robert; et al.

Systemic proteolytic markers are increased and associate with comorbidities in individuals with COPD and restrictive spirometric pattern

European Respiratory Journal, European Respiratory Society 2020, Vol. 56

Nilsson, Ulf; Pleiborn, Viktoria; Linder, Robert; et al.

Chronic airflow limitation and its relation to respiratory symptoms among ever-smokers and never-smokers: a cross-sectional study

BMJ Open Respiratory Research, BMJ Publishing Group Ltd 2020, Vol. 7, (1)

Toren, Kjell; Schioler, Linus; Lindberg, Anne; et al.

Surfactant Protein A in particles in exhaled air (PExA), bronchial lavage and bronchial wash - a methodological comparison

Respiratory Research, BioMed Central 2019, Vol. 20, (1)

Behndig, Annelie F.; Mirgorodskaya, Ekaterina; Blomberg, Anders; et al.

Rapid decline in lung function in COPD is associated with decreased CD25brightFoxP3 regulatory T cells in BAL

European Respiratory Journal, Sheffield: European Respiratory Society Journals 2019, Vol. 54

Eriksson Ström, Jonas; Pourazar, Jamshid; Linder, Robert; et al.

European Respiratory Journal, European Respiratory Society Journals 2019, Vol. 54

Frølich, Andreas; Kumar, Abhinav; Bicer, Elif Melis; et al.

Wood smoke effects on epithelial cell lines and human airway cells

European Respiratory Journal, European Respiratory Society Journals 2019, Vol. 54

Hansson, Alva; Rankin, Gregory; Uski, Oskari; et al.

A combined gene expression tool for parallel histological prediction and gene fusion detection in non-small cell lung cancer

Scientific Reports, Nature Publishing Group 2019, Vol. 9

Karlsson, Anna; Cirenajwis, Helena; Ericson-Lindquist, Kajsa; et al.

Small airways effects of exposure to wood smoke

European Respiratory Journal, Sheffield: European Respiratory Society Journals 2019, Vol. 54

Muala, Ala; Österdahl, Rebecka; Sehlstedt, Maria; et al.

Exposure to wood smoke induced activation of lymphocyte subtypes in peripheral blood

European Respiratory Journal, Sheffield: European Respiratory Society Journals 2019, Vol. 54

Pourazar, Jamshid; Sehlstedt, Maria; Rankin, Gregory; et al.

Wood smoke exposure induces the activation of bronchoalveolar lavage lymphocytes

European Respiratory Journal, European Respiratory Society Journals 2019, Vol. 54

Sehlstedt, Maria; Muala, Ala; Pourazar, Jamshid; et al.

Cytotoxic lymphocytes in COPD airways: increased NK cells associated with disease, iNKT and NKT-like cells with current smoking

Respiratory Research, BMC 2018, Vol. 19

Eriksson Ström, Jonas; Pourazar, Jamshid; Linder, Robert; et al.

Mass spectrometry profiling reveals altered plasma levels of monohydroxy fatty acids and related lipids in healthy humans after controlled exposure to biodiesel exhaust

Analytica Chimica Acta, Elsevier 2018, Vol. 1018 : 62-69

Gouveia-Figueira, Sandra C.; Karimpour, Masoumeh; Bosson, Jenny A.; et al.

Proteolytic biomarkers are related to prognosis in COPD: report from a population-based cohort

Respiratory Research, London: BioMed Central 2018, Vol. 19

Linder, Robert; Rönmark, Eva; Pourazar, Jamshid; et al.

A Nation-Wide Population-Based Mapping of Targetable Alterations in Smoking-Independent Lung Cancer

Journal of Thoracic Oncology, Elsevier 2018, Vol. 13, (10) : S431-S432

Salomonsson, A.; Patthey, Annika; Reuterswärd, C.; et al.

Heparin-binding protein in ventilator-induced lung injury.

Intensive Care Medicine Experimental, SpringerOpen 2018, Vol. 6, (1)

Tydén, Jonas; Larsson, Niklas; Lehtipalo, Stefan; et al.

Mass spectrometry profiling of oxylipins, endocannabinoids, and N-acylethanolamines in human lung lavage fluids reveals responsiveness of prostaglandin E2 and associated lipid metabolites to biodiesel exhaust exposure

Analytical and Bioanalytical Chemistry, SPRINGER HEIDELBERG 2017, Vol. 409, (11) : 2967-2980

Gouveia-Figueira, Sandra; Karimpour, Masoumeh; Bosson, Jenny A.; et al.

Differences in the coronal proteome acquired by particles depositing in the lungs of asthmatic versus healthy humans

Nanomedicine: Nanotechnology, Biology and Medicine, Elsevier 2017, Vol. 13, (8) : 2517-2521

Kumar, Abhinav; Bicer, Elif Melis; Pfeffer, Paul; et al.

From COPD epidemiology to studies of pathophysiological disease mechanisms: challenges with regard to study design and recruitment process

European Clinical Respiratory Journal, Taylor & Francis 2017, Vol. 4

Lindberg, Anne; Linder, Robert; Backman, Helena; et al.

Dendritic Cells and Monocytes with Distinct Inflammatory Responses Reside in Lung Mucosa of Healthy Humans

Journal of Immunology, Vol. 196, (11) : 4498-4509

Baharom, Faezzah; Thomas, Saskia; Rankin, Gregory; et al.

Enrichment of immunoregulatory proteins in the biomolecular corona of nanoparticles within human respiratory tract lining fluid

Nanomedicine: Nanotechnology, Biology and Medicine, Vol. 12, (4) : 1033-1043

Kumar, Abhinav; Bicer, Elif Melis; Morgan, Anna Babin; et al.

Multi-platform metabolomics assays for human lung lavage fluids in an air pollution exposure study

Analytical and Bioanalytical Chemistry, Vol. 408, (17) : 4751-4764

Surowiec, Izabella; Karimpour, Masoumeh; Gouveia-Figueira, Sandra; et al.

Inflammatory Markers In Different COPD Subgroups Compared To Smokers And Healthy Controls

American Journal of Respiratory and Critical Care Medicine, Vol. 191

Behndig, Annelie F.; Linder, Robert; Lindberg, Anne; et al.

Effects of controlled diesel exhaust exposure on apoptosis and proliferation markers in bronchial epithelium: an in vivo bronchoscopy study on asthmatics, rhinitics and healthy subjects

BMC Pulmonary Medicine, Vol. 15

Behndig, Annelie F.; Shanmuganathan, Karthika; Whitmarsh, Laura; et al.

Cigarette smoke-induced induction of antioxidant enzyme activities in airway leukocytes is absent in active smokers with COPD

European Clinical Respiratory Journal, Taylor & Francis 2015, Vol. 2

Dove, Rosamund E.; Leong-Smith, Pheneatia; Roos-Engstrand, Ester; et al.

Relative and absolute reliability of measures of linoleic acid-derived oxylipins in human plasma

Prostaglandins & other lipid mediators, Elsevier 2015, Vol. 121, (Part B) : 227-233

Gouveia-Figueira, Sandra; Bosson, Jenny A.; Unosson, Jon; et al.

COX-2 Expression Does Not Predict Outcome of Celecoxib in Addition to Standard Chemotherapy in Advanced Non-Small Cell Lung Cancer

Journal of Thoracic Oncology, Elsevier 2015, Vol. 10, (9) : S541-S542

Gulyas, Miklos; Mattsson, Johanna S. M.; Lindgren, Andrea; et al.

Inhaled Nanoparticles Develop A Complex Protein Corona Of Biological Importance

Journal of Aerosol Medicine, Vol. 28, (4) : A3-A4

Kumar, Abhinav; Bicer, Elif Melis; Pfeffer, Paul; et al.

Identification of vitamin C transporters in the human airways: a cross-sectional in vivo study

BMJ Open, Vol. 5, (4)

Larsson, Nirina; Rankin, Gregory D.; Bicer, Elif M.; et al.

Serum metalloproteinase-9 is related to COPD severity and symptoms - cross-sectional data from a population based cohort-study

Respiratory Research, BioMed Central 2015, Vol. 16

Linder, Robert; Rönmark, Eva; Pourazar, Jamshid; et al.

Acute exposure to wood smoke from incomplete combustion - indications of cytotoxicity

Particle and Fibre Toxicology, Vol. 12

Muala, Ala; Rankin, Gregory; Sehlstedt, Maria; et al.

Airway Inflammatory Response In Healthy Subjects Following Chamber Exposure To 100% Rme Biodiesel

American Journal of Respiratory and Critical Care Medicine, Vol. 191

Pourazar, Jamshid; Behndig, Annelie F.; Helleday, Ragnberth; et al.

Lipid mediator profiles differ between lung compartments in asthmatic and healthy humans

European Respiratory Journal, Vol. 43, (2) : 453-463

Larsson, Nirina; Lundström, Susanna; Pinto, Rui; et al.

Assessment of the capacity of vehicle cabin air inlet filters to reduce diesel exhaust-induced symptoms in human volunteers

Environmental Health, BioMed Central (BMC) 2014, Vol. 13, (1)

Muala, Ala; Sehlstedt, Maria; Bion, Anne; et al.

Peripheral blood neutrophilia as a biomarker of ozone-induced pulmonary inflammation

PLOS ONE, Public Library of Science 2013, Vol. 8, (12)

Bosson, Jenny A; Blomberg, Anders; Stenfors, Nikolai; et al.

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