Anna Linusson Jonsson

Research qualifications: Docent

Contact

anna.linusson@umu.se

+46 90 786 68 90

Works at

Professor at Department of Chemistry

KB.C4, Linnaeus väg 10, C4-31-07 Umeå universitet, 901 87 Umeå

Enzyme dynamics determine the potency and selectivity of inhibitors targeting disease-transmitting mosquitoes

ACS - Infectious Diseases, American Chemical Society (ACS) 2024, Vol. 10, (10) : 3664-3680

Kumari, Rashmi; Lindgren, Cecilia; Kumar, Rajendra; et al.

Bioisosteric replacement based on 1,2,4-oxadiazoles in the discovery of 1H-indazole-bearing neuroprotective MAO B inhibitors

European Journal of Medicinal Chemistry, Elsevier 2023, Vol. 255

Rullo, Mariagrazia; La Spada, Gabriella; Miniero, Daniela Valeria; et al.

Structure-function study of a Ca²⁺-independent metacaspase involved in lateral root emergence

Proceedings of the National Academy of Sciences of the United States of America, Proceedings of the National Academy of Sciences (PNAS) 2023, Vol. 120, (22)

Stael, Simon; Sabljić, Igor; Audenaert, Dominique; et al.

Structure-activity relationships reveal beneficial selectivity profiles of inhibitors targeting acetylcholinesterase of disease-transmitting mosquitoes

Journal of Medicinal Chemistry, American Chemical Society (ACS) 2023, Vol. 66, (9) : 6333-6353

Vidal-Albalat, Andreu; Kindahl, Tomas; Rajeshwari, Rajeshwari; et al.

Broad-Spectrum Antidote Discovery by Untangling the Reactivation Mechanism of Nerve-Agent-Inhibited Acetylcholinesterase

Chemistry - A European Journal, John Wiley & Sons 2022, Vol. 28, (40)

Lindgren, Cecilia; Forsgren, Nina; Hoster, Norman; et al.

Probing Fluorinated Motifs onto Dual AChE-MAO B Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Early-ADME Studies

Journal of Medicinal Chemistry, American Chemical Society (ACS) 2022, Vol. 65, (5) : 3962-3977

Rullo, Mariagrazia; Cipolloni, Marco; Catto, Marco; et al.

In Situ Assembly of Choline Acetyltransferase Ligands by a Hydrothiolation Reaction Reveals Key Determinants for Inhibitor Design

Angewandte Chemie International Edition, Wiley-VCH Verlagsgesellschaft 2021, Vol. 60, (2) : 813-819

Wiktelius, Daniel; Allgardsson, Anders; Bergström, Tomas; et al.

Physical Mechanisms Governing Substituent Effects on Arene-Arene Interactions in a Protein Milieu

Journal of Physical Chemistry B, American Chemical Society (ACS) 2020, Vol. 124, (30) : 6529-6539

Andersson, C. David; Mishra, Brijesh Kumar; Forsgren, Nina; et al.

Classification and Nomenclature of Metacaspases and Paracaspases: No More Confusion with Caspases

Molecular Cell, Elsevier 2020, Vol. 77, (5) : 927-929

Minina, Elena A.; Staal, Jens; Alvarez, Vanina E.; et al.

Nucleation of an Activating Conformational Change by a Cation−Π Interaction

Biochemistry, American Chemical Society (ACS) 2019, Vol. 58, (32) : 3408-3412

Rogne, Per; Andersson, David; Grundström, Christin; et al.

Influence of Enantiomeric Inhibitors on the Dynamics of Acetylcholinesterase Measured by Elastic Incoherent Neutron Scattering

Journal of Physical Chemistry B, American Chemical Society (ACS) 2018, Vol. 122, (36) : 8516-8525

Andersson, C. David; Martinez, Nicolas; Zeller, Dominik; et al.

Noncovalent Inhibitors of Mosquito Acetylcholinesterase 1 with Resistance-Breaking Potency

Journal of Medicinal Chemistry, American Chemical Society (ACS) 2018, Vol. 61, (23) : 10545-10557

Knutsson, Sofie; Engdahl, Cecilia; Kumari, Rashmi; et al.

Identification of potential aryl hydrocarbon receptor ligands by virtual screening of industrial chemicals

Environmental Science and Pollution Research, Springer 2018, Vol. 25, (3) : 2436-2449

Larsson, Malin; Fraccalvieri, Domenico; Andersson, C. David; et al.

Dynamics Determine Signaling in a Multicomponent System Associated with Rheumatoid Arthritis

Journal of Medicinal Chemistry, American Chemical Society (ACS) 2018, Vol. 61, (11) : 4774-4790

Lindgren, Cecilia; Tyagi, Mohit; Viljanen, Johan; et al.

Retention-time prediction in comprehensive two-dimensional gas chromatography to aid identification of unknown contaminants

Analytical and Bioanalytical Chemistry, Springer Berlin/Heidelberg 2018, Vol. 410, (30) : 7931-7941

Veenaas, Cathrin; Linusson, Anna; Haglund, Peter

An unusual dimeric inhibitor of acetylcholinesterase: cooperative binding of crystal violet

Molecules, MDPI AG 2017, Vol. 22, (9)

Allgardsson, Anders; Andersson, C. David; Akfur, Christine; et al.

Changes in dynamics of alpha-chymotrypsin due to covalent inhibitors investigated by elastic incoherent neutron scattering

Physical Chemistry, Chemical Physics - PCCP, ROYAL SOC CHEMISTRY 2017, Vol. 19, (37) : 25369-25379

Andersson, David C.; Martinez, N.; Zeller, D.; et al.

N-Aryl-N'-ethyleneaminothioureas effectively inhibit acetylcholinesterase 1 from disease-transmitting mosquitoes

European Journal of Medicinal Chemistry, Vol. 134 : 415-427

Knutsson, Sofie; Kindahl, Tomas; Engdahl, Cecilia; et al.

Structure of a prereaction complex between the nerve agent sarin, its biological target acetylcholinesterase, and the antidote HI-6

Proceedings of the National Academy of Sciences of the United States of America, Vol. 113, (20) : 5514-5519

Allgardsson, Anders; Berg, Lotta; Akfur, Christine; et al.

The Nature of Activated Non-classical Hydrogen Bonds: A Case Study on Acetylcholinesterase-Ligand Complexes

Chemistry - A European Journal, Wiley-VCH Verlagsgesellschaft 2016, Vol. 22, (8) : 2672-2681

Berg, Lotta; Mishra, Brijesh Kumar; Andersson, C. David; et al.

Discovery of selective inhibitors targeting acetylcholinesterase 1 from disease-transmitting mosquitoes

Journal of Medicinal Chemistry, American Chemical Society (ACS) 2016, Vol. 59, (20) : 9409-9421

Engdahl, Cecilia; Knutsson, Sofie; Ekström, Fredrik; et al.

Benefits of statistical molecular design, covariance analysis, and reference models in QSAR: a case study on acetylcholinesterase

Journal of Computer-Aided Molecular Design, Vol. 29, (3) : 199-215

Andersson, C. David; Hillgren, J. Mikael; Lindgren, Cecilia; et al.

Towards small molecule inhibitors of mono-ADP-ribosyltransferases

European Journal of Medicinal Chemistry, Vol. 95 : 546-551

Ekblad, Torun; Lindgren, Anders E. G.; Andersson, C. David; et al.

Acetylcholinesterases from the Disease Vectors Aedes aegypti and Anopheles gambiae: Functional Characterization and Comparisons with Vertebrate Orthologues

PLOS ONE, Vol. 10, (10)

Engdahl, Cecilia; Knutsson, Sofie; Fredriksson, Sten-Åke; et al.

Structural Basis for Lack of ADP-ribosyltransferase Activity in Poly(ADP-ribose) Polymerase-13/Zinc Finger Antiviral Protein

Journal of Biological Chemistry, Vol. 290, (12) : 7336-7344

Karlberg, Tobias; Klepsch, Mirjam; Thorsell, Ann-Gerd; et al.

Hydroxyethylene isosteres introduced in type II collagen fragments substantially alter the structure and dynamics of class II MHC A(q)/glycopeptide complexes

Organic and biomolecular chemistry, Vol. 13, (22) : 6203-6216

Lindgren, Cecilia; Andersson, Ida E.; Berg, Lotta; et al.

Statistical molecular design: a tool to follow up hits from small-molecule screening.

Methods in Molecular Biology, Springer 2014, Vol. 1056 : 169-188

Lindgren, Anders E G; Larsson, Andreas; Linusson, Anna; et al.

Divergent Structure-Activity Relationships of Structurally Similar Acetylcholinesterase Inhibitors

Journal of Medicinal Chemistry, American Chemical Society (ACS) 2013, Vol. 56, (19) : 7615-7624

Andersson, C. David; Forsgren, Nina; Akfur, Christine; et al.

Catalytic-site conformational equilibrium in nerve-agent adducts of acetylcholinesterase: Possible implications for the HI-6 antidote substrate specificity

Biochemical Pharmacology, Elsevier 2013, Vol. 85, (9) : 1389-1397

Artursson, Elisabet; Andersson, Per Ola; Akfur, Christine; et al.

On the use of electronic descriptors for QSAR modelling of PCDDs, PCDFs and dioxin-like PCBs^£:

SAR and QSAR in environmental research (Print), Taylor & Francis Group 2013, Vol. 24, (6) : 461-479

Larsson, Malin; Kumar Mishra, Brijesh; Tysklind, Mats; et al.

Chemical Probes to Study ADP-Ribosylation: Synthesis and Biochemical Evaluation of Inhibitors of the Human ADP-Ribosyltransferase ARTD3/PARP3

Journal of Medicinal Chemistry, American Chemical Society (ACS) 2013, Vol. 56, (23) : 9556-9568

Lindgren, Anders E. G.; Karlberg, Tobias; Ekblad, Torun; et al.

PARP Inhibitor with Selectivity Toward ADP-Ribosyltransferase ARTD3/PARP3

ACS Chemical Biology, Vol. 8, (8) : 1698-1703

Lindgren, Anders E. G.; Karlberg, Tobias; Thorsell, Ann-Gerd; et al.

Determinants for simultaneous binding of copper and platinum to human chaperone Atox1: hitchhiking not hijacking

PLOS ONE, Public Library Science 2013, Vol. 8, (7)

Palm-Espling, Maria; Andersson, David C.; Björn, Erik; et al.

Discovery of Ligands for ADP-Ribosyltransferases via Docking-Based Virtual Screening

Journal of Medicinal Chemistry, Vol. 55, (17) : 7706-7718

Andersson, C David; Karlberg, Tobias; Ekblad, Torun; et al.

Angewandte Chemie International Edition, Vol. 51, (51) : 12716-12720

Berg, Lotta; Niemiec, Moritz S.; Qian, Weixing; et al.

Mapping pilicide anti-virulence effect in Escherichia coli, a comprehensive structure-activity study

Bioorganic & Medicinal Chemistry, Elsevier 2012, Vol. 20, (9) : 3128-3142

Chorell, Erik; Pinkner, Jerome S; Bengtsson, Christoffer; et al.

Design of glycopeptides used to investigate class II MHC binding and T-Cell responses associated with autoimmune arthritis

PLOS ONE, Public Library of Science 2011, Vol. 6, (3) : e17881-

Andersson, Ida E; Andersson, C David; Batsalova, Tsvetelina; et al.

(E)-Alkene and Ethylene Isosteres Substantially Alter the Hydrogen-Bonding Network in Class II MHC A^q/Glycopeptide Complexes and Affect T-Cell Recognition

Journal of the American Chemical Society, American Chemical Society 2011, Vol. 133, (36) : 14368-14378

Andersson, Ida E.; Batsalova, Tsvetelina; Haag, Sabrina; et al.

Targeting Acetylcholinesterase: Identification of Chemical Leads by High Throughput Screening, Structure Determination and Molecular Modeling

PLOS ONE, San Francisco: Public Library of Science 2011, Vol. 6, (11)

Berg, Lotta; Andersson, C. David; Artursson, Elisabet; et al.

Postprocessing of docked protein-ligand complexes using implicit solvation models

Journal of chemical information and modeling, Vol. 51, (2) : 267-282

Lindström, Anton; Edvinsson, Lotta; Johansson, Andreas; et al.

Multivariate assessment of virtual screening experiments

Journal of Chemometrics, John Wiley & Sons, Ltd 2010, Vol. 24, (11-12) : 757-767

Andersson, C David; Chen, Brian Y; Linusson, Anna

Mapping of ligand-binding cavities in proteins

Proteins: Structure, Function, and Bioinformatics, John Wiley & Sons, Inc 2010, Vol. 78, (6) : 1408-1422

Andersson, David C.; Chen, Brian Y; Linusson Jonsson, Anna

Oxazole-modified glycopeptides that target arthritis-associated class II MHC A^q and DR4 proteins

Organic and biomolecular chemistry, RSC Publishing 2010, Vol. 8, (13) : 2931-2940

Andersson, Ida E.; Batsalova, Tsvetelina; Dzhambazov, Balik; et al.

Statistical molecular design of a focused salicylidene acylhydrazide library and multivariate QSAR of inhibition of type III secretion in the Gram-negative bacterium Yersinia

Bioorganic & Medicinal Chemistry, Vol. 18, (7) : 2686-2703

Dahlgren, Markus K; Zetterström, Caroline E; Gylfe, Åsa; et al.

Statistical molecular design of balanced compound libraries for QSAR modeling

Current Medicinal Chemistry, Vol. 17, (19) : 2001-2016

Linusson, Anna; Elofsson, Mikael; Andersson, Ida E; et al.

Quantitative protein descriptors for secondary structure characterization and protein classification

Chemometrics and Intelligent Laboratory Systems, Vol. 95, (1) : 74-85

Lindström, Anton; Pettersson, Fredrik; Linusson, Anna

Transthyretin-related and transthyretin-like proteins

Recent advances in Transthyretin evolution, structure and biological functions, Springer Berlin/Heidelberg 2009 : 109-122

Sauer-Eriksson, Elisabeth; Linusson, Anna; Lundberg, Erik

A multivariate chemical map of industrial chemicals: Assessment of various protocols for identification of chemicals of potential concern

Chemosphere, Elsevier 2009, Vol. 76, (7) : 878-884

Stenberg, Mia; Linusson, Anna; Tysklind, Mats; et al.

A multivariate approach to investigate docking parameters' effects on docking performance

Journal of chemical information and modeling, American Chemical Society Publications 2007, Vol. 47, (4) : 1673-1687

Andersson, David C.; Thysell, Elin; Lindström, Anton; et al.

Probing molecular interactions within Class II MHC Aq/Glycopeptide/T-Cell Receptor Complexes associated with Collagen-Induced Arthritis

Journal of Medicinal Chemistry, Vol. 50, (23) : 5627-5643

Andersson, Ida E.; Dzhambazov, Balik; Holmdahl, Rikard; et al.

View publications in DiVA

Research groups

Head of research

Anna Linusson Lab

Research projects

1 December 2018 until 30 November 2023

New Medical Countermeasures against Neurotoxicity Caused by Nerve Agents and Insecticides

Published: 13 Mar, 2020

Collaboration award to pharmaceutical chemist

Published: 24 Jun, 2019

Seed money sows seeds for new doctoral students at the Industrial Doctoral School for Research and Innovation

Published: 14 Jan, 2019

IDS celebrates 10-year jubilee and continues to strive upwards

Published: 03 May, 2016

New drug against nerve agents in sight

Published: 30 Jun, 2014

Med upptäckande som drivkraft