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Staff photo Anna Arnqvist Björklund

Anna Arnqvist Björklund

PhD

Professor of Biomedicine

Associate Dean for Research of the Faculty of Medicine

0000-0002-5699-613X

Contact

E-mail
anna.arnqvist@umu.se
Phone
+46 90 786 65 39, +46 70 636 99 83

Works at

Affiliation
Professor at Department of Medical Biochemistry and Biophysics
Location
KB. A6, Campus, Umeå Umeå universitet, 901 87 Umeå

Helicobacter pylori colonizes the human stomach and is established to cause chronic active gastritis and peptic ulcer disease as well as gastric cancer. We want to elucidate molecular mechanisms involved in activation and de-activation H. pylori adherence properties.

Campylobacter jejuni surface-bound protease HtrA, but not the secreted protease nor protease in shed membrane vesicles, disrupts epithelial cell-to-cell junctions
Cells, MDPI 2024, Vol. 13, (3)
Sharafutdinov, Irshad; Tegtmeyer, Nicole; Rohde, Manfred; et al.
Molecular insights into the fine-tuning of pH-dependent ArsR-mediated regulation of the SabA adhesin in Helicobacter pylori
Nucleic Acids Research, Oxford University Press 2024, Vol. 52, (10) : 5572-5595
Åberg, Anna; Gideonsson, Pär; Bhat, Abhayprasad; et al.
Phosphatidic acid-mediated binding and mammalian cell internalization of the Vibrio cholerae cytotoxin MakA
PLoS Pathogens, Public Library of Science 2021, Vol. 17, (3)
Nadeem, Aftab; Alam, Athar; Toh, Eric; et al.
Helicobacter pylori Outer Membrane Vesicles Protect the Pathogen From Reactive Oxygen Species of the Respiratory Burst
Frontiers in Microbiology, Frontiers Media S.A. 2018, Vol. 9
Lekmeechai, Sujinna; Su, Yu-Ching; Brant, Marta; et al.
Helicobacter pylori Adapts to Chronic Infection and Gastric Disease via pH-Responsive BabA-Mediated Adherence
Cell Host and Microbe, CELL PRESS 2017, Vol. 21, (3) : 376-389
Bugaytsova, Jeanna A.; Björnham, Oscar; Chernov, Yevgen A.; et al.
Fakultetsaudit: Intern bedömning av kvalitetsarbete för utbildning på grund- och avancerad nivå vid Teknisk-naturvetenskaplig fakultet hösten 2016
Umeå: Umeå universitet 2017
Fjellström, Mona; Larsson, Malin; Edlund, Ann-Catrine; et al.
BabA dependent binding of Helicobacter pylori to human gastric mucins cause aggregation that inhibits proliferation and is regulated via ArsS
Scientific Reports, Vol. 7
Skoog, Emma C.; Padra, Medea; Åberg, Anna; et al.
Roles of the BabA and the SabA adhesins in gastroduodenal diseases
Helicobacter pylori research: from bench to bedside, Tokyo: Springer 2016 : 143-164
Arnqvist, Anna
Structural Insights into Polymorphic ABO Glycan Binding by Helicobacter pylori
Cell Host and Microbe, Vol. 19, (1) : 55-66
Moonens, Kristof; Gideonsson, Pär; Subedi, Suresh; et al.
Kvalitetssystem för utbildning på grund- och avancerad nivå vid Umeå universitet
Umeå: Umeå universitet 2015
Haake, Ulrika; Fjellström, Mona; Wilhelmsson, Birgitta; et al.
Helicobacter pylori vesicles carrying CagA localize in the vicinity of cell-cell contacts and induce histone H1 binding to ATP in epithelial cells
FEMS Microbiology Letters, Vol. 362, (11)
Turkina, Maria V.; Olofsson, Annelie; Magnusson, Karl-Eric; et al.
Uptake of Helicobacter pylori vesicles is facilitated by clathrin-dependent and clathrin-independent endocytic pathways
mBio, Vol. 5, (3) : e00979-14-
Olofsson, Annelie; Nygård Skalman, Lars; Obi, Ikenna; et al.
A Repetitive DNA Element Regulates Expression of the Helicobacter pylori Sialic Acid Binding Adhesin by a Rheostat-like Mechanism
PLoS Pathogens, Vol. 10, (7)
Åberg, Anna; Gideonsson, Pär; Vallström, Anna; et al.
The Complement Regulator CD46 Is Bactericidal to Helicobacter pylori and Blocks Urease Activity
Gastroenterology, Baltimore: Williams & Wilkins Co 2011, Vol. 141, (3) : 918-928
Basmarke-Wehelie, Rahma; Sjolinder, Hong; Jurkowski, Wiktor; et al.
Effects of blood group antigen-binding adhesin expression during Helicobacter pylori infection of Mongolian gerbils
Journal of Infectious Diseases, Vol. 203, (5) : 726-735
Ohno, Tomoyuki; Vallström, Anna; Rugge, Massimo; et al.
Helicobacter pylori Adhesion to the Gastric Surface
Helicobacter pylori in the 21st Century, WALLINGFORD: CABI Publishing 2010 : 248-268
Lindén, S. K.; Arnqvist, Anna; Teneberg, S.; et al.
Biochemical and functional characterization of Helicobacter pylori vesicles
Molecular Microbiology, Wiley 2010, Vol. 77, (6) : 1539-1555
Olofsson, Annelie; Vallström, Anna; Petzold, Katja; et al.
Semiconstant-Time P,H-COSY NMR: Analysis of Complex Mixtures of Phospholipids Originating from Helicobacter pylori
Journal of the American Chemical Society, ACS Publications ASAP 2009, Vol. 131, (40) : 14150-1
Petzold, Katja; Olofsson, Annelie; Arnqvist, Anna; et al.
Helicobacter pylori BabA expression, gastric mucosal injury, and clinical outcome.
Clin Gastroenterol Hepatol, Vol. 5, (1) : 49-58
Fujimoto, Saori; Olaniyi Ojo, Olabisi; Arnqvist, Anna; et al.
Helicobacter pylori outer membrane vesicles and properties for intimate host interactions
BLACKWELL PUBLISHING, 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND 2007
Olofsson, Annelie; Bäckström, Anna; Petzold, Katjaj; et al.
Helicobacter pylori adhesion to carbohydrates.
Methods in enzymology, Vol. 417 : 293-339
Aspholm, Marina; Kalia, Awdhesh; Ruhl, Stefan; et al.
SabA is the H. pylori hemagglutinin and is polymorphic in binding to sialylated glycans.
PLoS Pathog, Vol. 2, (10) : e110-
Aspholm, Marina; Olfat, Farzad O; Nordén, Jenny; et al.
Immunoproteomics of Actinobacillus actinomycetemcomitans outer-membrane proteins reveal a highly immunoreactive peptidoglycan-associated lipoprotein.
Journal of Medical Microbiology, Vol. 55, (7) : 931-942
Paul-Satyaseela, M; Karched, M; Bian, Z; et al.
Helicobacter pylori outer membrane proteins and gastroduodenal disease.
Gut, Vol. 55, (6) : 775-81
Yamaoka, Y; Ojo, O; Fujimoto, S; et al.
Functional adaptation of BabA, the H. pylori ABO blood group antigen binding adhesin
Science, American Association for the Advancement of Science 2004, Vol. 305, (5683) : 519-522
Aspholm-Hurtig, Marina; Dailide, Giedrius; Lahmann, Martina; et al.
Metastability of Helicobacter pylori bab adhesin genes and dynamics in Lewis b antigen binding
Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, (48) : 16923-16928
Bäckström, Anna; Lundberg, Carina; Kersulyte, Dangeruta; et al.
Helicobacter pylori SabA adhesin in persistent infection and chronic inflammation
Science, American Association for the Advancement of Science 2002, Vol. 297, (5581) : 573-578
Mahdavi, Jafar; Sondén, B; Hurtig, Marina; et al.
Discrimination between cases of duodenal ulcer and gastritis on the basis of putative virulence factors of Helicobacter pylori.
Journal of Clinical Microbiology, Vol. 40, (6) : 2244-2246
Yamaoka, Yoshio; Souchek, Julianne; Odenbreit, Stefan; et al.
Helicobacter pylori adhesin binding fucosylated histo-blood group antigens revealed by retagging.
Science, Vol. 279, (5349) : 373-7
Ilver, D; Arnqvist, Anna; Ogren, J; et al.
Expression of two csg operons is required for production of fibronectin- and congo red-binding curli polymers in Escherichia coli K-12.
Molecular Microbiology, Vol. 18, (4) : 661-70
Hammar, M; Arnqvist, Anna; Bian, Z; et al.
Sigma S-dependent growth-phase induction of the csgBA promoter in Escherichia coli can be achieved in vivo by sigma 70 in the absence of the nucleoid-associated protein H-NS.
Molecular Microbiology, Vol. 13, (6) : 1021-32
Arnqvist, Anna; Olsén, A; Normark, S
Environmental regulation of curli production in Escherichia coli.
Infectious agents and disease, Vol. 2, (4) : 272-4
Olsén, A; Arnqvist, Anna; Hammar, M; et al.
The RpoS sigma factor relieves H-NS-mediated transcriptional repression of csgA, the subunit gene of fibronectin-binding curli in Escherichia coli.
Molecular Microbiology, Vol. 7, (4) : 523-36
Olsén, A; Arnqvist, Anna; Hammar, M; et al.
The Crl protein activates cryptic genes for curli formation and fibronectin binding in Escherichia coli HB101.
Molecular Microbiology, Vol. 6, (17) : 2443-52
Arnqvist, Anna; Olsén, A; Pfeifer, J; et al.
Fibronectin binding mediated by a novel class of surface organelles on Escherichia coli
Nature, Vol. 338, (6217) : 652-5
Olsén, Arne; Jonsson, Anna; Normark, Staffan
pH regulated H. pylori adherence: implications for persistent infection and disease
Bugaytsova, Jeanna; Björnhamn, Oscar; Henriksson, Sara; et al.
Acid Responsive Helicobacter pylori Adherence: Implications for Chronic Infection and Disease
Bugaytsova, Jeanna; Chernov, Yevgen A; Gideonsson, Pär; et al.
Effects of BabA expression during H. pylori infection of Mongolian gerbils
Ohno, Tomoyuki; Vallström, Anna; Wu, MJ; et al.
Characterization of Helicobacter pylori vesicles and their cognate properties for intimate host interactions
Olofsson, Annelie; Vallström, Anna; Petzold, Katja; et al.
The Helicobacter pylori sialic acid binding adhesin SabA is regulated via a network of two-component systems
Åberg, Anna; Gideonsson, Pär; Brännström, Kristoffer; et al.
Phase variation and expression mechanisms of the sialic acid binding adhesin SabA in Helicobacter pylori
Öhman, Carina; Vallström, Anna; Olofsson, Annelie; et al.
View publications in DiVA

Research groups

Head of research
Anna Arnqvist Lab

Research projects

20 November 2007 until 31 December 2008
Helicobacter pylori: Regulatory mechanisms for expression of adhesins during persistent infection