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Staff photo Anders Sjöstedt

Anders Sjöstedt

Professor in Clinical Microbiology

Senior consultant (attending) physician in Clinical Microbiology

0000-0002-0768-8405

Contact

E-mail
anders.sjostedt@umu.se
Phone
+46 90 785 11 20

Works at

Affiliation
Professor, senior consultant (attending) physician at Department of Clinical Microbiology Section: Clinical Bacteriology, Section of Infection and Immunology
Location
6D, , Universitetssjukhuset, 14 Umeå universitet, 901 85 Umeå

I have worked on Francisella tularensis for more than 30 years and during this period published more than 130 papers related to the pathogen. My ongoing Francisella research is aimed to elucidate its virulence factors and to understand host mechanisms controlling tularemia. My research focus on elucidation of F. tularensis virulence mechanisms has also been the basis for the identification of suitable targets to obtain attenuated vaccine candidates. I am also actively involved in developing a F. tularensis vaccine. The work related to virulence mechanisms has a focus to elucidate mechanisms of the type VI secretion system of F. tularensis. More detailed description of the projects follow below.

My research is highly cited and in Google Scholar, I have in total 199 papers that have been cited 13,200 times, with an h-index of 68 and an i10-index of 140. I have been the supervisor of twelve post-docs and supervisor or co-supervisor of 18 PhD students.

Bibliography

 

Francisella tularensis-specific antibody levels in sera from Swedish patients with suspected tularemia during a 13-year period
Frontiers in Cellular and Infection Microbiology, Frontiers Media S.A. 2024, Vol. 14
Lindgren, Helena; Liu, Xijia; Sjöstedt, Anders
Tularemia: a storied history, an ongoing threat
Clinical Infectious Diseases, Oxford University Press 2024, Vol. 78, (Supplement_1) : S1-S3
Nelson, Christina A; Sjöstedt, Anders
Targeting tularemia: clinical, laboratory, and treatment outcomes from an 11-year retrospective observational cohort in northern sweden
Clinical Infectious Diseases, Oxford University Press 2024, Vol. 78, (5) : 1222-1231
Plymoth, Martin; Lundqvist, Robert; Nystedt, Anders; et al.
Of hares and men: exposure and prediction of human tularaemia outbreaks using a reporting system for deceased wild animals
Zoonoses Conference 2024, Sydney, Australia, July 5-6, 2024
Plymoth, Martin; Lundqvist, Robert; Nystedt, Anders; et al.
Kinetics of the serological response up to one year after tularemia
Frontiers in Cellular and Infection Microbiology, Frontiers Media S.A. 2023, Vol. 12
Lindgren, Helena; Eklund, Johan; Eneslätt, Kjell; et al.
Analyses of human immune responses to Francisella tularensis identify correlates of protection
Frontiers in Immunology, Frontiers Media S.A. 2023, Vol. 14
Lindgren, Helena; Eneslätt, Kjell; Golovliov, Igor; et al.
Utility of Borrelia-specific IgM and IgG antibody titer determinations during a 12-year period: results from a clinical laboratory in Northern Sweden
Frontiers in Cellular and Infection Microbiology, Frontiers Media S.A. 2023, Vol. 13
Liu, Xijia; Tabibzada, Nazanin; Lindgren, Helena; et al.
Protein-lipid interaction at low pH induces oligomerization of the MakA cytotoxin from Vibrio cholerae
eLIFE, eLife Sciences Publications, Ltd 2022, Vol. 11
Nadeem, Aftab; Berg, Alexandra; Pace, Hudson; et al.
The type IV pili component PilO is a virulence determinant of Francisella novicida
PLOS ONE, Public Library of Science 2022, Vol. 17, (1 1)
Ozanic, Mateja; Marecic, Valentina; Knezevic, Masa; et al.
Backbone chemical shift assignment and dynamics of the N-terminal domain of ClpB from Francisella tularensis type VI secretion system
Biomolecular NMR Assignments, Springer 2022, Vol. 16 : 75-79
Ul Mushtaq, Ameeq; Ådén, Jörgen; Alam, Athar; et al.
The Role of ClpB in Bacterial Stress Responses and Virulence
Frontiers in Molecular Biosciences, Frontiers Media S.A. 2021, Vol. 8
Alam, Athar; Bröms, Jeanette E; Kumar, Rajender; et al.
Francisella FlmX broadly affects lipopolysaccharide modification and virulence
Cell Reports, Elsevier 2021, Vol. 35, (11)
Chin, Chui-Yoke; Zhao, Jinshi; Llewellyn, Anna C.; et al.
Modern Development and Production of a New Live Attenuated Bacterial Vaccine, SCHU S4 Delta clpB, to Prevent Tularemia
Pathogens, MDPI 2021, Vol. 10, (7)
Conlan, J. Wayne; Sjöstedt, Anders; Gelhaus, H. Carl; et al.
Healthy ecosystems for human and animal health: Science diplomacy for responsible development in the Arctic
Polar Record, Cambridges Institutes Press 2021, Vol. 57
Evengård, Birgitta; Destouni, G.; Kalantari, Z.; et al.
Macrophages Demonstrate Guanylate-Binding Protein-Dependent and Bacterial Strain-Dependent Responses to Francisella tularensis
Frontiers in Cellular and Infection Microbiology, Frontiers Media S.A. 2021, Vol. 11
Mohammadi, Nasibeh; Lindgren, Helena; Yamamoto, Masahiro; et al.
A tripartite cytolytic toxin formed by Vibrio cholerae proteins with flagellum-facilitated secretion
Proceedings of the National Academy of Sciences of the United States of America, Vol. 118, (47)
Nadeem, Aftab; Nagampalli, Raghavendra; Toh, Eric; et al.
Structure-Based Virtual Screening to Discover Potential Lead Molecules for the SARS-CoV-2 Main Protease.
Journal of Chemical Information and Modeling, American Chemical Society (ACS) 2020, Vol. 60, (12) : 5781-5793
Gahlawat, Anuj; Kumar, Navneet; Kumar, Rajender; et al.
Atg5-Deficient Mice Infected with Francisella tularensis LVS Demonstrate Increased Survival and Less Severe Pathology in Internal Organs
Microorganisms, MDPI 2020, Vol. 8, (10)
Kelava, Ina; Mihelčić, Mirna; Ožanič, Mateja; et al.
Exploring the Diversity Within the Genus Francisella – An Integrated Pan-Genome and Genome-Mining Approach
Frontiers in Microbiology, Frontiers Media S.A. 2020, Vol. 11
Kumar, Rajender; Bröms, Jeanette E; Sjöstedt, Anders
Vaccine-Mediated Mechanisms Controlling Francisella tularensis SCHU S4 Growth in a Rat Co-Culture System
Pathogens, MDPI 2020, Vol. 9, (5)
Lindgren, Helena; Eneslätt, Kjell; Golovliov, Igor; et al.
Multidrug- and Extensively Drug-Resistant Mycobacterium tuberculosis Beijing Clades, Ukraine, 2015
Emerging Infectious Diseases, Centers for Disease Control and Prevention (CDC) 2020, Vol. 26, (3) : 481-490
Merker, Matthias; Nikolaevskaya, Elena; Kohl, Thomas A.; et al.
Guanylate-Binding Proteins Are Critical for Effective Control of Francisella tularensis Strains in a Mouse Co-Culture System of Adaptive Immunity
Frontiers in Cellular and Infection Microbiology, Frontiers Media S.A. 2020, Vol. 10
Mohammadi, Nasibeh; Lindgren, Helena; Golovliov, Igor; et al.
Control of Francisella tularensis Virulence at Gene Level: Network of Transcription Factors
Microorganisms, MDPI 2020, Vol. 8, (10)
Spidlova, Petra; Stojková, Pavla; Sjöstedt, Anders; et al.
Phospholipid Levels in Blood during Community-Acquired Pneumonia
PLOS ONE, Public Library of Science 2019, Vol. 14, (5)
Müller, Daniel C.; Kauppi, Anna; Edin, Alicia; et al.
Francisella tularensis: FupA mutation contributes to fluoroquinolone resistance by increasing vesicle secretion and biofilm formation
Emerging Microbes & Infections, Taylor & Francis 2019, Vol. 8, (1)
Siebert, Claire; Lindgren, Helena; Ferre, Sabrina; et al.
ClpB mutants of Francisella tularensis subspecies holarctica and tularensis are defective for type VI secretion and intracellular replication
Scientific Reports, Nature Publishing Group 2018, Vol. 8
Alam, Athar; Golovliov, Igor; Javed, Eram; et al.
Vaccine-mediated mechanisms controlling replication of Francisella tularensis in human peripheral blood mononuclear cells using a co-culture system
Frontiers in Cellular and Infection Microbiology, Frontiers Media S.A. 2018, Vol. 8
Eneslätt, Kjell; Golovliov, Igor; Rydén, Patrik; et al.
Characterization of clinically relevant model bacterial strains of Pseudomonas aeruginosa for anti-biofilm testing of materials
Acta Biomaterialia, Elsevier 2018, Vol. 76 : 99-107
Rzhepishevska, Olena I.; Limanska, Nataliia; Galkin, Mykola; et al.
A mutagenesis-based approach identifies amino acids in the N-terminal part of Francisella tularensis IglE that critically control type VI system-mediated secretion
Virulence, TAYLOR & FRANCIS INC 2017, Vol. 8, (6) : 821-847
Bröms, Jeanette E.; Meyer, Lena; Sjöstedt, Anders
High-risk regions and outbreak modelling of tularemia in humans
Epidemiology and Infection, CAMBRIDGE UNIV PRESS 2017, Vol. 145, (3) : 482-490
Desvars-Larrive, Amélie; Liu, X.; Hjertqvist, M.; et al.
Lack of OxyR and KatG Results in Extreme Susceptibility of Francisella tularensis LVS to Oxidative Stress and Marked Attenuation In vivo
Frontiers in Cellular and Infection Microbiology, Vol. 7
Honn, Marie; Lindgren, Helena; Bharath, Gurram Kumar; et al.
The role and mechanism of erythrocyte invasion by Francisella tularensis
Frontiers in Cellular and Infection Microbiology, Frontiers Media S.A. 2017, Vol. 7
Schmitt, Deanna M.; Barnes, Rebecca; Rogerson, Taylor; et al.
IFN-gamma extends the immune functions of Guanylate Binding Proteins to inflammasome-independent antibacterial activities during Francisella novicida infection
PLoS Pathogens, Public Library Science 2017, Vol. 13, (10)
Wallet, Pierre; Benaoudia, Sacha; Mosnier, Amandine; et al.
An In Vitro Co-culture Mouse Model Demonstrates Efficient Vaccine-Mediated Control of Francisella tularensis SCHU S4 and Identifies Nitric Oxide as a Predictor of Efficacy
Frontiers in Cellular and Infection Microbiology, Vol. 6
Golovliov, Igor; Lindgren, Helena; Eneslätt, Kjell; et al.
Metabolites in Blood for Prediction of Bacteremic Sepsis in the Emergency Room
PLOS ONE, Vol. 11, (1)
Kauppi, Anna M.; Edin, Alicia; Ziegler, Ingrid; et al.
Dissection of Francisella-Host Cell Interactions in Dictyostelium discoideum
Applied and Environmental Microbiology, American Society for Microbiology 2016, Vol. 82, (5) : 1586-1598
Lampe, Elisabeth O.; Brenz, Yannick; Herrmann, Lydia; et al.
Reclassification of Wolbachia persica as Francisella persica comb. nov. and emended description of the family Francisellaceae
International Journal of Systematic and Evolutionary Microbiology, Vol. 66, (3) : 1200-1205
Larson, Marilynn A.; Nalbantoglu, Ufuk; Sayood, Khalid; et al.
Gallium Potentiates the Antibacterial Effect of Gentamicin against Francisella tularensis
Antimicrobial Agents and Chemotherapy, Vol. 60, (1) : 288-295
Lindgren, Helena; Sjöstedt, Anders
Phenotypic characterization of the Francisella tularensis Delta pdpC and Delta iglG mutants
Microbes and infection, Vol. 18, (12) : 768-776
Ozanic, Mateja; Marecic, Valentina; Lindgren, Marie; et al.
Francisella tularensis IglG Belongs to a Novel Family of PAAR-Like T6SS Proteins and Harbors a Unique N-terminal Extension Required for Virulence
PLoS Pathogens, Vol. 12, (9)
Rigard, Melanie; Bröms, Jeanette E.; Mosnier, Amandine; et al.
Clinical manifestations and the epidemiology of tularemia Klinička slika i epidemiologija tularemije: [Klinička slika i epidemiologija tularemije]
Medicina Fluminensis, Croatian Medical Association and School of Medicine 2016, Vol. 52, (2) : 211-216
Sjöstedt, Anders
Roles of Reactive Oxygen Species-Degrading Enzymes of Francisella tularensis SCHU S4
Infection and Immunity, Vol. 83, (6) : 2255-2263
Binesse, Johan; Lindgren, Helena; Lindgren, Lena; et al.
Epidemiology and Ecology of Tularemia in Sweden, 1984-2012
Emerging Infectious Diseases, Vol. 21, (1) : 32-39
Desvars, Amélie; Furberg, Maria; Hjertqvist, Marika; et al.
Epidemiology and Ecology of Tularemia in Sweden
International Journal of Epidemiology, Vol. 44 : 58-58
Desvars, Amélie; Furberg, Maria; Hjertqvist, Marika; et al.
Development and Laboratory Evaluation of a Real-Time PCR Assay for Detecting Viruses and Bacteria of Relevance for Community-Acquired Pneumonia
Journal of Molecular Diagnostics, Vol. 17, (3) : 315-324
Edin, Alicia; Granholm, Susanne; Koskiniemi, Satu; et al.
Mechanisms of heme utilization by Francisella tularensis
PLOS ONE, Vol. 10, (3)
Lindgren, Helena; Lindgren, Lena; Golovliov, Igor; et al.
Microinjection of Francisella tularensis and Listeria monocytogenes reveals the importance of bacterial and host factors for successful replication
Infection and Immunity, Vol. 83, (8) : 3233-3242
Meyer, Lena; Bröms, Jeanette; Liu, Xijia; et al.
Models Derived from In Vitro Analyses of Spleen, Liver, and Lung Leukocyte Functions Predict Vaccine Efficacy against the Francisella tularensis Live Vaccine Strain (LVS)
mBio, Vol. 5, (2)
De Pascalis, Roberto; Chou, Alicia Y.; Ryden, Patrik; et al.
Identification of Mechanisms for Attenuation of the FSC043 Mutant of Francisella tularensis SCHU S4
Infection and Immunity, American Society for Microbiology 2014, Vol. 82, (9) : 3622-3635
Lindgren, Marie; Tancred, Linda; Golovliov, Igor; et al.
Climate change and infectious diseases in the Arctic: Establishment of a circumpolar working group
International Journal of Circumpolar Health, Taylor & Francis 2014, Vol. 73
Parkinson, Alan J.; Evengård, Birgitta; Semenza, Jan C.; et al.
View publications in DiVA
The Department of Clinical Microbiology

There are two sections in the department: The section of Infection and Immunology and The section of Virology.