UCMR Day är centrumets årliga konferens. Uppdatera dig om forskning och nya forskare inom UCMR samt senaste nytt kring forskningsinfrastrukturer. Vi välkomnar rekordmånga 145 deltagare på torsdag 19 januari!
UCMR Day 2023 hålls i Aula Nordica vid Umeå universitet.
Endagskonferensen vänder sig till forskare och personal inom Umeå Centre for Microbial Research, UCMR, samarbetspartners och andra forskare med intresse för mikrobiell forskning eller infektionsbiologi.
Programmet erbjuder inspirerande keynote-föreläsningar, hiss-pitchar och presentationer av posters och visuella abstracts, men framför allt är det ett utmärkt tillfälle för nätverkande och initiering av multidisciplinära samarbeten. Dagen innehåller flera sessioner för deltagarna att interagera och nätverka med varandra.
Tobias Dörr, PhD, Assistant professor, Cornell University
The Dörr lab studerar hur bakterier bygger och upprätthåller ett friskt cellhölje och motstår dödande av antibiotika.
Titel på föredraget: Stress signaling promotes antibiotic resistance and tolerance in Gram-negative pathogens
The bacterial cell wall, made primarily from peptidoglycan (PG) ensures bacterial structural integrity and thus survival. Consequently, our most powerful antibiotics are those that target PG synthesis, typically resulting in rapid lysis and cell death. However, many bacteria are “tolerant” against cell wall-active antibiotics, i.e. they survive destruction of their cell wall and recover to growing cells upon dissipation of the drug. In this talk, I will delineate molecular mechanisms by which Gram-negative bacteria maintain structural integrity during normal growth and when exposed to cell wall-acting antibiotics.
Maria Grazia Masucci, MD PhD, Professor i virologi, Karolinska Institutet
Masuccis grupp studerar molekylära mekanismer för viral onkogenes.
Titel på föredraget: Host cell remodeling by herpes virus encoded deconjugases
Post-translational modification of proteins by covalent conjugation of ubiquitin or ubiquitin-like (UBL) polypeptides regulates numerous cellular processes. The effect of the modification is reversed by deconjugases that hydrolyze the covalent bond and recycle ubiquitin and the UBLs. The importance of protein ubiquitination to for the control of viral infections is underscored by the finding that many DNA and RNA viruses, including human pathogenic coronaviruses, encode Ub and UbL deconjugases that interfere with cellular processes captured by viruses to promote infection and suppress antiviral responses.
Epstein-Barr virus (EBV) is a human lymphotropic herpesvirus that is implicated in the pathogenesis of lymphoid and epithelial cell malignancies. The N-terminal domains of the herpesvirus large tegument proteins encode a conserve cysteine protease with ubiquitin and NEDD8 specific deconjugase activity. The protein is expressed during productive infection and is incorporated into virus particles suggesting possible roles during both the early and late phases of infection. We found that the EBV encoded member of this vial protein family interacts with many cellular proteins and protein complexes, which correlates with regulation of viral genome replication and the release of virus particles as well as inhibition of cellular antiviral responses including the type I IFN production and autophagy. The conserved nature of the viral enzymes and their double role in the regulation of the virus life cycle and the host antiviral response suggest that the development of specific inhibitors may be a promising new avenue of the development of effective antiviral drugs.
Sponsorer
Priser för bästa postrar sponsras av UCMR och Agrisera.
Program UCMR Day 2023:
Det färdiga programmet är publicerat på den engelska motsvarigheten av denna sida. Tryck på "English site" längst upp till höger på denna sida så kommer du dit!
