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Pernilla Wikström
Vetenskaplig meritering:
Docent
Kontakt
E-post
pernilla.wikstrom@umu.se
Telefon
090-785 37 52
Verksam vid
Anknytning
Professor vid
Institutionen för medicinsk biovetenskap
Enhet: Patologi
Plats
By 6M, vån 2, Sjukhusområdet
Umeå universitet, 901 85 Umeå
Anknytning
Anknuten som övrig/annan befattning till
Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM)
Roll: Biträdande föreståndare
Plats
Umeå universitet, 901 87 Umeå
Publikationer
Publikationer
Forskning
Forskning
Omnämnanden
Omnämnanden
2024
Toll-like receptor-2 induced inflammation causes local bone formation and activates canonical Wnt signaling
Frontiers in Immunology
, Frontiers Media S.A. 2024, Vol. 15
Henning, Petra; Kassem, Ali; Westerlund, Anna; et al.
2024
Molekylära subtyper och avancerad prostatacancer: nya möjligheter för anpassad behandling: [Molecular subtypes provide possibilities for precision medicine in a advanced prostate cancer]
Läkartidningen
, Läkartidningen Förlag AB 2024, Vol. 121
Wikström, Pernilla; Bergh, Anders; Josefsson, Andreas; et al.
2023
Metabolomic profiles of intact tissues reflect clinically relevant prostate cancer subtypes
Journal of Translational Medicine
, BioMed Central (BMC) 2023, Vol. 21, (1)
Dudka, Ilona; Lundquist, Kristina; Wikström, Pernilla; et al.
2023
Investigating microRNA Profiles in Prostate Cancer Bone Metastases and Functional Effects of microRNA-23c and microRNA-4328
Cancers
, MDPI 2023, Vol. 15, (9)
Järemo, Helena; Semenas, Julius; Halin Bergström, Sofia; et al.
2023
Ki67 and prostate specific antigen are prognostic in metastatic hormone naïve prostate cancer
Acta Oncologica
, Taylor & Francis 2023, Vol. 6212 : 1698-1706
Spyratou, Vasiliki; Freyhult, Eva; Bergh, Anders; et al.
2023
A novel radiographic pattern related to poor prognosis in patients with prostate cancer with metastatic spinal cord compression
European Urology Open Science
, Elsevier 2023, Vol. 48 : 44-53
Wänman, Johan; Abul-Kasim, Kasim; Semenas, Julius; et al.
2023
Co-evolution of AR gene copy number and structural complexity in endocrine therapy resistant prostate cancer
NAR Cancer
, Oxford University Press 2023, Vol. 5, (3)
Zivanovic, Andrej; Miller, Jeffrey T.; Munro, Sarah A.; et al.
2022
Clinical and biological relevance of the transcriptomic-based prostate cancer metastasis subtypes MetA-C
Molecular Oncology
, John Wiley & Sons 2022, (4)
Thysell, Elin; Köhn, Linda; Semenas, Julius; et al.
2022
Epithelial and stromal characteristics of primary tumors predict the bone metastatic subtype of prostate cancer and patient survival after androgen-deprivation therapy
Cancers
, MDPI 2022, Vol. 14, (21)
Wikström, Pernilla; Halin Bergström, Sofia; Josefsson, Andreas; et al.
2021
A novel DNA methylation signature is associated with androgen receptor activity and patient prognosis in bone metastatic prostate cancer
Clinical Epigenetics
, BioMed Central 2021, Vol. 13, (1)
Bovinder Ylitalo, Erik; Thysell, Elin; Landfors, Mattias; et al.
2021
High-grade tumours promote growth of other less-malignant tumours in the same prostate
Journal of Pathology
, John Wiley & Sons 2021, Vol. 253, (4) : 396-403
Halin Bergström, Sofia; Rudolfsson, Stina H.; Lundholm, Marie; et al.
2021
Klk4t2 is a hormonally regulated transcript from the klk4 locus
International Journal of Molecular Sciences
, MDPI 2021, Vol. 22, (23)
Lundwall, Åke; Bovinder Ylitalo, Erik; Wikström, Pernilla; et al.
2021
High monocyte count and expression of s100a9 and s100a12 in peripheral blood mononuclear cells are associated with poor outcome in patients with metastatic prostate cancer
Cancers
, MDPI 2021, Vol. 13, (10)
Åberg, Anna-Maja; Halin Bergström, Sofia; Thysell, Elin; et al.
2020
Marked response to cabazitaxel in prostate cancer xenografts expressing androgen receptor variant 7 and reversion of acquired resistance by anti-androgens
The Prostate
, John Wiley & Sons 2020, Vol. 80, (2) : 214-224
Bovinder Ylitalo, Erik; Thysell, Elin; Thellenberg-Karlsson, Camilla; et al.
2020
Comprehensive metabolomics analysis of prostate cancer tissue in relation to tumor aggressiveness and
TMPRSS2-ERG
fusion status
BMC Cancer
, BioMed Central 2020, Vol. 20, (1)
Dudka, Ilona; Thysell, Elin; Lundquist, Kristina; et al.
2020
Tumor-educated platelets for early prostate cancer diagnosis, and therapy stratification in patients with metastasized castration resistant prostate cancer
Clinical Cancer Research
, American Association for Cancer Research 2020, Vol. 26, (11) : 73-74
Tjon-Kon-Fat, Lee-Ann; Köhn, Linda; Best, Myron; et al.
2020
Regulation of cell-cell adhesion in prostate cancer cells by microRNA-96 through upregulation of E-Cadherin and EpCAM
Carcinogenesis
, Oxford University Press 2020, Vol. 41, (7) : 865-874
Voss, Gjendine; Haflidadottir, Benedikta S.; Järemo, Helena; et al.
2019
Immunoreactivity for prostate specific antigen and Ki67 differentiates subgroups of prostate cancer related to outcome
Modern Pathology
, Vol. 32, (9) : 1310-1319
Hammarsten, Peter; Josefsson, Andreas; Thysell, Elin; et al.
2019
Vitamin A decreases the anabolic bone response to mechanical loading by suppressing bone formation
The FASEB Journal
, Federation of American Societies for Experimental Biology 2019, Vol. 33, (4) : 5237-5247
Lionikaite, Vikte; Henning, Petra; Drevinge, Christina; et al.
2019
Gene expression profiles define molecular subtypes of prostate cancer bone metastases with different outcomes and morphology traceable back to the primary tumor
Molecular Oncology
, John Wiley & Sons 2019, Vol. 13, (8) : 1763-1777
Thysell, Elin; Vidman, Linda; Bovinder Ylitalo, Erik; et al.
2018
Bone remodeling in relation to androgen receptor activity in prostate cancer bone metastases
Cancer Research
, American Association for Cancer Research 2018, Vol. 78, (16) : 50-50
Bovinder Ylitalo, Erik; Nordstrand, Annika; Thysell, Elin; et al.
2018
High inducible nitric oxide synthase in prostate tumor epithelium is associated with lethal prostate cancer
Scandinavian journal of urology
, Taylor & Francis 2018, Vol. 52, (2) : 129-133
Erlandsson, Ann; Carlsson, Jessica; Andersson, Sven-Olof; et al.
2018
The proteome of prostate cancer bone metastases
Cancer Research
, American Association for Cancer Research 2018, Vol. 78, (16) : 91-92
Iglesias-Gato, Diego; Thysell, Elin; Crnalic, Sead; et al.
2018
The Proteome of Prostate Cancer Bone Metastasis Reveals Heterogeneity with Prognostic Implications
Clinical Cancer Research
, American Association for Cancer Research 2018, Vol. 24, (21) : 5433-5444
Iglesias-Gato, Diego; Thysell, Elin; Tyanova, Stefka; et al.
2018
Bone Cell Activity in Clinical Prostate Cancer Bone Metastasis and Its Inverse Relation to Tumor Cell Androgen Receptor Activity
International Journal of Molecular Sciences
, MDPI 2018, Vol. 19, (4)
Nordstrand, Annika; Bovinder Ylitalo, Erik; Thysell, Elin; et al.
2018
Clinically relevant molecular subgroups of prostate cancer bone metastases
Cancer Research
, American Association for Cancer Research 2018, Vol. 78, (16) : 123-123
Thysell, Elin; Bovinder Ylitalo, Erik; Jernberg, Emma; et al.
2018
Platelets harbor prostate cancer biomarkers and the ability to predict therapeutic response to abiraterone in castration resistant patients
The Prostate
, Wiley-Blackwell 2018, Vol. 78, (1) : 48-53
Tjon-Kon-Fat, Lee-Ann; Lundholm, Marie; Schröder, Mona; et al.
2017
Subgroups of castration-resistant prostate cancer bone metastases defined through an inverse relationship between androgen receptor activity and immune response
European Urology
, Vol. 71, (5) : 776-787
Bovinder Ylitalo, Erik; Thysell, Elin; Jernberg, Emma; et al.
2017
High Levels of the AR-V7 Splice Variant and Co-Amplification of the Golgi Protein Coding YIPF6 in AR Amplified Prostate Cancer Bone Metastases
The Prostate
, Wiley-Blackwell Publishing Inc. 2017, Vol. 77, (6) : 625-638
Djusberg, Erik; Jernberg, Emma; Thysell, Elin; et al.
2017
Clinical relevance of androgen receptor alterations in prostate cancer
Endocrine Connections
, Vol. 6, (8) : R146-R161
Jernberg, Emma; Bergh, Anders; Wikström, Pernilla
2017
Inhibition of the insulin-like growth factor-1 receptor potentiates acute effects of castration in a rat model for prostate cancer growth in bone
Clinical and Experimental Metastasis
, Springer 2017, Vol. 34, (3-4) : 261-271
Nordstrand, Annika; Halin Bergström, Sofia; Thysell, Elin; et al.
2017
Long leukocyte telomere length in prostate cancer patients at diagnosis is associated with poor metastasis-free and cancer-specific survival
Tumor Biology
, SAGE PUBLICATIONS LTD 2017, Vol. 39, (2)
Svenson, Ulrika; Roos, Göran; Wikström, Pernilla
2017
A Systems Approach to Prostate Cancer Classification: Letter
Cancer Research
, American Association for Cancer Research 2017, Vol. 77, (24) : 7131-7132
Thysell, Elin; Bovinder Ylitalo, Erik; Jernberg, Emma; et al.
2017
Reply to Isabel Heidegger, Renate Pichler, and Andreas Pircher's Letter to the Editor re: Erik Bovinder Ylitalo, Elin Thysell, Emma Jernberg, et al. Subgroups of Castration-resistant Prostate Cancer Bone Metastases Defined Through an Inverse Relationship Between Androgen Receptor Activity and Immune Response. Eur Urol 2017;71:776-87
European Urology
, Elsevier 2017, Vol. 72, (4) : E104-E105
Thysell, Elin; Ylitalo, Erik B.; Jernberg, Emma; et al.
2017
Reply to Isabel Heidegger, Renate Pichler, and Andreas Pircher's Letter to the Editor re: Erik Bovinder Ylitalo, Elin Thysell, Emma Jernberg, et al. Subgroups of Castration-resistant Prostate Cancer Bone Metastases Defined Through an Inverse Relationship Between Androgen Receptor Activity and Immune Response. Eur Urol 2017;71:776-87
European Urology
, ELSEVIER SCIENCE BV 2017, Vol. 72, (4) : e104-e105
Thysell, Elin; Ylitalo, Erik B.; Jernberg, Emma; et al.
2016
Extracellular Vesicles from Metastatic Rat Prostate Tumors Prime the Normal Prostate Tissue to Facilitate Tumor Growth
Scientific Reports
, Nature Publishing Group 2016, Vol. 6
Halin Bergström, Sofia; Hägglöf, Christina; Thysell, Elin; et al.
2016
Extratumoral Heme Oxygenase-1 (HO-1) Expressing Macrophages Likely Promote Primary and Metastatic Prostate Tumor Growth
PLOS ONE
, Vol. 11, (6)
Halin Bergström, Sofia; Nilsson, Maria; Adamo, Hanibal; et al.
2016
High Caveolin-1 Expression in Tumor Stroma Is Associated with a Favourable Outcome in Prostate Cancer Patients Managed by Watchful Waiting
PLOS ONE
, Vol. 11, (10)
Hammarsten, Peter; Scherdin, Tove Dahl; Hagglöf, Christina; et al.
2016
The Proteome of Primary Prostate Cancer
European Urology
, Vol. 69, (5) : 942-952
Iglesias-Gato, Diego; Wikström, Pernilla; Tyanova, Stefka; et al.
2015
OTUB1 de-ubiquitinating enzyme promotes prostate cancer cell invasion in vitro and tumorigenesis in vivo
Molecular Cancer
, BioMed Central (BMC) 2015, Vol. 14
Iglesias-Gato, Diego; Chuan, Yin-Choy; Jiang, Ning; et al.
2015
Erratum: OTUB1 de-ubiquitinating enzyme promotes prostate cancer cell invasion in vitro and tumorigenesis in vivo (vol 14, 8, 2015)
Molecular Cancer
, Vol. 14, (1)
Iglesias-Gato, Diego; Chuan, Yin-Choy; Jiang, Ning; et al.
2015
Constrained randomization and multivariate effect projections improve information extraction and biomarker pattern discovery in metabolomics studies involving dependent samples
Metabolomics
, Springer 2015, Vol. 11, (6) : 1667-1678
Jonsson, Pär; Wuolikainen, Anna; Thysell, Elin; et al.
2015
Secreted Factors from Colorectal and Prostate Cancer Cells Skew the Immune Response in Opposite Directions
Scientific Reports
, Nature Publishing Group 2015, Vol. 5
Lundholm, Marie; Hägglöf, Christina; Wikberg, Maria L.; et al.
2015
High Lysyl Oxidase (LOX) in the Non-Malignant Prostate Epithelium Predicts a Poor Outcome in Prostate Cancer Patient Managed by Watchful Waiting
PLOS ONE
, Public library science 2015, Vol. 10, (10)
Nilsson, Maria; Hägglöf, Christina; Hammarsten, Peter; et al.
2014
SOCS2 mediates the cross talk between androgen and growth hormone signaling in prostate cancer
Carcinogenesis
, Oxford University Press 2014, Vol. 35, (1) : 24-33
Iglesias-Gato, Diego; Chuan, Yin-Choy; Wikström, Pernilla; et al.
2014
Prostate Tumor-Derived Exosomes Down-Regulate NKG2D Expression on Natural Killer Cells and CD8(+) T Cells: Mechanism of Immune Evasion
PLOS ONE
, Vol. 9, (9) : e108925-
Lundholm, Marie; Schröder, Mona; Nagaeva, Olga; et al.
2014
High density of S100A9 positive inflammatory cells in prostate cancer stroma is associated with poor outcome
European Journal of Cancer
, Vol. 50, (10) : 1829-1835
Tidehag, Viktor; Hammarsten, Peter; Egevad, Lars; et al.
2013
Tumour epithelial expression levels of endocannabinoid markers modulate the value of endoglin-positive vascular density as a prognostic marker in prostate cancer
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
, Vol. 1831, (10) : 1579-1587
Fowler, Christopher J.; Josefsson, Andreas; Thors, Lina; et al.
2013
Characterization of prostate cancer bone metastases according to expression levels of steroidogenic enzymes and androgen receptor splice variants
PLOS ONE
, Public Library of Science 2013, Vol. 8, (11) : e77407-
Jernberg, Emma; Thysell, Elin; Bovinder Ylitalo, Erik; et al.
2013
The Mitochondrial and Autosomal Mutation Landscapes of Prostate Cancer
European Urology
, Vol. 63, (4) : 702-708
Lindberg, Johan; Mills, Ian G.; Klevebring, Daniel; et al.
Visa publikationer i DiVA
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Pernilla Wikströms labb
Forskningsprojekt
1 september 2023
SPRINTR
1 augusti 2020 till 31 december 2027
APACA-studien: Kan CTC fungera som ett surrogat för biopsier från metastaser?
1 januari 2019 till 31 december 2022
Biomarkörer för säkrare prognostisering och förbättrad behandling av aggressiv prostatacancer
28 februari 2007 till 31 december 2010
Biomarkörer för aggressiv prostatacancer
Publicerad: 15 feb, 2022
Nya forskningsmedel till prostataforskning
Publicerad: 23 nov, 2021
Nya Cancerfondsmiljoner till Umeå
Publicerad: 17 dec, 2020
Sjöberg-miljoner till cancerforskare
Publicerad: 12 nov, 2020
Nya Cancerfondsmiljoner till forskning vid Umeå universitet
Publicerad: 31 jan, 2020
Farlig prostatacancer var många varianter
Publicerad: 29 nov, 2019
Fondmedel till prostataforskning
Publicerad: 10 dec, 2010
Dottertumörer vid prostatacancer kan spåras via kolesterol
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