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Umeå universitet
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Huvudmenyn dold.
Personalbild Lena Gunhaga

Lena Gunhaga

Professor i Utvecklingsbiologi.

Min forskargrupp intresserar sig för utvecklingen och funktion av nervsystemet med fokus på hjärnan och sensoriska system.

Vetenskaplig meritering: Docent

Kontakt

E-post
lena.gunhaga@umu.se
Telefon
090-786 68 17

Verksam vid

Anknytning
Professor vid Institutionen för medicinsk och translationell biologi Enhet: Avdelningen för molekylär medicin
Plats
hus H, Johan Bures väg 12, Biologihuset Umeå universitet, 901 87 Umeå

Min forskargrupp intresserar sig för att bättre förstå molekylära mekanismer som reglerar utvecklingen av nervsystemet, med fokus på hjärnan och sensoriska system. Detta för att förstå normal utveckling och funktion av nervsystemet i relation till olika sjukdomar som drabbar hjärnan och sensoriska system. Vi arbetar för tillfället med fyra större projekt med fokus på icke-visuella opsiner, vilka är fotoreceptorer som aktiveras av ljus.

 

1)      Hur inverkar ljus på nervsystemets utveckling och senare funktion?

2)      Hur regleras pupillens ljusreflex direkt i iris (regnbågshinnan)?

3)      Hur utvecklas ögats strukturer i relation till ögonsjukdomar?

4)      Hur utvecklas luktepitelet? En studie i relation till nybildning av nervceller.

 

För mer information besök Lena Gunhagas hemsida: Hemsida

 

Non-image-forming functional roles of OPN3, OPN4 and OPN5 photopigments
Journal of Photochemistry and Photobiology, Elsevier 2023, Vol. 15
Karthikeyan, Ramanujam; Davies, Wayne I. L.; Gunhaga, Lena
CAM-Delam assay to score metastatic properties by quantifying delamination and invasion capacity of cancer cells
Journal of Visualized Experiments, Journal of Visualized Experiments 2022, (184)
Green, Tami; Slekiene, Lina; Gunhaga, Lena
PIP5K1α is Required for Promoting Tumor Progression in Castration-Resistant Prostate Cancer
Frontiers in Cell and Developmental Biology, Frontiers Media S.A. 2022, Vol. 10
Wang, Tianyan; Sarwar, Martuza; Whitchurch, Jonathan B.; et al.
Chick fetal organ spheroids as a model to study development and disease
BMC Molecular and Cell Biology, BioMed Central (BMC) 2021, Vol. 22, (1)
Dakhel, Soran; Davies, Wayne I. L.; Joseph, Justin V.; et al.
Distinct opsin 3 (Opn3) expression in the developing nervous system during mammalian embryogenesis
eNeuro, Society for Neuroscience 2021, Vol. 8, (5)
Davies, Wayne I. L.; Sghari, Soufien; Upton, Brian A.; et al.
CAM-Delam: an in vivo approach to visualize and quantify the delamination and invasion capacity of human cancer cells
Scientific Reports, Nature Publishing Group 2020, Vol. 10, (1)
Panaliappan, Tamilarasan K.; Slekiene, Lina; Jonasson, Anna-Karin; et al.
Elucidation of Cellular Mechanisms That Regulate the Sustained Contraction and Relaxation of the Mammalian Iris
Investigative Ophthalmology and Visual Science, Rockville: Association of Research in Vision and Ophthalmology 2020, Vol. 61, (11)
Sghari, Soufien; Davies, Wayne I. L.; Gunhaga, Lena
Extensive apoptosis during the formation of the terminal nerve ganglion by olfactory placode-derived cells with distinct molecular markers
Differentiation, Elsevier 2019, Vol. 110 : 8-16
Panaliappan, Tamilarasan K.; Slekiene, Lina; Gunhaga, Lena; et al.
Sox2 is required for olfactory pit formation and olfactory neurogenesis through BMP restriction and Hes5 upregulation
Development, Company of Biologists Ltd 2018, Vol. 145, (2)
Panaliappan, Tamilarasan K.; Wittmann, Walter; Jidigam, Vijay K.; et al.
Temporal Requirement of Mab21l2 During Eye Development in Chick Reveals Stage-Dependent Functions for Retinogenesis
Investigative Ophthalmology and Visual Science, ASSOC RESEARCH VISION OPHTHALMOLOGY INC 2018, Vol. 59, (10) : 3869-3878
Sghari, Soufien; Gunhaga, Lena
Negative and positive auto-regulation of BMP expression in early eye development
Developmental Biology, Vol. 407, (2) : 256-264
Huang, Jie; Liu, Ying; Filas, Benjamen; et al.
Apical constriction and epithelial invagination are regulated by BMP activity
Biology open, Vol. 4, (12) : 1782-1791
Jidigam, Vijay K.; Srinivasan, Raghuraman C.; Patthey, Cedric; et al.
Neural retina identity is specified by lens-derived BMP signals
Development, The Company of Biologists LTD 2015, Vol. 142, (10) : 1850-1859
Pandit, Tanushree; Jidigam, Vijay Kumar; Patthey, Cedric; et al.
Role of BMP signaling on cytoskeleton elements in the sensory placode invagination
Molecular Biology of the Cell, Vol. 25
Jidigam, Vijay; Gunhaga, Lena
Signaling pathways regulating ectodermal cell fate choices
Experimental Cell Research, Vol. 321, (1) : 11-16
Patthey, Cedric; Gunhaga, Lena
Cux2 acts as a critical regulator for neurogenesis in the olfactory epithelium of vertebrates
Developmental Biology, Vol. 388, (1) : 35-47
Wittmann, Walter; Iulianella, Angelo; Gunhaga, Lena
Progressive effects of N-myc deficiency on proliferation, neurogenesis, and morphogenesis in the olfactory epithelium
Developmental Neurobiology, Vol. 74, (6) : 643-656
Wittmann, Walter; Schimmang, Thomas; Gunhaga, Lena
Development of cranial placodes: insights from studies in chick
Development, Growth and Differentiation, Vol. 55, (1) : 79-95
Jidigam, Vijay K.; Gunhaga, Lena
Survivin expression is associated with lens epithelial cell proliferation and fiber cell differentiation
Molecular Vision, Vol. 18, (283-86) : 2758-2769
Jarrin, Miguel; Mansergh, Fiona C; Boulton, Michael E; et al.
A balance of FGF and BMP signals regulates cell cycle exit and Equarin expression in lens cells
Molecular Biology of the Cell, Vol. 23, (16) : 3266-3274
Jarrin, Miguel; Pandit, Tanushree; Gunhaga, Lena
The lens: a classical model of embryonic induction providing new insights into cell determination in early development
Philosophical Transactions of the Royal Society of London. Biological Sciences, Vol. 366, (1568) : 1193-1203
Gunhaga, Lena
A balance of BMP and notch activity regulates neurogenesis and olfactory nerve formation
PloS one, Vol. 6, (2) : e17379-
Maier, Esther; Nord, Hanna; von Hofsten, Jonas; et al.
BMP-induced L-Maf regulates subsequent BMP-independent differentiation of primary lens fibre cells
Developmental Dynamics, Vol. 240, (8) : 1917-1928
Pandit, Tanushree; Jidigam, Vijay K; Gunhaga, Lena
Specification and regionalisation of the neural plate border
European Journal of Neuroscience, Malden: Wiley-Blackwell 2011, Vol. 34, (10) : 1516-1528
Patthey, Cedric; Gunhaga, Lena
Opposing Fgf and Bmp activities regulate the specification of olfactory sensory and respiratory epithelial cell fates.
Development, Vol. 137, (10) : 1601-1611
Maier, Esther; von Hofsten, Jonas; Nord, Hanna; et al.
FGF signals induce Caprin2 expression in the vertebrate lens.
Differentiation, Vol. 77, (4) : 386-394
Lorén, Christina E; Schrader, John W; Ahlgren, Ulf; et al.
Wnt-regulated temporal control of BMP exposure directs the choice between neural plate border and epidermal fate
Development, Vol. 136, (1) : 73-83
Patthey, Cédric; Edlund, Thomas; Gunhaga, Lena
Early development of the central and peripheral nervous systems is coordinated by Wnt and BMP signals
PloS one, Vol. 3, (2) : e1625-
Patthey, Cédric; Gunhaga, Lena; Edlund, Thomas
Retinoic acid signalling specifies intermediate character in the developing telencephalon.
Development, Vol. 131, (17) : 4323-4332
Marklund, Matthew; Sjödal, My; Beehler, Blake C; et al.
Specification of dorsal telencephalic character by sequential Wnt and FGF signaling.
Nature Neuroscience, Vol. 6, (7) : 701-707
Gunhaga, Lena; Marklund, Matthew; Sjödal, My; et al.
Sonic hedgehog signaling at gastrula stages specifies ventral telencephalic cells in the chick embryo
Development, Vol. 127, (15) : 3283-3293
Gunhaga, Lena; Jessell, T M; Edlund, Thomas
Visa publikationer i DiVA

Forskargrupper

Forskningsledare
Lena Gunhaga

Jag är undervisar på Läkarutbildningen som T10-koordinator.

Film: Min forskning – på ett ögonblick
Min forskning – på ett ögonblick