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Lars Thelander
Vetenskaplig meritering:
Docent
Kontakt
E-post
lars.thelander@umu.se
Telefon
Verksam vid
Anknytning
Anknuten som professor emeritus till
Institutionen för medicinsk kemi och biofysik
Plats
KB. H6, Campus, Umeå
Umeå universitet, 901 87 Umeå
Publikationer
Publikationer
Forskning
Forskning
2019
De novo dNTP production is essential for normal postnatal murine heart development
Journal of Biological Chemistry
, American Society for Biochemistry and Molecular Biology 2019, Vol. 394, (44) : 15889-15897
Tran, Phong; Wanrooij, Paulina H.; Lorenzon, Paolo; et al.
2012
Trypanosoma brucei thymidine kinase is tandem protein consisting of two homologous parts, which together enable efficient substrate binding
Journal of Biological Chemistry
, Vol. 287, (21) : 17628-17636
Ranjbarian, Farahnaz; Vodnala, Munender; Vodnala, Sharvani Munender; et al.
2009
Metal binding and activity of ribonucleotide reductase protein R2 mutants: conditions for formation of the mixed manganese-iron cofactor
Biochemistry
, Vol. 48, (27) : 6532-6539
Popović-Bijelić, Ana; Voevodskaya, Nina; Domkin, Vladimir; et al.
2008
Ribonucleotide reduction is a cytosolic process in mammalian cells independently of DNA damage.
Proceedings of the National Academy of Sciences of the United States of America
, National Academy of Sciences 2008, Vol. 105, (46) : 17801-17806
Pontarin, Giovanna; Fijolek, Artur; Pizzo, Paola; et al.
2007
Expression, purification, characterization, and in vivo targeting of trypanosome CTP synthetase for treatment of African sleeping sickness.
Journal of biological chemistry
, Vol. 282, (16) : 11858-11865
Fijolek, Artur; Hofer, Anders; Thelander, Lars
2007
p53R2-dependent ribonucleotide reduction provides deoxyribonucleotides in quiescent human fibroblasts in the absence of induced DNA damage
Journal of Biological Chemistry
, American Society for Biochemistry and Molecular Biology 2007, Vol. 282, (23) : 16820-16828
Pontarin, Giovanna; Ferraro, Paola; Håkansson, Pelle; et al.
2007
Ribonucleotide reductase and mitochondrial DNA synthesis.
Nature. Genetics
, Vol. 39, (6) : 703-4
Thelander, Lars
2006
The Schizosaccharomyces pombe replication inhibitor Spd1 regulates ribonucleotide reductase activity and dNTPs by binding to the large Cdc22 subunit.
Journal of Biological Chemistry
, Vol. 281, (3) : 1778-1783
Håkansson, Pelle; Dahl, Lina; Chilkova, Olga; et al.
2006
Regulation of mammalian ribonucleotide reduction and dNTP pools after DNA damage and in resting cells.
Journal of Biological Chemistry
, Vol. 281, (12) : 7834-7841
Håkansson, Pelle; Hofer, Anders; Thelander, Lars
2006
The involvement of Arg265 of mouse ribonucleotide reductase R2 protein in proton transfer and catalysis.
Journal of biological chemistry
, Vol. 281, (36) : 26022-8
Narváez, Ana J; Voevodskaya, Nina; Thelander, Lars; et al.
2006
Chlamydial ribonucleotide reductase: tyrosyl radical function in catalysis replaced by the FeIII-FeIV cluster.
Proceedings of the National Academy of Sciences of the United States of America
, Vol. 103, (26) : 9850-4
Voevodskaya, N; Narvaez, A-J; Domkin, Vladimir; et al.
2004
S Phase-specific transcription of the mouse ribonucleotide reductase R2 gene requires both a proximal repressive E2F-binding site and an upstream promoter activating region.
Journal of biological chemistry
, Vol. 279, (11) : 10796-807
Chabes, Anna Lena; Björklund, Stefan; Thelander, Lars
2004
The ribonucleotide reductase R1 homolog of murine cytomegalovirus is not a functional enzyme subunit but is required for pathogenesis.
Journal of virology
, Vol. 78, (8) : 4278-88
Lembo, David; Donalisio, Manuela; Hofer, Anders; et al.
2003
Survival of DNA damage in yeast directly depends on increased dNTP levels allowed by relaxed feedback inhibition of ribonucleotide reductase.
Cell
, Vol. 112, (3) : 391-401
Chabes, Andrei; Georgieva, Bilyana; Domkin, Vladimir; et al.
2003
DNA building blocks at the foundation of better survival.
Cell Cycle
, Vol. 2, (3) : 171-3
Chabes, Andrei; Thelander, Lars
2003
Mouse ribonucleotide reductase R2 protein: A new target for anaphase-promoting complex-Cdh1-mediated proteolysis.
Proc. Natl. Acad. Sci. U S A.
, Vol. 100, (7) : 3925-3929
Chabes, Anna Lena; Pfleger, C.M.; Kirschner, M.W.; et al.
2003
Sequences downstream of the transcription initiation site are important for proper initiation and regulation of mouse ribonucleotide reductase R2 gene transcription
European Journal of Biochemistry
, Blackwell Publishing 2003, Vol. 270, (8) : 1791-1801
Kotova, Irina; Chabes, Anna Lena; Lobov, Sergei; et al.
2002
Yeast DNA damage-inducible Rnr3 has a very low catalytic activity strongly stimulated after the formation of a cross-talking Rnr1/Rnr3 complex.
Journal of Biological Chemistry
, Vol. 277, (21) : 18574-8
Domkin, Vladimir; Thelander, Lars; Chabes, Andrei
2002
Cid13 is a cytoplasmic poly(A) polymerase that regulates ribonucleotide reductase mRNA.
Cell
, Vol. 109, (5) : 563-73
Saitoh, Shigeaki; Chabes, Andrei; McDonald, W Hayes; et al.
2001
Mammalian p53R2 protein forms an active ribonucleotide reductase in vitro with the R1 protein, which is expressed both in resting cells in response to DNA damage and in proliferating cells
Journal of Biological Chemistry
, Vol. 276, (44) : 40647-40651
Guittet, Olivier; Håkansson, Pelle; Voevodskaya, Nina; et al.
2001
Trypanosoma brucei CTP synthetase: a target for the treatment of African sleeping sickness.
Proceedings of the National Academy of Sciences of the U S A
, Vol. 98, (11) : 6412-6
Hofer, Anders; Steverding, D; Chabes, Andrei; et al.
2001
A mouse in vitro transcription system reconstituted from highly purified RNA polymerase II, TFIIH, and recombinant TBP, TFIIB, TFIIE and TFIIF.
European Journal of Biochemistry
, Vol. 268, (16) : 4527-4536
Kotova, Irina; Chabes, Anna Lena; Segerman, Bo; et al.
2000
Yeast ribonucleotide reductase has a heterodimeric iron-radical-containing subunit
Proceedings of the National Academy of Sciences of the United States of America
, Vol. 97, (6) : 2474-2479
Chabes, Andrei; Domkin, Vladimir; Larsson, Göran; et al.
2000
Expression of an altered ribonucleotide reductase activity associated with the replication of murine cytomegalovirus in quiescent fibroblasts.
Journal of Virology
, Vol. 74, (24) : 11557-65
Lembo, D; Gribaudo, G; Hofer, Anders; et al.
2000
Mutational and structural analyses of the ribonucleotide reductase inhibitor Sml1 define its Rnr1 interaction domain whose inactivation allows suppression of mec1 and rad53 lethality.
Mol Cell Biol
, Vol. 20, (23) : 9076-83
Zhao, X; Georgieva, B; Chabes, Andrei; et al.
1999
Metabolic fate of oxidized guanine ribonucleotides in mammalian cells.
Biochemistry
, Vol. 38, (12) : 3610-4
Hayakawa, H; Hofer, Anders; Thelander, Lars; et al.
1998
Allosteric regulation of Trypanosoma brucei ribonucleotide reductase studied in vitro and in vivo.
Journal of Biological Chemistry
, Vol. 273, (51) : 34098-104
Hofer, Anders; Ekanem, J T; Thelander, Lars
1998
Two YY-1-binding proximal elements regulate the promoter strength of the TATA-less mouse ribonucleotide reductase R1 gene.
Journal of Biological Chemistry
, Vol. 273, (45) : 29816-21
Johansson, Erik; Hjortsberg, K; Thelander, Lars
1997
Cloning and characterization of the R1 and R2 subunits of ribonucleotide reductase from Trypanosoma brucei.
Proceedings of the National Academy of Sciences of the U S A
, Vol. 94, (13) : 6959-64
Hofer, Anders; Schmidt, P P; Gräslund, Astrid; et al.
1996
Induction of the mouse ribonucleotide reductase R1 and R2 genes in response to DNA damage by UV light.
Journal of Biological Chemistry
, Vol. 271, (39) : 23698-704
Filatov, D; Björklund, Stefan; Johansson, Erik; et al.
1995
The TATA-less promoter of mouse ribonucleotide reductase R1 gene contains a TFII-I binding initiator element essential for cell cycle-regulated transcription.
Journal of Biological Chemistry
, Vol. 270, (50) : 30162-7
Johansson, Erik; Skogman, E; Thelander, Lars
1994
Gene structure and regulation of the expression of the R1 and R2 subunits of mouse ribonucleotide reductase.
Advances in Experimental Medicine and Biology
, Vol. 370 : 721-4
Johansson, Erik; Björklund, Stefan; Thelander, Lars
1993
Structure and promoter characterization of the gene encoding the large subunit (R1 protein) of mouse ribonucleotide reductase.
Proceedings of the National Academy of Science U S A
, Vol. 90, (23) : 11322-6
Björklund, Stefan; Hjortsberg, K; Johansson, Erik; et al.
1992
An S-phase specific release from a transcriptional block regulates the expression of mouse ribonucleotide reductase R2 subunit
EMBO Journal
, Vol. 11, (13) : 4953-4959
Björklund, Stefan; Skogman, E; Thelander, Lars
1990
S-phase-specific expression of mammalian ribonucleotide reductase R1 and R2 subunit mRNAs
Biochemistry
, Vol. 29, (23) : 5452-5458
Björklund, Stefan; Skog, Sven; Tribukait, Bernard; et al.
S phase-specific transcription of the mouse ribonucleotide reductase R2 gene is dependent on an upstream promoter activating region and a proximal repressive E2F binding site.
Chabes, Anna Lena; Björklund, Stefan; Thelander, Lars
Characterization of the promoters of the mouse ribonucleotide reductase R1, R2 and p53R2-genes
Elfving, Anna; Thelander, Lars
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Forskningsprojekt
26 februari 2007 till 31 december 2008
Reglering av deoxyribonukleotidsyntesen under DNA replikation och reparation hos eukaryoter
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