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Umeå universitet
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Personalbild Jörgen Ådén

Jörgen Ådén

Kontakt

E-post
jorgen.aden@umu.se
Telefon
090-786 65 76

Verksam vid

Anknytning
Staff scientist vid Kemiska institutionen
Plats
KB.A3, Linnaeus väg 10 Umeå universitet, 901 87 Umeå
Magnesium induced structural reorganization in the active site of adenylate kinase
Science Advances, American Association for the Advancement of Science (AAAS) 2024, Vol. 10, (32)
Nam, Kwangho; Thodika, Abdul Raafik Arattu; Tischlik, Sonja; et al.
Intra-striatal infusion of the small molecule alpha-synuclein aggregator, FN075, does not enhance parkinsonism in a subclinical AAV-alpha-synuclein rat model
European Journal of Neuroscience, John Wiley & Sons 2024, Vol. 60, (6) : 5234-5248
Patton, Tommy; Comini, Giulia; Narasimhan, Kaushik; et al.
Insight into Bcl-2 proteins' functioning at mitochondrial membrane level
Biophysical Journal, Elsevier 2023, Vol. 122, (3S1) : 232a-232a
Clifton, Luke A.; Ul Mushtaq, Ameeq; Ådén, Jörgen; et al.
Creation of distinctive Bax-lipid complexes at mitochondrial membrane surfaces drives pore formation to initiate apoptosis
Science Advances, American Association for the Advancement of Science (AAAS) 2023, Vol. 9, (22)
Clifton, Luke A.; Wacklin-Knecht, Hanna P.; Ådén, Jörgen; et al.
Mechanistic basis for a connection between the catalytic step and slow opening dynamics of adenylate kinase
Journal of Chemical Information and Modeling, American Chemical Society (ACS) 2023, Vol. 63, (5) : 1556-1569
Dulko-Smith, Beata; Ojeda-May, Pedro; Ådén, Jörgen; et al.
Protein-lipid interaction at low pH induces oligomerization of the MakA cytotoxin from Vibrio cholerae
eLIFE, eLife Sciences Publications, Ltd 2022, Vol. 11
Nadeem, Aftab; Berg, Alexandra; Pace, Hudson; et al.
Backbone chemical shift assignment and dynamics of the N-terminal domain of ClpB from Francisella tularensis type VI secretion system
Biomolecular NMR Assignments, Springer 2022, Vol. 16 : 75-79
Ul Mushtaq, Ameeq; Ådén, Jörgen; Alam, Athar; et al.
Domain-specific insight into the recognition of BH3-death motifs by the pro-survival Bcl-2 protein
Biophysical Journal, Elsevier 2022, Vol. 121, (23) : 4517-4525
Ul Mushtaq, Ameeq; Ådén, Jörgen; Ali, Katan; et al.
K2S2O8-mediated coupling of 6-amino-7-aminomethyl-thiazolino-pyridones with aldehydes to construct amyloid affecting pyrimidine-fused thiazolino-2-pyridones
Organic and biomolecular chemistry, The Royal Society of Chemistry 2021, Vol. 19, (44) : 9758-9772
Bharate, Jaideep B.; Ådén, Jörgen; Gharibyan, Anna; et al.
The Small Molecule Alpha-Synuclein Aggregator, FN075, Enhances Alpha-Synuclein Pathology in Subclinical AAV Rat Models
Biomolecules, MDPI 2021, Vol. 11, (11)
Kelly, Rachel; Cairns, Andrew G.; Ådén, Jörgen; et al.
Synthetic NAC 71-82 Peptides Designed to Produce Fibrils with Different Protofilament Interface Contacts
International Journal of Molecular Sciences, MDPI 2021, Vol. 22, (17)
Näsström, Thomas; Dahlberg, Tobias; Malyshev, Dmitry; et al.
Tandem Ring Opening/Intramolecular [2 + 2] Cycloaddition Reaction for the Synthesis of Cyclobutane Fused Thiazolino-2-Pyridones
Journal of Organic Chemistry, American Chemical Society (ACS) 2021, Vol. 86, (23) : 16582-16592
Tyagi, Mohit; Adolfsson, Dan E.; Singh, Pardeep; et al.
Neutron reflectometry and NMR spectroscopy of full-length Bcl-2 protein reveal its membrane localization and conformation
Communications Biology, Springer Nature 2021, Vol. 4, (1)
Ul Mushtaq, Ameeq; Ådén, Jörgen; Clifton, Luke A.; et al.
Insight into Functional Membrane Proteins by Solution NMR: The Human Bcl-2 Protein - A Promising Cancer Drug Target
Molecules, MDPI 2021, Vol. 26, (5)
Ul Mushtaq, Ameeq; Ådén, Jörgen; Sparrman, Tobias; et al.
Intramolecular Povarov Reactions for the Synthesis of Chromenopyridine fused 2-Pyridone Polyheterocycles Binding to α-Synuclein and Amyloid-β fibrils
Journal of Organic Chemistry, American Chemical Society (ACS) 2020, Vol. 85, (21) : 14174-14189
Adolfsson, Dan E.; Tyagi, Mohit; Singh, Pardeep; et al.
Dissociation between the critical role of ClpB of Francisella tularensis for the heat shock response and the DnaK interaction and its important role for efficient type VI secretion and bacterial virulence
PLoS Pathogens, Public Library of Science 2020, Vol. 16, (4) : 1-27
Alam, Athar; Golovliov, Igor; Javed, Eram; et al.
A Capped Peptide of the Aggregation Prone NAC 71-82 Amino Acid Stretch of α-Synuclein Folds into Soluble β-Sheet Oligomers at Low and Elevated Peptide Concentrations
International Journal of Molecular Sciences, MDPI 2020, Vol. 21, (5)
Näsström, Thomas; Ådén, Jörgen; Shibata, Fumina; et al.
A novel recombinant expression and purification approach for the full-length anti-apoptotic membrane protein Bcl-2
Protein Expression and Purification, Elsevier 2020, Vol. 172
Ådén, Jörgen; Ul Mushtaq, Ameeq; Dingeldein, Artur P. G.; et al.
Mitochondrial Membranes Involved in Apoptosis: the Bcl-2 Proteins
Biophysical Journal, Cell Press 2020, Vol. 118, (3) : 394A-394A
Ådén, Jörgen; Ul Mushtaq, Ameeq; Sparrman, Tobias; et al.
Mitochondrial Membrane Organization under Oxidative Stress: Insight by Solid-State NMR and Neutron Reflectometry
Biophysical Journal, CELL PRESS 2019, Vol. 116, (3) : 508A-508A
Dingeldein, Artur P. G.; Sparrman, Tobias; Ådén, Jörgen; et al.
Bax to the future: A novel, high-yielding approach for purification and expression of full-length Bax protein for structural studies
Protein Expression and Purification, Elsevier 2019, Vol. 158 : 20-26
Dingeldein, Artur Peter Günther; Lindberg, Mikael J.; Ådén, Jörgen; et al.
Viral mimetic priming enhances α-synuclein-induced degeneration: implications for Parkinson's disease
Brain, behavior, and immunity, Elsevier 2019, Vol. 80 : 525-535
Olsen, Laura K.; Cairns, Andrew G.; Ådén, Jörgen; et al.
Pyridine-Fused 2-Pyridones via Povarov and A3 Reactions: Rapid Generation of Highly Functionalized Tricyclic Heterocycles Capable of Amyloid Fibril Binding
Journal of Organic Chemistry, American Chemical Society (ACS) 2019, Vol. 84, (7) : 3887-3903
Singh, Pardeep; Adolfsson, Dan E.; Ådén, Jörgen; et al.
Synthesis of Densely Functionalized N-Alkenyl 2-Pyridones via Benzyne-Induced Ring Opening of Thiazolino-Fused 2-Pyridones
Organic Letters, American Chemical Society (ACS) 2019, Vol. 21 : 6946-6950
Singh, Pardeep; Cairns, Andrew G.; Adolfsson, Dan E.; et al.
Increased Brain Exposure of an Alpha-Synuclein Fibrillization Modulator by Utilization of an Activated Ester Prodrug Strategy
ACS Chemical Neuroscience, American Chemical Society (ACS) 2018, Vol. 9, (11) : 2542-2547
Cairns, Andrew G.; Vazquez-Romero, Ana; Mahdi-Moein, Mohammad; et al.
Helicobacter pylori Adapts to Chronic Infection and Gastric Disease via pH-Responsive BabA-Mediated Adherence
Cell Host and Microbe, CELL PRESS 2017, Vol. 21, (3) : 376-389
Bugaytsova, Jeanna A.; Björnham, Oscar; Chernov, Yevgen A.; et al.
Inhibition of curli assembly and Escherichia coli biofilm formation by the human systemic amyloid precursor transthyretin
Proceedings of the National Academy of Sciences of the United States of America, Vol. 114, (46) : 12184-12189
Jain, Neha; Ådén, Jörgen; Nagamatsu, Kanna; et al.
Copper binding triggers compaction in N-terminal tail of human copper pump ATP7B
Biochemical and Biophysical Research Communications - BBRC, Elsevier 2016, Vol. 470, (3) : 663-669
Mondol, Tanumoy; Ådén, Jörgen; Wittung-Stafshede, Pernilla
Bacterial Chaperones CsgE and CsgC Differentially Modulate Human α-Synuclein Amyloid Formation via Transient Contacts
PLOS ONE, Vol. 10, (10) : 1-11
Chorell, Erik; Andersson, Emma; Evans, Margery L.; et al.
The Bacterial Curli System Possesses a Potent and Selective Inhibitor of Amyloid Formation
Molecular Cell, Vol. 57, (3) : 445-455
Evans, Margery L.; Chorell, Erik; Taylor, Jonathan D.; et al.
Structural basis for catalytically restrictive dynamics of a high-energy enzyme state
Nature Communications, Macmillan Publishers Ltd. 2015, Vol. 6
Kovermann, Michael; Ådén, Jörgen; Grundström, Christin; et al.
Human cytoplasmic copper chaperones Atox1 and CCS exchange copper ions in vitro
Biometals, Springer 2015, Vol. 28, (3) : 577-585
Petzoldt, Svenja; Kahra, Dana; Kovermann, Michael; et al.
Synthesis of multiring fused 2‑pyridones via a nitrene insertion reaction: fluorescent modulators of α‑synuclein amyloid formation
Organic Letters, American Chemical Society (ACS) 2015, Vol. 17, (24) : 6194-6197
Singh, Pardeep; Chorell, Erik; Krishnan, K Syam; et al.
Correlated Inter-Domain Motions in Adenylate Kinase
PloS Computational Biology, PLOS 2014, Vol. 10, (7) : e1003721-
Esteban-Martin, Santiago; Fenwick, Robert Bryn; Ådén, Jörgen; et al.
Macromolecular crowding effects on two homologs of ribosomal protein S16: protein-dependent structural changes and local interactions
Biophysical Journal, Vol. 107, (2) : 401-410
Mikaelsson, Therese; Ådén, Jörgen; Wittung-Stafshede, Pernilla; et al.
Folding of an unfolded protein by macromolecular crowding in vitro
Biochemistry, American Chemical Society (ACS) 2014, Vol. 53, (14) : 2271-2277
Ådén, Jörgen; Wittung-Stafshede, Pernilla
Direct Observation of Protein Unfolded State Compaction in the Presence of Macromolecular Crowding
Biophysical Journal, Cell Press 2013, Vol. 104, (3) : 694-704
Mikaelsson, Therese; Ådén, Jörgen; Johansson, Lennart B-Å; et al.
Small pH and Salt Variations Radically Alter the Thermal Stability of Metal-Binding Domains in the Copper Transporter, Wilson Disease Protein
Journal of Physical Chemistry B, American Chemical Society (ACS) 2013, Vol. 117, (42) : 13038-13050
Nilsson, Lina; Ådén, Jörgen; Niemiec, Moritz S.; et al.
Structural topology and activation of an initial adenylate kinase-substrate complex
Biochemistry, Vol. 52, (6) : 1055-1061
Ådén, Jörgen; Weise, Christoph; Brännström, Kristoffer; et al.
Modulation of a pre-existing conformational equilibrium tunes adenylate kinase activity
Journal of the American Chemical Society, Washington: American Chemical Society (ACS) 2012, Vol. 134, (40) : 16562-16570
Ådén, Jörgen; Verma, Abhinav; Schug, Alexander; et al.
Extraordinary μs-ms backbone dynamics in Arabidopsis thaliana peroxiredoxin Q
Biochimica et Biophysica Acta, Elsevier 2011, Vol. 1814, (12) : 1880-1890
Ådén, Jörgen; Wallgren, Marcus; Storm, Patrik; et al.
NMR studies of protein dynamics and structure
Umeå: Umeå universitet. Kemiska institutionen 2010
Ådén, Jörgen
Noncooperative folding of subdomains in Adenylate Kinase
Biochemistry, ACS Publications 2009, Vol. 48, (9) : 1911-1927
Rundqvist, Louise; Ådén, Jörgen; Sparrman, Tobias; et al.
Extreme temperature tolerance of a hyperthermophilic protein coupled to residual structure in the unfolded state
Journal of Molecular Biology, Vol. 379, (4) : 845-858
Wallgren, Marcus; Ådén, Jörgen; Pylypenko, Olena; et al.
NMR identification of transient complexes critical to adenylate kinase catalysis
Journal of the American Chemical Society, Vol. 129, (45) : 14003-12
Ådén, Jörgen; Wolf-Watz, Magnus
Enhanement of amyloid fibril binding by ring expansion of thiazolino fused 2-pyridone peptidomimetics
Adolfsson, Dan E.; Tyagi, Mohit; Singh, Pardeep; et al.
K2S2O8-mediated aerobic oxidative coupling of 6-amino-7-(aminomethyl)-thiazolino-pyridones with aldehydes: Direct access to highly functionalized pyrimidine fused thiazolino-2-pyridones with amyloid fibril binding activity or inhibitors of Amyloid-β fibril formation
Bharate, Jaideep B.; Ådén, Jörgen; Gharibyan, Anna; et al.
Functionalization of Thiazolino fused 2-Pyridones by thiazoline ring opening and closing: Identification of new Amyloid Binding Heterocycles
Tyagi, Mohit; Adolfsson, Dan E.; Ådén, Jörgen; et al.
Arabidopsis thaliana peroxiredoxin Q is extraordinarily dynamic on the μs-ms timescale
Ådén, Jörgen; Wallgren, Marcus; Storm, Patrik; et al.
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