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Umeå universitet
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Personalbild Jonas von Hofsten

Jonas von Hofsten

Forskar om muskelceller - inom ämnesområdena embryonalutveckling, regeneration och cancer.

Vetenskaplig meritering: Docent

Kontakt

E-post
jonas.von.hofsten@umu.se
Telefon
090-786 67 36

Verksam vid

Anknytning
Universitetslektor vid Institutionen för medicinsk och translationell biologi Enhet: Grupp Jonas von Hofsten, Lärare A-flygeln, Lärare D1-flygeln
Plats
hus H, Johan Bures väg 12, Biologihuset Umeå universitet, 901 87 Umeå

Min forskning syftar till att studera hur bildandet av olika muskelceller regleras under regenereringsprocessen där satellitceller nybildar fibrer. Ett av målen är att hitta vägar för att styra regenereringen av specifika fibertyper. Jag studerar även hur cancerformen rhabdomyosarkom, som har sitt ursprung i muskelvävnad, påverkas av genetiska förändringar.

I min forskargrupp använder vi zebrafisk som modellsystem och jag ansvarar för driften av Umeå Zebrafish Facility (UZF).

I gruppen ingår:

Hanna Nord, förste forskningsingenjör

Eva Rodriguez Marquez, doktorand

Sara Destpak, forskaraspirant

fhl2b mediates extraocular muscle protection in zebrafish models of muscular dystrophies and its ectopic expression ameliorates affected body muscles
Nature Communications, Springer Nature 2024, Vol. 15, (1)
Dennhag, Nils; Kahsay, Abraha; Nissen, Itzel; et al.
Obscurin maintains myofiber identity in extraocular muscles
Investigative Ophthalmology and Visual Science, Association for Research in Vision and Ophthalmology 2024, Vol. 65, (2)
Kahsay, Abraha; Dennhag, Nils; Liu, Jing-Xia; et al.
Desmin gene expression is not ubiquitous in all upper airway myofibers and the pattern differs between healthy and sleep apnea subjects
European Journal of Medical Research, BioMed Central (BMC) 2024, Vol. 29, (1)
Stål, Per; Nord, Hanna; von Hofsten, Jonas; et al.
A new G-quadruplex-specific photosensitizer inducing genome instability in cancer cells by triggering oxidative DNA damage and impeding replication fork progression
Nucleic Acids Research, Oxford University Press 2023, Vol. 51, (12) : 6264-6285
Deiana, Marco; Andrés Castán, José María; Josse, Pierre; et al.
Pax3 loss of function delays tumour progression in kRAS-induced zebrafish rhabdomyosarcoma models
Scientific Reports, Nature Publishing Group 2022, Vol. 12, (1)
Kahsay, Abraha; Rodriguez-Marquez, Eva; López-Pérez, Ana R.; et al.
Genetic compensation between Pax3 and Pax7 in zebrafish appendicular muscle formation
Developmental Dynamics, John Wiley & Sons 2022, Vol. 251, (9) : 1423-1438
Nord, Hanna; Kahsay, Abraha; Dennhag, Nils; et al.
Absence of Desmin in Myofibers of the Zebrafish Extraocular Muscles
Translational Vision Science & Technology, Association for Research in Vision and Ophthalmology 2020, Vol. 9, (10)
Dennhag, Nils; Liu, Jing-Xia; Nord, Hanna; et al.
TRAF6 function as a novel co-regulator of Wnt3a target genes in prostate cancer
EBioMedicine, Elsevier 2019, Vol. 45 : 192-207
Aripaka, Karthik; Gudey, Shyam Kumar; Zang, Guangxiang; et al.
The zebrafish HGF receptor met controls migration of myogenic progenitor cells in appendicular development
PLOS ONE, Public Library of Science 2019, Vol. 14, (7)
Nord, Hanna; Dennhag, Nils; Tydinger, Hanna; et al.
De novo dNTP production is essential for normal postnatal murine heart development
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology 2019, Vol. 394, (44) : 15889-15897
Tran, Phong; Wanrooij, Paulina H.; Lorenzon, Paolo; et al.
Flagella-mediated secretion of a novel Vibrio cholerae cytotoxin affecting both vertebrate and invertebrate hosts
Communications Biology, Springer Nature Publishing AG 2018, Vol. 1
Dongre, Mitesh; Singh, Bhupender; Aung, Kyaw Min; et al.
Pax7 is required for establishment of the xanthophore lineage in zebrafish embryos
Molecular Biology of the Cell, Vol. 27, (11) : 1853-1862
Nord, Hanna; Dennhag, Nils; Muck, Joscha; et al.
Desmin in extraocular muscles
Investigative Ophthalmology and Visual Science, ASSOC RESEARCH VISION OPHTHALMOLOGY 2015, Vol. 56, (7)
Domellöf, Fatima Pedrosa; Parkkonen, Kimmo; Lindström, Mona; et al.
Differential regulation of myosin heavy chains defines new muscle domains in zebrafish
Molecular Biology of the Cell, American Society for Cell Biology 2014, Vol. 25, (8) : 1384-1395
Nord, Hanna; Burguiere, Anne-Cecile; Muck, Joscha; et al.
Differential regulation of the rainbow trout (Oncorhynchus mykiss) MT-A gene by nuclear factor interleukin-6 and activator protein-1
BMC Molecular Biology, Vol. 14, (28)
Kling, Peter; Modig, Carina; Mujahed, Huthayfa; et al.
Six1 regulates proliferation of Pax7-positive muscle progenitors in zebrafish
Journal of Cell Science, Cambridge, England: Company of Biologists Ltd 2013, Vol. 126, (8) : 1868-1880
Nord, Hanna; Skalman, Lars Nygard; von Hofsten, Jonas
Alkali-like myosin light chain-1 (myl1) is an early marker for differentiating fast muscle cells in zebrafish
Developmental Dynamics, John Wiley & Sons 2011, Vol. 240, (7) : 1856-1863
Burguière, Anne-Cecile; Nord, Hanna; von Hofsten, Jonas
The company of biologists’ workshop - fish muscle growth and repair: models linking biomedicine and aquaculture
Journal of Experimental Biology, London: Company of Biologists Ltd. Society for Experimental Biology 2011, Vol. 214, (18) : 2995-2996
Knight, Kathryn; Leslie, Jonathan; de la Serrana, Daniel Garcia; et al.
The Company of Biologists' Workshop: Fish muscle growth and repair. Models linking biomedicine and aquaculture
The Journal of experimental biology, Vol. 214, (Pt 18) : 2995-6
Knight, Kathryn; Leslie, Jonathan; de la Serrana, Daniel García; et al.
A balance of BMP and notch activity regulates neurogenesis and olfactory nerve formation
PloS one, Vol. 6, (2) : e17379-
Maier, Esther; Nord, Hanna; von Hofsten, Jonas; et al.
Opposing Fgf and Bmp activities regulate the specification of olfactory sensory and respiratory epithelial cell fates.
Development, Vol. 137, (10) : 1601-1611
Maier, Esther; von Hofsten, Jonas; Nord, Hanna; et al.
Prdm1- and Sox6-mediated transcriptional repression specifies muscle fibre type in the zebrafish embryo
EMBO Reports, Vol. 9, (7) : 683-689
von Hofsten, Jonas; Elworthy, Stone; Gilchrist, Michael J; et al.
P53 mediated regulation of metalolothionen transcription in breast cancer cells
Journal of Cellular Biochemistry, Hoboken: John Wiley & Sons 2007, Vol. 102, (6) : 1571-1583
Ostrakhovitch, Elena A; Olsson, Per-Erik; von Hofsten, Jonas; et al.
Molecular characterization and expression pattern of zona pellucida proteins in gilthead seabream (Sparus aurata)
Biology of Reproduction, Madison: Society for the study of reproduction 2006, Vol. 75, (5) : 717-725
Modig, Carina; Modesto, Teresa; Canario, Adelino; et al.
Molecular cloning and characterization of a nuclear androgen receptor activated by 11-ketotestosterone
Reproductive Biology and Endocrinology, London: BioMed Central (BMC) 2005, Vol. 3
Olsson, Per-Erik; Berg, A Håkan; von Hofsten, Jonas; et al.
Novel steroidogenic factor-1 homolog (ff1d) is coexpressed with anti-Mullerian hormone (AMH) in zebrafish.
Developmental Dynamics, Vol. 233, (2) : 595-604
von Hofsten, Jonas; Larsson, Anders; Olsson, Per-Erik
Determination of the expression pattern of the dual promoter of zebrafish fushi tarazu factor-1a following microinjections into zebrafish one cell stage embryos
General and Comparative Endocrinology, San Diego: Academic Press 2005, Vol. 142, (1-2) : 222-226
von Hofsten, Jonas; Modig, C; Larsson, A; et al.
Zebrafish sex determination and differentiation: involvement of FTZ-F1 genes
Reproductive Biology and Endocrinology, London: BioMed Central (BMC) 2005, Vol. 3
von Hofsten, Jonas; Olsson, Per-Erik
Developmental and reproductive regulation of NR5A genes in teleosts
Umeå: Molekylärbiologi (Teknisk-naturvetenskaplig fakultet) 2004
von Hofsten, Jonas
Fushi tarazu factor-1 mRNA and protein is expressed in steroidogenic and cholesterol metabolising tissues during different life stages in Arctic char (Salvelinus alpinus)
General and Comparative Endocrinology, Elsevier 2003, Vol. 132, (1) : 96-102
von Hofsten, Jonas; Karlsson, Johnny; Olsson, Per-Erik
Expression and Regulation of Fushi Tarazu Factor-1 and Steroidogenic Genes During Reproduction in Arctic Char (Salvelinus alpinus)
Biology of Reproduction, Society for the Study of Reproduction 2002, Vol. 67, (4) : 1297-1304
von Hofsten, Jonas; Karlsson, Johnny; Jones, Iwan; et al.
Developmental expression patterns of FTZ-F1 homologues in zebrafish (Danio rerio)
General and Comparative Endocrinology, Academic Press 2001, Vol. 121, (2) : 146-155
von Hofsten, Jonas; Jones, Iwan; Karlsson, Johnny; et al.
fhl2b expression ameliorates muscular dystrophy
Dennhag, Nils; Kahsay, Abraha; Nissen, Itzel; et al.
Visa publikationer i DiVA

Forskargrupper

Forskningsledare
Jonas von Hofsten lab
Jonas von Hofsten: Zebrafisken - en modell med muskler

Zebrafisk används i forskning om muskeldystrofi, en genetisk åkomma som leder till att muskelvävnad bryts ned.

Umeå Zebrafisk-facilitet
Umeå Zebrafisk-facilitet

Zebrafisk-modellsystemet kan användas för ett brett spektrum av ändamål.

Vill lura kroppen bli frisk

Jonas von Hofsten forskar om en sjuk muskelcell kan luras bete sig som om den är en frisk muskelcell.

Film: Forskning på ett ögonblick med Jonas
Forskning på ett ögonblick med Jonas

Syftet är att studera hur bildandet av olika muskelceller regleras.