Jan Larsson

Jag är professor i genetik och min forskning är inriktad på att förstå kromosomernas betydelse och funktion för att organisera arvsmassan och för att den ska fungera på rätt sätt.

Kontakt

jan.larsson@umu.se

090-785 67 85

Verksam vid

Professor vid Institutionen för molekylärbiologi Enhet: Grupp Jan Larsson

6K och 6L, Sjukhusområdet, 6L-247 Umeå universitet, 901 87 Umeå

Methylation of lysine 36 on histone H3 is required to control transposon activities in somatic cells

Life Science Alliance, NLM (Medline) 2023, Vol. 6, (8)

Lindehell, Henrik; Schwartz, Yuri B.; Larsson, Jan

Modulation of RNA stability regulates gene expression in two opposite ways: through buffering of RNA levels upon global perturbations and by supporting adapted differential expression

Nucleic Acids Research, Oxford University Press 2022, Vol. 50, (8) : 4372-4388

Faucillion, Marie-Line; Johansson, Anna-Mia; Larsson, Jan

Transposon activity, local duplications and propagation of structural variants across haplotypes drive the evolution of the Drosophila S2 cell line

BMC Genomics, BioMed Central 2022, Vol. 23, (1)

Lewerentz, Jacob; Johansson, Anna-Mia; Larsson, Jan; et al.

The role of H3K36 methylation and associated methyltransferases in chromosome-specific gene regulation

Science Advances, American Association for the Advancement of Science 2021, Vol. 7, (40)

Lindehell, Henrik; Glotov, Alexander; Dorafshan, Eshagh; et al.

DamID transcriptional profiling identifies the Snail/Scratch transcription factor Kahuli as an Alk target in the Drosophila visceral mesoderm

Development, The Company of Biologists 2021, Vol. 148, (23)

Mendoza-Garcia, Patricia; Basu, Swaraj; Sukumar, Sanjay Kumar; et al.

Painting of Fourth and the X-Linked 1.688 Satellite in D. melanogaster is Involved in Chromosome-Wide Gene Regulation

Cells, MDPI 2020, Vol. 9, (2)

Ekhteraei-Tousi, Samaneh; Lewerentz, Jacob; Larsson, Jan

Polytene chromosomes reflect functional organization of the Drosophila genome

Vavilovski Zhurnal Genetiki i Selektsii, Russian Academy of Sciences 2019, Vol. 23, (2) : 148-153

Sidorenko, D. S.; Zykova, T. Yu; Khoroshko, V. A.; et al.

Molecular and genetic organization of bands and interbands in the dot chromosome of Drosophila melanogaster

Chromosoma, Springer 2019, Vol. 128, (2) : 97-117

Sidorenko, Darya S.; Sidorenko, Ivan A.; Zykova, Tatyana Yu.; et al.

The X-linked 1.688 satellite in Drosophila melanogaster promotes specific targeting by Painting of Fourth

Genetics, Bethesda: The Genetics Society 2018, Vol. 208, (2) : 623-632

Kim, Maria; Ekhteraei-Tousi, Samaneh; Lewerentz, Jacob; et al.

RNA-on-X 1 and 2 in Drosophila melanogaster fulfill separate functions in dosage compensation

PLOS Genetics, Public Library Science 2018, Vol. 14, (12)

Kim, Maria; Faucillion, Marie-Line; Larsson, Jan

Increased expression of X-linked genes in mammals is associated with a higher stability of transcripts and an increased ribosome density

Genome Biology and Evolution, Oxford University Press 2015, Vol. 7, (4) : 1039-1052

Faucillion, Marie-Line; Larsson, Jan

Proximity ligation assays of protein and RNA interactions in the male-specific lethal complex on Drosophila melanogaster polytene chromosomes

Chromosoma, Vol. 124, (3) : 385-395

Lindehell, Henrik; Kim, Maria; Larsson, Jan

Non-coding roX RNAs prevent the binding of the MSL-complex to heterochromatic regions

PLOS Genetics, Vol. 10, (12) : e1004865-

Figueiredo, Margarida L. A.; Kim, Maria; Philip, Philge; et al.

Genome-wide mapping of Painting of fourth on Drosophila melanogaster salivary gland polytene chromosomes

Genomics Data, Vol. 2 : 63-65

Johansson, Anna-Mia; Larsson, Jan

Gene regulation by the lysine demethylase KDM4A in Drosophila

Developmental Biology, Elsevier 2013, Vol. 737, (2) : 453-463

Crona, Filip; Dahlberg, Olle; Lundberg, Lina E; et al.

Targeting of painting of fourth to roX1 and roX2 proximal sites suggests evolutionary links between dosage compensation and the regulation of the 4th chromosome in Drosophila melanogaster

G3: Genes, Genomes, Genetics, Vol. 3, (8) : 1325-1334

Lundberg, Lina E; Kim, Maria; Johansson, Anna-Mia; et al.

HP1a, Su(var)3-9, SETDB1 and POF stimulate or repress gene expression depending on genomic position, gene length and expression pattern in Drosophila melanogaster

Nucleic Acids Research, Vol. 41, (8) : 4481-4494

Lundberg, Lina E; Stenberg, Per; Larsson, Jan

HP1a Recruitment to Promoters Is Independent of H3K9 Methylation in Drosophila melanogaster

PLOS Genetics, Vol. 8, (11) : e1003061-

Figueiredo, Margarida L A; Philip, Philge; Stenberg, Per; et al.

POF Regulates the Expression of Genes on the Fourth Chromosome in Drosophila melanogaster by Binding to Nascent RNA

Molecular and Cellular Biology, American Society for Microbiology 2012, Vol. 32, (11) : 2121-2134

Johansson, Anna-Mia; Stenberg, Per; Allgardsson, Anders; et al.

Buffering and proteolysis are induced by segmental monosomy in Drosophila melanogaster

Nucleic Acids Research, Oxford: Oxford University Press 2012, Vol. 40, (13) : 5926-5937

Lundberg, Lina E; Figueiredo, Margarida L A; Stenberg, Per; et al.

msl2 mRNA is bound by free nuclear MSL complex in Drosophila melanogaster

Nucleic Acids Research, Oxford University Press 2011, Vol. 39, (15) : 6428-6439

Johansson, Anna-Mia; Allgardsson, Anders; Stenberg, Per; et al.

Buffering and the evolution of chromosome-wide gene regulation

Chromosoma, Springer 2011, Vol. 120, (3) : 213-225

Stenberg, Per; Larsson, Jan

Buffering of segmental and chromosomal aneuploidies in Drosophila melanogaster

PLOS Genetics, Vol. 5, (5)

Stenberg, Per; Lundberg, Lina E.; Johansson, Anna-Mia; et al.

Painting of fourth and chromosome-wide regulation of the 4th chromosome in Drosophila melanogaster.

EMBO J, Vol. 26, (9) : 2307-2316

Johansson, Anna-Mia; Stenberg, Per; Bernhardsson, Carolina; et al.

POF and HP1 bind expressed exons, suggesting a balancing mechanism for gene regulation

PLoS Genet, Vol. 3, (11) : e209-

Johansson, Anna-Mia; Stenberg, Per; Pettersson, Fredrik; et al.

Drosophila dSet2 functions in H3-K36 methylation and is required for development.

Biochem Biophys Res Commun, Vol. 359, (3) : 784-9

Stabell, Marianne; Larsson, Jan; Aalen, Reidunn B; et al.

Thioredoxin-2 affects lifespan and oxidative stress in Drosophila

Hereditas, Oxford: Blackwell 2007, Vol. 144, (1) : 25-32

Svensson, Malin J; Larsson, Jan

Organization and regulation of sex-specific thioredoxin encoding genes in the genus Drosophila.

Dev Genes Evol, Vol. 217, (9) : 639-50

Svensson, Malin J; Stenberg, Per; Larsson, Jan

Dosage compensation, the origin and the afterlife of sex chromosomes.

Chromosome Res, Vol. 14, (4) : 417-31

Larsson, Jan; Meller, Victoria H

The Drosophila G9a gene encodes a multi-catalytic histone methyltransferase required for normal development.

Nucleic Acids Res, Vol. 34, (16) : 4609-21

Stabell, Marianne; Eskeland, Ragnhild; Bjørkmo, Mona; et al.

Sequence signature analysis of chromosome identity in three Drosophila species

BMC Bioinformatics, Vol. 6, (158) : 1-17

Stenberg, Per; Pettersson, Fredrik; Saura, Anja O; et al.

Painting of fourth in genus Drosophila suggests autosome-specific gene regulation

Proceedings of the National Academy of Sciences of the United States of America, Washington: National Academy of Sciences 2004, Vol. 101, (26) : 9728-9733

Larsson, Jan; Svensson, Malin J; Stenberg, Per; et al.

Drosophila Ada2b is required for viability and normal histone H3 acetylation.

Mol Cell Biol, Vol. 24, (18) : 8080-9

Qi, Dai; Larsson, Jan; Mannervik, Mattias

Silencing the Drosophila ribosomal protein L14 gene using targeted RNA interference causes distinct somatic anomalies.

Gene, Vol. 320 : 41-8

Enerly, Espen; Larsson, Jan; Lambertsson, Andrew

The ThioredoxinT and deadhead gene pair encode testis- and ovary-specific thioredoxins in Drosophila melanogaster.

Chromosoma, Vol. 112, (3) : 133-43

Svensson, Malin J; Chen, J Don; Pirrotta, Vincenzo; et al.

NELF and DSIF cause promoter proximal pausing on the hsp70 promoter in Drosophila.

Genes Dev, Vol. 17, (11) : 1402-14