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Umeå universitet
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Personalbild Intissar Anan

Intissar Anan

Kontakt

E-post
intissar.anan@umu.se
Telefon
090-785 00 00

Verksam vid

Anknytning
Anknuten som läkare till Institutionen för folkhälsa och klinisk medicin
Plats
Byggnad 1A, plan 4, målpunkt B41, Norrlands universitetssjukhus Norrlands universitetssjukhus, 90185 Umeå
Misfolding of transthyretin in vivo is controlled by the redox environment and macromolecular crowding
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology 2025, Vol. 301, (1)
Jayaweera, Sanduni Wasana; Sahin, Melisnur; Lundkvist, Fabian; et al.
Assessing left atrial dysfunction in cardiac amyloidosis using LA-LV strain slope
European Heart Journal - Imaging Methods and Practice, Oxford University Press 2024, Vol. 2, (3)
Edbom, Fredrik; Lindqvist, Per; Wiklund, Urban; et al.
Anti-PEG antibodies associated with reduced therapeutic effect of patisiran in patients with hereditary transthyretin amyloidosis
Amyloid: Journal of Protein Folding Disorders, Taylor & Francis 2024, Vol. 31, (4) : 342-343
Pilebro, Björn; Wixner, Jonas; Anan, Intissar
Enlarged cross-sectional area in peripheral nerves in Swedish patients with hereditary V30M transthyretin amyloidosis
Annals of Medicine, Taylor & Francis Group 2023, Vol. 55, (2)
Arvidsson, Sandra; Eriksson, Robert; Anan, Intissar; et al.
A multicentric study of the disease risks and first manifestations in Hereditary transthyretin amyloidosis (ATTRv): insights for an earlier diagnosis
Amyloid: Journal of Protein Folding Disorders, Taylor & Francis 2023, Vol. 30, (3) : 313-320
Planté-Bordeneuve, Violaine; Gorram, Farida; Olsson, Malin; et al.
Amyloid fibril composition type is consistent over time in patients with Val30Met (p. Val50Met) transthyretin amyloidosis
PLOS ONE, Public Library of Science 2022, Vol. 17, (3)
Anan, Intissar; Suhr, Ole B.; Liszewska, Katarzyna; et al.
Endogenous Human Proteins Interfering with Amyloid Formation
Biomolecules, MDPI 2022, Vol. 12, (3)
Gharibyan, Anna; Jayaweera, Sanduni Wasana; Lehmann, Manuela; et al.
Epidemiology of hereditary transthyretin amyloidosis in the northernmost region of Sweden: a retrospective cohort study
Amyloid: Journal of Protein Folding Disorders, Taylor & Francis 2022, Vol. 29, (2) : 120-127
Mejia Baranda, Jorge; Ljungberg, Jenny; Wixner, Jonas; et al.
Hereditary transthyretin amyloidosis in Sweden: Comparisons between a non-endemic and an endemic region
Amyloid: Journal of Protein Folding Disorders, Taylor & Francis 2022, Vol. 29, (4) : 220-227
Samuelsson, Kristin; Jovanovic, Ana; Egervall, Karl; et al.
Patisiran treatment in patients with hereditary transthyretin-mediated amyloidosis with polyneuropathy after liver transplantation
American Journal of Transplantation, John Wiley & Sons 2022, Vol. 22, (6) : 1646-1657
Schmidt, Hartmut H.; Wixner, Jonas; Planté-Bordeneuve, Violaine; et al.
Cerebellar and Cerebral Amyloid Visualized by [18F]flutemetamol PET in Long-Term Hereditary V30M (p.V50M) Transthyretin Amyloidosis Survivors
Frontiers in Neurology, Frontiers Media S.A. 2022, Vol. 13
Unéus, Erica Irene; Wilhelmsson, Christer; Bäckström, David; et al.
New data on the genetic profile and penetrance of hereditary Val30Met transthyretin amyloidosis in Sweden
Amyloid: Journal of Protein Folding Disorders, Taylor & Francis 2021, Vol. 28, (2) : 84-90
Gorram, Farida; Olsson, Malin; Alarcon, Flora; et al.
Structural basis for transthyretin amyloid formation in vitreous body of the eye
Nature Communications, Nature Publishing Group 2021, Vol. 12, (1)
Iakovleva, Irina; Hall, Michael; Oelker, Melanie; et al.
Mechanisms of Transthyretin Inhibition of IAPP Amyloid Formation
Biomolecules, MDPI 2021, Vol. 11, (3)
Jayaweera, Sanduni Wasana; Surano, Solmaz; Pettersson, Nina; et al.
Combining ECG and echocardiography to identify transthyretin cardiac amyloidosis in heart failure
Clinical Physiology and Functional Imaging, John Wiley & Sons 2021, Vol. 41, (5) : 408-416
Löfbacka, Viktor; Suhr, Ole B.; Pilebro, Björn; et al.
Metabolomics analysis for diagnosis and biomarker discovery of transthyretin amyloidosis
Amyloid: Journal of Protein Folding Disorders, Taylor & Francis Group 2021, Vol. 28, (4) : 234-242
Olsson, Malin; Hellman, Urban; Wixner, Jonas; et al.
Abdominal fat pad biopsies exhibit good diagnostic accuracy in patients with suspected transthyretin amyloidosis
Orphanet Journal of Rare Diseases, BioMed Central (BMC) 2020, Vol. 15, (1)
Paulsson Rokke, Hedvig; Sadat Gousheh, Nima; Westermark, Per; et al.
A case report of osteoarthritis associated with hereditary transthyretin amyloidosis ATTRV30M
Amyloid: Journal of Protein Folding Disorders, Taylor & Francis 2019, Vol. 26 : 29-30
Anan, Intissar; Bång, Joakim; Lundgren, Hans-Erik; et al.
Transthyretin Glu54Leu - an unknown mutation within the Swedish population associated with amyloid cardiomyopathy and a unique fibril type
Scandinavian Journal of Clinical and Laboratory Investigation, Taylor & Francis 2019, Vol. 79, (6) : 372-376
Hellman, Urban; Lång, Kenneth; Ihse, Elisabet; et al.
Prevalence of transthyretin cardiac amyloidosis in a community-based heart failure population
European Heart Journal, Oxford University Press 2019, Vol. 40 : 132-132
Lindmark, Krister; Pilebro, Björn; Solekrans, L.; et al.
Self-reported gastrointestinal symptoms are more common in liver transplanted transthyretin amyloidosis patients than in healthy controls and in patients transplanted for end-stage liver disease
Amyloid: Journal of Protein Folding Disorders, Taylor & Francis 2019, Vol. 26 : 47-48
Marberg, Therese; Karling, Pontus; Söderberg, Karin; et al.
Amyloid fibril composition within hereditary Val30Met (p. Val50Met) transthyretin amyloidosis families
PLOS ONE, Public Library Science 2019, Vol. 14, (2)
Suhr, Ole Bernt; Wixner, Jonas; Anan, Intissar; et al.
Visualisation of amyloid deposition within the brain of long-term hereditary transthyretin amyloidosis survivors by 18F-flutemetamol positron emission tomography
European Journal of Neurology, John Wiley & Sons 2019, Vol. 26, (S1) : 287-287
Unéus, Erica; Wilhelmsson, Christer; Suhr, Ole; et al.
The Swedish open-label diflunisal trial (DFNS01) on hereditary transthyretin amyloidosis and the impact of amyloid fibril composition
Amyloid: Journal of Protein Folding Disorders, Taylor & Francis Group 2019, Vol. 26 : 39-40
Wixner, Jonas; Westermark, Per; Ihse, Elisabet; et al.
Atrial Fibrillation and Central Nervous Complications in Liver Transplanted Hereditary Transthyretin Amyloidosis Patients
Transplantation, LIPPINCOTT WILLIAMS & WILKINS 2018, Vol. 102, (2) : e59-e66
Wange, Niklas; Anan, Intissar; Ericzon, Bo-Göran; et al.
Management of gastrointestinal complications in hereditary transthyretin amyloidosis: a single-center experience over 40 years
Expert Review of Gastroenterology & Hepatology, Taylor & Francis 2018, Vol. 12, (1) : 73-81
Wixner, Jonas; Suhr, Ole B.; Anan, Intissar
Abnormal small bowel motility in patients with hereditary transthyretin amyloidosis
Neurogastroenterology and Motility, Wiley-Blackwell 2018, Vol. 30, (9)
Wixner, Jonas; Törnblom, H.; Karling, Pontus; et al.
The Swedish landscape of hereditary ATTR amyloidosis
Amyloid: Journal of Protein Folding Disorders, Vol. 24, (1) : 93-94
Suhr, Ole B; Wixner, Jonas; Pilebro, Björn; et al.
Effect of doxycycline and ursodeoxycholic acid on transthyretin amyloidosis
Amyloid: Journal of Protein Folding Disorders, Vol. 24, (1) : 78-79
Wixner, Jonas; Pilebro, Bjorn; Lundgren, Hans-Erik; et al.
Enthalpic Forces Correlate with Selectivity of Transthyretin-Stabilizing Ligands in Human Plasma
Journal of Medicinal Chemistry, Vol. 58, (16) : 6507-6515
Iakovleva, Irina; Brännström, Kristoffer; Nilsson, Lina; et al.
Outcome of gastric emptying and gastrointestinal symptoms after liver transplantation for hereditary transthyretin amyloidosis
BMC Gastroenterology, Vol. 15
Wixner, Jonas; Sundström, Torbjorn; Karling, Pontus; et al.
THAOS: Gastrointestinal manifestations of transthyretin amyloidosis - common complications of a rare disease
Orphanet Journal of Rare Diseases, BioMed Central (BMC) 2014, Vol. 9, (1) : 61-
Wixner, Jonas; Mundayat, Rajiv; Karayal, Onur N; et al.
Impact of antibodies against amyloidogenic transthyretin (ATTR) on phenotypes of patients with familial amyloidotic polyneuropathy (FAP) ATTR Valine30Methionine
Clinica Chimica Acta, Vol. 419C : 127-131
Obayashi, Konen; Tasaki, Masayoshi; Jono, Hirofumi; et al.
Loss of gastric interstitial cells of Cajal in patients with hereditary transthyretin amyloidosis
Amyloid: Journal of Protein Folding Disorders, Informa Healthcare 2013, Vol. 20, (2) : 99-106
Wixner, Jonas; Obayashi, Konen; Ando, Yukio; et al.
Gastric emptying in hereditary transthyretin amyloidosis: the impact of autonomic neuropathy
Neurogastroenterology and Motility, Wiley-Blackwell 2012, Vol. 24, (12) : 1111-e568
Wixner, Jonas; Karling, Pontus; Rydh, Anders; et al.
Serum transthyretin levels in Swedish TTR V30M carriers
Amyloid: Journal of Protein Folding Disorders, Vol. 17, (2) : 83-85
Buxbaum, Joel; Anan, Intissar; Suhr, Ole B
Impact of serotonin transporter and catechol-O-methyl transferase genes polymorphism on gastrointestinal dysfunction in Swedish and Japanese familial amyloidotic polyneuropathy patients.
Clinica Chimica Acta, Vol. 398, (1-2) : 10-4
Obayashi, Konen; Olsson, Malin; Anan, Intissar; et al.
Do troponin and B-natriuretic peptide detect cardiomyopathy in transthyretin amyloidosis?
Journal of Internal Medicine, John Wiley & Sons 2008, Vol. 263, (3) : 294-301
Suhr, Ole B; Anan, Intissar; Backman, Clas; et al.
Cardiomyopathy in Swedish patients with the Gly53Glu and His88Arg transthyretin variants.
Amyloid, Vol. 12, (3) : 184-8
Holmgren, Gösta; Hellman, Urban; Anan, Intissar; et al.
Advanced glycation end product is implicated in amyloid-related kidney complications
Scandinavian Journal of Clinical and Laboratory Investigation, Informa Healthcare 2005, Vol. 65, (4) : 263-272
Matsunaga, N; Anan, Intissar; Rosenberg, P; et al.
Gastric emptying before and after liver transplantation for familial amyloidotic polyneuropathy, Portuguese type (Val30Met).
Amyloid: Journal of Protein Folding Disorders, Vol. 10, (2) : 121-6
Suhr, Ole B; Anan, Intissar; Åhlström Riklund, Katrine; et al.
Advanced glycation end products (AGE) and the receptor for AGE are present in gastrointestinal tract of familial amyloidotic polyneuropathy patients but do not induce NF-kappaB activation.
Acta Neuropathologica, Vol. 104, (5) : 441-7
Matsunaga, Noriko; Anan, Intissar; Forsgren, Sture; et al.
Reduction of free radical activity in amyloid deposits following liver transplantation for familial amyloidotic polyneuropathy.
Journal of Internal Medicine, Vol. 251, (2) : 136-41
Nyhlin, N; Anan, Intissar; El, Salhy M; et al.
Comparison of amyloid deposits and infiltration of enteric nervous system in the upper with those in the lower gastrointestinal tract in patients with familial amyloidotic polyneuropathy.
Acta Neuropathologica, Vol. 102, (3) : 227-32
Anan, Intissar; El-salhy, M; Ando, Y; et al.
Scavenger treatment of free radical injury in familial amyloidotic polyneuropathy: a study on Swedish transplanted and non-transplanted patients.
Scandinavian Journal of Clinical and Laboratory Investigation, Vol. 61, (1) : 11-8
Suhr, Ole B; Lång, K; Wikström, L; et al.
Liver transplantation restores endocrine cells in patients with familial amyloidotic polyneuropathy.
Transplantation, Vol. 70, (5) : 794-9
Anan, Intissar; El-Salhy, M; Nyhlin, N; et al.
Heart failure caused by a novel amyloidogenic mutation of the transthyretin gene: ATTR Ala45Ser.
Amyloid: Journal of Protein Folding Disorders, Vol. 7, (2) : 137-40
Janunger, T; Anan, Intissar; Holmgren, G; et al.
Enhancement of AA-amyloid formation in mice by transthyretin amyloid fragments and polyethylene glycol.
Biochimica et Biophysica Acta, Vol. 1474, (3) : 331-6
Mambule, C; Ando, Y; Anan, Intissar; et al.
Colonic enteric nervous system in patients with familial amyloidotic neuropathy.
Acta Neuropathologica, Vol. 98, (1) : 48-54
Anan, Intissar; El-Salhy, M; Ando, Y; et al.
Colonic endocrine cells in patients with familial amyloidotic polyneuropathy.
Journal of Internal Medicine, Vol. 245, (5) : 469-73
Anan, Intissar; El-Salhy, M; Ando, Y; et al.
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Intissar Anan: Gåtan Skelleftesjukan – på väg att lösas?

Intissar Anan berättar om forskning kring Skelleftesjukan, och om gåtan Skelleftesjukan är på väg att lösas.

Film: Forskning på ett ögonblick
Forskning på ett ögonblick

Jag forskar om amyloidos, särskilt den sällsynta, ärftliga sjudomen transtyretinamyloidos. På engelska, med svensk undertext.