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Helena Lindgren
Kontakt
E-post
helena.e.lindgren@umu.se
Telefon
090-785 87 87
Verksam vid
Anknytning
Staff scientist vid
Institutionen för klinisk mikrobiologi
Enhet: Klinisk bakteriologi
Plats
6B,, Universitetssjukhuset, 22B
Umeå universitet, 901 85 Umeå
Publikationer
Publikationer
Forskning
Forskning
2024
Francisella tularensis-specific antibody levels in sera from Swedish patients with suspected tularemia during a 13-year period
Frontiers in Cellular and Infection Microbiology
, Frontiers Media S.A. 2024, Vol. 14
Lindgren, Helena; Liu, Xijia; Sjöstedt, Anders
2023
Kinetics of the serological response up to one year after tularemia
Frontiers in Cellular and Infection Microbiology
, Frontiers Media S.A. 2023, Vol. 12
Lindgren, Helena; Eklund, Johan; Eneslätt, Kjell; et al.
2023
Analyses of human immune responses to Francisella tularensis identify correlates of protection
Frontiers in Immunology
, Frontiers Media S.A. 2023, Vol. 14
Lindgren, Helena; Eneslätt, Kjell; Golovliov, Igor; et al.
2023
Utility of
Borrelia
-specific IgM and IgG antibody titer determinations during a 12-year period: results from a clinical laboratory in Northern Sweden
Frontiers in Cellular and Infection Microbiology
, Frontiers Media S.A. 2023, Vol. 13
Liu, Xijia; Tabibzada, Nazanin; Lindgren, Helena; et al.
2021
Macrophages Demonstrate Guanylate-Binding Protein-Dependent and Bacterial Strain-Dependent Responses to Francisella tularensis
Frontiers in Cellular and Infection Microbiology
, Frontiers Media S.A. 2021, Vol. 11
Mohammadi, Nasibeh; Lindgren, Helena; Yamamoto, Masahiro; et al.
2020
Vaccine-Mediated Mechanisms Controlling Francisella tularensis SCHU S4 Growth in a Rat Co-Culture System
Pathogens
, MDPI 2020, Vol. 9, (5)
Lindgren, Helena; Eneslätt, Kjell; Golovliov, Igor; et al.
2020
Guanylate-Binding Proteins Are Critical for Effective Control of Francisella tularensis Strains in a Mouse Co-Culture System of Adaptive Immunity
Frontiers in Cellular and Infection Microbiology
, Frontiers Media S.A. 2020, Vol. 10
Mohammadi, Nasibeh; Lindgren, Helena; Golovliov, Igor; et al.
2019
Francisella tularensis: FupA mutation contributes to fluoroquinolone resistance by increasing vesicle secretion and biofilm formation
Emerging Microbes & Infections
, Taylor & Francis 2019, Vol. 8, (1)
Siebert, Claire; Lindgren, Helena; Ferre, Sabrina; et al.
2017
Lack of OxyR and KatG Results in Extreme Susceptibility of Francisella tularensis LVS to Oxidative Stress and Marked Attenuation In vivo
Frontiers in Cellular and Infection Microbiology
, Vol. 7
Honn, Marie; Lindgren, Helena; Bharath, Gurram Kumar; et al.
2017
IFN-gamma extends the immune functions of Guanylate Binding Proteins to inflammasome-independent antibacterial activities during Francisella novicida infection
PLoS Pathogens
, Public Library Science 2017, Vol. 13, (10)
Wallet, Pierre; Benaoudia, Sacha; Mosnier, Amandine; et al.
2016
An In Vitro Co-culture Mouse Model Demonstrates Efficient Vaccine-Mediated Control of Francisella tularensis SCHU S4 and Identifies Nitric Oxide as a Predictor of Efficacy
Frontiers in Cellular and Infection Microbiology
, Vol. 6
Golovliov, Igor; Lindgren, Helena; Eneslätt, Kjell; et al.
2016
Gallium Potentiates the Antibacterial Effect of Gentamicin against Francisella tularensis
Antimicrobial Agents and Chemotherapy
, Vol. 60, (1) : 288-295
Lindgren, Helena; Sjöstedt, Anders
2015
Roles of Reactive Oxygen Species-Degrading Enzymes of Francisella tularensis SCHU S4
Infection and Immunity
, Vol. 83, (6) : 2255-2263
Binesse, Johan; Lindgren, Helena; Lindgren, Lena; et al.
2015
Mechanisms of heme utilization by Francisella tularensis
PLOS ONE
, Vol. 10, (3)
Lindgren, Helena; Lindgren, Lena; Golovliov, Igor; et al.
2012
The Rift Valley Fever virus protein NSm and putative cellular protein interactions
Virology Journal
, Vol. 9 : 139-
Engdahl, Cecilia; Näslund, Jonas; Lindgren, Lena; et al.
2012
The role of MglA for adaptation to oxidative stress of Francisella tularensis LVS
BMC Microbiology
, London: BioMed Central 2012, Vol. 12 : 14-
Honn, Marie; Lindgren, Helena; Sjöstedt, Anders
2012
Roles for wbtC, wbtI, and kdtA genes in lipopolysaccharide biosynthesis, protein glycosylation, virulence, and immunogenicity in Francisella tularensis strain SCHU S4
Pathogens
, MDPI 2012, Vol. 1, (1) : 12-29
Twine, Susan M; Vinogradov, Evguenii; Lindgren, Helena; et al.
2011
Iron content differs between Francisella tularensis subspecies tularensis and subspecies holarctica strains and correlates to their susceptibility to H(2)O(2)-induced killing
Infection and Immunity
, Vol. 79, (3) : 1218-1224
Lindgren, Helena; Honn, Marie; Salomonsson, Emelie; et al.
2011
Administration of a donor of nitric oxide inhibits
mglA
expression of intracellular
Francisella tularensis
and counteracts phagosomal escape and subversion of TNF-α secretion
Journal of Medical Microbiology
, Vol. 30, (11) : 1570-1583
Tancred, Linda; Telepnev, Maxim; Golovlev, Igor; et al.
2009
The 58-kilodalton major virulence factor of Francisella tularensis is required for efficient utilization of iron
Infection and Immunity
, Vol. 77, (10) : 4429-4436
Lindgren, Helena; Honn, Marie; Golovlev, Igor; et al.
2008
MglA and Igl proteins contribute to the modulation of Francisella tularensis live vaccine strain-containing phagosomes in murine macrophages
Infection and Immunity
, Vol. 76, (8) : 3502-3510
Bönquist, Linda; Lindgren, Helena; Golovliov, Igor; et al.
2005
The contribution of reactive nitrogen and oxygen species to the killing of Francisella tularensis LVS by murine macrophages.
Microbes and infection
, Vol. 7, (3) : 467-475
Lindgren, Helena; Stenman, Linda; Tärnvik, Arne; et al.
2005
A mutant of Francisella tularensis strain SCHU S4 lacking the ability to express a 58-kilodalton protein is attenuated for virulence and is an effective live vaccine
Infection and Immunity
, Vol. 73, (12) : 8345-8352
Twine, Susan; Byström, Mona; Chen, Wangxue; et al.
2004
Distinct roles of reactive nitrogen and oxygen species to control infection with the facultative intracellular bacterium Francisella tularensis.
Infection and Immunity
, Vol. 72, (12) : 7172-7182
Lindgren, Helena; Stenmark, Stephan; Chen, Wangxue; et al.
Infection with Francisella novicida leads to killing of murine macrophages by necrosis
Lai, Xin-He; Lindgren, Helena; Luan, Shi-Lu; et al.
T-cell-dependent and independent protection against Francisella tularensis
Stenmark, Stephan; Lindgren, Helena; Tärnvik, Arne; et al.
Inhibition of the oxidative burst by
Francisella tularensis
LVS is dependent on expression of MglA and the pathogenicity island proteins IglB, IglC, and IglD, but is not affected by IFN-γ
Tancred, Linda; Binesse, Johan; Lindgren, Helena; et al.
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Anders Sjöstedt
Forskningsprojekt
1 januari 2021 till 31 december 2025
Utveckling av ett tularemivaccin
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