"False"
Hoppa direkt till innehållet
umu.se
För studenter
Bibliotek
För medarbetare
Logga in
Student
Alla studenter måste byta lösenord efter 7 maj.
Redigera
Redigera innehåll på umu.se
English site
Sök
Meny
X stäng menyn
Meny
Sök
Sök inom:
Sök inom:
Allt
Utbildning
Forskning
Personal
Studentwebb
Nyheter
Andra söktjänster
Hitta kurser och program
Sök kursplan
Sök välkomstbrev
Bibliotekets söktjänst
Sök i regelverket
Huvudmenyn dold.
Logga in
Student
Alla studenter måste byta lösenord efter 7 maj.
Redigera
Redigera innehåll på umu.se
English
Hans Wolf-Watz
Vetenskaplig meritering:
Docent
Kontakt
E-post
hans.wolf-watz@umu.se
Telefon
090-785 25 30
Verksam vid
Anknytning
Anknuten som professor emeritus till
Institutionen för molekylärbiologi
Enhet: Grupp Hans Wolf-Watz
Plats
6K och 6L, Sjukhusområdet
Umeå universitet, 901 87 Umeå
Publikationer
Publikationer
Forskning
Forskning
2019
A bacterial secreted translocator hijacks riboregulators to control type III secretion in response to host cell contact
PLoS Pathogens
, Public Library Science 2019, Vol. 15, (6)
Kusmierek, Maria; Hossmann, Joern; Witte, Rebekka; et al.
2017
Global Disordering in Stereo-Specific Protein Association
Biophysical Journal
, CELL PRESS 2017, Vol. 112, (3) : 33A-33A
Gupta, Arun; Reinartz, Ines; Spilotros, Alessandro; et al.
2017
Characterization of the Ruler Protein Interaction Interface on the Substrate Specificity SwitchProtein in the
Yersinia
Type III Secretion System
Journal of Biological Chemistry
, Vol. 292, (8) : 3299-3311
Ho, Oanh; Rogne, Per; Edgren, Tomas; et al.
2016
Increased plasmid copy number is essential for Yersinia T3SS function and virulence
Science
, Vol. 353, (6298) : 492-495
Wang, He; Avican, Kemal; Fahlgren, Anna; et al.
2015
A 2-Pyridone-Amide Inhibitor Targets the Glucose Metabolism Pathway of Chlamydia trachomatis
mBio
, Vol. 6, (1)
Engström, Patrik; Krishnan, K. Syam; Ngyuen, Bidong D.; et al.
2015
YscU/FlhB of Yersinia pseudotuberculosis Harbors a C-terminal Type III Secretion Signal
Journal of Biological Chemistry
, Umea Univ, Dept Mol Biol, Umea Ctr Microbial Res, SE-90187 Umea, Sweden. Umea Univ, Lab Mol Infect Med Sweden MIMS, Umea Ctr Microbial Res, SE-90187 Umea, Sweden.: 2015, Vol. 290, (43) : 26282-26291
Login, Frederic H.; Wolf-Watz, Hans
2014
Negatively charged lipid membranes promote a disorder-order transition in the Yersinia YscU protein
Biophysical Journal
, Cell Press 2014, Vol. 107, (8) : 1950-1961
Weise, Christoph F; Login, Frédéric H; Ho, Oanh; et al.
2013
Metabolic profiling for detection of staphylococcus aureus infection and antibiotic resistance
PLOS ONE
, Vol. 8, (2)
Antti, Henrik; Fahlgren, Anna; Näsström, Elin; et al.
2013
Type III secretion translocon assemblies that attenuate Yersinia virulence
Cellular Microbiology
, Wiley-Blackwell 2013, Vol. 15, (7) : 1088-1110
Costa, Tiago; Amer, Ayad; Farag, Salah; et al.
2013
Mutations in hemG Mediate Resistance to Salicylidene Acylhydrazides, Demonstrating a Novel Link between Protoporphyrinogen Oxidase (HemG) and Chlamydia trachomatis Infectivity
Journal of Bacteriology
, Washington DC, USA: American Society for Microbiology 2013, Vol. 195, (18) : 4221-4230
Engström, Patrik; Nguyen, Bidong D.; Normark, Johan; et al.
2012
Concerted Actions of a Thermo-labile Regulator and a Unique Intergenic RNA Thermosensor Control Yersinia Virulence
PLOS PATHOGENS
, Vol. 8, (2) : e1002518-
Boehme, Katja; Steinmann, Rebekka; Kortmann, Jens; et al.
2012
Type III Secretion in Yersinia: Injectisome or Not?
PLoS pathogens
, Vol. 8, (5) : e1002669-
Edgren, Tomas; Forsberg, Åke; Rosqvist, Roland; et al.
2012
Small Molecule Screening for Inhibitors of the YopH Phosphatase of Yersinia pseudotuberculosis
Advances in Yersinia Research
, New York: Springer 2012 : 357-363
Eriksson, Jonas; Grundström, Christin; Sauer-Eriksson, A Elisabeth; et al.
2012
Autoproteolysis and Intramolecular Dissociation of Yersinia YscU Precedes Secretion of Its C-Terminal Polypeptide YscU CC
PLOS ONE
, Vol. 7, (11)
Frost, Stefan; Ho, Oanh; Login, Frédéric H; et al.
2012
Yersinia pseudotuberculosis Effector YopJ Subverts the Nod2/RICK/TAK1 Pathway and Activates Caspase-1 to Induce Intestinal Barrier Dysfunction
Cell Host and Microbe
, Elsevier 2012, Vol. 11, (4) : 337-351
Meinzer, Ulrich; Barreau, Frederick; Esmiol-Welterlin, Sophie; et al.
2011
Translocation of surface-localized effectors in type III secretion
Proceedings of the National Academy of Sciences of the United States of America
, Vol. 108, (4) : 1639-1644
Akopyan, Karen; Edgren, Tomas; Wang-Edgren, Helen; et al.
2011
Optimization of a sample preparation method for the metabolomic analysis of clinically relevant bacteria
Journal of Microbiological Methods
, Elsevier 2011, Vol. 87, (1) : 24-31
Marcinowska, Renata; Trygg, Johan; Wolf-Watz, Hans; et al.
2011
The RACK1 signaling scaffold protein selectively interacts with Yersinia pseudotuberculosis virulence function
PLOS ONE
, San Francisco: Public Library of Science 2011, Vol. 6, (2) : e16784-
Thorslund, Sara E; Edgren, Tomas; Pettersson, Jonas; et al.
2010
Alternative Endogenous Protein Processing via an Autophagy-Dependent Pathway Compensates for Yersinia-Mediated Inhibition of Endosomal Major Histocompatibility Complex Class II Antigen Presentation
Infection and Immunity
, American Society for Microbiology 2010, Vol. 78, (12) : 5138-5150
Rüssmann, Holger; Panthel, Klaus; Kohn, Brigitte; et al.
2009
Autoproteolysis of YscU of Yersinia pseudotuberculosis is important for regulation of expression and secretion of Yop proteins
Journal of Bacteriology
, Vol. 191, (13) : 4259-4267
Björnfot, Ann-Catrin; Lavander, Moa; Forsberg, Åke; et al.
2009
The membrane localization domain is required for intracellular localization and autoregulation of YopE in Yersinia pseudotuberculosis.
Infection and Immunity
, American Society for Microbiology 2009, Vol. 77, (11) : 4740-4749
Isaksson, Elin L; Aili, Margareta; Fahlgren, Anna; et al.
2009
Attenuation and preserved immunogenic potential of Yersinia pseudotuberculosis mutant strains evidenced in oral pig model
Zoonoses and Public Health
, John Wiley & Sons 2009, Vol. 56, (4) : 157-168
Najdenski, H; Golkocheva-Markova, E; Kussovski, V; et al.
2009
Virulensblockerande antibiotika: Antibakteriella medel med helt ny verkningsmekanism
Läkartidningen
, Vol. 106, (40) : 2543-2545
Sundin, Charlotta; Elofsson, Mikael; Wolf-Watz, Hans; et al.
2008
Regulation of Yersinia Yop-effector delivery by translocated YopE
International Journal of Medical Microbiology
, Elsevier 2008, Vol. 298, (3-4) : 183-192
Aili, Margareta; Isaksson, Elin L; Carlsson, Sara E; et al.
2008
The influence of in vitro fitness defects on pneumococcal ability to colonize and to cause invasive disease.
BMC Microbiology
, Vol. 8 : 65-
Fernebro, Jenny; Blomberg, Christel; Morfeldt, Eva; et al.
2008
Virulence blockers as alternatives to antibiotics: type III secretion inhibitors against Gram-negative bacteria
Journal of Internal Medicine
, Wiley-Blackwell 2008, Vol. 264, (1) : 17-29
Keyser, P.; Elofsson, Mikael; Rosell, S.; et al.
2008
Nod2 mediates susceptibility to Yersinia pseudotuberculosis in mice.
PLoS ONE
, Vol. 3, (7) : e2769-
Meinzer, Ulrich; Esmiol-Welterlin, Sophie; Barreau, Frederick; et al.
2007
Small molecule inhibitors of type III secretion in Yersinia block the Chlamydia pneumoniae infection cycle
FEBS Letters
, Elsevier 2007, Vol. 581, (4) : 587-595
Bailey, Leslie; Gylfe, Åsa; Sundin, Charlotta; et al.
2007
Phenotypic characterization of a virulence-associated protein, VagH, of Yersinia pseudotuberculosis reveals a tight link between VagH and the type III secretion system.
Microbiology
, Society for General Microbiology 2007, Vol. 153, (Pt 5) : 1464-73
Garbom, Sara; Olofsson, Martina; Björnfot, Ann-Catrin; et al.
2007
Inhibition of Type III Secretion in Salmonella enterica Serovar Typhimurium by Small-Molecule Inhibitors
Antimicrobial Agents and Chemotherapy
, Vol. 51, (7) : 2631-5
Hudson, Debra L; Layton, Abigail N; Field, Terry R; et al.
2007
Identification of a molecular target for the Yersinia protein kinase A.
Mol Cell
, Vol. 26, (4) : 465-77
Navarro, Lorena; Koller, Antonius; Nordfelth, Roland; et al.
2007
Salicylidene Acylhydrazides That Affect Type III Protein Secretion in Salmonella enterica Serovar Typhimurium
Antimicrobial Agents and Chemotherapy
, Vol. 51, (8) : 2867-76
Negrea, Aurel; Bjur, Eva; Eriksson Ygberg, Sofia; et al.
2006
Functional analysis of the YopE GTPase-activating protein (GAP) activity of Yersinia pseudotuberculosis
Cellular Microbiology
, Wiley 2006, Vol. 8, (6) : 1020-1033
Aili, Margareta; Isaksson, Elin L; Hallberg, Bengt; et al.
2006
Protein delivery into eukaryotic cells by type III secretion machines.
Nature
, Vol. 444, (7119) : 567-73
Galán, Jorge E; Wolf-Watz, Hans
2006
A small-molecule inhibitor of type III secretion inhibits different stages of the infectious cycle of Chlamydia trachomatis
Proceedings of the National Academy of Sciences of the United States of America
, Washington: The Acad. 2006, Vol. 103, (39) : 14566-14571
Muschiol, Sandra; Bailey, Leslie; Gylfe, Asa; et al.
2006
A small-molecule inhibitor of type III secretion inhibits different stages of the infectious cycle of Chlamydia trachomatis
National Academy of Sciences, USA: A small-molecule inhibitor of type III secretion inhibits different stages of the infectious cycle of Chlamydia trachomatis
: 14566-71
Muschiol, Sandra; Bailey, Leslie; Gylfe, Åsa; et al.
2006
The Ser/Thr kinase activity of the Yersinia protein kinase A (YpkA) is necessary for full virulence in the mouse, mollifying phagocytes, and disrupting the eukaryotic cytoskeleton.
Microb Pathog
, Vol. 40, (5) : 234-43
Wiley, David J; Nordfeldth, Roland; Rosenzweig, Jason; et al.
2005
Small-molecule inhibitors specifically targeting type III secretion
Infection and Immunity
, Washington: American Society for Microbiology 2005, Vol. 73, (5) : 3104-3114
Nordfelth, R.; Kauppi, Anna M.; Norberg, H. A.; et al.
2005
Induction of CD8+ T cell responses by Yersinia vaccine carrier strains.
Vaccine
, Vol. 23, (42) : 4984-98
Wiedig, Carolin A; Kramer, Uwe; Garbom, Sara; et al.
2004
Type III secretion systems in animal- and plant-interacting bacteria
Cellular Microbiology
, ASM Press, Washington, D.C. 2004 : 362-392
Francis, Matthew S; Schesser, Kurt; Forsberg, Åke; et al.
2004
Identification of novel virulence-associated genes via genome analysis of hypothetical genes.
Infection and Immunity
, Vol. 72, (3) : 1333-1340
Garbom, Sara; Forsberg, Ake; Wolf-Watz, Hans; et al.
2004
The YopD translocator of Yersinia pseudotuberculosis is a multifunctional protein comprised of discrete domains.
Journal of Bacteriology
, Vol. 186, (13) : 4110-4123
Olsson, Jan; Edqvist, Petra J; Bröms, Jeanette E; et al.
2004
Visualisation of zebrafish infection by GFP-labelled Vibrio anguillarum.
Microb Pathog
, Vol. 37, (1) : 41-6
O'Toole, Ronan; Von Hofsten, Jonas; Rosqvist, Roland; et al.
2003
In vitro GAP activity towards RhoA, Rac1 and Cdc42 is not a prerequisite for YopE induced HeLa cell cytotoxicity
Microbial Pathogenesis
, Elsevier 2003, Vol. 34, (6) : 297-308
Aili, Margareta; Telepnev, Max; Hallberg, Bengt; et al.
2003
Interaction between the Yersinia protein tyrosine phosphatase YopH and eukaryotic Cas/Fyb is an important virulence mechanism
Cellular Microbiology
, Blackwell Publishing 2003, Vol. 5, (1) : 53-64
Deleuil, Fabienne; Mogemark, Lena; Francis, Matthew S; et al.
2003
YscP and YscU Regulate Substrate Specificity of the Yersinia Type III Secretion System
Journal of Bacteriology
, American Society for Microbiology 2003, Vol. 185, (7) : 2259-2266
Edqvist, Petra; Olsson, Jan; Lavander, Moa; et al.
2003
Salicylanilides are potent inhibitors of type III secretion in Yersinia
Advances in Experimental Medicine and Biology
, Vol. 529 : 97-100
Kauppi, Anna; Nordfelth, Roland; Hägglund, U; et al.
2003
Targeting bacterial Virulence: Inhibitors of type III secretion in Yersinia
Chemistry and Biology
, Vol. 10, (3) : 241-249
Kauppi, Anna; Nordfelth, Roland; Uvell, Hanna; et al.
2003
Characterisation of the type III secretion protein YscU in Yersinia pseudotuberculosis: YscU cleavage--dispensable for TTSS but essential for survival
Advances in Experimental Medicine and Biology
, Vol. 529 : 109-112
Lavander, Moa; Sundberg, Lena; Edqvist, Petra J; et al.
2002
GAP activity of Yersinia YopE
Methods in Enzymology
, Vol. 358 : 359-70
Aili, Margareta; Hallberg, Bengt; Wolf-Watz, Hans; et al.
Visa publikationer i DiVA
Forskargrupper
Forskningsledare
Hans Wolf-Watz lab
+ Visa mer
- Visa mindre