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Umeå universitet
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Huvudmenyn dold.
Personalbild Elisabeth Sauer-Eriksson

Elisabeth Sauer-Eriksson

Röntgenkristallografi på makromolekyler

Vetenskaplig meritering: Docent
0000-0003-0124-0199

Kontakt

E-post
elisabeth.sauer-eriksson@umu.se
Telefon
090-786 59 23, 070-633 53 20

Verksam vid

Anknytning
Professor vid Kemiska institutionen
Plats
KB.E4, Linnaeus väg 10, (rum: 4.07.02) Umeå universitet, 901 87 Umeå

Elisabeth Sauer-Erikssons är strukturbiolog och hennes grupp studerar kopplingen mellan struktur och funktion i de interaktioner som finns mellan RNA-RNA och mellan RNA-proteiner. Gruppen studierar även amyloidbildning och molekylära mekanismer för värd-patogen interaktioner. Syftet med det senare projektet är att förbättra våra möjligheter att få fram nya och förbättrade läkemedel mot infektionssjukdomar. För sin forskning används tekniker som röntgenkristallografi, kemisk biologi och olika biokemiska och biofysiska metoder. 

 

För mer information se hemsidan för Integrated Structural Biology

Magnesium induced structural reorganization in the active site of adenylate kinase
Science Advances, American Association for the Advancement of Science (AAAS) 2024, Vol. 10, (32)
Nam, Kwangho; Thodika, Abdul Raafik Arattu; Tischlik, Sonja; et al.
Structural insights into CodY activation and DNA recognition
Nucleic Acids Research, Oxford University Press 2023, Vol. 51, (14) : 7631-7648
Hainzl, Tobias; Bonde, Mari; Almqvist, Fredrik; et al.
Insights into Enzymatic Catalysis from Binding and Hydrolysis of Diadenosine Tetraphosphate by E. coli Adenylate Kinase
Biochemistry, American Chemical Society (ACS) 2023, Vol. 62, (15) : 2238-2243
Tischlik, Sonja; Oelker, Melanie; Rogne, Per; et al.
A highly substituted ring-fused 2-pyridone compound targeting PrfA and the efflux regulator BrtA in listeria monocytogenes
mBio, American Society for Microbiology 2023, Vol. 14, (3)
Tükenmez, Hasan; Singh, Pardeep; Sarkar, Souvik; et al.
Inhibition of the master regulator of Listeria monocytogenes virulence enables bacterial clearance from spacious replication vacuoles in infected macrophages
PLoS Pathogens, Public Library Science 2022, Vol. 18, (1)
Tran, Thao Thanh; Mathmann, Carmen D.; Gatica-Andrades, Marcela; et al.
Insights into the evolution of enzymatic specificity and catalysis: from Asgard archaea to human adenylate kinases
Science Advances, American Association for the Advancement of Science (AAAS) 2022, Vol. 8, (44)
Verma, Apoorv; Åberg-Zingmark, Emma; Sparrman, Tobias; et al.
Structural basis for transthyretin amyloid formation in vitreous body of the eye
Nature Communications, Nature Publishing Group 2021, Vol. 12, (1)
Iakovleva, Irina; Hall, Michael; Oelker, Melanie; et al.
A Novel Growth-Based Selection Strategy Identifies New Constitutively Active Variants of the Major Virulence Regulator PrfA in Listeria monocytogenes
Journal of Bacteriology, American Society for Microbiology 2020, Vol. 202, (11)
Hansen, Sabine; Hall, Michael; Grundström, Christin; et al.
Structural Basis for GTP versus ATP Selectivity in the NMP Kinase AK3
Biochemistry, American Chemical Society (ACS) 2020, Vol. 59, (38) : 3570-3581
Rogne, Per; Dulko-Smith, Beata; Goodman, Jack; et al.
Principles of ATP and GTP Selectivity in NMP Kinases
Biophysical Journal, Cell Press 2020, Vol. 118, (3) : 193A-193A
Rogne, Per; Sauer-Eriksson, Elisabeth; Sauer, Uwe H.; et al.
Control of Bacterial Virulence through the Peptide Signature of the Habitat
Cell Reports, Elsevier 2019, Vol. 26, (7) : 1815-1827
Krypotou, Emilia; Scortti, Mariela; Grundström, Christin; et al.
Nucleation of an Activating Conformational Change by a Cation−Π Interaction
Biochemistry, American Chemical Society (ACS) 2019, Vol. 58, (32) : 3408-3412
Rogne, Per; Andersson, David; Grundström, Christin; et al.
Structural evidence for an essential Fe–S cluster in the catalytic core domain of DNA polymerase ϵ
Nucleic Acids Research, Oxford University Press 2019, Vol. 47, (11) : 5712-5722
ter Beek, Josy; Parkash, Vimal; Bylund, Göran; et al.
Positive and Negative Substrate Interference Supported by Coinciding Enzyme Residues
Biophysical Journal, CELL PRESS 2019, Vol. 116, (3) : 485A-485A
Wolf-Watz, Magnus; Rogne, Per; Sauer-Eriksson, A. Elisabeth; et al.
Structure-based design of inhibitors targeting PrfA, the master virulence regulator of Listeria monocytogenes
Journal of Medicinal Chemistry, American Chemical Society (ACS) 2018, Vol. 61, (9) : 4165-4175
Kulén, Martina; Lindgren, Marie; Hansen, Sabine; et al.
Interspecies variation between fish and human transthyretins in their binding of thyroid-disrupting chemicals
Environmental Science and Technology, American Chemical Society (ACS) 2018, Vol. 52, (20) : 11865-11874
Zhang, Jin; Grundström, Christin; Brännström, Kristoffer; et al.
Structural basis for ligand binding to an enzyme by a conformational selection pathway
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences 2017, Vol. 114, (24) : 6298-6303
Kovermann, Michael; Grundström, Christin; Sauer-Eriksson, A. Elisabeth; et al.
Attenuating Listeria monocytogenes virulence by targeting the regulatory protein PrfA
Cell chemical biology, Vol. 23, (3) : 404-414
Good, James A. D.; Andersson, Christopher; Hansen, Sabine; et al.
Structural basis for glutathione-mediated activation of the virulence regulatory protein PrfA in Listeria
Proceedings of the National Academy of Sciences of the United States of America, Vol. 113, (51) : 14733-14738
Hall, Michael; Grundström, Christin; Begum, Afshan; et al.
Tetrabromobisphenol A Is an Efficient Stabilizer of the Transthyretin Tetramer
PLOS ONE, Public Library Science 2016, Vol. 11, (4)
Iakovleva, Irina; Begum, Afshan; Brännström, Kristoffer; et al.
Modifications of the 7-Hydroxyl Group of the Transthyretin Ligand Luteolin Provide Mechanistic Insights into Its Binding Properties and High Plasma Specificity
PLOS ONE, Public Library Science 2016, Vol. 11, (4)
Nilsson, Lina; Larsson, Andreas; Begum, Afshan; et al.
Structure-based Virtual Screening Protocol for in silico Identification of Potential Thyroid Disrupting Chemicals Targeting Transthyretin
Environmental Science and Technology, Vol. 50, (21) : 11984-11993
Zhang, Jin; Begum, Afshan; Brännström, Kristoffer; et al.
Crystal structure and functional characterization of Photosystem II-associated carbonic anhydrase CAH3 in Chlamydomonas reinhardtii
Plant Physiology, American Society of Plant Biologists 2015, Vol. 167, (3) : 950-962
Benlloch, Reyes; Shevela, Dmitriy; Hainzl, Tobias; et al.
Signal-sequence induced conformational changes in the signal recognition particle
Nature Communications, Vol. 6
Hainzl, Tobias; Sauer-Eriksson, A. Elisabeth
The flavonoid luteolin, but not luteolin-7-o-glucoside, prevents a transthyretin mediated toxic response
PLOS ONE, Public Library Science 2015, Vol. 10, (5)
Iakovleva, Irina; Begum, Afshan; Pokrzywa, Malgorzata; et al.
Enthalpic Forces Correlate with Selectivity of Transthyretin-Stabilizing Ligands in Human Plasma
Journal of Medicinal Chemistry, Vol. 58, (16) : 6507-6515
Iakovleva, Irina; Brännström, Kristoffer; Nilsson, Lina; et al.
Structural basis for catalytically restrictive dynamics of a high-energy enzyme state
Nature Communications, Macmillan Publishers Ltd. 2015, Vol. 6
Kovermann, Michael; Ådén, Jörgen; Grundström, Christin; et al.
Domain isolation, expression, purification and proteolytic activity of the metalloprotease PrtV from Vibrio cholerae
Protein Expression and Purification, Elsevier 2014, Vol. 96 : 39-47
Edwin, Aaron; Grundström, Christin; Wai, Sun Nyunt; et al.
Structural basis for processive DNA synthesis by yeast DNA polymerase ε
Nature Structural & Molecular Biology, Nature Publishing Group 2014, Vol. 21, (1) : 49-56
Hogg, Matthew; Osterman, Pia; Bylund, Göran; et al.
Calcium binding by the PKD1 domain regulates interdomain flexibility in Vibrio cholerae metalloprotease PrtV
FEBS Open Bio, Elsevier 2013, Vol. 3 : 263-270
Edwin, Aaron; Rompikuntal, Pramod; Björn, Erik; et al.
Small Molecule Screening for Inhibitors of the YopH Phosphatase of Yersinia pseudotuberculosis
Advances in Yersinia Research, New York: Springer 2012 : 357-363
Eriksson, Jonas; Grundström, Christin; Sauer-Eriksson, A Elisabeth; et al.
Promiscuous DNA synthesis by human DNA polymerase θ
Nucleic Acids Research, Vol. 40, (6) : 2611-2622
Hogg, Matthew; Sauer-Eriksson, A Elisabeth; Johansson, Erik
Expression and purification of SfaXII, a protein involved in regulating adhesion and motility genes in extraintestinal pathogenic Escherichia coli
Protein Expression and Purification, Elsevier 2012, Vol. 86, (2) : 127-134
Paracuellos, Patricia; Öhman, Anders; Sauer-Eriksson, A Elisabeth; et al.
Assembly and function of the signal recognition particle from archaea
Macromolecular Crystallography, Dordrecht: Springer 2012 : 125-133
Sauer-Eriksson, A. Elisabeth; Huang, Shenghua; Hainzl, Tobias
Structural basis of signal-sequence recognition by the signal recognition particle 
Nature Structural & Molecular Biology, Vol. 18, (3) : 389-391
Hainzl, Tobias; Huang, Shenghua; Meriläinen, Gitte; et al.
Structural studies of β-Carbonic Anhydrase from the Green Alga Coccomyxa: Inhibitor complexes with Anions and Acetazolamide
PLOS ONE, Vol. 6, (12) : e28458-
Huang, Shenghua; Hainzl, Tobias; Grundström, Christin; et al.
Purification, crystallization and preliminary data analysis of FocB, a transcription factor regulating fimbrial adhesin expression in uropathogenic Escherichia coli
Acta Crystallographica. Section F: Structural Biology and Crystallization Communications, Vol. 66, (Pt 3) : 337-341
Wikström Hultdin, Ulrika; Lindberg, Stina; Grundström, Christin; et al.
Structure of FocB: a member of a family of transcription factors regulating fimbrial adhesin expression in uropathogenic Escherichia coli
The FEBS Journal, Wiley 2010, Vol. 277, (16) : 3368-3381
Wikström Hultdin, Ulrika; Lindberg, Stina; Grundström, Christin; et al.
Stability and fibril formation properties of human and fish transthyretin, and of the Escherichia coli transthyretin-related protein
The FEBS Journal, Wiley InterScience 2009, Vol. 276, (7) : 1999-2011
Lundberg, Erik; Olofsson, Anders; Westermark, Gunilla T; et al.
Quenched hydrogen/deuterium exchange NMR characterization of amyloid-β peptide aggregates formed in the presence of Cu2+ or Zn2+
The FEBS Journal, Wiley InterScience 2009, Vol. 276, (15) : 4051-4060
Olofsson, Anders; Lindhagen Persson, Malin; Vestling, Monika; et al.
Amyloid fibril dynamics revealed by combined hydrogen/deuterium exchange and nuclear magnetic resonance
Analytical Biochemistry, Elsevier 2009, Vol. 385, (2) : 374-376
Olofsson, Anders; Sauer-Eriksson, A Elisabeth; Öhman, Anders
Transthyretin-related and transthyretin-like proteins
Recent advances in Transthyretin evolution, structure and biological functions, Springer Berlin/Heidelberg 2009 : 109-122
Sauer-Eriksson, Elisabeth; Linusson, Anna; Lundberg, Erik
Hormone affinity and fibril formation of piscine transthyretin: The role of the N-terminal
Molecular and Cellular Endocrinology, Elsevier Ireland Ltd 2008, Vol. 295, (1-2) : 48-58
Morgado, Isabel; Melo, Eduardo P; Lundberg, Erik; et al.
Interaction of signal-recognition particle 54 GTPase domain and signal-recognition particle RNA in the free signal-recognition particle.
Proc Natl Acad Sci U S A, Vol. 104, (38) : 14911-6
Hainzl, Tobias; Huang, Shenghua; Sauer-Eriksson, Elisabeth
Heating of proteins as a means of improving crystallization: a successful case study on a highly amyloidogenic triple mutant of human transthyretin.
Acta Crystallographica. Section F: Structural Biology and Crystallization Communications, Vol. 63, (Pt 8) : 695-700
Karlsson, Anders; Sauer-Eriksson, Elisabeth
Negatively Charged Phospholipid Membranes Induce Amyloid Formation of Medin via an alpha-Helical Intermediate
Journal of Molecular Biology, Vol. 374, (1) : 186-94
Olofsson, Anders; Borowik, Tomasz; Gröbner, Gerhard; et al.
Amide solvent protection analysis demonstrates that amyloid-beta(1-40) and amyloid-beta(1-42) form different fibrillar structures under identical conditions.
Biochem J, Vol. 404, (1) : 63-70
Olofsson, Anders; Lindhagen-Persson, Malin; Sauer-Eriksson, Elisabeth; et al.
Conformational variability of the GTPase domain of the signal recognition particle receptor FtsY.
J Struct Biol, Vol. 153, (1) : 85-96
Gariani, Talal; Samuelsson, Tore; Sauer-Eriksson, Elisabeth
The transthyretin-related protein: structural investigation of a novel protein family
Journal of Structural Biology, San Diego: Academic Press 2006, Vol. 155, (3) : 445-457
Lundberg, Erik; Bäckström, Stefan; Sauer, Uwe; et al.
The solvent protection of alzheimer amyloid-beta-(1-42) fibrils as determined by solution NMR spectroscopy.
Journal of Biological Chemistry, Vol. 281, (1) : 477-83
Olofsson, Anders; Sauer-Eriksson, Elisabeth; Öhman, Anders
Visa publikationer i DiVA

Forskargrupper

Forskningsledare
Elisabeth Sauer-Eriksson Lab

Forskningsprojekt

1 januari 2020 till 31 december 2023
Utforskande om de molekylära mekanismer som styr bakteriell virulens