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Umeå universitet
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Huvudmenyn dold.
Personalbild Elin Thysell

Elin Thysell

Biträdande huvudprojektledare för forskningsprojektet PREDICT

Translationell forskare och bioinformatiker vars arbete fokuserar på molekylär epidemiologi och tumörbiologi inom prostatacancer

Kontakt

E-post
elin.thysell@umu.se
Telefon
090-786 54 80

Verksam vid

Anknytning
Staff scientist vid Institutionen för medicinsk biovetenskap Enhet: Patologi
Plats
By 6M, Sjukhusområdet Umeå universitet, 901 85 Umeå

Disputerad forskare in om läkemedelskemi och bioinformatik, vars arbete hittills har inriktats på att upptäcka och förstå sjukdomsprocesser, särskilt kopplat till prognos och behandlingsval hos patienter med prostatacancer.

Dr Thysell är delaktig i flera stora internationella samarbeten som kopplar ihop riskfaktorer som livsstil och miljö med dess roll i sjukdomsutveckling av prostatacancer men även mjed forskning inom andra områden så som osteoporos och Covid19.

Hon har bred kunskap kopplat till flerårigt arbete inom de populationsbaserade biobanker, samt stor erfarenhet av samverkan med flertalet intressenter och organisationer inom life science och läkemedelssektorn.

Molekylära subtyper och avancerad prostatacancer: nya möjligheter för anpassad behandling: [Molecular subtypes provide possibilities for precision medicine in a advanced prostate cancer]
Läkartidningen, Läkartidningen Förlag AB 2024, Vol. 121
Wikström, Pernilla; Bergh, Anders; Josefsson, Andreas; et al.
Intake of the total, classes, and subclasses of (poly)phenols and risk of prostate cancer: a prospective analysis of the EPIC study
Cancers, MDPI 2023, Vol. 15, (16)
Almanza-Aguilera, Enrique; Guiñón-Fort, Daniel; Perez-Cornago, Aurora; et al.
Investigating microRNA Profiles in Prostate Cancer Bone Metastases and Functional Effects of microRNA-23c and microRNA-4328
Cancers, MDPI 2023, Vol. 15, (9)
Järemo, Helena; Semenas, Julius; Halin Bergström, Sofia; et al.
Protein and amino acid intakes in relation to prostate cancer risk and mortality: A prospective study in the European Prospective Investigation into Cancer and Nutrition
Cancer Medicine, John Wiley & Sons 2023, Vol. 12, (4) : 4725-4738
Schmidt, Julie A.; Huybrechts, Inge; Overvad, Kim; et al.
Circulating insulin-like growth factors and risks of overall, aggressive and early-onset prostate cancer: a collaborative analysis of 20 prospective studies and Mendelian randomization analysis
International Journal of Epidemiology, Oxford University Press 2023, Vol. 52, (1) : 71-86
Watts, Eleanor L.; Perez-Cornago, Aurora; Fensom, Georgina K.; et al.
A novel radiographic pattern related to poor prognosis in patients with prostate cancer with metastatic spinal cord compression
European Urology Open Science, Elsevier 2023, Vol. 48 : 44-53
Wänman, Johan; Abul-Kasim, Kasim; Semenas, Julius; et al.
Prostate cancer polygenic risk score and prediction of lethal prostate cancer
npj Precision Oncology, Nature Publishing Group 2022, Vol. 6, (1)
Klein, Robert J.; Vertosick, Emily; Sjoberg, Dan; et al.
Clinical and biological relevance of the transcriptomic-based prostate cancer metastasis subtypes MetA-C
Molecular Oncology, John Wiley & Sons 2022, (4)
Thysell, Elin; Köhn, Linda; Semenas, Julius; et al.
Circulating free testosterone and risk of aggressive prostate cancer: Prospective and Mendelian randomisation analyses in international consortia
International Journal of Cancer, John Wiley & Sons 2022, Vol. 151, (7) : 1033-1046
Watts, Eleanor L.; Perez-Cornago, Aurora; Fensom, Georgina K.; et al.
Epithelial and stromal characteristics of primary tumors predict the bone metastatic subtype of prostate cancer and patient survival after androgen-deprivation therapy
Cancers, MDPI 2022, Vol. 14, (21)
Wikström, Pernilla; Halin Bergström, Sofia; Josefsson, Andreas; et al.
Identification of prediagnostic metabolites associated with prostate cancer risk by untargeted mass spectrometry-based metabolomics: a case-control study nested in the Northern Sweden Health and Disease Study
International Journal of Cancer, John Wiley & Sons 2022, Vol. 151, (12) : 2115-2127
Östman, Johnny R.; Pinto, Rui C.; Ebbels, Timothy M. D.; et al.
A novel DNA methylation signature is associated with androgen receptor activity and patient prognosis in bone metastatic prostate cancer
Clinical Epigenetics, BioMed Central 2021, Vol. 13, (1)
Bovinder Ylitalo, Erik; Thysell, Elin; Landfors, Mattias; et al.
A Neanderthal OAS1 isoform protects individuals of European ancestry against COVID-19 susceptibility and severity
Nature Medicine, Nature Publishing Group 2021, Vol. 27 : 659-667
Zhou, Sirui; Butler-Laporte, Guillaume; Nakanishi, Tomoko; et al.
High monocyte count and expression of s100a9 and s100a12 in peripheral blood mononuclear cells are associated with poor outcome in patients with metastatic prostate cancer
Cancers, MDPI 2021, Vol. 13, (10)
Åberg, Anna-Maja; Halin Bergström, Sofia; Thysell, Elin; et al.
Marked response to cabazitaxel in prostate cancer xenografts expressing androgen receptor variant 7 and reversion of acquired resistance by anti-androgens
The Prostate, John Wiley & Sons 2020, Vol. 80, (2) : 214-224
Bovinder Ylitalo, Erik; Thysell, Elin; Thellenberg-Karlsson, Camilla; et al.
Comprehensive metabolomics analysis of prostate cancer tissue in relation to tumor aggressiveness and TMPRSS2-ERG fusion status
BMC Cancer, BioMed Central 2020, Vol. 20, (1)
Dudka, Ilona; Thysell, Elin; Lundquist, Kristina; et al.
A nutrient-wide association study for risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition and the Netherlands Cohort Study
European Journal of Nutrition, Springer Berlin/Heidelberg 2020, Vol. 59, (7) : 2929-2937
Papadimitriou, Nikos; Muller, David; van den Brandt, Piet A.; et al.
Identification of metabolites associated with prostate cancer risk: a nested case-control study with long follow-up in the Northern Sweden Health and Disease Study
BMC Medicine, BioMed Central 2020, Vol. 18, (1)
Röhnisch, Hanna E.; Kyro, Cecilie; Olsen, Anja; et al.
Immunoreactivity for prostate specific antigen and Ki67 differentiates subgroups of prostate cancer related to outcome
Modern Pathology, Vol. 32, (9) : 1310-1319
Hammarsten, Peter; Josefsson, Andreas; Thysell, Elin; et al.
Gene expression profiles define molecular subtypes of prostate cancer bone metastases with different outcomes and morphology traceable back to the primary tumor
Molecular Oncology, John Wiley & Sons 2019, Vol. 13, (8) : 1763-1777
Thysell, Elin; Vidman, Linda; Bovinder Ylitalo, Erik; et al.
The associations of anthropometric, behavioural and sociodemographic factors with circulating concentrations of IGF‐I, IGF‐II, IGFBP‐1, IGFBP‐2 and IGFBP‐3 in a pooled analysis of 16,024 men from 22 studies
International Journal of Cancer, John Wiley & Sons 2019, Vol. 145, (12) : 3244-3256
Watts, Eleanor L.; Perez-Cornago, Aurora; Appleby, Paul N.; et al.
Bone remodeling in relation to androgen receptor activity in prostate cancer bone metastases
Cancer Research, American Association for Cancer Research 2018, Vol. 78, (16) : 50-50
Bovinder Ylitalo, Erik; Nordstrand, Annika; Thysell, Elin; et al.
The proteome of prostate cancer bone metastases
Cancer Research, American Association for Cancer Research 2018, Vol. 78, (16) : 91-92
Iglesias-Gato, Diego; Thysell, Elin; Crnalic, Sead; et al.
The Proteome of Prostate Cancer Bone Metastasis Reveals Heterogeneity with Prognostic Implications
Clinical Cancer Research, American Association for Cancer Research 2018, Vol. 24, (21) : 5433-5444
Iglesias-Gato, Diego; Thysell, Elin; Tyanova, Stefka; et al.
Bone Cell Activity in Clinical Prostate Cancer Bone Metastasis and Its Inverse Relation to Tumor Cell Androgen Receptor Activity
International Journal of Molecular Sciences, MDPI 2018, Vol. 19, (4)
Nordstrand, Annika; Bovinder Ylitalo, Erik; Thysell, Elin; et al.
Clinically relevant molecular subgroups of prostate cancer bone metastases
Cancer Research, American Association for Cancer Research 2018, Vol. 78, (16) : 123-123
Thysell, Elin; Bovinder Ylitalo, Erik; Jernberg, Emma; et al.
Subgroups of castration-resistant prostate cancer bone metastases defined through an inverse relationship between androgen receptor activity and immune response
European Urology, Vol. 71, (5) : 776-787
Bovinder Ylitalo, Erik; Thysell, Elin; Jernberg, Emma; et al.
High Levels of the AR-V7 Splice Variant and Co-Amplification of the Golgi Protein Coding YIPF6 in AR Amplified Prostate Cancer Bone Metastases
The Prostate, Wiley-Blackwell Publishing Inc. 2017, Vol. 77, (6) : 625-638
Djusberg, Erik; Jernberg, Emma; Thysell, Elin; et al.
Inhibition of the insulin-like growth factor-1 receptor potentiates acute effects of castration in a rat model for prostate cancer growth in bone
Clinical and Experimental Metastasis, Springer 2017, Vol. 34, (3-4) : 261-271
Nordstrand, Annika; Halin Bergström, Sofia; Thysell, Elin; et al.
Highly aggressive rat prostate tumors rapidly precondition regional lymph nodes for subsequent metastatic growth
PLOS ONE, San Fransisco: Public Library of Science (PLoS) 2017, Vol. 12, (10)
Strömvall, Kerstin; Lundholm, Marie; Thysell, Elin; et al.
Aggressive rat prostate tumors reprogram the benign parts of the prostate and regional lymph nodes prior to metastasis
PLOS ONE, Public library science 2017, Vol. 12, (5)
Strömvall, Kerstin; Thysell, Elin; Halin Bergström, Sofia; et al.
A Systems Approach to Prostate Cancer Classification: Letter
Cancer Research, American Association for Cancer Research 2017, Vol. 77, (24) : 7131-7132
Thysell, Elin; Bovinder Ylitalo, Erik; Jernberg, Emma; et al.
Reply to Isabel Heidegger, Renate Pichler, and Andreas Pircher's Letter to the Editor re: Erik Bovinder Ylitalo, Elin Thysell, Emma Jernberg, et al. Subgroups of Castration-resistant Prostate Cancer Bone Metastases Defined Through an Inverse Relationship Between Androgen Receptor Activity and Immune Response. Eur Urol 2017;71:776-87
European Urology, Elsevier 2017, Vol. 72, (4) : E104-E105
Thysell, Elin; Ylitalo, Erik B.; Jernberg, Emma; et al.
Reply to Isabel Heidegger, Renate Pichler, and Andreas Pircher's Letter to the Editor re: Erik Bovinder Ylitalo, Elin Thysell, Emma Jernberg, et al. Subgroups of Castration-resistant Prostate Cancer Bone Metastases Defined Through an Inverse Relationship Between Androgen Receptor Activity and Immune Response. Eur Urol 2017;71:776-87
European Urology, ELSEVIER SCIENCE BV 2017, Vol. 72, (4) : e104-e105
Thysell, Elin; Ylitalo, Erik B.; Jernberg, Emma; et al.
Extracellular Vesicles from Metastatic Rat Prostate Tumors Prime the Normal Prostate Tissue to Facilitate Tumor Growth
Scientific Reports, Nature Publishing Group 2016, Vol. 6
Halin Bergström, Sofia; Hägglöf, Christina; Thysell, Elin; et al.
Extratumoral Heme Oxygenase-1 (HO-1) Expressing Macrophages Likely Promote Primary and Metastatic Prostate Tumor Growth
PLOS ONE, Vol. 11, (6)
Halin Bergström, Sofia; Nilsson, Maria; Adamo, Hanibal; et al.
The Proteome of Primary Prostate Cancer
European Urology, Vol. 69, (5) : 942-952
Iglesias-Gato, Diego; Wikström, Pernilla; Tyanova, Stefka; et al.
Constrained randomization and multivariate effect projections improve information extraction and biomarker pattern discovery in metabolomics studies involving dependent samples
Metabolomics, Springer 2015, Vol. 11, (6) : 1667-1678
Jonsson, Pär; Wuolikainen, Anna; Thysell, Elin; et al.
High Lysyl Oxidase (LOX) in the Non-Malignant Prostate Epithelium Predicts a Poor Outcome in Prostate Cancer Patient Managed by Watchful Waiting
PLOS ONE, Public library science 2015, Vol. 10, (10)
Nilsson, Maria; Hägglöf, Christina; Hammarsten, Peter; et al.
Characterization of prostate cancer bone metastases according to expression levels of steroidogenic enzymes and androgen receptor splice variants
PLOS ONE, Public Library of Science 2013, Vol. 8, (11) : e77407-
Jernberg, Emma; Thysell, Elin; Bovinder Ylitalo, Erik; et al.
Multivariate profiling of metabolites in human disease: Method evaluation and application to prostate cancer
Umeå: Umeå Universitet 2012
Thysell, Elin
Validated and Predictive Processing of Gas Chromatography-Mass Spectrometry Based Metabolomics Data for Large Scale Screening Studies, Diagnostics and Metabolite Pattern Verification
Metabolites, Basel: MDPI 2012, Vol. 2 : 796-817
Thysell, Elin; Chorell, Elin; Svensson, Michael B; et al.
Validated and predictive processing of gas chromatography-mass spectra screening studies, diagnostics and metabolite pattern verification
Metabolites, M D P I AG 2012, Vol. 2, (4) : 796-817
Thysell, Elin; Chorell, Elin; Svensson, Michael; et al.
Metabolomic characterization of human prostate cancer bone metastases reveals increased levels of cholesterol
PLoS One, Public Library of Science 2010, Vol. 5, (12)
Thysell, Elin; Surowiec, Izabella; Hörnberg, Emma; et al.
Increased levels of macrophage-secreted Cathepsin S during Prostate Cancer progression in TRAMP mice and patients
Cancer Genomics and Proteomics, The International Institute of Anticancer Research 2009, Vol. 6, (3) : 149-159
Lindahl, Charlotta; Simonsson, Monika; Bergh, Anders; et al.
A multivariate approach to investigate docking parameters' effects on docking performance
Journal of chemical information and modeling, American Chemical Society Publications 2007, Vol. 47, (4) : 1673-1687
Andersson, David C.; Thysell, Elin; Lindström, Anton; et al.
A Multivariate Screening Strategy for Investigating Metabolic Effects of Strenuous Physical Exercise in Human Serum
Journal of Proteome Research, American Chemical Society 2007, Vol. 6, (6) : 2113-2120
Chorell, Elin; Thysell, Elin; Jonsson, Pär; et al.
SELDI-TOF MS versus prostate specific antigen analysis of prospective plasma samples in a nested case-control study of prostate cancer
International Journal of Cancer, Vol. 121, (3) : 615-20
Skytt, Åsa; Thysell, Elin; Stattin, Pär; et al.
Reliable Profile Detection in Comparative Metabolomics
Omics, Mary Ann Liebert 2007, Vol. 11, (2) : 209-224
Thysell, Elin; Pohjanen, Elin; Lindberg, Johan; et al.
Statistical multivariate metabolite profiling for aiding biomarker pattern detection and mechanistic interpretations in GC/MS based metabolomics
Metabolomics, Vol. 2, (4) : 257-68
Chorell, Elin; Thysell, Elin; Lindberg, Johan; et al.
Visa publikationer i DiVA

Forskargrupper

Gruppmedlem
Pernilla Wikströms labb

Forskningsprojekt

1 januari 2019 till 31 december 2022
Biomarkörer för säkrare prognostisering och förbättrad behandling av aggressiv prostatacancer
Elin Thysell Ditt blod – en nyckel i covid-forskning

Varför dör till synes friska personer av ett förkylningsvirus, medan andra knappt märker att de är sjuka?