Anders Olofsson

Vetenskaplig meritering: Docent

Kontakt

anders.olofsson@umu.se

Verksam vid

Universitetslektor vid Institutionen för klinisk mikrobiologi Enhet: Biomedicinsk laboratorievetenskap

KBC huset, Linneus väg 6 , Biomedicinsk analytikerprogrammet BML Umeå universitet, 901 85 Umeå

Misfolding of transthyretin in vivo is controlled by the redox environment and macromolecular crowding

Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology 2025, Vol. 301, (1)

Jayaweera, Sanduni Wasana; Sahin, Melisnur; Lundkvist, Fabian; et al.

ApoE isoforms inhibit amyloid aggregation of proinflammatory protein S100a9

International Journal of Molecular Sciences, MDPI 2024, Vol. 25, (4)

Ghosh, Shamasree; Tamilselvi, Shanmugam; Williams, Chloe; et al.

Plasma IAPP-autoantibody levels in Alzheimer’s disease patients are affected by APOE4 status

International Journal of Molecular Sciences, MDPI 2023, Vol. 24, (4)

Pocevičiūtė, Dovilė; Roth, Bodil; Schultz, Nina; et al.

Endogenous Human Proteins Interfering with Amyloid Formation

Biomolecules, MDPI 2022, Vol. 12, (3)

Gharibyan, Anna; Jayaweera, Sanduni Wasana; Lehmann, Manuela; et al.

K₂S₂O₈-mediated coupling of 6-amino-7-aminomethyl-thiazolino-pyridones with aldehydes to construct amyloid affecting pyrimidine-fused thiazolino-2-pyridones

Organic and biomolecular chemistry, The Royal Society of Chemistry 2021, Vol. 19, (44) : 9758-9772

Bharate, Jaideep B.; Ådén, Jörgen; Gharibyan, Anna; et al.

Mechanisms of Transthyretin Inhibition of IAPP Amyloid Formation

Biomolecules, MDPI 2021, Vol. 11, (3)

Jayaweera, Sanduni Wasana; Surano, Solmaz; Pettersson, Nina; et al.

Tandem Ring Opening/Intramolecular [2 + 2] Cycloaddition Reaction for the Synthesis of Cyclobutane Fused Thiazolino-2-Pyridones

Journal of Organic Chemistry, American Chemical Society (ACS) 2021, Vol. 86, (23) : 16582-16592

Tyagi, Mohit; Adolfsson, Dan E.; Singh, Pardeep; et al.

Intramolecular Povarov Reactions for the Synthesis of Chromenopyridine fused 2-Pyridone Polyheterocycles Binding to α-Synuclein and Amyloid-β fibrils

Journal of Organic Chemistry, American Chemical Society (ACS) 2020, Vol. 85, (21) : 14174-14189

Adolfsson, Dan E.; Tyagi, Mohit; Singh, Pardeep; et al.

Apolipoprotein E Interferes with IAPP Aggregation and Protects Pericytes from IAPP-Induced Toxicity

Biomolecules, MDPI 2020, Vol. 10, (1)

Gharibyan, Anna; Islam, Tohidul; Pettersson, Nina; et al.

Apolipoprotein E impairs amyloid-β fibril elongation and maturation

The FEBS Journal, Wiley-Blackwell 2020, Vol. 287, (6) : 1208-1219

Islam, Tohidul; Gharibyan, Anna L.; Golchin, Solmaz A.; et al.

Morphological analysis of Apolipoprotein E binding to A beta Amyloid using a combination of Surface Plasmon Resonance, Immunogold Labeling and Scanning Electron Microscopy

BMC Biotechnology, BMC 2019, Vol. 19, (1)

Islam, Tohidul; Gharibyan, Anna L.; Lee, Cheng Choo; et al.

Pyridine-Fused 2-Pyridones via Povarov and A³ Reactions: Rapid Generation of Highly Functionalized Tricyclic Heterocycles Capable of Amyloid Fibril Binding

Journal of Organic Chemistry, American Chemical Society (ACS) 2019, Vol. 84, (7) : 3887-3903

Singh, Pardeep; Adolfsson, Dan E.; Ådén, Jörgen; et al.

Scanning electron microscopy as a tool for evaluating morphology of amyloid structures formed on surface plasmon resonance chips

Data in Brief, Elsevier 2018, Vol. 19 : 1166-1170

Brännström, Kristoffer; Gharibyan, Anna L.; Islam, Tohidul; et al.

The Properties of Amyloid-β Fibrils Are Determined by their Path of Formation

Journal of Molecular Biology, Elsevier 2018, Vol. 430, (13) : 1940-1949

Brännström, Kristoffer; Islam, Tohidul; Gharibyan, Anna L.; et al.

Transthyretin Interferes with Aβ Amyloid Formation by Redirecting Oligomeric Nuclei into Non-Amyloid Aggregates

Journal of Molecular Biology, Elsevier 2018, Vol. 430, (17) : 2722-2733

Nilsson, Lina; Pamrén, Annelie; Islam, Tohidul; et al.

Amyloid-beta 1-40 is associated with alterations in NG2+ pericyte population ex vivo and in vitro

Aging Cell, John Wiley & Sons 2018, Vol. 17, (3)

Schultz, Nina; Brännström, Kristoffer; Byman, Elin; et al.

Interspecies variation between fish and human transthyretins in their binding of thyroid-disrupting chemicals

Environmental Science and Technology, American Chemical Society (ACS) 2018, Vol. 52, (20) : 11865-11874

Zhang, Jin; Grundström, Christin; Brännström, Kristoffer; et al.

The role of histidines in amyloid β fibril assembly

FEBS Letters, Vol. 591, (8) : 1167-1175

Brännström, Kristoffer; Islam, Tohidul; Sandblad, Linda; et al.

Helicobacter pylori Adapts to Chronic Infection and Gastric Disease via pH-Responsive BabA-Mediated Adherence

Cell Host and Microbe, CELL PRESS 2017, Vol. 21, (3) : 376-389

Bugaytsova, Jeanna A.; Björnham, Oscar; Chernov, Yevgen A.; et al.

Tetrabromobisphenol A Is an Efficient Stabilizer of the Transthyretin Tetramer

PLOS ONE, Public Library Science 2016, Vol. 11, (4)

Iakovleva, Irina; Begum, Afshan; Brännström, Kristoffer; et al.

Modifications of the 7-Hydroxyl Group of the Transthyretin Ligand Luteolin Provide Mechanistic Insights into Its Binding Properties and High Plasma Specificity

PLOS ONE, Public Library Science 2016, Vol. 11, (4)

Nilsson, Lina; Larsson, Andreas; Begum, Afshan; et al.

Structure-based Virtual Screening Protocol for in silico Identification of Potential Thyroid Disrupting Chemicals Targeting Transthyretin

Environmental Science and Technology, Vol. 50, (21) : 11984-11993

Zhang, Jin; Begum, Afshan; Brännström, Kristoffer; et al.

The flavonoid luteolin, but not luteolin-7-o-glucoside, prevents a transthyretin mediated toxic response

PLOS ONE, Public Library Science 2015, Vol. 10, (5)

Iakovleva, Irina; Begum, Afshan; Pokrzywa, Malgorzata; et al.

Enthalpic Forces Correlate with Selectivity of Transthyretin-Stabilizing Ligands in Human Plasma

Journal of Medicinal Chemistry, Vol. 58, (16) : 6507-6515

Iakovleva, Irina; Brännström, Kristoffer; Nilsson, Lina; et al.

Interaction Studies of the Human and Arabidopsis thaliana Med25-ACID Proteins with the Herpes Simplex Virus VP16-and Plant-Specific Dreb2a Transcription Factors

PLOS ONE, Vol. 9, (5) : e98575-

Aguilar, Ximena; Blomberg, Jeanette; Brännström, Kristoffer; et al.

A Generic Method for Design of Oligomer-Specific Antibodies

PLOS ONE, Vol. 9, (3) : e90857-

Brännström, Kristoffer; Lindhagen-Persson, Malin; Gharibyan, Anna L.; et al.

The N-terminal Region of Amyloid β Controls the Aggregation Rate and Fibril Stability at Low pH Through a Gain of Function Mechanism

Journal of the American Chemical Society, American Chemical Society (ACS) 2014, Vol. 136, (31) : 10956-10964

Brännström, Kristoffer; Öhman, Anders; Nilsson, Lina; et al.

The role of pro-inflammatory S100A9 in Alzheimer's disease amyloid-neuroinflammatory cascade

Acta Neuropathologica, Vol. 127, (4) : 507-522

Wang, Chao; Klechikov, Alexey G.; Gharibyan, Anna L.; et al.

Ca2+ enhances Aβ polymerization rate and fibrillar stability in a dynamic manner

Biochemical Journal, Portland Press 2013, Vol. 450 : 189-197

Brännström, Kristoffer; Öhman, Anders; Lindhagen-Persson, Malin; et al.

Modulation of α-synuclein fibrillization by ring-fused 2-pyridones: templation and inhibition involve oligomers with different structure

Archives of Biochemistry and Biophysics, Elsevier 2013, Vol. 532, (2) : 84-90

Horvath, Istvan; Sellstedt, Magnus; Weise, Christoph; et al.

Transthyretin is dysregulated in preeclampsia, and its native form prevents the onset of disease in a preclinical mouse model

American Journal of Pathology, Elsevier 2013, Vol. 183, (5) : 1425-1436

Kalkunte, Satyan S.; Neubeck, Stefan; Norris, Wendy E.; et al.

Structural topology and activation of an initial adenylate kinase-substrate complex

Biochemistry, Vol. 52, (6) : 1055-1061

Ådén, Jörgen; Weise, Christoph; Brännström, Kristoffer; et al.

Interactions between DNA, transcriptional regulator Dreb2a and the Med25 mediator subunit from Arabidopsis thaliana involve conformational changes

Nucleic Acids Research, Oxford: Oxford University Press 2012, Vol. 40, (13) : 5938-5950

Blomberg, Jeanette; Aguilar, Ximena; Brännström, Kristoffer; et al.

Characterization of SPINK9, a KLK5-specific inhibitor expressed in palmo-plantar epidermis

Biological chemistry (Print), Walter de Gruyter 2012, Vol. 393, (5) : 369-377

Brännström, Kristoffer; Öhman, Anders; von Pawel-Rammingen, Ulrich; et al.

The C-terminal repeating units of CsgB direct bacterial functional amyloid nucleation

Journal of Molecular Biology, Elsevier 2012, Vol. 422, (3) : 376-389

Hammer, Neal D; McGuffie, Bryan A; Zhou, Yizhou; et al.

Mechanisms of Protein Oligomerization: Inhibitor of Functional Amyloids Templates α-Synuclein Fibrillation

Journal of the American Chemical Society, American Chemical Society (ACS) 2012, Vol. 134, (7) : 3439-3444

Horvath, Istvan; Weise, Christoph F; Andersson, Emma K; et al.

Aβ peptide fibrillar architectures controlled by conformational constraints of the monomer

PLOS ONE, San Francisco, CA: Public Library of Science 2011, Vol. 6, (9) : e25157-

Brännström, Kristoffer; Öhman, Anders; Olofsson, Anders

Neuroprotective and nootropic drug noopept rescues α-synuclein amyloid cytotoxicity

Journal of Molecular Biology, Vol. 414, (5) : 699-712

Jia, Xueen; Gharibyan, Anna; Öhman, Anders; et al.

Clicked tacrine conjugates as acetylcholinesterase and β-amyloid directed compounds

Organic and biomolecular chemistry, The Royal Society of Chemistry 2011, Vol. 9, (4) : 1140-1147

Ouberai, Myriam; Brännström, Kristoffer; Vestling, Monika; et al.

Functional links between Aβ toxicity, endocytic trafficking, and Alzheimer's disease risk factors in yeast

Science, Washington: American association of advancement in science 2011, Vol. 334, (6060) : 1241-1245

Treusch, Sebastian; Hamamichi, Shusei; Goodman, Jessica L; et al.

Amyloid-β oligomer specificity mediated by the IgM isotype: implications for a specific protective mechanism exerted by endogenous auto-antibodies

PLOS ONE, Public Library of Science 2010, Vol. 5, (11) : e13928-

Lindhagen-Persson, Malin; Brännström, Kristoffer; Vestling, Monika; et al.

Designed fluorescent probes reveal interactions between Amyloid-β(1-40) Peptides and G_M1 Gangliosides in Micelles and Lipid Vesicles

Biophysical Journal, Vol. 99, (5) : 1510-1519

Mikhalyov, I; Olofsson, Anders; Gröbner, Gerhard; et al.

Stability and fibril formation properties of human and fish transthyretin, and of the Escherichia coli transthyretin-related protein

The FEBS Journal, Wiley InterScience 2009, Vol. 276, (7) : 1999-2011

Lundberg, Erik; Olofsson, Anders; Westermark, Gunilla T; et al.

Quenched hydrogen/deuterium exchange NMR characterization of amyloid-β peptide aggregates formed in the presence of Cu²⁺ or Zn²⁺

The FEBS Journal, Wiley InterScience 2009, Vol. 276, (15) : 4051-4060

Olofsson, Anders; Lindhagen Persson, Malin; Vestling, Monika; et al.

Amyloid fibril dynamics revealed by combined hydrogen/deuterium exchange and nuclear magnetic resonance

Analytical Biochemistry, Elsevier 2009, Vol. 385, (2) : 374-376

Olofsson, Anders; Sauer-Eriksson, A Elisabeth; Öhman, Anders

Disordered proteins: Biological membranes as two-dimensional aggregation matrices

Cell Biochemistry and Biophysics, Vol. 52, (3) : 175-189

Byström, Roberth; Aisenbrey, Christopher; Borowik, Tomasz; et al.

Formation of cytotoxic transthyretin is not dependent on inter-molecular disulphide bridges commonly found within the amyloid form

Amyloid: Journal of Protein Folding Disorders, Vol. 15, (4) : 240-245

Lindhagen-Persson, Malin; Vestling, M; Reixach, N; et al.

Negatively Charged Phospholipid Membranes Induce Amyloid Formation of Medin via an alpha-Helical Intermediate

Journal of Molecular Biology, Vol. 374, (1) : 186-94

Olofsson, Anders; Borowik, Tomasz; Gröbner, Gerhard; et al.

Amide solvent protection analysis demonstrates that amyloid-beta(1-40) and amyloid-beta(1-42) form different fibrillar structures under identical conditions.

Biochem J, Vol. 404, (1) : 63-70

Olofsson, Anders; Lindhagen-Persson, Malin; Sauer-Eriksson, Elisabeth; et al.

The solvent protection of alzheimer amyloid-beta-(1-42) fibrils as determined by solution NMR spectroscopy.

Journal of Biological Chemistry, Vol. 281, (1) : 477-83

Olofsson, Anders; Sauer-Eriksson, Elisabeth; Öhman, Anders

Visa publikationer i DiVA

Forskargrupper

Forskningsledare

Anders Olofsson

Publicerad: 27 dec, 2024

Ny upptäckt banar väg för nya strategier mot skelleftesjukan

Publicerad: 06 nov, 2023

Friska miljoner från Vetenskapsrådet till medicinsk forskning

Publicerad: 05 dec, 2022

Söderberg-anslag till Umeåforskare

Publicerad: 14 jun, 2022

Umeåforskare prisas för sin forskning om Skelleftesjukan

Publicerad: 07 feb, 2019

WCMM beviljar postdoktorresurser

Anders Olofsson: Går det att stoppa Alzheimers sjukdom?

Antalet som drabbas av Alzheimers ökar med stigande ålder. Det finns ännu inget botemedel men detta är en livs...