López-Pérez, A., Norlin, S., Steneberg, P., Remeseiro, S., Edlund, H#., and Hörnblad, A#. Pan-AMPK activator O304 prevents gene expression changes and remobilisation of histone marks in islets of diet-induced obese mice. Scientific Rep. 11:24410, 2021. doi: 10.1038/s41598-021-03567-3. (#co-senior authors)
Ericsson, M., Steneberg, P., Nyrén, P., Edlund, H. AMPK activator O304 improves metabolic and cardiac function, and exercise capacity in aged mice. Commun. Biol. 4:1306. 2021. doi: 10.1038/s42003-021-02837-0.
Mucibabic, M., Steneberg, P., Lidh, E., Straseviciene, J., Ziolkowska, A., Dahl, U., Lindahl, E., and Edlund, H. α-Synuclein promotes IAPP fibril formation in vitro and β-cell amyloid formation in vivo in mice. Scientific Rep. 10: 20438, 2020
Steneberg, P., Lindahl, E., Dahl, U., Lidh, E., Straseviciene, J., Backlund, F., Kjellkvist, E., Berggren, E., Lundberg, I., Bergqvist, I., Ericsson, M., Eriksson, B., Linde, K., Westman, J., Edlund, T., and Edlund, H. PAN-AMPK activator O304 improves glucose homeostasis and microvascular perfusion in mice and type 2 diabetes patients. JCI Insight 3:e99114, 2018
Norlin S, Parekh V, Edlund H. The ATPase activity of Asna1/TRC40 is required for pancreatic progenitor cell survival. Development, 145: dev1544682018, 2018
Norlin, S., Parekh, V.S., Naredi, P., Edlund, H. Asna1/TRC40 Controls β-Cell Function and Endoplasmic ReticulumHomeostasis by Ensuring Retrograde Transport. Diabetes 65:110-119, 2016
Sharma, S.K., Chorell, E., Steneberg, P., Vernersson-Lindahl, E., Edlund, H., Wittung-Stafshede, P. Insulin-degrading enzyme prevents α-synuclein fibril formation in a nonproteolytical manner. Scientific Rep. 5:12531, 2015
Steneberg, P., Sykaras, A.G., Backlund, F., Straseviciene, J., Söderström, I., Edlund H. Hyperinsulinemia Enhances Hepatic Expression of the Fatty Acid Transporter Cd36 and Provokes Hepatosteatosis and Hepatic Insulin Resistance. J Biol Chem. 290:19034-19043, 2015
Gao, T., McKenna, B., Li, C., Reichert, M., Nguyen, J., Singh, T., Yang, C., Pannikar, A., Doliba, N., Edlund, H., Matschinsky, F., Stein, R., and Stanger, B.Z. Pdx1 maintains β-cell identity and function by repressing an α-cell program. Cell Metabolism 19:259–271, 2014
Steneberg, P., Bernardo, L., Edfalk, S., Backlund, F., Lundberg, L., Östenson, C.G., and Edlund, H. The type 2 diabetes associated gene Ide is required for insulin secretion and suppression of α-synuclein levels in β-cells. Diabetes 62: 2004-2014 2013
Medina, M.C., Molina, J., Gadea, Y., Fachado, A., Murillo, M., Simovic, G., Pileggi, A., Hernández, A., Edlund, H., and Bianco AC. The thyroid hormone-inactivating type III deiodinase is expressed in mouse and human beta-cells and its targeted inactivation impairs insulin secretion. Endocrinology 152:3717-3727. 2011
Svensson P, Bergqvist I, Norlin S, and Edlund H. MFng is dispensable for mouse pancreas development and function. Mol Cell Biol. 8:2129-2138, 2009. (Epub 2009 Feb 17.)
Correa-Medina, M., Bravo-Egana, V., Rosero, S., Ricordi, C., Edlund, H., Diez, J., and Pastori, R.L. MicroRNA miR-7 is preferentially expressed in endocrine cells of the developing and adult human pancreas. Gene Expression Patterns 4,193-199 2009 (Epub ahead of print 2008 Dec 24)
Boucher, M-J., Simoneau, M., and Edlund, H. The homeodomain-interacting protein kinase 2 (HIPK2) regulates IPF1/PDX1 transcriptional activity. Endocrinology, 150:87-97, 2009 (Epub 2008 Sep 4)
Öström, M., Loffler, K. A., Edfalk, S, Selander, L, Dahl, U., Ricordi, C., Jeon. J., Correa-Medina, M., Diez, J., and Edlund, H. Retinoic Acid Promotes the Generation of Pancreatic Endocrine Progenitor Cells and their Further Differentiation into -cells. PLoSONE 3:e2841, 2008.
Edfalk, S., Steneberg, P., and Edlund, H. Gpr40 is expressed in enteroendocrine cells and mediates FFA stimulation of incretin secretion. Diabetes 57:2280-2287, 2008.
Svensson, P., Williams, C., Lundeberg, J., Ryden, P., Bergqvist, I., and Edlund, H. Gene array identification of Ipf1/Pdx1-/- regulated genes in pancreatic progenitor cells. BMC developmental biology 7: 129, 2007.
Goulley, J., Dahl.U., Beaza, N., Mishina, Y., and Edlund H. BMP4-BMPRIA signalling in cells is required for and augments glucose stimulated insulin secretion. Cell Metabolism , 5, 207-219, 2007.
Boucher, M-J., Selander, L, Carlsson, L, and Edlund, H. Phosphorylation marks IPF1/PDX1 protein for degradation by GSK3-dependent mechanisms. JBC 281, 6395-6403, 2006.
Papadopoulou, S., and Edlund, H. Attenuated Wnt signaling perturbs pancreatic growth but not pancreatc function. Diabetes, 54:2844-2851, 2005.
Steneberg, P., Rubins, N., Bartoov-Shifman, R., Walker, M.D. Edlund, H. The FFA-receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse. Cell Metabolism, 1, 245-258, 2005.
Norlin, S., Ahlgren, U., Edlund, H. NF B activity in ?-cells is required for glucose stimulated insulin secretion. Diabetes 54:125-132, 2005.
Edlund H. Islet Differentiation and Development - A Background for Stem Cell Therapy. International Diabetes Monitor, 16:10-17, 2004.
Hart, A.W., Papadopoulou, S., and Edlund, H. Fgf10 maintains notch activation, stimulates proliferation, and blocks differentiation of pancreatic epithelial cells. Dev. Dyn. 228:185-193 2003.
Edlund H. Pancreatic organogenesis - developmental mechanisms and implications for therapy. Nat Rev Genet 3:524-532, 2002.
Selander, L., and Edlund, H. Nestin is expressed in mesenchymal and not epithelial cells of the developing mouse pancreas. Mech. of Dev., 113:189-192, 2002.
Hart, A.W., Baeza, N., Apelqvist, Å., Edlund, H.: Attenuation of FGF-signaling in Mouse -cells Leads to Diabetes. Nature 408:864-868, 2000.
Li H, Arber S, Jessell TM and Edlund H. Selective agenesis of the dorsal pancreas in mice lacking homeobox gene Hb9. Nat Genet 23:67-70, 1999.
Apelqvist A, Li H, Sommer L, Beatus P, Anderson DJ, Honjo T, Hrabe de Angelis M, Lendahl U and Edlund H. Notch-signalling controls pancreatic cell fate differentiation. Nature 400:877-881, 1999.
Ahlgren U, Johnsson J, Johnsson L, Simu K and Edlund H. Beta-cell-specific inativation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes. Genes & Dev 12:1763-1768, 1998.
Ahlgren U, Pfaff SL, Jessells TM, Edlund T and Edlund H. Independent requirement for ISL1 in the formation of pancreatic mesenchyme and islet cells. Nature 385:257-260, 1997.
Apelqvist A, Ahlgren, U and Edlund H. Sonic hedgehog directs specialized mesoderm differentiation in the intestine and pancreas. Curr Biol 7:801-804, 1997.
Ahlgren U, Jonsson J, and Edlund H. The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/PDX1-deficient mice. Development 122:1409-1416, 1996.
Jonsson J, Carlsson L, Edlund T, and Edlund H. Insulin-promoter-factor 1 is required for pancreas development in mice. Nature 371:606-609, 1994.
