The UCMR Day 2023 is held at Aula Nordica on Umeå University campus !
The one-day conference is aimed at scientists and staff members within Umeå Centre for Microbial Research, UCMR, collaboration partners and other researchers with an interest in microbial research or infection biology.
The programme offers inspiring keynote lectures, elevator talks, and presentations of posters and visual abstracts, but foremost it is an excellent opportunity for networking and initiation of multidisciplinary collaborations. The day includes several sessions for the attendants to interact and network with each other.
Read and download the abstract book of the conference.
Tobias Dörr, PhD, Assistant professor, Cornell University
The Dörr lab studies how bacteria build and maintain a healthy cell envelope and resist killing by antibiotics.
Title of the lecture: “Stress signaling promotes antibiotic resistance and tolerance in Gram-negative pathogens”
The bacterial cell wall, made primarily from peptidoglycan (PG) ensures bacterial structural integrity and thus survival. Consequently, our most powerful antibiotics are those that target PG synthesis, typically resulting in rapid lysis and cell death. However, many bacteria are “tolerant” against cell wall-active antibiotics, i.e. they survive destruction of their cell wall and recover to growing cells upon dissipation of the drug.
In this talk, Tobias Dörr will delineate molecular mechanisms by which Gram-negative bacteria maintain structural integrity during normal growth and when exposed to cell wall-acting antibiotics.
Maria Grazia Masucci, MD PhD, Professor of Virology, Karolinska Institutet
Masucci's group studies molecular mechanisms of viral oncogenesis.
Title of the lecture: Host cell remodeling by herpes virus encoded deconjugases
Post-translational modification of proteins by covalent conjugation of ubiquitin or ubiquitin-like (UBL) polypeptides regulates numerous cellular processes. The effect of the modification is reversed by deconjugases that hydrolyze the covalent bond and recycle ubiquitin and the UBLs. The importance of protein ubiquitination to for the control of viral infections is underscored by the finding that many DNA and RNA viruses, including human pathogenic coronaviruses, encode Ub and UbL deconjugases that interfere with cellular processes captured by viruses to promote infection and suppress antiviral responses.
Epstein-Barr virus (EBV) is a human lymphotropic herpesvirus that is implicated in the pathogenesis of lymphoid and epithelial cell malignancies. The N-terminal domains of the herpesvirus large tegument proteins encode a conserve cysteine protease with ubiquitin and NEDD8 specific deconjugase activity. The protein is expressed during productive infection and is incorporated into virus particles suggesting possible roles during both the early and late phases of infection. We found that the EBV encoded member of this vial protein family interacts with many cellular proteins and protein complexes, which correlates with regulation of viral genome replication and the release of virus particles as well as inhibition of cellular antiviral responses including the type I IFN production and autophagy. The conserved nature of the viral enzymes and their double role in the regulation of the virus life cycle and the host antiviral response suggest that the development of specific inhibitors may be a promising new avenue of the development of effective antiviral drugs.
The best poster awards are sponsored by CUMR and Agrisera
8:30 - 9:00 REGISTRATION and MOUNTING OF POSTERS/VISUAL ABSTRACTS
9:00 - 9:10 WELCOME
Mikael Elofsson, Dean at the Faculty of Science and Technology, Umeå University
9:10 - 9:30 UCMR UPDATE
Yaowen Wu, Director of UCMR, Umeå University
9:30 - 10:15 ELEVATOR TALKS I (3 minutes talks)
Chair: Barbara Sixt
#P1. Insights into the genetic contexts of sulfonamide resistance among early clinical isolates of Acinetobacter baumannii
Anju Bala, Dept of Molecular Biolgy and UCMR, Umeå University
#P2. Metabolic and Morphotypic Trade-offs within the Eco-Evolutionary Dynamics of Escherichia coli
Nikola Zlatkov, Dept of Molecular Biology, Umeå University
#P3. Siderophore transporter-based vaccines promote protection in sole fish against Aeromonas salmonicida infection
Diego Rey-Varela, Dept de Microbioloxía e Parasitoloxía, Instituto de Acuicultura, Universidade de Santiago de Compostela, Spain
#P5. Characterization of Fluorescent Filovirus Pseudotypes
Kerstin Seier, Dept of Clinical Microbiology and Wallenberg Centre for Molecular Medicine, Umeå University
#P6. Sulfation patterns of heparan sulfate modulate the interactions between human papillomavirus and cell surface glycosaminoglycans at the single particle level
Fouzia Bano, Dept of Clinical Microbiology and Wallenberg Centre for Molecular Medicine, Umeå University
#P11. Streptococcus pyogenes FASII regulator FabT avoids unnecessary energy expenditure and is required for human tissue infection
Clara Lambert, Université Paris Cité, Institut Cochin, Paris, France
#P12. Towards structural characterization of diacylglyceryl transferase (Lgt) from P. gingivalis
Sampath Kumar Yalamanchili, Department of Chemistry, Umeå University
#P13. In vivo transcriptomics of Salmonella Typhimurium persistence
Ummehan Avican, Dept of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, and UCMR, Umeå University
#P16. Recruitment of apolipoprotein E facilitates Herpes simplex virus 1 release from infected cells
Lifeng Liu, Dept of Clinical Microbiology and Wallenberg Centre for Molecular Medicine, Umeå University
#P19. Temperature and nutrient control of aquatic prokaryotic maintenance respiration, growth efficiency, and community composition
Ashish Verma, Dept of Ecology and Environmental Science and Umeå Marine Sciences Center, Umeå University
#P22. Tissue-specific effects of genotoxigenic Salmonella during in vivo infection
María López Chiloeches, Dept of Molecular Biology and UCMR, Umeå University
#P24 Study of the SaPI2 De-repression Complex
Gianluca Debiasi-Anders, Dept of Medical Biochemistry and Biophysics and Wallenberg Centre for Molecular Medicine, Umeå University
10:15 - 10:45 COFFEE AND SANDWICH
Served in the Lounge
10:45-11:15 ELEVATOR TALKS II (3 minutes talks)
Chair: Felipe Cava
#P25. Enterovirus 2C protein and cellular membrane: what could go wrong??
Kasturika Shankar, Dept of Medical Biochemistry and Biophysics, Wallenberg Centre for Molecular Medicine, MIMS, Umeå University
#P26. The effect of the lipid membrane environment on the binding kinetics of norovirus to glycolipids
Konrad Thorsteinsson, Dept of Clinical Microbiology and Wallenberg Centre for Molecular Medicine, Umeå University
#P27. Evaluating the role of NUPs in TBEV infection
Marie Berit Akpiroro Peters, Dept of Clinical Microbiology and MIMS, Umeå University
#P28. Transient Glycolytic Complexation of Arsenate Enhances Resistance in the Enteropathogen Vibrio cholerae
Emilio Bueno, MIMS, Dept of Molecular Biology and UCMR, Umeå University
#P29. Characterization of a primase-polymerase encoded by Phage-inducible chromosomal islands
Cuncun Qiao, Dept of Medical Biochemistry and Biophysics and Wallenberg Centre for Molecular Medicine, Umeå University
#P30. Undecaprenyl phosphate translocases confer conditional microbial fitness
Emilio Bueno, MIMS, Dept of Molecular Biology and UCMR, Umeå University
#P31. Investigating Key Microbiota Molecules to Rescue Western-style Diet-induced Mucus Defects in Mice
Sandra Holmberg, Dept of Molecular Biology and MIMS, Umeå University
#P32. Chemo-optogenetic systems for reversible control of protein function in live cells
Jun Zhang, Dept of Chemistry and UCMR, Umeå University
11:15 - 12:00 KEY NOTE LECTURE I
Chair: Felipe Cava
Stress signaling promotes antibiotic resistance and tolerance in Gram-negative pathogens
Dr. Tobias Dörr, Cornell University, USA
12:00 - 13:00 LUNCH
Buffet, Universum resaturant
Reserved tables to the left
13:00 - 14:00 ELEVATOR TALKS III (3 minutes talks)
Chair: Ignacio Mir-Sanchis
#P33. Combination of gallium citrate with linezolid or levofloxacin potentiate growth inhibition of drug resistant Mycobacterium tuberculosis and results in differential metabolome changes
Oleksandr Ilchenko, Umeå University, and Odessa National University, Ukraine
#P34.The importance of dietary fibre for gut health
Rachel Feeney, Dept of Molecular Biology and MIMS, Umeå University
#P35. In-situ structural analysis of the chikungunya virus double-stranded RNA
Timothée Laurent, Dept of Medical Biochemistry and Biophysics, Wallenberg Centre for Molecular Medicine, MIMS, Umeå University
#P36. Metabolic cooperation in dual-species biofilms related to catheter associated urinary tract infections
Dmytro Sokol, Umeå University, and Odesa I. I. Mechnikov National University, Ukraine
#P37. Insights into alphaviral genome capping - A mechanistic study
Karim Rafie, Dept of Medical Biochemistry and Biophysics, Wallenberg Centre for Molecular Medicine, and MIMS, Umeå University
#P38. An alternative ATG12-ATG5-TECPR1 E3-like conjugation complex regulates unconventional LC3 lipidation at damaged membranes
Dale Corkery, Dept of Chemistry and UCMR, Umeå University
#P39. Molecular mechanisms of Salmonella invasion and persistence via in vivo transcriptomics
Barbara Forró, Dept of Molecular Biology, MIMS and UCMR, Umeå University
#P43. Tantalosin impaires the assembly of ESCRT complex with a normal topology
Shuang Li, Dept of Chemistry and UCMR, Umeå University
#P44. Role of binding avidity and membrane complexity in the attachment of SARS-CoV-2 variants
Dario Conca, Dept of Clinical Microbiology and Wallenberg Centre for Molecular Medicine, Umeå University
#P45. Discovery of novel anti-chlamydial compounds through a multi-strategy screening approach
Magnus Ölander, Dept of Molecular Biology, MIMS and UCMR Umeå University
#P46. Characterization of a novel penicillin-binding protein in Vibrio cholera
Víctor Pinedo, Dept of Molecular Biology, MIMS, Umeå University
#P18. Structural insights of Mak proteins from Vibrio cholera
Nandita Bodra, Department of Chemistry, Umeå University
#P21 Association between Legionella species and humic substances during early summer in the northern Baltic Sea
Karolina Eriksson, Department of Ecology and Environmental Sciences and Umeå Marine Sciences Centre, Umeå University
#P48. Umeå Postdoc Society: By postdocs, for postdocs
Umeå Postdoc Society (UPS), Umeå University, and Swedish University of Agricultural Sciences, SLU
14:00 - 14:10 GROUP PHOTO
The photo is taken in Aula Nordica, please remain seated for instructions
14:10 - 15:30 POSTER WALKS and COFFEE AND CAKE
Six groups led by PIs for organised walks during 40 minutes.
Posters are shown in Brashörnan
Coffee is served in the Lounge
15:30 - 17:00 GROUP DISCUSSIONS
Mixed group with different expertise, your group is marked on the name tag
Find your table number in the Universum restaurant
Refill your coffee cup in the Lounge
17:00 - 17:45 KEY NOTE LECTURE II
Chair: Teresa Frisan
Host cell remodeling by herpes virus encoded deconjugases
Professor Maria Grazia Masucci, Karolinska Institutet
17:45 - 18:00 CONCLUDING REMARKS AND POSTER AWARDS
Chair: Teresa Frisan
18:00 - 18:30 RECEPTION AND MINGLE
Mingle in the Lounge
18:30 THREE COURSE DINNER
The dinner takes place in Universum restaurant
