Yuri Schwartz

Research qualifications: Docent

Contact

yuri.schwartz@umu.se

+46 90 785 67 84

Works at

Associate professor at Department of Molecular Biology Section: Research group Yuri Schwartz

6K och 6L, Sjukhusområdet Umeå universitet, 901 87 Umeå

The scales, mechanisms, and dynamics of the genome architecture

Science Advances, American Association for the Advancement of Science (AAAS) 2024, Vol. 10, (15)

Lizana, Ludvig; Schwartz, Yuri B.

DNA elements tether canonical Polycomb Repressive Complex 1 to human genes

Nucleic Acids Research, Oxford University Press 2023, Vol. 51, (21) : 11613-11633

Barrasa, Juan I.; Kahn, Tatyana G.; Lundkvist, Moa J.; et al.

Topological screen identifies hundreds of Cp190- and CTCF-dependent Drosophila chromatin insulator elements

Science Advances, Vol. 9, (5)

Kahn, Tatyana G.; Savitsky, Mikhail; Kuong, Chikuan; et al.

Methylation of lysine 36 on histone H3 is required to control transposon activities in somatic cells

Life Science Alliance, NLM (Medline) 2023, Vol. 6, (8)

Lindehell, Henrik; Schwartz, Yuri B.; Larsson, Jan

Polycomb proteins translate histone methylation to chromatin folding

Journal of Biological Chemistry, Elsevier 2023, Vol. 299, (9)

Lizana, Ludvig; Nahali, Negar; Schwartz, Yuri B.

Forecasting histone methylation by Polycomb complexes with minute-scale precision

Science Advances, American Association for the Advancement of Science (AAAS) 2023, Vol. 9, (51)

Lundkvist, Moa J.; Lizana, Ludvig; Schwartz, Yuri B.

Variant Polycomb complexes in Drosophila consistent with ancient functional diversity

Science Advances, NLM (Medline) 2022, Vol. 8, (36)

Kang, Hyuckjoon; Cabrera, Janel R.; Zee, Barry M.; et al.

The role of H3K36 methylation and associated methyltransferases in chromosome-specific gene regulation

Science Advances, American Association for the Advancement of Science 2021, Vol. 7, (40)

Lindehell, Henrik; Glotov, Alexander; Dorafshan, Eshagh; et al.

Pervasive head-to-tail insertions of DNA templates mask desired CRISPR-Cas9-mediated genome editing events

Science Advances, American Association for the Advancement of Science 2020, Vol. 6, (7)

Skryabin, Boris, V; Kummerfeld, Delf-Magnus; Gubar, Leonid; et al.

Genetic Dissection Reveals the Role of Ash1 Domains in Counteracting Polycomb Repression

G3: Genes, Genomes, Genetics, The Genetics Society of America 2019, Vol. 9, (11) : 3801-3812

Dorafshan, Eshagh; Kahn, Tatyana G.; Glotov, Alexander; et al.

Ash1 counteracts Polycomb repression independent of histone H3 lysine 36 methylation

EMBO Reports, WILEY 2019, Vol. 20, (4)

Dorafshan, Eshagh; Kahn, Tatyana G.; Glotov, Alexander; et al.

PTE, a novel module to target Polycomb Repressive Complex 1 to the human cyclin D2 (CCND2) oncogene

Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology 2018, Vol. 293, (37) : 14342-14358

Cameron, Sarina R.; Nandi, Soumyadeep; Kahn, Tatyana G.; et al.

Hierarchical recruitment of Polycomb complexes revisited

Nucleus, Taylor & Francis Group 2017, Vol. 8, (5) : 496-505

Dorafshan, Eshagh; Kahn, Tatyana G.; Schwartz, Yuri B.

Cooperative recruitment of polycomb complexes by polycomb response elements

Polycomb group proteins, Academic Press 2017 : 111-129

Schwartz, Yuri B.

Three-Dimensional Genome Organization and Function in Drosophila

Genetics, GENETICS SOCIETY AMERICA 2017, Vol. 205, (1) : 5-24

Schwartz, Yuri B.; Cavalli, Giacomo

Interdependence of PRC1 and PRC2 for recruitment to Polycomb Response Elements

Nucleic Acids Research, Vol. 44, (21) : 10132-10149

Kahn, Tatyana G.; Dorafshan, Eshagh; Schultheis, Dorothea; et al.

Distinct Roles of Chromatin Insulator Proteins in Control of the Drosophila Bithorax Complex

Genetics, Vol. 202, (2) : 601-+

Savitsky, Mikhail; Kim, Maria; Kravchuk, Oksana; et al.

Genome-wide activities of Polycomb complexes control pervasive transcription

Genome Research, Vol. 25, (8) : 1170-1181

Lee, Hun-Goo; Kahn, Tatyana G.; Simcox, Amanda; et al.

Comparative analysis of metazoan chromatin organization

Nature, Vol. 512, (7515) : 449-U507

Ho, Joshua W. K.; June, Youngsook L.; Liu, Tao; et al.

Combinatorial Interactions Are Required for the Efficient Recruitment of Pho Repressive Complex (PhoRC) to Polycomb Response Elements

PLOS Genetics, PLOS 2014, Vol. 10, (7) : e1004495-

Kahn, Tatyana G.; Stenberg, Per; Pirrotta, Vincenzo; et al.

Ruled by ubiquitylation: a new order for Polycomb recruitment

Cell Reports, Cell Press 2014, Vol. 8, (2) : 321-325

Schwartz, Yuri B.; Pirrotta, Vincenzo

A new world of Polycombs: unexpected partnerships and emerging functions

Nature reviews genetics, Nature Publishing Group 2013, Vol. 14, (12) : 853-864

Schwartz, Yuri B.; Pirrotta, Vincenzo

Sequence-Specific Targeting of Dosage Compensation in Drosophila Favors an Active Chromatin Context

PLoS Genetics, San Francisco: Public Library of Science 2012, Vol. 8, (4) : e1002646-

Alekeyenko, Artyom A.; Ho, Joshua W. K.; Peng, Shouyong; et al.

Regulation of Polycomb group genes Psc and Su(z)2 in Drosophila melanogaster

Mechanisms of Development, Elsevier Ireland Ltd. 2012, Vol. 128, (11-12) : 536-547

Park, Sung Yeon; Schwartz, Yuri B; Kahn, Tatyana G; et al.

Enrichment of HP1a on drosophila chromosome 4 genes creates an alternate chromatin structure critical for regulation in this heterochromatic domain

PLOS Genetics, Public Library of Science, PLOS 2012, Vol. 8, (9) : e1002954-

Riddle, Nicole C; Jung, Youngsook L; Gu, Tingting; et al.

Nature and function of insulator protein binding sites in the Drosophila genome

Genome Research, Vol. 22 : 2188-2198

Schwartz, Yuri B; Linder-Basso, Daniela; Kharchenko, Peter V; et al.

An assessment of histone-modification antibody quality

Nature Structural & Molecular Biology, Vol. 18, (1) : 91-93

Egelhofer, Thea A; Minoda, Aki; Klugman, Sarit; et al.

Comprehensive analysis of the chromatin landscape in Drosophila melanogaster

Nature, Vol. 471, (7339) : 480-485

Kharchenko, Peter V; Alekseyenko, Artyom A; Schwartz, Yuri B; et al.

Plasticity in patterns of histone modifications and chromosomal proteins in Drosophila heterochromatin

Genome Research, Vol. 21, (2) : 147-163

Riddle, Nicole C; Minoda, Aki; Kharchenko, Peter V; et al.

Identification of functional elements and regulatory circuits by Drosophila modENCODE.

Science (New York, N.Y.), Vol. 330, (6012) : 1787-1797

Roy, Sushmita; Ernst, Jason; Kharchenko, Peter V; et al.

Alternative Epigenetic Chromatin States of Polycomb Target Genes

PLoS Genetics, Public Library of Science 2010, Vol. 6, (1) : e1000805-

Schwartz, Yuri B.; Kahn, Tatyana G.; Stenberg, Per; et al.

[Polycomb and trithorax control genome expression by determining the alternative epigenetic states of chromatin for key developmental regulators].

Journal Genetika, Vol. 46, (10) : 1413-1416

Shwartz, Yuri B; Kahn, Tatiana G; Pirrotta, V

Functional analysis of Drosophila polytene chromosomes decompacted unit: the interband

Chromosome Research, Vol. 17, (6) : 745-754

Berkaeva, Maria; Demakov, Sergei; Schwartz, Yuri B; et al.

Regulation of the Drosophila Enhancer of split and invected-engrailed gene complexes by sister chromatid cohesion proteins

PloS one, Vol. 4, (7) : e6202-

Schaaf, Cheri A; Misulovin, Ziva; Sahota, Gurmukh; et al.

A little bit of sugar makes polycomb better

Journal of molecular cell biology, Vol. 1, (1) : 11-12

Schwartz, Yuri B; Pirrotta, Vincenzo

Association of cohesin and Nipped-B with transcriptionally active regions of the Drosophila melanogaster genome

Chromosoma, Vol. 117, (1) : 89-102

Misulovin, Ziva; Schwartz, Yuri B; Li, Xiao-Yong; et al.

Polycomb complexes and epigenetic states

Current Opinion in Cell Biology, Vol. 20, (3) : 266-273

Schwartz, Yuri B; Pirrotta, Vincenzo

Polycomb silencing mechanisms and the management of genomic programmes

Nature reviews genetics, Vol. 8, (1) : 9-22

Schwartz, Yuri B; Pirrotta, Vincenzo

Polycomb complexes and the propagation of the methylation mark at the Drosophila ubx gene

Journal of Biological Chemistry, Vol. 281, (39) : 29064-29075

Kahn, Tatyana G; Schwartz, Yuri B; Dellino, Gaetano I; et al.

Genome-wide analysis of Polycomb targets in Drosophila melanogaster

Nature Genetics, Vol. 38, (6) : 700-705

Schwartz, Yuri B; Kahn, Tatyana G; Nix, David A; et al.

Characteristic low density and shear sensitivity of cross-linked chromatin containing polycomb complexes

Molecular and Cellular Biology, Vol. 25, (1) : 432-439

Schwartz, Yuri B; Kahn, Tatyana G; Pirrotta, Vincenzo

Polycomb silencing blocks transcription initiation.

Molecular Cell, Vol. 13, (6) : 887-93

Dellino, Gaetano I; Schwartz, Yuri B; Farkas, Gabriella; et al.

Molecular and genetic organization of Drosophila melanogaster polytene chromosomes: evidence for two types of interband regions

Genetica, Vol. 122, (3) : 311-324

Demakov, Sergei; Gortchakov, Andrei; Schwartz, Yuri B; et al.

Molecular characterization of the singed wings locus of Drosophila melanogaster

BMC Genetics, Vol. 5 : 15-

Schwartz, Yuri B; Boykova, Tatiana; Belyaeva, Elena S; et al.

Polycomb silencing mechanisms in Drosophila

Cold Spring Harbor Symposia on Quantitative Biology, Vol. 69 : 301-308

Schwartz, Yuri B; Kahn, Tatiana G; Dellino, G I; et al.

Polytene chromosome interband DNA is organized into nucleosomes

Molecular Genetics and Genomics, Vol. 265, (2) : 311-315

Schwartz, Yuri B; Demakov, S A; Zhimulev, I F

Interbands of Drosophila melanogaster polytene chromosomes contain matrix association regions.

Journal of Cellular Biochemistry, Vol. 72, (3) : 368-372

Schwartz, Yuri B; Ioudinkova, E S; Demakov, S A; et al.

Functional dissection of Drosophila Ash1 domains

Dorafshan, Eshagh; Kahn, Tatyana G.; Glotov, Alexander; et al.

Does Ash1 counteract Polycomb repression by methylating H3K36?

Dorafshan, Eshagh; Kahn, Tatyana G.; Glotov, Alexander; et al.

View publications in DiVA

Research groups

Head of research

Yuri Schwartz lab

Research projects

1 January 2022 until 31 December 2025

Epigenetic regulation by Polycomb-Trithorax system: leaving the mark on histones and other proteins