Uwe Sauer

I m head of the Protein Expertise Platform (PEP).

Contact

uwe.sauer@umu.se

+46 90 786 59 30

Works at

Associate professor at Department of Chemistry

KB.E4, Linnaeus väg 10, (rum: 4.02.02) Umeå universitet, 901 87 Umeå

Targeting the main protease (M^pro, nsp5) by growth of fragment scaffolds exploiting structure-based methodologies

ACS Chemical Biology, American Chemical Society (ACS) 2024, Vol. 19, (2) : 563-574

Altincekic, Nadide; Jores, Nathalie; Löhr, Frank; et al.

Elucidating dynamics of Adenylate kinase from enzyme opening to ligand release

Journal of Chemical Information and Modeling, American Chemical Society (ACS) 2024, Vol. 64, (1) : 150-163

Nam, Kwangho; Arattu Thodika, Abdul Raafik; Grundström, Christin; et al.

Insights into the evolution of enzymatic specificity and catalysis: from Asgard archaea to human adenylate kinases

Science Advances, American Association for the Advancement of Science (AAAS) 2022, Vol. 8, (44)

Verma, Apoorv; Åberg-Zingmark, Emma; Sparrman, Tobias; et al.

Dynamic Connection between Enzymatic Catalysis and Collective Protein Motions

Biochemistry, American Chemical Society (ACS) 2021, Vol. 60, (28) : 2246-2258

Ojeda-May, Pedro; Ul Mushtaq, Ameeq; Rogne, Per; et al.

Principles of ATP and GTP Selectivity in NMP Kinases

Biophysical Journal, Cell Press 2020, Vol. 118, (3) : 193A-193A

Rogne, Per; Sauer-Eriksson, Elisabeth; Sauer, Uwe H.; et al.

The Y233 gatekeeper of DmpR modulates effector-responsive transcriptional control of δ⁵⁴-RNA polymerase

Environmental Microbiology, Vol. 21, (4) : 1321-1330

Seibt, Henrik; Sauer, Uwe H.; Shingler, Victoria

Synthesis of Densely Functionalized N-Alkenyl 2-Pyridones via Benzyne-Induced Ring Opening of Thiazolino-Fused 2-Pyridones

Organic Letters, American Chemical Society (ACS) 2019, Vol. 21 : 6946-6950

Singh, Pardeep; Cairns, Andrew G.; Adolfsson, Dan E.; et al.

Positive and Negative Substrate Interference Supported by Coinciding Enzyme Residues

Biophysical Journal, CELL PRESS 2019, Vol. 116, (3) : 485A-485A

Wolf-Watz, Magnus; Rogne, Per; Sauer-Eriksson, A. Elisabeth; et al.

Structure-based design of inhibitors targeting PrfA, the master virulence regulator of Listeria monocytogenes

Journal of Medicinal Chemistry, American Chemical Society (ACS) 2018, Vol. 61, (9) : 4165-4175

Kulén, Martina; Lindgren, Marie; Hansen, Sabine; et al.

Molecular mechanism of ATP versus GTP selectivity of adenylate kinase

Proceedings of the National Academy of Sciences of the United States of America, Vol. 115, (12) : 3012-3017

Rogne, Per; Rosselin, Marie; Grundström, Christin; et al.

Structural basis for ligand binding to an enzyme by a conformational selection pathway

Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences 2017, Vol. 114, (24) : 6298-6303

Kovermann, Michael; Grundström, Christin; Sauer-Eriksson, A. Elisabeth; et al.

Active-site plasticity revealed in the asymmetric dimer of AnPrx6 the 1-Cys peroxiredoxin and molecular chaperone from Anabaena sp. PCC 7120

Scientific Reports, Nature Publishing Group 2017, Vol. 7

Mishra, Yogesh; Hall, Michael; Locmelis, Roland; et al.

Attenuating Listeria monocytogenes virulence by targeting the regulatory protein PrfA

Cell chemical biology, Vol. 23, (3) : 404-414

Good, James A. D.; Andersson, Christopher; Hansen, Sabine; et al.

Structural basis for glutathione-mediated activation of the virulence regulatory protein PrfA in Listeria

Proceedings of the National Academy of Sciences of the United States of America, Vol. 113, (51) : 14733-14738

Hall, Michael; Grundström, Christin; Begum, Afshan; et al.

Structural basis for catalytically restrictive dynamics of a high-energy enzyme state

Nature Communications, Macmillan Publishers Ltd. 2015, Vol. 6

Kovermann, Michael; Ådén, Jörgen; Grundström, Christin; et al.

Four-Component Assembly of Natural-Product-Like Ring-Fused Isoquinuclidines

European Journal of Organic Chemistry, John Wiley & Sons 2013, Vol. 2013, (33) : 7476-7479

Sellstedt, Magnus; Dang, Hung The; Prasad, G. Krishna; et al.

Small Molecule Screening for Inhibitors of the YopH Phosphatase of Yersinia pseudotuberculosis

Advances in Yersinia Research, New York: Springer 2012 : 357-363

Eriksson, Jonas; Grundström, Christin; Sauer-Eriksson, A Elisabeth; et al.

Purification, crystallization and preliminary X-ray analysis of PPD6, a PsbP-domain protein from Arabidopsis thaliana

Acta Crystallographica. Section F: Structural Biology and Crystallization Communications, Vol. 68, (3) : 278-280

Hall, Michael; Kieselbach, Thomas; Sauer, Uwe; et al.

Redox-mediated Mechanisms Regulate DNA Binding Activity of the G-group of Basic Region Leucine Zipper (bZIP) Transcription Factors in Arabidopsis

Journal of Biological Chemistry, Rockville: The American Society for Biochemistry and Molecular Biology 2012, Vol. 287, (33) : 27510-27525

Shaikhali, Jehad; Norén, Louise; Barajas-Lopez, Juan de Dios; et al.

Crystallization and preliminary X-ray analysis of the Entamoeba histolytica α-actinin-2 rod domain

Acta Crystallographica. Section F: Structural Biology and Crystallization Communications, International Union of Crystallography 2011, Vol. 67, (10) : 1214-1217

Addario, Barbara; Huang, Shenghua; Sauer, Uwe; et al.

Expression, purification, crystallization and preliminary X-ray crystallographic studies of alkyl hydroperoxide reductase (AhpC) from the cyanobacterium Anabaena sp. PCC 7120

Acta Crystallographica. Section F: Structural Biology and Crystallization Communications, International Union of Crystallography 2011, Vol. 67, (10) : 1203-1206

Mishra, Yogesh; Hall, Michael; Chaurasia, Neha; et al.

Accurate Domain Identification with Structure-Anchored Hidden Markov Models, saHMMs

Proteins: Structure, Function, and Bioinformatics, Vol. 76, (2) : 343-352

Tångrot, Jeanette; Kågström, Bo; Sauer, Uwe

OnD-CRF: predicting order and disorder in proteins using [corrected] conditional random fields

Bioinformatics, Oxford: Oxford university press 2008, Vol. 24, (11) : 1401-1402

Wang, Lixiao; Sauer, Uwe H

Design, construction and use of the FISH server

Applied parallel computing: state of the art in scientific computing, Springer Link 2007 : 647-657

Tångrot, Jeanette; Wang, Lixiao; Kågström, Bo; et al.

The transthyretin-related protein: structural investigation of a novel protein family

Journal of Structural Biology, San Diego: Academic Press 2006, Vol. 155, (3) : 445-457