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Sushma Sharma
Contact
E-mail
sushma.sharma@umu.se
Phone
+46 70 361 99 45
Works at
Affiliation
Staff scientist at
Department of Medical Biochemistry and Biophysics
Section: Andrei Chabes group
Location
KB. H6, Campus, Umeå
Umeå universitet, 901 87 Umeå
Publications
Publications
Research
Research
2024
Physical interactions between specifically regulated subpopulations of the MCM and RNR complexes prevent genetic instability
PLOS Genetics
, Public Library of Science (PLoS) 2024, Vol. 20, (5)
Yáñez-Vilches, Aurora; Romero, Antonia M.; Barrientos-Moreno, Marta; et al.
2023
Impairment of the non-catalytic subunit Dpb2 of DNA Pol ɛ results in increased involvement of Pol δ on the leading strand
DNA Repair
, Elsevier 2023, Vol. 129
Dmowski, Michal; Makiela-Dzbenska, Karolina; Sharma, Sushma; et al.
2023
Quantitative analysis of nucleoside triphosphate pools in mouse muscle using hydrophilic interaction liquid chromatography coupled with tandem mass spectrometry detection
Mitochondrial DNA: methods and protocols
, New York: Humana Press 2023 : 267-280
Sharma, Sushma; Kong, Ziqing; Jia, Shaodong; et al.
2022
Chl1 helicase controls replication fork progression by regulating dNTP pools
Life Science Alliance
, Vol. 5, (4)
Batté, Amandine; van der Horst, Sophie C.; Tittel-Elmer, Mireille; et al.
2022
dNTP concentrations do not increase in mammalian cells in response to DNA damage
Cell Metabolism
, Elsevier 2022, Vol. 34, (12) : 1895-1896
Das, Biswajit; Mishra, Pradeep; Pandey, Praveen; et al.
2022
Increased contribution of DNA polymerase delta to the leading strand replication in yeast with an impaired CMG helicase complex
DNA Repair
, Elsevier 2022, Vol. 110
Dmowski, Michal; Jedrychowska, Malgorzata; Makiela-Dzbenska, Karolina; et al.
2022
Isocratic HPLC analysis for the simultaneous determination of dNTPs, rNTPs and ADP in biological samples
Nucleic Acids Research
, Oxford University Press 2022, Vol. 50, (3)
Ranjbarian, Farahnaz; Sharma, Sushma; Falappa, Giulia; et al.
2020
High density of unrepaired genomic ribonucleotides leads to Topoisomerase 1-mediated severe growth defects in absence of ribonucleotide reductase
Nucleic Acids Research
, Oxford Academic 2020, Vol. 48, (8) : 4274-4297
Cerritelli, Susana M; Iranzo, Jaime; Sharma, Sushma; et al.
2020
SAMHD1 agit sur les fourches de réplication bloquées pour empêcher l’induction d’interféron: [SAMHD1 acts at stalled replication forks to prevent interferon induction]
Comptes rendus. Biologies
, Académie des Sciences 2020, Vol. 343, (1) : 9-21
Coquel, F.; Silva, M. J.; Techer, H.; et al.
2020
SAMHD1 Limits the Efficacy of Forodesine in Leukemia by Protecting Cells against the Cytotoxicity of dGTP.
Cell Reports
, Elsevier 2020, Vol. 31, (6)
Davenne, Tamara; Klintman, Jenny; Sharma, Sushma; et al.
2020
Mec1 Is Activated at the Onset of Normal S Phase by Low-dNTP Pools Impeding DNA Replication
Molecular Cell
, Elsevier 2020, Vol. 78, (3) : 496-410.e4
Forey, Romain; Poveda, Ana; Sharma, Sushma; et al.
2020
Inactivation of folylpolyglutamate synthetase Met7 results in genome instability driven by an increased dUTP/dTTP ratio
Nucleic Acids Research
, Oxford University Press 2020, Vol. 48, (1) : 264-277
Schmidt, Tobias T; Sharma, Sushma; Reyes, Gloria X; et al.
2020
Proofreading deficiency in mitochondrial DNA polymerase does not affect total dNTP pools in mouse embryos
Nature Metabolism
, Nature Publishing Group 2020, Vol. 2, (8) : 673-675
Sharma, Sushma; Koolmeister, Camilla; Tran, Phong; et al.
2020
Elimination of rNMPs from mitochondrial DNA has no effect on its stability
Proceedings of the National Academy of Sciences of the United States of America
, National Academy of Sciences 2020, Vol. 117, (25) : 14306-14313
Wanrooij, Paulina H.; Tran, Phong; Thompson, Liam J.; et al.
2019
Ribonucleotide reductase from
Fusarium oxysporum
does not Respond to DNA replication stress
DNA Repair
, Elsevier 2019, Vol. 83
Cohen, Rotem; Milo, Shira; Sharma, Sushma; et al.
2019
The absence of the catalytic domains of
Saccharomyces cerevisiae
DNA polymerase ϵ strongly reduces DNA replication fidelity
Nucleic Acids Research
, Oxford University Press 2019, Vol. 47, (8) : 3986-3995
Garbacz, Marta A.; Cox, Phillip B.; Sharma, Sushma; et al.
2019
Mck1 defines a key S-phase checkpoint effector in response to various degrees of replication threats
PLOS Genetics
, San Francisco: Public Library of Science 2019, Vol. 15, (8)
Li, Xiaoli; Jin, Xuejiao; Sharma, Sushma; et al.
2019
Dinucleotide Degradation by REXO2 Maintains Promoter Specificity in Mammalian Mitochondria
Molecular Cell
, Elsevier 2019, Vol. 76, (5) : 784-+
Nicholls, Thomas J.; Spåhr, Henrik; Jiang, Shan; et al.
2019
A genetic screen pinpoints ribonucleotide reductase residues that sustain dNTP homeostasis and specifies a highly mutagenic type of dNTP imbalance
Nucleic Acids Research
, Oxford University Press 2019, Vol. 47, (1) : 237-252
Schmidt, Tobias T.; Sharma, Sushma; Reyes, Gloria X.; et al.
2019
De novo dNTP production is essential for normal postnatal murine heart development
Journal of Biological Chemistry
, American Society for Biochemistry and Molecular Biology 2019, Vol. 394, (44) : 15889-15897
Tran, Phong; Wanrooij, Paulina H.; Lorenzon, Paolo; et al.
2019
A recurrent cancer-associated substitution in DNA polymerase ε produces a hyperactive enzyme
Nature Communications
, Nature Publishing Group 2019, Vol. 10
Xing, Xuanxuan; Kane, Daniel P.; Bulock, Chelsea R.; et al.
2018
Mrc1 and Rad9 cooperate to regulate initiation and elongation of DNA replication in response to DNA damage
EMBO Journal
, Wiley-VCH Verlagsgesellschaft 2018, Vol. 37, (21)
Bacal, Julien; Moriel-Carretero, María; Pardo, Benjamin; et al.
2018
SAMHD1 acts at stalled replication forks to prevent interferon induction
Nature
, Vol. 557, (7703) : 57-61
Coquel, Flavie; Silva, Maria-Joao; Técher, Hervé; et al.
2018
Separable roles for Mec1/ATR in genome maintenance, DNA replication, and checkpoint signaling
Genes & Development
, Vol. 32, (11-12) : 822-835
Lanz, Michael Charles; Oberly, Susannah; Sanford, Ethan James; et al.
2018
Rtt105 functions as a chaperone for replication protein A to preserve genome stability
EMBO Journal
, Wiley-VCH Verlagsgesellschaft 2018, Vol. 37, (17)
Li, Shuqi; Xu, Zhiyun; Xu, Jiawei; et al.
2018
Upregulation of dNTP Levels After Telomerase Inactivation Influences Telomerase-Independent Telomere Maintenance Pathway Choice in
Saccharomyces cerevisiae
G3: Genes, Genomes, Genetics
, Vol. 8, (8) : 2551-2558
van Mourik, Paula M; de Jong, Jannie; Sharma, Sushma; et al.
2018
A mechanism for preventing asymmetric histone segregation onto replicating DNA strands
Science
, American Association for the Advancement of Science 2018, Vol. 361, (6409) : 1386-+-
Yu, Chuanhe; Gan, Haiyun; Serra-Cardona, Albert; et al.
2017
Checkpoint Kinase Rad53 Couples Leading- and Lagging-Strand DNA Synthesis under Replication Stress
Molecular Cell
, Elsevier 2017, Vol. 68, (2) : 446-455
Gan, Haiyun; Yu, Chuanhe; Devbhandari, Sujan; et al.
2017
Rnr1, but not Rnr3, facilitates the sustained telomerase-dependent elongation of telomeres
PLOS Genetics
, Vol. 13, (10)
Maicher, André; Gazy, Inbal; Sharma, Sushma; et al.
2017
Alterations in cellular metabolism triggered by URA7 or GLN3 inactivation cause imbalanced dNTP pools and increased mutagenesis
Proceedings of the National Academy of Sciences of the United States of America
, Vol. 114, (22) : E4442-E4451
Schmidt, Tobias T; Reyes, Gloria; Gries, Kerstin; et al.
2016
Polyphosphate is involved in cell cycle progression and genomic stability in Saccharomyces cerevisiae
Molecular Microbiology
, Vol. 101, (3) : 367-380
Bru, Samuel; Marc Martinez-Lainez, Joan; Hernandez-Ortega, Sara; et al.
2015
Determination of deoxyribonucleoside triphosphate concentrations in yeast cells by strong anion-exchange high-performance liquid chromatography coupled with ultraviolet detection
DNA Replikation: Methods and Protocols
, New York: Springer-Verlag New York 2015 : 113-121
Jia, Shaodong; Marjavaara, Lisette; Buckland, Robert; et al.
2015
Colon cancer-associated mutator DNA polymerase δ variant causes expansion of dNTP pools increasing its own infidelity
Proceedings of the National Academy of Sciences of the United States of America
, Vol. 112, (19) : E2467-E2476
Mertz, Tony M; Sharma, Sushma; Chabes, Andrei; et al.
2014
Loss of the thioredoxin reductase Trr1 suppresses the genomic instability of peroxiredoxin tsa1 mutants
PLOS ONE
, Vol. 9, (9)
Ragu, Sandrine; Dardalhon, Michele; Sharma, Sushma; et al.
2013
Telomere Length Homeostasis Responds to Changes in Intracellular dNTP Pools
Genetics
, The Genetics Society 2013, Vol. 193, (4) : 1095-1105
Gupta, Amitabha; Sharma, Sushma; Reichenbach, Patrick; et al.
2012
Replication fork collapse and genome instability in dCMP deaminase mutant
Molecular and Cellular Biology
, Washington: American Society Microbiology 2012, Vol. 32, (21) : 4445-4454
Sánchez, Arancha; Sharma, Sushma; Rozenzhak, Sophie; et al.
Imbalanced dNTP pools induce mutator and cancer phenotypes in mice
Tran, Phong; Moskalenko, Roman; Sharma, Sushma; et al.
View publications in DiVA
Research groups
Group member
Andrei Chabes Lab
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