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Per-Arne Oldenborg
Contact
E-mail
per-arne.oldenborg@umu.se
Phone
+46 90 786 59 74
,
+46 70 337 59 74
Works at
Affiliation
Professor at
Department of Medical and Translational Biology
Section: Administration IMB, Group Per-Arne Oldenborg
Location
Umeå universitet, 901 87 Umeå
Publications
Publications
Research
Research
2024
The expression of signal regulatory protein alpha (SIRPα) in periodontal cells and tissue
Acta Odontologica Scandinavica
, Medical Journals Sweden 2024, Vol. 83 : 486-492
Koskinen Holm, Cecilia; Rosendahl, Sara; Oldenborg, Per-Arne; et al.
2020
Thrombospondin-1/CD47 signaling modulates transmembrane cation conductance, survival, and deformability of human red blood cells
Cell Communication and Signaling
, Springer Nature 2020, Vol. 18, (1)
Bissinger, Rosi; Petkova-Kirova, Polina; Mykhailova, Olga; et al.
2020
In
vitro
phagocytosis of liquid-stored red blood cells requires serum and can be inhibited with fucoidan and dextran sulphate
Vox Sanguinis
, John Wiley & Sons 2020, Vol. 115, (8) : 647-654
Hult, Andreas; Toss, Fredrik; Malm, Christer B.; et al.
2019
Microglial SIRP alpha regulates the emergence of CD11c(+) microglia and demyelination damage in white matter
eLIFE
, eLIFE Sciences Publications 2019, Vol. 8
Sato-Hashimoto, Miho; Nozu, Tomomi; Toriba, Riho; et al.
2018
Anti-human SIRP antibody is a new tool for cancer immunotherapy
Cancer Science
, WILEY 2018, Vol. 109, (5) : 1300-1308
Murata, Yoji; Tanaka, Daisuke; Hazama, Daisuke; et al.
2017
Human and murine splenic neutrophils are potent phagocytes of IgG-opsonized red blood cells
Blood Advances
, American Society of Hematology 2017, Vol. 1, (14) : 875-886
Meinderts, Sanne M.; Oldenborg, Per-Arne; Beuger, Boukje M.; et al.
2017
Eryptosis in health and disease: A paradigm shift towards understanding the (patho)physiological implications of programmed cell death of erythrocytes
Blood reviews
, CHURCHILL LIVINGSTONE 2017, Vol. 31, (6) : 349-361
Qadri, Syed M.; Bissinger, Rosi; Solh, Ziad; et al.
2017
Anti-SIRP alpha antibodies as a potential new tool for cancer immunotherapy
JCI Insight
, American Society for Clinical Investigation 2017, Vol. 2, (1)
Yanagita, Tadahiko; Murata, Yoji; Tanaka, Daisuke; et al.
2016
Lack of SIRP alpha phosphorylation and concomitantly reduced SHP-2-PI3K-Akt2 signaling decrease osteoblast differentiation
Biochemical and Biophysical Research Communications - BBRC
, Vol. 478, (1) : 268-273
Holm, Cecilia Koskinen; Engman, Sara; Sulniute, Rima; et al.
2016
Red blood cells with elevated cytoplasmic Ca2+ are primarily taken up by splenic marginal zone macrophages and CD207+dendritic cells
Transfusion
, Vol. 56, (7) : 1834-1844
Larsson, Anders; Hult, Andreas; Nilsson, Anna; et al.
2016
Antibody-mediated phagocytosis of red blood cells by neutrophils in the human spleen
European Journal of Clinical Investigation
, Vol. 46 : 77-77
Meinderts, S. M.; Oldenborg, Per-Arne; Beuger, B.; et al.
2015
Lack of non-hematopoietic SIRPα signaling disturbs the splenic marginal zone architecture resulting in accumulation and displacement of marginal zone B cells
Biochemical and Biophysical Research Communications - BBRC
, Vol. 460, (3) : 645-650
Kolan, Shrikant; Boman, Andreas; Matozaki, Takashi; et al.
2015
Non-Hematopoietic and Hematopoietic SIRPα Signaling Differently Regulates Murine B Cell Maturation in Bone Marrow and Spleen
PLoS One
, plos one 2015, Vol. 10, (7)
Kolan, Shrikant; Lejon, Kristina; Koskinen Holm, Cecilia; et al.
2014
Signal regulatory protein alpha is present in several neutrophil granule populations and is rapidly mobilized to the cell surface to negatively fine-tune neutrophil accumulation in inflammation
Journal of Innate Immunity
, Vol. 6, (4) : 553-560
Stenberg, Åsa; Karlsson, Anna; Feuk-Lagerstedt, Elisabeth; et al.
2013
Macrophages: Good guys in colorectal cancer
Oncoimmunology
, Vol. 2, (2) : e23038-
Edin, Sofia; Wikberg, Maria L; Oldenborg, Per-Arne; et al.
2013
Phenotypic skewing of macrophages in vitro by secreted factors from colorectal cancer cells
PLOS ONE
, PLoS, Public Library of Science 2013, Vol. 8, (9) : e74982-
Edin, Sofia; Wikberg, Maria L; Rutegård, Jörgen; et al.
2013
Transfusion of cryopreserved human red blood cells into healthy humans is associated with rapid extravascular hemolysis without a proinflammatory cytokine response
Transfusion
, John Wiley & Sons 2013, Vol. 53, (1) : 28-33
Hult, Andreas; Malm, Christer; Oldenborg, Per-Arne
2013
Lack of CD47 impairs bone cell differentiation and results in an osteopenic phenotype in vivo due to impaired signal regulatory protein α (SIRPα) signaling
Journal of Biological Chemistry
, Vol. 288, (41) : 29333-29344
Koskinen, Cecilia; Persson, Emelie; Baldock, Paul; et al.
2013
CD47: a cell surface glycoprotein which regulates multiple functions of hematopoietic cells in health and disease.
ISRN Hematology
, Vol. 2013 : 614619-
Oldenborg, Per-Arne
2013
Neutrophil apoptosis is associated with loss of signal regulatory protein alpha (SIRP alpha) from the cell surface
Journal of Leukocyte Biology
, Vol. 93, (3) : 403-412
Stenberg, Åsa; Sehlin, Janove; Oldenborg, Per-Arne
2012
The Distribution of Macrophages with a M1 or M2 Phenotype in Relation to Prognosis and the Molecular Characteristics of Colorectal Cancer
PLOS ONE
, PLoS One 2012, Vol. 7, (10) : e47045-
Edin, Sofia; Wikberg, Maria L.; Dahlin, Anna M.; et al.
2012
Lack of CD47 leads to impaired bone cell differentiation and results in an osteopenic bone phenotype
Bone
, Vol. 50, (Supplement 1) : S42-S43
Koskinen, Cecilia; Persson, Emma; Baldock, P.; et al.
2012
The absence of CD47 promotes nerve fiber growth from cultured ventral mesencephalic dopamine neurons
PLOS ONE
, Public library of science 2012, Vol. 7, (9) : e45218-
Marschinke, Franziska; Hashemian, Sanaz Alsadat; Matozaki, Takashi; et al.
2012
Hypothermia-induced tyrosine phosphorylation of SIRPα in the brain
Journal of Neurochemistry
, John Wiley & Sons 2012, Vol. 121, (6) : 891-902
Maruyama, Toshi; Kusakari, Shinya; Sato-Hashimoto, Miho; et al.
2012
Macrophage expression of LRP1, a receptor for apoptotic cells and unopsonized erythrocytes, can be regulated by glucocorticoids
Biochemical and Biophysical Research Communications - BBRC
, San Diego: Elsevier 2012, Vol. 417, (4) : 1304-1309
Nilsson, Anna; Vesterlund, Liselotte; Oldenborg, Per-Arne
2012
Role of CD47 and Signal Regulatory Protein Alpha (SIRP alpha) in Regulating the Clearance of Viable or Aged Blood Cells
Transfusion Medicine and Hemotherapy
, Vol. 39, (5) : 315-320
Oldenborg, Per-Arne
2012
CD47-deficient mice have decreased production of intestinal IgA following oral immunization but a maintained capacity to induce oral tolerance
Immunology
, Malden: Wiley-Blackwell 2012, Vol. 135, (3) : 236-244
Westlund, Jessica; Livingston, Megan; Fahlen-Yrlid, Linda; et al.
2011
Myelin down-regulates myelin phagocytosis by microglia and macrophages through interactions between CD47 on myelin and SIRPalpha (signal regulatory protein-alpha) on phagocytes
Journal of Neuroinflammation
, Vol. 8, (1) : 24-
Gitik, Miri; Liraz Zaltsman, Sigal; Oldenborg, Per-Arne; et al.
2011
Blocking cd47/ox101 makes the astrocytes permissive for nerve fiber growth
Glia: 10th European meeting on Glial Cells in Health and Disease
, New York, N.Y.: Wiley-Liss, Inc. 2011 : S105-S106
Hashemian, Sanaz Alsadat; Marschinke, Franziska; Oldenborg, Per-Arne; et al.
2011
Colorectal Cancer Cells Activate Adjacent Fibroblasts Resulting in FGF1/FGFR3 Signaling and Increased Invasion.
American Journal of Pathology
, Elsevier 2011, Vol. 178, (3) : 1387-1394
Henriksson, Maria L; Edin, Sofia; Dahlin, Anna M; et al.
2011
Signal regulatory protein α regulates the homeostasis of T lymphocytes in the spleen.
Journal of Immunology
, American Association of Immunologists 2011, Vol. 187, (1) : 291-297
Sato-Hashimoto, Miho; Saito, Yasuyuki; Ohnishi, Hiroshi; et al.
2010
Stress-evoked tyrosine phosphorylation of signal regulatory protein α regulates behavioral immobility in the forced swim test
Journal of Neuroscience
, Vol. 30, (31) : 10472-10483
Ohnishi, Hiroshi; Murata, Takaaki; Kusakari, Shinya; et al.
2010
Regulation by SIRPα of dendritic cell homeostasis in lymphoid tissues
Blood
, Vol. 116, (18) : 3517-3525
Saito, Yasuyuki; Iwamura, Hiroko; Kaneko, Tetsuya; et al.
2010
CD47 is required for suppression of allograft rejection by donor-specific transfusion
Journal of Immunology
, Vol. 184, (7) : 3401-3407
Wang, Hui; Wu, Xiaojian; Wang, Yuantao; et al.
2009
CD47 regulates collagen I-induced cyclooxygenase-2 expression and intestinal epithelial cell migration.
PloS one
, Vol. 4, (7) : e6371-
Broom, Oliver Jay; Zhang, Yuan; Oldenborg, Per-Arne; et al.
2009
CD47 promotes both phosphatidylserine-independent and phosphatidylserine-dependent phagocytosis of apoptotic murine thymocytes by non-activated macrophages
Biochemical and Biophysical Research Communications - BBRC
, Elsevier 2009, Vol. 387, (1) : 58-63
Nilsson, Anna; Oldenborg, Per-Arne
2008
Essential roles of SHPS-1 in induction of contact hypersensitivity of skin.
Immunology Letters
, Vol. 121, (1) : 52-60
Motegi, Sei-Ichiro; Okazawa, Hideki; Murata, Yoji; et al.
2008
CD47 on experimentally senescent murine RBCs inhibits phagocytosis following Fcgamma receptor-mediated but not scavenger receptor-mediated recognition by macrophages.
Blood
, Vol. 112, (10) : 4259-67
Olsson, Mattias; Oldenborg, Per-Arne
2007
Osteoclast formation is strongly reduced both in vivo and in vitro in the absence of CD47/SIRPalpha-interaction
Biochemical and Biophysical Research Communications - BBRC
, Vol. 352, (2) : 444-448
Lundberg, Pernilla; Koskinen, Cecilia; Baldock, Paul A; et al.
2007
Dose-dependent inhibitory effect of CD47 in macrophage uptake of IgG-opsonized murine erythrocytes.
Biochemical and Biophysical Research Communications - BBRC
, Vol. 352, (1) : 193-197
Olsson, Mattias; Nilsson, Anna; Oldenborg, Per-Arne
2007
Lack of CD47 on nonhematopoietic cells induces split macrophage tolerance to CD47null cells
Proceedings of the National Academy of Sciences of the United States of America
, National academy of sciences 2007, Vol. 104, (34) : 13744-13749
Wang, Hui; Madariaga, Maria Lucia; Wang, Shumei; et al.
2007
Attenuation of phagocytosis of xenogeneic cells by manipulating CD47.
Blood
, Vol. 109, (2) : 836-42
Wang, Hui; VerHalen, Jon; Madariaga, Maria Lucia; et al.
2006
Deficit of CD47 results in a defect of marginal zone dendritic cells, blunted immune response to particulate antigen and impairment of skin dendritic cell migration.
Journal of Immunology
, Vol. 176, (10) : 5772-8
Hagnerud, Sven; Manna, Partha Pratim; Cella, Marina; et al.
2006
Mutational analysis of the mechanism of negative regulation by SRC homology 2 domain-containing protein tyrosine phosphatase substrate-1 of phagocytosis in macrophages.
Journal of Immunology
, Vol. 177, (5) : 3123-32
Ikeda, Hiroshi; Okazawa, Hideki; Ohnishi, Hiroshi; et al.
2006
Enhanced phagocytosis of CD47-deficient red blood cells by splenic macrophages requires SHPS-1.
Biochemical and Biophysical Research Communications - BBRC
, Vol. 343, (4) : 1197-200
Ishikawa-Sekigami, Tomomi; Kaneko, Yoriaki; Saito, Yasuyuki; et al.
2006
CD47 promotes neuronal development through Src- and FRG/Vav2-mediated activation of Rac and Cdc42.
Journal of Neuroscience
, Vol. 26, (48) : 12397-407
Murata, Takaaki; Ohnishi, Hiroshi; Okazawa, Hideki; et al.
2006
Hematologic Diseases: Autoimmune Hemolytic Anemia and Immune Thrombocytopenic Purpura
Immunogenetics of Autoimmune Disease
: -
Olsson, Mattias; Hagnerud, Sven; Hedelius, David U R; et al.
2006
Target cell CD47 regulates macrophage activation and erythrophagocytosis.
Transfusion Clinique et Biologique
, Vol. 13, (1-2) : 39-43
Olsson, Mattias; Nilsson, Anna; Oldenborg, Per-Arne
2006
Insulin inhibits phagocytosis in normal human neutrophils via PKCalpha/beta-dependent priming of F-actin assembly.
Inflammation Research
, Vol. 55, (3) : 85-91
Saiepour, Daniel; Sehlin, Janove; Oldenborg, Per-Arne
2005
Cell-surface calreticulin initiates clearance of viable or apoptotic cells through trans-activation of LRP on the phagocyte
Cell
, Vol. 123, (2) : 321-334
Gardai, Shyra J; McPhillips, Kathleen A; Frasch, S Courtney; et al.
View publications in DiVA
Research groups
Head of research
Per-Arne Oldenborg-research group
Research projects
28 October 2011 until 31 December 2013
CD47 and signal regulatory protein a (SIRP a) modulates innate immune and autoimmune responses
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