Press photo

Patrik Danielson

M.D., Ph.D.

Professor of Anatomy

Senior Consultant Ophthalmologist

Dean of the Faculty of Medicine

Contact

patrik.danielson@umu.se

Visiting address, view map

+46 90 786 58 93, +46 70 336 80 30

Works as

Professor, senior consultant (attending) physician at Department of Medical and Translational Biology Section: Teachers A-wing, Group Patrik Danielson

Affiliated as professor at Faculty Office of Medicine

Dean's Secretary: Anna Olson

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Professor of Anatomy at Umeå University and Senior Consultant (Attending) Ophthalmologist at the University Hospital of Umeå.

Dean of the Faculty of Medicine.

List of Publications:
Google Scholar Profile for Patrik Danielson

Research Project:
Mechanisms of scar-formation and degeneration in collagen-rich tissues

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CV | Curriculum Vitae | Patrik Danielson, MD, PhD

Personal information

Born 1980

Professional Preparation and Academic Appointments

2016 | Professor and Senior Consultant Ophthalmologist
2014 | Professor (full)
2012 | Reader/Associate Professor
2009 | Senior Lecturer/Associate Professor
2007 | Doctor of Philosophy, Medicine (Ph.D.)
2007 | Medical License (Registered Physician)
2005 | Medical Degree (M.D.)

Commissions of Trust (selection)

Dean, Faculty of Medicine, Umeå University, 2017-
Member of the Government's Adivisory Board for Life Science, 2024-
Vice President of the Swedish Society of Medicine, 2024-07-01--
Member of the Board of the Swedish Society for Medical Research, 2019-
Chair of the National Steering Committee for the ALF-agreement, 2021
Government-appointed Member of the National Steering Committee for the ALF-agreement, 2015-18; 2019-2022
Government-appointed Member of the Committee for Clinical Studies, national Swedish Research Council, 2018-2020
Member of the Board of the Swedish Society of Medicine, 2015-18
Deputy Dean, Faculty of Medicine, Umeå University, 2014-17
Member of the Faculty Board, Faculty of Medicine, Umeå University (elected faculty representative), 2011-14
Member of the Board of Directors for Umeå University (student representative), 2002-04
Member of the Faculty Board, Faculty of Medicine, Umeå University (student representative), 2001-04
President and Chairman, Umeå Medical Sciences Student Union (formerly Corpus), 2002-04

External Research Grants as Main Applicant (selection)

2018-21 | National Swedish Research Council: 4 800 kSEK
2014-17 | National Swedish Research Council: 5 044 kSEK
2010-12 | National Swedish Research Council: 2 100 kSEK
2017-23 | Ögonfonden Foundation: 1 160 kSEK
2011-15 | Swedish Society of Medicine: 1 200 kSEK
2011-17 | Cronqvists Foundation: 900 kSEK

List of Scientifc Publications

Link to Google Scholar-profile

Awards and Honours

Invited European Society of Ophthalmology (SOE) Speaker of the Year, at the Annual Meeting of the Swedish Ophthalmological Society 2017
The Swedish Society of Medicine's Best Translational Research Award 2013
Umeå University Young Researcher Award 2011
The Royal Skytteanska Society's Distinguished Young Researcher Award in Medicine 2010
Honorary Member for Life of Umeå Medical Sciences Student Union, 2007

Corneal strain influences keratocyte proliferation and migration through upregulation of ALDH3A1 expression

The FASEB Journal, John Wiley & Sons 2024, Vol. 38, (23)

Zhang, Qian; Zhou, Xin; Zhang, Wei; et al.

Keratocyte Differentiation Is Regulated by NF-κB and TGFβ Signaling Crosstalk

International Journal of Molecular Sciences, MDPI 2022, Vol. 23, (19)

Zhou, Xin; Li, Junhong; Backman, Ludvig J.; et al.

Microstructured collagen films for 3D corneal stroma modelling

Connective Tissue Research, Taylor & Francis Group 2022, Vol. 63, (5) : 443-452

Prittinen, Juha; Zhou, Xin; Bano, Fouzia; et al.

Activation of NF-κB signaling via cytosolic mitochondrial RNA sensing in kerotocytes with mitochondrial DNA common deletion

Scientific Reports, Nature Publishing Group 2021, Vol. 11, (1)

Zhou, Xin; Backman, Ludvig J.; Danielson, Patrik

Acetylcholine decreases formation of myofibroblasts and excessive extracellular matrix production in an in vitro human corneal fibrosis model

Journal of Cellular and Molecular Medicine, John Wiley & Sons 2020, Vol. 24, (8) : 4850-4862

Sloniecka, Marta; Danielson, Patrik

Regulation of Keratocyte Phenotype and Cell Behavior by Substrate Stiffness

ACS Biomaterials Science & Engineering, American Chemical Society (ACS) 2020, Vol. 6, (9) : 5162-5171

Chen, Jialin; Backman, Ludvig J.; Zhang, Wei; et al.

Sustained Release of TPCA-1 from Silk Fibroin Hydrogels Preserves Keratocyte Phenotype and Promotes Corneal Regeneration by Inhibiting Interleukin-1β Signaling

Advanced Healthcare Materials, Wiley-VCH Verlagsgesellschaft 2020, Vol. 9, (17)

Zhang, Wei; Chen, Jialin; Qu, Mingli; et al.

Induction of Fibroblast Senescence During Mouse Corneal Wound Healing

Investigative Ophthalmology and Visual Science, ASSOC RESEARCH VISION OPHTHALMOLOGY INC 2019, Vol. 60, (10) : 3669-3679

Wang, Xiaolei; Qu, Mingli; Li, Jing; et al.

Substance P induces fibrotic changes through activation of the RhoA/ROCK pathway in an in vitro human corneal fibrosis model

Journal of Molecular Medicine, Springer Berlin/Heidelberg 2019, Vol. 97, (10) : 1477-1489

Sloniecka, Marta; Danielson, Patrik

Mechanical stress potentiates the differentiation of periodontal ligament stem cells into keratocytes

British Journal of Ophthalmology, BMJ Publishing Group Ltd 2018, Vol. 102, (4) : 562-569

Chen, Jialin; Zhang, Wei; Backman, Ludvig J.; et al.

Ascorbic Acid Promotes the Stemness of Corneal Epithelial Stem/Progenitor Cells and Accelerates Epithelial Wound Healing in the Cornea

Stem Cells Translational Medicine, WILEY 2017, Vol. 6, (5) : 1356-1365

Chen, Jialin; Lan, Jie; Liu, Dongle; et al.

Corneal Epithelium-Derived Neurotrophic Factors Promote Nerve Regeneration

Investigative Ophthalmology and Visual Science, ASSOC RESEARCH VISION OPHTHALMOLOGY INC 2017, Vol. 58, (11) : 4695-4702

Di, Guohu; Qi, Xia; Zhao, Xiaowen; et al.

Glutamate signaling through the NMDA receptor reduces the expression of scleraxis in plantaris tendon derived cells

BMC Musculoskeletal Disorders, Vol. 18

Spang, Christoph; Backman, Ludvig J.; Le Roux, Sandrine; et al.

Substance P and patterned silk biomaterial stimulate periodontal ligament stem cells to form corneal stroma in a bioengineered three-dimensional model

Stem Cell Research & Therapy, BIOMED CENTRAL LTD 2017, Vol. 8

Chen, Jialin; Zhang, Wei; Kelk, Peyman; et al.

Surface Topography and Mechanical Strain Promote Keratocyte Phenotype and Extracellular Matrix Formation in a Biomimetic 3D Corneal Model

Advanced Healthcare Materials, Wiley-VCH Verlagsgesellschaft 2017, Vol. 6, (5)

Zhang, Wei; Chen, Jialin; Backman, Ludvig J.; et al.

Antiapoptotic Effect of Acetylcholine in Fas-Induced Apoptosis in Human Keratocytes

Investigative Ophthalmology and Visual Science, Vol. 57, (14) : 5892-5902

Sloniecka, Marta; Backman, Ludvig J.; Danielson, Patrik

Ciliary Neurotrophic Factor Promotes the Migration of Corneal Epithelial Stem/progenitor Cells by Up-regulation of MMPs through the Phosphorylation of Akt

Scientific Reports, Vol. 6

Chen, Jialin; Chen, Peng; Backman, Ludvig J.; et al.

Substance P Enhances Keratocyte Migration and Neutrophil Recruitment through Interleukin-8

Molecular Pharmacology, Vol. 89, (2) : 215-225

Sloniecka, Marta; Le Roux, Sandrine; Zhou, Qingjun; et al.

Acetylcholine enhances keratocyte proliferation through muscarinic receptor activation.

International Immunopharmacology, Vol. 29, (1) : 57-62

Słoniecka, Marta; Backman, Ludvig J; Danielson, Patrik

Expression Profiles of Neuropeptides, Neurotransmitters, and Their Receptors in Human Keratocytes In Vitro and In Situ

PLOS ONE, Public library science 2015, Vol. 10, (7)

Sloniecka, Marta; Le Roux, Sandrine; Boman, Peter; et al.

Mutations in Collagen, Type XVII, Alpha 1 (COL17A1) Cause Epithelial Recurrent Erosion Dystrophy (ERED)

Human Mutation, John Wiley & Sons 2015, Vol. 36, (4) : 463-473

Jonsson, Frida; Byström, Berit; Davidson, Alice E.; et al.

Substance P promotes diabetic corneal epithelial wound healing through molecular mechanisms mediated via the neurokinin-1 receptor.

Diabetes, Vol. 63, (12) : 4262-4274

Yang, Lingling; Di, Guohu; Qi, Xia; et al.

Substance P reduces TNF-α-induced apoptosis in human tenocytes through NK-1 receptor stimulation

British Journal of Sports Medicine, BMJ Publishing Group Ltd 2014, Vol. 48, (19) : 1414-1420

Backman, Ludvig J.; Eriksson, Daniella E.; Danielson, Patrik

Akt-mediated anti-apoptotic effects of substance P in Anti-Fas-induced apoptosis of human tenocytes

Journal of Cellular and Molecular Medicine, Wiley-Blackwell 2013, Vol. 17, (6) : 723-733

Backman, Ludvig J; Danielson, Patrik

Alpha-2 adrenergic stimulation triggers Achilles tenocyte hypercellularity: comparison between two model systems

Scandinavian Journal of Medicine and Science in Sports, John Wiley & Sons 2013, Vol. 23, (6) : 687-696

Backman, Ludvig J; Andersson, Gustav; Fong, Gloria; et al.

Human tenocytes are stimulated to proliferate by acetylcholine through an EGFR signalling pathway

Cell and Tissue Research, Springer-Verlag New York 2013, Vol. 351, (3) : 465-475

Fong, Gloria; Backman, Ludvig; Andersson, Gustav; et al.

Sports and exercise-related tendinopathies: a review of selected topical issues by participants of the second International Scientific Tendinopathy Symposium (ISTS) Vancouver 2012

British Journal of Sports Medicine, London, England: BMJ Publishing Group 2013, Vol. 47, (9) : 536-+

Scott, Alex; Docking, Sean; Vicenzino, Bill; et al.

Substance P enhances collagen remodeling and MMP-3 expression by human tenocytes

Journal of Orthopaedic Research, HOBOKEN, NJ, USA: Wiley-Blackwell 2013, Vol. 31, (1) : 91-98

Fong, Gloria; Backman, Ludvig J.; Hart, David A.; et al.

In situ hybridization studies favouring the occurrence of a local production of BDNF in the human Achilles tendon

Histology and Histopathology, Vol. 27, (9) : 1239-1246

Bagge, Johan; Danielson, Patrik; Forsgren, Sture

Endogenous substance P production in the Achilles tendon increases with loading in an in vivo model of tendinopathy: peptidergic elevation preceding tendinosis-like tissue changes

Journal of Musculoskeletal and Neuronal Interactions - JMNI, International Society of Musculoskeletal and Neuronal Interactions 2011, Vol. 11, (2) : 133-140

Backman, Ludvig; Andersson, Gustav; Wennstig, Gabriel; et al.

Low range of ankle dorsiflexion predisposes for patellar tendinopathy in junior elite basketball players: a 1-year prospective study

American Journal of Sports Medicine, Vol. 39, (12) : 2626-2633

Backman, Ludvig J; Danielson, Patrik

Mechanical force modulates scleraxis expression in bioartificial tendons

Journal of Musculoskeletal and Neuronal Interactions - JMNI, International Society of Musculoskeletal and Neuronal Interactions 2011, Vol. 11, (2) : 124-132

Scott, A; Danielson, Patrik; Abraham, T; et al.

Physical activity level in Achilles tendinosis is associated with blood levels of pain-related factors: a pilot study

Scandinavian Journal of Medicine and Science in Sports, Vol. 21, (6) : E430-E438

Bagge, Johan; Gaida, JE; Danielson, Patrik; et al.

Substance P accelerates hypercellularity and angiogenesis in tendon tissue and enhances paratendinitis in response to Achilles tendon overuse in a tendinopathy model

British Journal of Sports Medicine, Loughborough: British Assoc. of Sport and Medicine 2011, Vol. 45, (13) : 1017-1022

Andersson, Gustav; Backman, Ludvig; Scott, Alexander; et al.

Substance P is a mechanoresponsive, autocrine regulator of human tenocyte proliferation

PLOS ONE, San Francisco, USA: Public Library of Science 2011, Vol. 6, (11) : e27209-

Backman, Ludvig; Fong, Gloria; Andersson, Gustav; et al.

Immunohistochemical evidence of local production of catecholamines in cells of the muscle origins at the lateral and medial humeral epicondyles: of importance for the development of tennis and golfer's elbow?

British Journal of Sports Medicine, Vol. 43, (4) : 269-275