Pardeep Singh

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Staff scientist at Department of Chemistry

KB.C4, Linnaeus väg 10, C4-39-07 Umeå universitet, 901 87 Umeå

Photoredox-catalyzed radical coupling of C7-chloromethyl-substituted thiazolino ring-fused 2-pyridones with quinoxalinones

Journal of Organic Chemistry, American Chemical Society (ACS) 2024, Vol. 89, (16) : 11802-11810

Hellgren, Victor; Singh, Pardeep; Kulkarni, Abhilash; et al.

Synthesis of three-dimensional ring fused heterocycles by a selective [4 + 2] cycloaddition between bicyclic thiazolo 2-pyridones and arynes

Journal of Organic Chemistry, American Chemical Society (ACS) 2024, Vol. 89, (1) : 731-739

Sarkar, Souvik; Singh, Pardeep; Edin, Simon; et al.

Dihydrothiazolo ring-fused 2-pyridone antimicrobial compounds treat Streptococcus pyogenes skin and soft tissue infection

Science Advances, American Association for the Advancement of Science (AAAS) 2024, Vol. 10, (31)

Zou, Zongsen; Singh, Pardeep; Pinkner, Jerome S.; et al.

A highly substituted ring-fused 2-pyridone compound targeting PrfA and the efflux regulator BrtA in listeria monocytogenes

mBio, American Society for Microbiology 2023, Vol. 14, (3)

Tükenmez, Hasan; Singh, Pardeep; Sarkar, Souvik; et al.

Ring-fused 2-pyridones effective against multidrug-resistant Gram-positive pathogens and synergistic with standard-of-care antibiotics

Proceedings of the National Academy of Sciences of the United States of America, PNAS 2022, Vol. 119, (43)

Nye, Taylor M.; Tükenmez, Hasan; Singh, Pardeep; et al.

K₂S₂O₈-mediated coupling of 6-amino-7-aminomethyl-thiazolino-pyridones with aldehydes to construct amyloid affecting pyrimidine-fused thiazolino-2-pyridones

Organic and biomolecular chemistry, The Royal Society of Chemistry 2021, Vol. 19, (44) : 9758-9772

Bharate, Jaideep B.; Ådén, Jörgen; Gharibyan, Anna; et al.

An efficient and scalable synthesis of thiazolo ring fused 2-pyridones using flow chemistry

ARKIVOC, Arkat 2021, Vol. 2020, (7) : 365-378

Cairns, Andrew G.; Sarkar, Souvik; Singh, Pardeep; et al.

A 2-pyridone amide inhibitor of transcriptional activity in Chlamydia trachomatis

Antimicrobial Agents and Chemotherapy, American Society for Microbiology 2021, Vol. 65, (5)

Núñez-Otero, Carlos; Bahnan, Wael; Vielfort, Katarina; et al.

Tandem Ring Opening/Intramolecular [2 + 2] Cycloaddition Reaction for the Synthesis of Cyclobutane Fused Thiazolino-2-Pyridones

Journal of Organic Chemistry, American Chemical Society (ACS) 2021, Vol. 86, (23) : 16582-16592

Tyagi, Mohit; Adolfsson, Dan E.; Singh, Pardeep; et al.

Intramolecular Povarov Reactions for the Synthesis of Chromenopyridine fused 2-Pyridone Polyheterocycles Binding to α-Synuclein and Amyloid-β fibrils

Journal of Organic Chemistry, American Chemical Society (ACS) 2020, Vol. 85, (21) : 14174-14189

Adolfsson, Dan E.; Tyagi, Mohit; Singh, Pardeep; et al.

Methyl sulfonamide substituents improve the pharmacokinetic properties of bicyclic 2-pyridone based Chlamydia trachomatis inhibitors

MedChemComm, Royal Society of Chemistry 2019, Vol. 10, (11) : 1966-1987

Kulén, Martina; Núñez-Otero, Carlos; Cairns, Andrew G.; et al.

Visible light mediated synthesis of β chloro ketones from aryl cyclopropanes

Angewandte Chemie International Edition, John Wiley & Sons 2019, Vol. 58 : 8577-8580

Petzold, Daniel; Singh, Pardeep; Almqvist, Fredrik; et al.

Pyridine-Fused 2-Pyridones via Povarov and A³ Reactions: Rapid Generation of Highly Functionalized Tricyclic Heterocycles Capable of Amyloid Fibril Binding

Journal of Organic Chemistry, American Chemical Society (ACS) 2019, Vol. 84, (7) : 3887-3903

Singh, Pardeep; Adolfsson, Dan E.; Ådén, Jörgen; et al.

Synthesis of Densely Functionalized N-Alkenyl 2-Pyridones via Benzyne-Induced Ring Opening of Thiazolino-Fused 2-Pyridones

Organic Letters, American Chemical Society (ACS) 2019, Vol. 21 : 6946-6950

Singh, Pardeep; Cairns, Andrew G.; Adolfsson, Dan E.; et al.

β‐Lactam‐Synthon Interceded Diastereoselective Synthesis of 2‐Azido‐γ‐amino Alcohols with Subsequent Transformations to Functionally Enriched Heterocycles

ChemistrySelect, John Wiley & Sons 2018, Vol. 3, (17) : 4764-4767

Singh, Amandeep; Sharma, Bharvi; Sachdeva, Divya; et al.

Synthesis of multiring fused 2‑pyridones via a nitrene insertion reaction: fluorescent modulators of α‑synuclein amyloid formation

Organic Letters, American Chemical Society (ACS) 2015, Vol. 17, (24) : 6194-6197

Singh, Pardeep; Chorell, Erik; Krishnan, K Syam; et al.

Enhanement of amyloid fibril binding by ring expansion of thiazolino fused 2-pyridone peptidomimetics

Adolfsson, Dan E.; Tyagi, Mohit; Singh, Pardeep; et al.

K₂S₂O₈-mediated aerobic oxidative coupling of 6-amino-7-(aminomethyl)-thiazolino-pyridones with aldehydes: Direct access to highly functionalized pyrimidine fused thiazolino-2-pyridones with amyloid fibril binding activity or inhibitors of Amyloid-β fibril formation

Bharate, Jaideep B.; Ådén, Jörgen; Gharibyan, Anna; et al.

Discovery of three new binding sites and modes of ring-fused 2-pyridones to PrfA: How can they contribute to drug design?

Oelker, Melanie; Vielfort, Katarina; Lindgren, Cecilia; et al.

Functionalization of Thiazolino fused 2-Pyridones by thiazoline ring opening and closing: Identification of new Amyloid Binding Heterocycles

Tyagi, Mohit; Adolfsson, Dan E.; Ådén, Jörgen; et al.

View publications in DiVA

Research groups

Group member

Fredrik Almqvist Lab

Research projects

1 January 2022

Design, synthesis and evaluation of novel ring-fused heterocycles targeting bacterial and human amyloid proteins