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Staff photo Magnus Wolf-Watz

Magnus Wolf-Watz

 Professor in biophysical chemistry.

Works at

Affiliation
Professor at Department of Chemistry Role: Assistant head of department
Location
KB.A3, Linnaeus väg 10, (rum: A3.13.07) Umeå universitet, 901 87 Umeå

The focus of my research is to uncover the complex linkages between protein dynamics and biological function.  Protein dynamics is in essence the plasticity that proteins display when they change their shape to perform their biological function. Understanding the mechanisms and energetics that control dynamics is currently at the fore-front of contemporary research in protein chemistry. In my lab protein dynamics is addressed in systems of varying complexity spanning from individual enzymes to complex biological systems and designed protein switches.

The main technique in the lab is solution state NMR spectroscopy which is the most powerful approach to quantify protein dynamics that can cover the entire range from fast (ps-ns) to slow (seconds to minutes) events. We use the full spectrum of structural biology techniques including: xray-crystallography, molecular dynamics simulations and single particle cryoEM. In all projects we carefully design functional assays that are used to connect protein dynamics with biological function.

Biography

Magnus Wolf-Watz obtained a master's degree in biochemistry at KTH in 1996. Five years later, he did his doctorate in structural biology at the same university. In the years 2001–2004, he was on a postdoctoral stay at Brandeis University outside Boston, USA. Since 2005, he has run a research group at Umeå University. In 2010 he was appointed associate professor in biological chemistry at Umeå University. In 2018 he was appointed professor i biophysical chemistry.

Journal of Biological Chemistry, Elsevier 2024, Vol. 300, (11)
Jönsson, Malin; Ul Mushtaq, Ameeq; Nagy, Tamás Milán; et al.
Journal of Chemical Information and Modeling, American Chemical Society (ACS) 2024, Vol. 64, (1) : 150-163
Nam, Kwangho; Arattu Thodika, Abdul Raafik; Grundström, Christin; et al.
ACS Omega, American Chemical Society (ACS) 2024, Vol. 9, (7) : 7393-7412
Nam, Kwangho; Shao, Yihan; Major, Dan T.; et al.
Science Advances, American Association for the Advancement of Science (AAAS) 2024, Vol. 10, (32)
Nam, Kwangho; Thodika, Abdul Raafik Arattu; Tischlik, Sonja; et al.
Journal of Chemical Information and Modeling, American Chemical Society (ACS) 2023, Vol. 63, (5) : 1556-1569
Dulko-Smith, Beata; Ojeda-May, Pedro; Ådén, Jörgen; et al.
Structural Dynamics, American Crystallographic Association 2023, Vol. 10, (1)
Nam, Kwangho; Wolf-Watz, Magnus
Biochemistry, American Chemical Society (ACS) 2023, Vol. 62, (15) : 2238-2243
Tischlik, Sonja; Oelker, Melanie; Rogne, Per; et al.
Biophysical Journal, Elsevier 2023, Vol. 122, (3S1) : 190a-190a
Wolf-Watz, Magnus; Jönsson, Malin; Ul Mushtaq, Ameeq; et al.
Science Advances, American Association for the Advancement of Science (AAAS) 2022, Vol. 8, (44)
Verma, Apoorv; Åberg-Zingmark, Emma; Sparrman, Tobias; et al.
Biochemistry, American Chemical Society (ACS) 2021, Vol. 60, (28) : 2246-2258
Ojeda-May, Pedro; Ul Mushtaq, Ameeq; Rogne, Per; et al.
Science Advances, American Association for the Advancement of Science 2021, Vol. 7, (47)
Orädd, Fredrik; Ravishankar, Harsha; Goodman, Jack; et al.
Protein Expression and Purification, Elsevier 2021, Vol. 186
Phoeurk, Chanrith; Ul Mushtaq, Ameeq; Rogne, Per; et al.
Biophysical Journal, Cell Press 2020, Vol. 118, (3) : 50A-50A
Ravishankar, Harsha; Goodman, Jack; Nors Pedersen, Martin; et al.
Biochemistry, American Chemical Society (ACS) 2020, Vol. 59, (38) : 3570-3581
Rogne, Per; Dulko-Smith, Beata; Goodman, Jack; et al.
Biophysical Journal, Cell Press 2020, Vol. 118, (3) : 193A-193A
Rogne, Per; Sauer-Eriksson, Elisabeth; Sauer, Uwe H.; et al.
Physiologia Plantarum, John Wiley & Sons 2019, Vol. 166, (1) : 288-299
Carius, Anke B.; Rogne, Per; Duchoslav, Miloš; et al.
Biochemistry, American Chemical Society (ACS) 2019, Vol. 58, (32) : 3408-3412
Rogne, Per; Andersson, David; Grundström, Christin; et al.
Biophysical Journal, CELL PRESS 2019, Vol. 116, (3) : 485A-485A
Wolf-Watz, Magnus; Rogne, Per; Sauer-Eriksson, A. Elisabeth; et al.
Journal of Molecular Biology, Elsevier 2018, Vol. 430, (18, Part B) : 3157-3169
Gupta, Arun A.; Reinartz, Ines; Karunanithy, Gogulan; et al.
Proceedings of the National Academy of Sciences of the United States of America, Vol. 115, (12) : 3012-3017
Rogne, Per; Rosselin, Marie; Grundström, Christin; et al.
Journal of Biological Chemistry, Vol. 292, (8) : 3299-3311
Ho, Oanh; Rogne, Per; Edgren, Tomas; et al.
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences 2017, Vol. 114, (24) : 6298-6303
Kovermann, Michael; Grundström, Christin; Sauer-Eriksson, A. Elisabeth; et al.
Quarterly reviews of biophysics (Print), Cambridge University Press 2016, Vol. 49
Kovermann, Michael; Rogne, Per; Wolf-Watz, Magnus
Biophysical Journal, Vol. 111, (7) : 1385-1395
Rogne, Per; Wolf-Watz, Magnus
PLOS ONE, Vol. 11, (9)
Tükenmez, Hasan; Magnussen, Helge; Kovermann, Michael; et al.
Nature Communications, Macmillan Publishers Ltd. 2015, Vol. 6
Kovermann, Michael; Ådén, Jörgen; Grundström, Christin; et al.
Scientific Reports, Springer 2015, Vol. 5
Perdersen, Martin Nors; Fodera, Vito; Horvath, Istvan; et al.
ChemSusChem, John Wiley & Sons 2015, Vol. 8, (2) : 3764-3768
Rogne, Per; Sparrman, Tobias; Anugwom, Ikenna; et al.
Biophysical Journal, Vol. 108, (2) : 30A-30A
Wolf-Watz, Magnus; Kovermann, Michael
PloS Computational Biology, PLOS 2014, Vol. 10, (7) : e1003721-
Esteban-Martin, Santiago; Fenwick, Robert Bryn; Ådén, Jörgen; et al.
Biophysical Journal, Cell Press 2014, Vol. 107, (8) : 1950-1961
Weise, Christoph F; Login, Frédéric H; Ho, Oanh; et al.
Biochemistry, Vol. 52, (6) : 1055-1061
Ådén, Jörgen; Weise, Christoph; Brännström, Kristoffer; et al.
Environmental Microbiology Reports, Hoboken: Wiley-Blackwell 2013, Vol. 5, (4) : 556-565
Österberg, Sofia; Åberg, Anna; Herrera Seitz, M. Karina; et al.
PLOS ONE, Vol. 7, (11)
Frost, Stefan; Ho, Oanh; Login, Frédéric H; et al.
Journal of the American Chemical Society, American Chemical Society (ACS) 2012, Vol. 134, (7) : 3439-3444
Horvath, Istvan; Weise, Christoph F; Andersson, Emma K; et al.
Journal of the American Chemical Society, Washington: American Chemical Society (ACS) 2012, Vol. 134, (40) : 16562-16570
Ådén, Jörgen; Verma, Abhinav; Schug, Alexander; et al.
Biochemistry, American Chemical Society (ACS) 2011, Vol. 50, (14) : 3034-3044
Aguilar, Ximena; Weise, Christoph; Sparrman, Tobias; et al.
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology 2011, Vol. 286, (47) : 40659-40670
Dossena, Silvia; Gandini, Rosaria; Tamma, Grazia; et al.
Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, (17) : 6951-6956
Palm, Maria E; Weise, Christoph F; Lundin, Christina; et al.
Fifteenth Annual Conference of the Swedish Structural Biology Network, Tällberg 17-20 June, 2011
Wolf-Watz, Magnus
Biochimica et Biophysica Acta, Elsevier 2011, Vol. 1814, (12) : 1880-1890
Ådén, Jörgen; Wallgren, Marcus; Storm, Patrik; et al.
Journal of Molecular Biology, Elsevier 2010, Vol. 403, (5) : 723-38
Bosco, Daryl A; Eisenmesser, Elan Zohar; Clarkson, Michael W; et al.
Journal of Molecular Biology, Elsevier 2010, Vol. 396, (1) : 60-74
Malisauskas, Mantas; Weise, Christoph; Yanamandra, Kiran; et al.
Nature communications, Vol. 1, (8) : 111-
Olsson, Ulrika; Wolf-Watz, Magnus
Cell, Vol. 139, (6) : 1109-18
Gardino, Alexandra K; Villali, Janice; Kivenson, Aleksandr; et al.
Biochemistry, ACS Publications 2009, Vol. 48, (9) : 1911-1927
Rundqvist, Louise; Ådén, Jörgen; Sparrman, Tobias; et al.
Journal of Molecular Biology, Vol. 379, (4) : 845-858
Wallgren, Marcus; Ådén, Jörgen; Pylypenko, Olena; et al.
Nature, Vol. 450 : 838-44
Henzler-Wildman, Katherine A; Thai, Vu; Lei, Ming; et al.
Journal of the American Chemical Society, Vol. 129, (45) : 14003-12
Ådén, Jörgen; Wolf-Watz, Magnus
Nature, Vol. 438 : 117-21
Eisenmesser, Elan Z; Millet, Oscar; Labeikovsky, Wladimir; et al.

Research groups

Head of research
Magnus Wolf-Watz lab