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Staff photo Ludvig Backman

Ludvig Backman

Associate Professor of Physical Therapy and Functional Anatomy

Research qualifications: Docent
Educational qualifications: Distinguished university teacher

Contact

E-mail
ludvig.backman@umu.se
Phone
+46 90 786 52 03, +46 70 233 87 09

Works at

Affiliation
Associate professor at Department of Community Medicine and Rehabilitation Section: Physiotherapy
Location
-, - Umeå universitet, 901 87 Umeå
Affiliation
Affiliated as associate professor at Department of Medical and Translational Biology Section: Teachers A-wing, Teachers D1-wing, Group Patrik Danielson
Location
hus H, Johan Bures väg 12, Biologihuset Umeå universitet, 901 87 Umeå

Ludvig Backman is Associate Professor of Physical Therapy and Functional Anatomy

List of Publications (on Google Scholar)

CURRICULUM VITAE LUDVIG BACKMAN

Personal information

Born 1983

Professional Preparation and Academic Appointments
• 2017 | Reader/Associate Professor
• 2017 | Senior Lecturer/Associate Professor
• 2013 | Doctor of Philosophy, Medicine (Ph.D)
• 2009 | Master of Science in Sports Medicine, Umea university
• 2008 | Bachelor of Science in physiotherapy, Karolinska Institutet

Controlled TPCA-1 delivery engineers a pro-tenogenic niche to initiate tendon regeneration by targeting IKKβ/NF-κB signaling
Bioactive Materials, Elsevier 2025, Vol. 44 : 319-338
Chen, Jialin; Sheng, Renwang; Mo, Qingyun; et al.
Corneal strain influences keratocyte proliferation and migration through upregulation of ALDH3A1 expression
The FASEB Journal, John Wiley & Sons 2024, Vol. 38, (23)
Zhang, Qian; Zhou, Xin; Zhang, Wei; et al.
fhl2b mediates extraocular muscle protection in zebrafish models of muscular dystrophies and its ectopic expression ameliorates affected body muscles
Nature Communications, Springer Nature 2024, Vol. 15, (1)
Dennhag, Nils; Kahsay, Abraha; Nissen, Itzel; et al.
Mechanical loading modulates AMPK and mTOR signaling in muscle cells
Journal of Proteome Research, American Chemical Society (ACS) 2024, Vol. 23, (10) : 4286-4295
Zhou, Xin; Zhu, Shaochun; Li, Junhong; et al.
Hydroxycamptothecin and substratum stiffness synergistically regulate fibrosis of human corneal fibroblasts
ACS Biomaterials Science & Engineering, American Chemical Society (ACS) 2023, Vol. 9, (2) : 959-967
Chen, Jialin; Mo, Qingyun; Long, Qiuzi; et al.
Material stiffness in cooperation with macrophage paracrine signals determines the tenogenic differentiation of mesenchymal stem cells
Advanced Science, John Wiley & Sons 2023, Vol. 10, (17)
Sheng, Renwang; Liu, Jia; Zhang, Wei; et al.
Secretome from myoblasts statically loaded at low intensity promotes tenocyte proliferation via the IGF-1 receptor pathway
The FASEB Journal, John Wiley & Sons 2023, Vol. 37, (10)
Li, Junhong; Zhou, Xin; Chen, Jialin; et al.
Advances in Regulatory Strategies of Differentiating Stem Cells towards Keratocytes
Stem Cells International, Hindawi Publishing Corporation 2022, Vol. 2022
Zhang, Aini; Zhang, Wei; Backman, Ludvig J.; et al.
Effects of Zinc, Magnesium, and Iron Ions on Bone Tissue Engineering
ACS Biomaterials Science & Engineering, American Chemical Society (ACS) 2022, Vol. 8, (6) : 2321-2335
Chen, Zhixuan; Zhang, Wei; Wang, Mingyue; et al.
Keratocyte Differentiation Is Regulated by NF-κB and TGFβ Signaling Crosstalk
International Journal of Molecular Sciences, MDPI 2022, Vol. 23, (19)
Zhou, Xin; Li, Junhong; Backman, Ludvig J.; et al.
Microstructured collagen films for 3D corneal stroma modelling
Connective Tissue Research, Taylor & Francis Group 2022, Vol. 63, (5) : 443-452
Prittinen, Juha; Zhou, Xin; Bano, Fouzia; et al.
Regulation of osteogenic differentiation by the pro-inflammatory cytokines IL-1β and TNF-α: current conclusions and controversies
Human Cell, Springer 2022, Vol. 35 : 957-971
Mo, Qingyun; Zhang, Wei; Zhu, Aijing; et al.
Topographic Orientation of Scaffolds for Tissue Regeneration: Recent Advances in Biomaterial Design and Applications
Biomimetics, MDPI 2022, Vol. 7, (3)
Chi, Jiayu; Wang, Mingyue; Chen, Jialin; et al.
Activation of NF-κB signaling via cytosolic mitochondrial RNA sensing in kerotocytes with mitochondrial DNA common deletion
Scientific Reports, Nature Publishing Group 2021, Vol. 11, (1)
Zhou, Xin; Backman, Ludvig J.; Danielson, Patrik
Anti-apoptotic effect of adipose tissue-derived stromal vascular fraction in denervated rat muscle
Stem Cell Research & Therapy, BioMed Central (BMC) 2021, Vol. 12, (1)
El-Habta, Roine; Andersson, Gustav; Kingham, Paul J.; et al.
Secretome from in vitro mechanically loaded myoblasts induces tenocyte migration, transition to a fibroblastic phenotype and suppression of collagen production
International Journal of Molecular Sciences, MDPI 2021, Vol. 22, (23)
Zhou, Xin; Li, Junhong; Giannopoulos, Antonios; et al.
Regulation of Keratocyte Phenotype and Cell Behavior by Substrate Stiffness
ACS Biomaterials Science & Engineering, American Chemical Society (ACS) 2020, Vol. 6, (9) : 5162-5171
Chen, Jialin; Backman, Ludvig J.; Zhang, Wei; et al.
Sustained Release of TPCA-1 from Silk Fibroin Hydrogels Preserves Keratocyte Phenotype and Promotes Corneal Regeneration by Inhibiting Interleukin-1β Signaling
Advanced Healthcare Materials, Wiley-VCH Verlagsgesellschaft 2020, Vol. 9, (17)
Zhang, Wei; Chen, Jialin; Qu, Mingli; et al.
Tannic acid-mediated dual peptide-functionalized scaffolds to direct stem cell behavior and osteochondral regeneration
Chemical Engineering Journal, Elsevier 2020, Vol. 396
Zhang, Wei; Ling, Chen; Liu, Haoyang; et al.
The Application of Mechanical Stimulations in Tendon Tissue Engineering
Stem Cells International, Hindawi Publishing Corporation 2020, Vol. 2020
Sheng, Renwang; Jiang, Yujie; Backman, Ludvig J.; et al.
Adipose stem cells enhance myoblast proliferation via acetylcholine and extracellular signal-regulated kinase 1/2 signaling
Muscle and Nerve, WILEY 2018, Vol. 57, (2) : 305-311
El-Habta, Roine; Kingham, Paul J.; Backman, Ludvig J.
Mechanical stress potentiates the differentiation of periodontal ligament stem cells into keratocytes
British Journal of Ophthalmology, BMJ Publishing Group Ltd 2018, Vol. 102, (4) : 562-569
Chen, Jialin; Zhang, Wei; Backman, Ludvig J.; et al.
Tendinosis-like changes in denervated rat Achilles tendon
BMC Musculoskeletal Disorders, BMC 2018, Vol. 19
El-Habta, Roine; Chen, Jialin; Pingel, Jessica; et al.
The adipose tissue stromal vascular fraction secretome enhances the proliferation but inhibits the differentiation of myoblasts
Stem Cell Research & Therapy, BioMed Central 2018, Vol. 9
El-Habta, Roine; Sloniecka, Marta; Kingham, Paul J.; et al.
Ascorbic Acid Promotes the Stemness of Corneal Epithelial Stem/Progenitor Cells and Accelerates Epithelial Wound Healing in the Cornea
Stem Cells Translational Medicine, WILEY 2017, Vol. 6, (5) : 1356-1365
Chen, Jialin; Lan, Jie; Liu, Dongle; et al.
Fos Promotes Early Stage Teno-Lineage Differentiation of Tendon Stem/Progenitor Cells in Tendon
Stem Cells Translational Medicine, John Wiley & Sons 2017, Vol. 6, (11) : 2009-2019
Chen, Jialin; Zhang, Erchen; Zhang, Wei; et al.
Glutamate signaling through the NMDA receptor reduces the expression of scleraxis in plantaris tendon derived cells
BMC Musculoskeletal Disorders, Vol. 18
Spang, Christoph; Backman, Ludvig J.; Le Roux, Sandrine; et al.
Nerve distributions in insertional Achilles tendinopathy - a comparison of bone, bursae and tendon
Histology and Histopathology, Vol. 32, (3) : 263-270
Andersson, Gustav; Backman, Ludvig J.; Christensen, Jens; et al.
Substance P and patterned silk biomaterial stimulate periodontal ligament stem cells to form corneal stroma in a bioengineered three-dimensional model
Stem Cell Research & Therapy, BIOMED CENTRAL LTD 2017, Vol. 8
Chen, Jialin; Zhang, Wei; Kelk, Peyman; et al.
Surface Topography and Mechanical Strain Promote Keratocyte Phenotype and Extracellular Matrix Formation in a Biomimetic 3D Corneal Model
Advanced Healthcare Materials, Wiley-VCH Verlagsgesellschaft 2017, Vol. 6, (5)
Zhang, Wei; Chen, Jialin; Backman, Ludvig J.; et al.
The Effects of Substance P and Acetylcholine on Human Tenocyte Proliferation Converge Mechanistically via TGF-β1
PLOS ONE, Vol. 12, (3)
Fong, Gloria; Backman, Ludvig J.; Alfredson, Håkan; et al.
Antiapoptotic Effect of Acetylcholine in Fas-Induced Apoptosis in Human Keratocytes
Investigative Ophthalmology and Visual Science, Vol. 57, (14) : 5892-5902
Sloniecka, Marta; Backman, Ludvig J.; Danielson, Patrik
Characterization and comparison of post-natal rat Achilles tendon-derived stem cells at different development stages
Scientific Reports, Vol. 6
Chen, Jialin; Zhang, Wei; Liu, Zeyu; et al.
Ciliary Neurotrophic Factor Promotes the Migration of Corneal Epithelial Stem/progenitor Cells by Up-regulation of MMPs through the Phosphorylation of Akt
Scientific Reports, Vol. 6
Chen, Jialin; Chen, Peng; Backman, Ludvig J.; et al.
Fat pads adjacent to tendinopathy: more than a coincidence?
British Journal of Sports Medicine, Vol. 50, (24) : 1491-1492
Ward, Ella Rose; Andersson, Gustav; Backman, Ludvig J.; et al.
The tenocyte phenotype of human primary tendon cells in vitro is reduced by glucocorticoids
BMC Musculoskeletal Disorders, Vol. 17
Spang, Christoph; Chen, Jialin; Backman, Ludvig J.
Transforming Growth Factor Beta 1 Modulates the Functional Expression of the Neurokinin-1 Receptor in Human Keratocytes
Current Eye Research, Vol. 41, (8) : 1035-1043
Roux, Sandrine Le; Borbely, Gabor; Słoniecka, Marta; et al.
Acetylcholine enhances keratocyte proliferation through muscarinic receptor activation.
International Immunopharmacology, Vol. 29, (1) : 57-62
Słoniecka, Marta; Backman, Ludvig J; Danielson, Patrik
Dexamethasone decreases substance P expression in human tendon cells: an in vitro study
Rheumatology, Oxford University Press 2015, Vol. 54, (2) : 318-323
Mousavizadeh, Rouhollah; Backman, Ludvig; McCormack, Robert G; et al.
Mutations in Collagen, Type XVII, Alpha 1 (COL17A1) Cause Epithelial Recurrent Erosion Dystrophy (ERED)
Human Mutation, John Wiley & Sons 2015, Vol. 36, (4) : 463-473
Jonsson, Frida; Byström, Berit; Davidson, Alice E.; et al.
Tendinopathy: Update on Pathophysiology
Journal of Orthopaedic and Sports Physical Therapy, Vol. 45, (11) : 833-841
Scott, Alex; Backman, Ludvig J.; Speed, Cathy
Substance P reduces TNF-α-induced apoptosis in human tenocytes through NK-1 receptor stimulation
British Journal of Sports Medicine, BMJ Publishing Group Ltd 2014, Vol. 48, (19) : 1414-1420
Backman, Ludvig J.; Eriksson, Daniella E.; Danielson, Patrik
Akt-mediated anti-apoptotic effects of substance P in Anti-Fas-induced apoptosis of human tenocytes
Journal of Cellular and Molecular Medicine, Wiley-Blackwell 2013, Vol. 17, (6) : 723-733
Backman, Ludvig J; Danielson, Patrik
Alpha-2 adrenergic stimulation triggers Achilles tenocyte hypercellularity: comparison between two model systems
Scandinavian Journal of Medicine and Science in Sports, John Wiley & Sons 2013, Vol. 23, (6) : 687-696
Backman, Ludvig J; Andersson, Gustav; Fong, Gloria; et al.
Human tenocytes are stimulated to proliferate by acetylcholine through an EGFR signalling pathway
Cell and Tissue Research, Springer-Verlag New York 2013, Vol. 351, (3) : 465-475
Fong, Gloria; Backman, Ludvig; Andersson, Gustav; et al.
Substance P enhances collagen remodeling and MMP-3 expression by human tenocytes
Journal of Orthopaedic Research, HOBOKEN, NJ, USA: Wiley-Blackwell 2013, Vol. 31, (1) : 91-98
Fong, Gloria; Backman, Ludvig J.; Hart, David A.; et al.
Endogenous substance P production in the Achilles tendon increases with loading in an in vivo model of tendinopathy: peptidergic elevation preceding tendinosis-like tissue changes
Journal of Musculoskeletal and Neuronal Interactions - JMNI, International Society of Musculoskeletal and Neuronal Interactions 2011, Vol. 11, (2) : 133-140
Backman, Ludvig; Andersson, Gustav; Wennstig, Gabriel; et al.
Low range of ankle dorsiflexion predisposes for patellar tendinopathy in junior elite basketball players: a 1-year prospective study
American Journal of Sports Medicine, Vol. 39, (12) : 2626-2633
Backman, Ludvig J; Danielson, Patrik
Substance P accelerates hypercellularity and angiogenesis in tendon tissue and enhances paratendinitis in response to Achilles tendon overuse in a tendinopathy model
British Journal of Sports Medicine, Loughborough: British Assoc. of Sport and Medicine 2011, Vol. 45, (13) : 1017-1022
Andersson, Gustav; Backman, Ludvig; Scott, Alexander; et al.
Substance P is a mechanoresponsive, autocrine regulator of human tenocyte proliferation
PLOS ONE, San Francisco, USA: Public Library of Science 2011, Vol. 6, (11) : e27209-
Backman, Ludvig; Fong, Gloria; Andersson, Gustav; et al.
View publications in DiVA

I primarily teach on the Physiotherapy and Medical programs in both descriptive, topographical, and functional anatomy. I am course leader for the anatomy course in the Physiotherapy program and have module leadership on the Medical program in topographical anatomy of the musculoskeletal system, with a focus on the lower extremities.

I was assigned as the coordinator for the formation of the new faculty-wide doctoral program by the Faculty of Medicine. I have a central role in the program since its implementation, both as a teacher and as the chair of the research education program council and deputy director of doctoral studies.

Pedagogical merits

-       Recognised university teacher 2019

-       Distinguished university teacher 2024