Lars Backman

My research group has a long-standing interest in spectrin and spectrin-like proteins, such as α-actinin. The major aim is to understand the structural and functional roles of these proteins.

Research qualifications: Docent

0000-0003-3044-1256

Contact

lars.backman@umu.se

Works at

Affiliated as professor emeritus at Department of Chemistry

KB.A3, Linnaeus väg 10, (rum:A3.39.07) Umeå universitet, 901 87 Umeå

My research group has a long-standing interest in spectrin and spectrin-like proteins. The major aim is to understand the structural and functional roles of these proteins.
Presently our efforts are focused on two different areas: to determine the structure and dynamics of a spectrin repeat by NMR and to characterise α-actinin from Entamoeba and S pombe.

Protein chemistry

Walter de Gruyter 2024

Backman, Lars

Insights into the evolution of enzymatic specificity and catalysis: from Asgard archaea to human adenylate kinases

Science Advances, American Association for the Advancement of Science (AAAS) 2022, Vol. 8, (44)

Verma, Apoorv; Åberg-Zingmark, Emma; Sparrman, Tobias; et al.

Tracking the ATP-binding response in adenylate kinase in real time

Science Advances, American Association for the Advancement of Science 2021, Vol. 7, (47)

Orädd, Fredrik; Ravishankar, Harsha; Goodman, Jack; et al.

Structural and functional characterization of a plant alpha-actinin

FEBS Open Bio, John Wiley & Sons 2021, Vol. 11, (8) : 2198-2210

Persson, Karina; Backman, Lars

Protein Chemistry

De Gruyter Textbook

Backman, Lars

Alpha-actinin of the chlorarchiniophyte Bigelowiella natans

PeerJ, Vol. 6

Backman, Lars

The no-nonsens SDS-PAGE

Schizosaccharomyces pombe: methods and protocols, Humana Press 2018 : 89-94

Backman, Lars; Persson, Karina

Crystallization of recombinant α-actinin and related proteins

Schizosaccharomyces pombe: methods and protocols, Humana Press 2018 : 95-103

Persson, Karina; Backman, Lars

Characterisation of Schizosaccharomyces pombe alpha-actinin

PeerJ, Vol. 4

Addario, Barbara; Sandblad, Linda; Persson, Karina; et al.

Solution structure of the calmodulin-like C-terminal domain of Entamoeba α-actinin2

Proteins: Structure, Function, and Bioinformatics, Wiley-Blackwell 2016, Vol. 84, (4) : 461-466

Karlsson, Göran; Persson, Cecilia; Mayzel, Maxim; et al.

Structure and calcium-binding studies of calmodulin-like domain of human non-muscle alpha-actinin-1

Scientific Reports, Vol. 6

Prebil, Sara Drmota; Slapsak, Urska; Pavsic, Miha; et al.

Calcium affinity of human α-actinin1

PeerJ, Vol. 3

Backman, Lars

Crystallization and preliminary X-ray analysis of the Entamoeba histolytica α-actinin-2 rod domain

Acta Crystallographica. Section F: Structural Biology and Crystallization Communications, International Union of Crystallography 2011, Vol. 67, (10) : 1214-1217

Addario, Barbara; Huang, Shenghua; Sauer, Uwe; et al.

The domain structure of Entamoeba α-actinin2

Cellular & Molecular Biology Letters (Druk), Springer 2010, Vol. 15, (4) : 665-78

Addario, Barbara; Backman, Lars

Folding of the αΙΙ-spectrin SH3 domain under physiological salt conditions

Archives of Biochemistry and Biophysics, Elsevier 2008, Vol. 474, (1) : 39-47

Petzold, Katja; Öhman, Anders; Backman, Lars

Calmodulin—Alias: Cyclic Nucleotide Phosphodiesterase Activator, Ca2+-Dependent Regulatory Protein

Calcium Binding Proteins, Vol. 2, (1) : 1-3

Backman, Lars

Characterization of Entamoeba histolytica α-actinin2

Molecular and Biochemical Parasitology, Vol. 154 : 82-89