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Kristina Lejon

Professor of Immunology

Deputy Dean of Medical Faculty

0000-0001-5025-6539

Contact

kristina.lejon@umu.se

+46 90 785 35 76

Works at

Professor at Department of Clinical Microbiology Section: Immunology

By 6M, Plan 4, Universitetssjukhuset Umeå universitet, 901 85 Umeå

Affiliated as professor at Faculty Office of Medicine

Förvaltningshuset, Plan 7 Umeå universitet, 901 87 Umeå

Immunological biomarkers in patients with radiographic axial spondyloarthritis, an exploratory longitudinal Swedish study

Modern Rheumatology, Oxford University Press 2025, Vol. 35, (1) : 134-143

Hellman, Urban; Lejon, Kristina; Do, Lan; et al.

Increased carotid intima-media thickness in patients with radiographic axial spondyloarthritis compared to controls and associations with markers of inflammation

Clinical Rheumatology, Springer Nature 2024, Vol. 43, (5) : 1559-1570

Law, Lucy; Lindqvist, Per; Liv, Per; et al.

Protein profiling in presymptomatic individuals separates myeloperoxidase-antineutrophil cytoplasmic antibody and proteinase 3-antineutrophil cytoplasmic antibody vasculitides

Arthritis & Rheumatology, Vol. 75, (6) : 996-1006

Brink, Mikael; Berglin, Ewa; Mohammad, Aladdin J.; et al.

Decreased levels of T follicular helper (CD4+CXCR5+) cells and CD27+CD38+ and CD27+CD38− B cells in ankylosing spondylitis patients correlate with markers of inflammation

Scandinavian Journal of Immunology, John Wiley & Sons 2023, Vol. 97, (1)

Lejon, Kristina; Hellman, Urban; Kumar, Anjani; et al.

Increased proportions of inflammatory T cells and their correlations with cytokines and clinical parameters in patients with ankylosing spondylitis from northern Sweden

Scandinavian Journal of Immunology, John Wiley & Sons 2022, Vol. 96, (3)

Lejon, Kristina; Hellman, Urban; Do, Lan; et al.

HSC70 is a novel binding partner involved in the capture of immunoglobulins on B cells in the NOD mouse

Autoimmunity, Taylor & Francis 2022, Vol. 55, (8) : 520-528

Renman, Emma; Ekici, Rifat; Sundström, Mia; et al.

Anti-CD74 IgA autoantibodies in radiographic axial spondyloarthritis: a longitudinal Swedish study

Rheumatology, Oxford University Press 2021, Vol. 60, (9) : 4085-4093

Do, Lan; Granåsen, Gabriel; Hellman, Urban; et al.

DECREASED LEVELS OF T FOLLICULAR HELPER (CD4+CXCR5+) CELLS AND CD27+CD38+ AND CD27+CD38- B CELLS IN ANKYLOSING SPONDYLITIS PATIENTS CORRELATE WITH MARKER OF INFLAMMATION

Annals of the Rheumatic Diseases, BMJ Publishing Group Ltd 2021, Vol. 80, (Suppl 1) : 13-14

Forsblad-D'elia, H.; Hellman, Urban; Kumar, A.; et al.

Dysregulated microRNA expression in rheumatoid arthritis families-a comparison between rheumatoid arthritis patients, their first-degree relatives, and healthy controls

Clinical Rheumatology, Springer 2021, Vol. 40, (6) : 2387-2394

Renman, Emma; Brink, Mikael; Ärlestig, Lisbeth; et al.

Atherosclerosis in rheumatoid arthritis: associations between anti-cytomegalovirus IgG antibodies, CD4+CD28null T-cells, CD8+CD28null T-cells and intima-media thickness

Clinical and Experimental Rheumatology, Clinical and Experimental Rheumatology S.A.S. 2021, Vol. 39, (3) : 578-586

Wahlin, Bengt; Fasth, Andreas; Karp, Kjell; et al.

Protein profiling in individuals before onset of anca-associated vasculitis

Annals of the Rheumatic Diseases, BMJ Publishing Group Ltd 2020, Vol. 79 : 372-372

Berglin, Ewa; Esberg, Anders; Dahlqvist, J.; et al.

Increased Proportion of TH17, TH22 and TC17 Cells and the Correlation to IL-22 and Clinical Parameters in Patients with Ankylosing Spondylitis from Northern Sweden

Arthritis & Rheumatology, John Wiley & Sons 2020, Vol. 72

Lejon, Kristina; Hellman, Urban; Do, Lan; et al.

Protein Profiling and Network Enrichment Analysis in Individuals Before and After the Onset of Rheumatoid Arthritis

Arthritis & Rheumatology, John Wiley & Sons 2019, Vol. 71

Brink, Mikael; Lundquist, Anders; Alexeyenko, Andrey; et al.

Protein profiling and network enrichment analysis in individuals before and after the onset of rheumatoid arthritis

Arthritis Research & Therapy , BioMed Central 2019, Vol. 21, (1)

Brink, Mikael; Lundquist, Anders; Alexeyenko, Andrey; et al.

Innate lymphoid cells are present in gingivitis and periodontitis

Journal of Periodontology, Wiley-Blackwell 2019, Vol. 90, (2) : 200-207

Kindstedt, Elin; Holm, Cecilia Koskinen; Palmqvist, Py; et al.

Elevated Systemic Glutamic Acid Level in the Non-Obese Diabetic Mouse is Idd Linked and Induces Beta Cell Apoptosis

Immunology, Vol. 150, (2) : 162-171

Banday, Viqar Showkat; Lejon, Kristina

Contribution of both B cell intrinsic alterations as well as non-hematopoietic derived factors in the enhanced immune response of the NOD mouse

Scandinavian Journal of Immunology, WILEY 2017, Vol. 86, (4) : 252-252

Banday, Viqar Showkat; Thyagarajan, Radha; Lejon, Kristina

Contribution of both B-cell intrinsic alterations as well as non-hematopoietic-derived factors in the enhanced immune response of the NOD mouse

Autoimmunity, TAYLOR & FRANCIS LTD 2017, Vol. 50, (6) : 363-369

Banday, Viqar Showkat; Thyagarajan, Radha; Lejon, Kristina

Immunsystemets fina balansgång

Sticket : informationsblad från Barndiabetesfonden, Linköping: Bandiabetesfonden 2017, Vol. 24, (3) : 4-4

Lejon, Kristina

Cd8+cd28- t-lymphocytes are associated with subclinical atherosclerosis in patients with rheumatoid arthritis

Annals of the Rheumatic Diseases, BMJ PUBLISHING GROUP 2017, Vol. 76 : 250-250

Wahlin, Bengt; Fasth, A. E.; Karp, Kjell; et al.

Increased expression of TACI on NOD B cells results in germinal centre reaction anomalies, enhanced plasma cell differentiation and immunoglobulin production

Immunology, Vol. 149, (3) : 297-305

Banday, Viqar Showkat; Thyagarajan, Radha; Sundström, Mia; et al.

Cytotoxic immune responses in the lungs correlate to disease severity in patients with hantavirus infection

European Journal of Clinical Microbiology and Infectious Diseases, Vol. 35, (4) : 713-721

Rasmuson, Johan; Pourazar, Jamshid; Mohamed, Nahla; et al.

Lack of non-hematopoietic SIRPα signaling disturbs the splenic marginal zone architecture resulting in accumulation and displacement of marginal zone B cells

Biochemical and Biophysical Research Communications - BBRC, Vol. 460, (3) : 645-650

Kolan, Shrikant; Boman, Andreas; Matozaki, Takashi; et al.

Non-Hematopoietic and Hematopoietic SIRPα Signaling Differently Regulates Murine B Cell Maturation in Bone Marrow and Spleen

PLoS One, plos one 2015, Vol. 10, (7)

Kolan, Shrikant; Lejon, Kristina; Koskinen Holm, Cecilia; et al.

Contribution of autoallergy to the pathogenesis in the NOD mice

Autoimmunity, Vol. 48, (5) : 298-304

Thyagarajan, Radha; Banday, Viqar; Ding, Zhoujie; et al.

B Regulatory Cells are Functionally Impaired in Patients with Rheumatoid Arthritis and in Their First-Degree Relatives Compared with Controls

Scandinavian Journal of Immunology, Vol. 79, (6) : 450-450

Brink, Mikael; Ärlestig, Lisbeth; Rantapää-Dahlqvist, Solbritt; et al.

B Cells and IgE in Type 1 Diabetes

Scandinavian Journal of Immunology, Vol. 79, (6) : 452-452

Thyagarajan, Radha; Lejon, Kristina

B-Regulatory-, CD19(+)CD20(+) CD24(high)CD38(high) -Cells Are Functionally Impaired In Patients With Rheumatoid Arthritis and Healthy First Degree Relatives Compared With Controls

Arthritis and Rheumatism, Wiley-Blackwell 2013, Vol. 65, (Special issue, Supplement 10) : S393-S394, Meeting Abstract: 917

Brink, Mikael; Lejon, Kristina; Ärlestig, Lisbeth; et al.

Två bitar i det stora pusslet

Sticket, Linköping: Barndiabetesfonden 2013, Vol. 2 : 4-

Lejon, Kristina

Välkomna till 2013 års Forskningens dag!

Cancerforskning på nya vägar: en bok från Forskningens dag 2013, Medicinska fakulteten vid Umeå universitet, Umeå: Umeå universitet 2013 : 7-14

Stigbrand, Torgny; Lejon, Kristina

Altered metabolic signature in Pre-Diabetic NOD Mice

PLOS ONE, Public Library of Science 2012, Vol. 7, (4) : e35445-

Madsen, Rasmus; Banday, Viqar Showkat; Moritz, Thomas; et al.

Up-regulation of cytokines and chemokines predates the onset of rheumatoid arthritis

Arthritis and Rheumatism, Vol. 62, (2) : 383-391

Kokkonen, Heidi; Söderström, Ingegerd; Rocklöv, Joacim; et al.

The prolonged and enhanced immune response in the non-obese diabetic mouse is dependent on genes in the Idd1/24, Idd12 and Idd18 regions

Journal of Autoimmunity, Vol. 35, (4) : 375-382

Sundström, Mia; Lejon, Kristina

Enhanced capture of extramembranous IgM and IgG on B cells in the NOD mouse: implications for immune complex trapping

International Immunology, Vol. 21, (5) : 533-541

Ekici, Rifat; Sundström, Mia; Thay, Bernard; et al.

The NOD allele of the Idd5 locus on chromosome 1 mediates a non-cell-autonomous defect in negative selection of T cells.

Journal of Autoimmunity, Vol. 28, (4) : 216-223

Motta, Vinicius; Lejon, Kristina; Holmberg, Dan

Idd-linked genetic regulation of TACIhigh expressing B cells in NOD mice

Journal of Autoimmunity, Vol. 29, (2-3) : 116-124

Sundström, Mia; Lejon, Kristina

EDAR mutation in autosomal dominant hypohidrotic ectodermal dysplasia in two Swedish families

BMC Medical Genetics, BioMed Central 2006, Vol. 7 : 80-

Lind, Lisbet K; Stecksén-Blicks, Christina; Lejon, Kristina; et al.

Expression of the NK-1 receptor on islet cells and invading immune cells in the non-obese diabetic mouse

Journal of Autoimmunity, Elsevier 2005, Vol. 24, (4) : 269-279

Persson-Sjögren, Solveig; Lejon, Kristina; Holmberg, Dan; et al.

Kompetens ingen efterfrågar

Kemivärlden Biotech, Svenska Kemistsamfundet 2004, Vol. 10, (21)

Lejon, Kristina

Diabetes protection and restoration of thymocyte apoptosis in NOD Idd6 congenic strains

Diabetes, American Diabetes Association 2003, Vol. 52, (7) : 1677-1682

Bergman, Marie-Louise; Duarte, Nadia; Campino, Susana; et al.

The CD8alpha⁺ dendritic cell is responsible for inducing peripheral self-tolerance to tissue-associated antigens.

Journal of Experimental Medicine, The Rockefeller University Press 2002, Vol. 196, (8) : 1099-1104

Belz, Gabrielle T; Behrens, Georg M N; Smith, Chris M; et al.

CTLA-4-/- mice display T cell-apoptosis resistance resembling that ascribed to autoimmune-prone non-obese diabetic (NOD) mice

Journal of Autoimmunity, Elsevier 2001, Vol. 16, (2) : 105-113

Bergman, Marie-Louise; Cilio, Corrado M; Penha-Gonçalves, Carlos; et al.

Low rate of proliferation in immature thymocytes of the non-obese diabetic mouse maps to the Idd6 diabetes susceptibility region

Diabetologia, Springer 2001, Vol. 44, (8) : 1054-1061

Bergman, Marie-Louise; Penha-Gonçalves, Carlos; Lejon, Kristina; et al.

CD4⁺CD25⁺ T cells facilitate the induction of T cell anergy

Journal of Immunology, Rockville Pike, Bethesda, MD: The American Association of Immunologists, Inc. 2001, Vol. 167, (8) : 4271-4275

Ermann, Joerg; Szanya, Veronika; Ford, Gregory S.; et al.

The identification and validation of common disease genes: relevance to the drug development process.

Current opinion in molecular therapeutics (Print), Vol. 3, (6) : 533-537

Holmberg, Mats; Lejon, Kristina

Isolation of self antigen-reactive cells from inflamed islets of nonobese diabetic mice using CD4^_high expression as a marker

Journal of Immunology, The American Association of Immunologists 1999, Vol. 163, (10) : 5708-5714

Lejon, Kristina; Garrison Fathman, C.

How murine genetics can help to identify susceptibility genes in human disease

Diabetes Metabolism Reviews, John Wiley & Sons 1998, Vol. 14, (2) : 190-191

Cilio, Corrado M.; Lejon, Kristina; Penha-Goncalves, Carlos; et al.

Diabetes induction in C57BL/6 mice reconstituted with lymphocytes of nonobese diabetic C57BL/6 mouse embryo aggregation chimeras

Scandinavian Journal of Immunology, Wiley-Blackwell 1998, Vol. 48, (6) : 571-576

Colucci, Francesco; Bergman, Marie-Louise; Lejon, Kristina; et al.

Programmed cell death in the pathogenesis of murine IDDM: resistance to apoptosis induced in lymphocytes by cyclophosphamide

Journal of Autoimmunity, Elsevier 1996, Vol. 9, (2) : 271-276

Colucci, Francesco; Cilio, Corrado M.; Lejon, Kristina; et al.

Induction of diabetes in NOD‹–›C57BL/6 embryo aggregation chimeras by cyclophosphamide through preferential depletion of C57BL/6 lymphocytes

Journal of Autoimmunity, Elsevier 1996, Vol. 9, (4) : 493-499

Colucci, Francesco; Lejon, Kristina; Cilio, Corrado M.; et al.

View publications in DiVA

Research groups

Head of research

Kristina Lejon