Karin Sixtensdotter Graffmo

Contact

karin.graffmo@umu.se

Works at

Affiliated as research fellow at Department of Medical Biosciences Section: Pathology

By 6M, vån 1, Sjukhusområdet Umeå universitet, 901 85 Umeå

Publications Publications

Widespread CNS pathology in amyotrophic lateral sclerosis homozygous for the D90A SOD1 mutation

Acta Neuropathologica, Springer-Verlag New York 2023, Vol. 145, (1) : 13-28

Forsberg, Karin; Graffmo, Karin Sixtensdotter; Stenvall, Erica; et al.

Misfolded SOD1 inclusions in patients with mutations in C9orf72 and other ALS/FTD-associated genes

Journal of Neurology, Neurosurgery and Psychiatry, BMJ Publishing Group Ltd 2019, Vol. 90, (8) : 861-869

Forsberg, Karin; Graffmo, Karin Sixtensdotter; Pakkenberg, Bente; et al.

Structural and kinetic analysis of protein-aggregate strains in vivo using binary epitope mapping

Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences 2015, Vol. 112, (14) : 4489-4494

Bergh, Johan; Zetterström, Per; Andersen, Peter M.; et al.

Extensive size variability of the GGGGCC expansion in C9orf72 in both neuronal and non-neuronal tissues in 18 patients with ALS or FTD

Human Molecular Genetics, Vol. 24, (11) : 3133-3142

Nordin, Angelica; Akimoto, Chizuru; Wuolikainen, Anna; et al.

PERIPHERAL MOTOR AXONS OF SOD1(G127X) MUTANT MICE ARE SUSCEPTIBLE TO ACTIVITY-DEPENDENT DEGENERATION

Neuroscience, Vol. 241 : 239-249

Alvarez, S.; Calin, A.; Sixtensdotter Graffmo, Karin; et al.

Expression of wild-type human superoxide dismutase-1 in mice causes amyotrophic lateral sclerosis

Human Molecular Genetics, Vol. 22, (1) : 51-60

Graffmo, Karin S.; Forsberg, Karin; Bergh, Johan; et al.

Composition of soluble misfolded superoxide Dismutase-1 in murine models of Amyotrophic Lateral Sclerosis

Neuromolecular medicine, Vol. 15, (1) : 147-158

Zetterström, Per; Graffmo, Karin S.; Andersen, Peter M; et al.

Nerve excitability changes related to axonal degeneration in amyotrophic lateral sclerosis: insights from the transgenic SOD1(G127X) mouse model

Experimental Neurology, Vol. 233, (1) : 408-420

Moldovan, Mihai; Alvarez, Susana; Pinchenko, Volodymyr; et al.

Proteins that bind to misfolded mutant superoxide dismutase-1 in spinal cords from transgenic ALS model mice

Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology 2011, Vol. 286, (23) : 20130-20136

Zetterström, Per; Graffmo, Karin S; Andersen, Peter M; et al.

Superoxide dismutase-1 and other proteins in inclusions from transgenic amyotrophic lateral sclerosis model mice

Journal of Neurochemistry, Vol. 114, (2) : 408-418

Bergemalm, Daniel; Forsberg, Karin; Srivastava, Vaibhav; et al.

Novel antibodies reveal inclusions containing non-native SOD1 in sporadic ALS patients

PLOS ONE, Public library of science 2010, Vol. 5, (7) : e11552-

Forsberg, Karin; Jonsson, P Andreas; Andersen, Peter M; et al.

Intrinsic properties of lumbar motor neurones in the adult G127insTGGG superoxide dismutase-1 mutant mouse in vivo: evidence for increased persistent inward currents

Acta Physiologica, Vol. 200, (4) : 361-376

Meehan, CF; Moldovan, M; Marklund, Stefan; et al.

Changes in the spinal cord proteome of an amyotrophic lateral sclerosis murine model determined by differential in-gel electrophoresis

Molecular and cellular proteomics, The American Society for Biochemistry and Molecular Biology,Inc 2009, Vol. 8, (6) : 1306-1317

Bergemalm, Daniel; Forsberg, Karin; Jonsson, P Andreas; et al.

Superoxide dismutase in amyotrophic lateral sclerosis patients homozygous for the D90A mutation

Neurobiology of Disease, Vol. 36, (3) : 421-424

Jonsson, P Andreas; Graffmo, Karin S; Andersen, Peter M; et al.

Soluble misfolded subfractions of mutant superoxide dismutase-1s are enriched in spinal cords throughout life in murine ALS models

Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, (35) : 14157-14162

Zetterström, Per; Stewart, Heather G; Bergemalm, Daniel; et al.

Overloading of stable and exclusion of unstable human superoxide dismutase-1 variants in mitochondria of murine amyotrophic lateral sclerosis models

Journal of Neuroscience, Society for Neuroscience 2006, Vol. 26, (16) : 4147-4154

Bergemalm, Daniel; Jonsson, Andreas P.; Graffmo, Karin S; et al.

Disulphide-reduced superoxide dismutase-1 in CNS of transgenic amyotrophic lateral sclerosis models

Brain, Oxford University Press 2006, Vol. 129, (Pt 2) : 451-644

Jonsson, Andreas P.; Graffmo, Karin; Andersen, Peter M; et al.

Motor neuron disease in mice expressing the wild type-like D90A mutant superoxide dismutase-1

Journal of Neuropathology and Experimental Neurology, Vol. 65, (12) : 1126-1136

Jonsson, Andreas P.; Graffmo, Karin; Brännström, Thomas; et al.

High expression of wild-type human superoxide dismutase-1 gives a model of sporadic ALS

Forsberg, Karin; Graffmo, Karin S; Zetterström, Per; et al.

ALS patients with the SOD1 D90A mutation show both spinal cord and frontal cortical pathology

Graffmo, Karin S; Forsberg, Karin; Marklund, Stefan L; et al.

Structure of soluble misfolded superoxide dismutase-1 in murine ALS models

Zetterström, Per; Graffmo, Karin S; Andersen, Peter M; et al.

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