Jörgen Ådén

Contact

jorgen.aden@umu.se

+46 90 786 65 76

Works at

Staff scientist at Department of Chemistry

KB.A3, Linnaeus väg 10 Umeå universitet, 901 87 Umeå

Magnesium induced structural reorganization in the active site of adenylate kinase

Science Advances, American Association for the Advancement of Science (AAAS) 2024, Vol. 10, (32)

Nam, Kwangho; Thodika, Abdul Raafik Arattu; Tischlik, Sonja; et al.

Intra-striatal infusion of the small molecule alpha-synuclein aggregator, FN075, does not enhance parkinsonism in a subclinical AAV-alpha-synuclein rat model

European Journal of Neuroscience, John Wiley & Sons 2024, Vol. 60, (6) : 5234-5248

Patton, Tommy; Comini, Giulia; Narasimhan, Kaushik; et al.

Insight into Bcl-2 proteins' functioning at mitochondrial membrane level

Biophysical Journal, Elsevier 2023, Vol. 122, (3S1) : 232a-232a

Clifton, Luke A.; Ul Mushtaq, Ameeq; Ådén, Jörgen; et al.

Creation of distinctive Bax-lipid complexes at mitochondrial membrane surfaces drives pore formation to initiate apoptosis

Science Advances, American Association for the Advancement of Science (AAAS) 2023, Vol. 9, (22)

Clifton, Luke A.; Wacklin-Knecht, Hanna P.; Ådén, Jörgen; et al.

Mechanistic basis for a connection between the catalytic step and slow opening dynamics of adenylate kinase

Journal of Chemical Information and Modeling, American Chemical Society (ACS) 2023, Vol. 63, (5) : 1556-1569

Dulko-Smith, Beata; Ojeda-May, Pedro; Ådén, Jörgen; et al.

Protein-lipid interaction at low pH induces oligomerization of the MakA cytotoxin from Vibrio cholerae

eLIFE, eLife Sciences Publications, Ltd 2022, Vol. 11

Nadeem, Aftab; Berg, Alexandra; Pace, Hudson; et al.

Backbone chemical shift assignment and dynamics of the N-terminal domain of ClpB from Francisella tularensis type VI secretion system

Biomolecular NMR Assignments, Springer 2022, Vol. 16 : 75-79

Ul Mushtaq, Ameeq; Ådén, Jörgen; Alam, Athar; et al.

Domain-specific insight into the recognition of BH3-death motifs by the pro-survival Bcl-2 protein

Biophysical Journal, Elsevier 2022, Vol. 121, (23) : 4517-4525

Ul Mushtaq, Ameeq; Ådén, Jörgen; Ali, Katan; et al.

K₂S₂O₈-mediated coupling of 6-amino-7-aminomethyl-thiazolino-pyridones with aldehydes to construct amyloid affecting pyrimidine-fused thiazolino-2-pyridones

Organic and biomolecular chemistry, The Royal Society of Chemistry 2021, Vol. 19, (44) : 9758-9772

Bharate, Jaideep B.; Ådén, Jörgen; Gharibyan, Anna; et al.

The Small Molecule Alpha-Synuclein Aggregator, FN075, Enhances Alpha-Synuclein Pathology in Subclinical AAV Rat Models

Biomolecules, MDPI 2021, Vol. 11, (11)

Kelly, Rachel; Cairns, Andrew G.; Ådén, Jörgen; et al.

Synthetic NAC 71-82 Peptides Designed to Produce Fibrils with Different Protofilament Interface Contacts

International Journal of Molecular Sciences, MDPI 2021, Vol. 22, (17)

Näsström, Thomas; Dahlberg, Tobias; Malyshev, Dmitry; et al.

Tandem Ring Opening/Intramolecular [2 + 2] Cycloaddition Reaction for the Synthesis of Cyclobutane Fused Thiazolino-2-Pyridones

Journal of Organic Chemistry, American Chemical Society (ACS) 2021, Vol. 86, (23) : 16582-16592

Tyagi, Mohit; Adolfsson, Dan E.; Singh, Pardeep; et al.

Neutron reflectometry and NMR spectroscopy of full-length Bcl-2 protein reveal its membrane localization and conformation

Communications Biology, Springer Nature 2021, Vol. 4, (1)

Ul Mushtaq, Ameeq; Ådén, Jörgen; Clifton, Luke A.; et al.

Insight into Functional Membrane Proteins by Solution NMR: The Human Bcl-2 Protein - A Promising Cancer Drug Target

Molecules, MDPI 2021, Vol. 26, (5)

Ul Mushtaq, Ameeq; Ådén, Jörgen; Sparrman, Tobias; et al.

Intramolecular Povarov Reactions for the Synthesis of Chromenopyridine fused 2-Pyridone Polyheterocycles Binding to α-Synuclein and Amyloid-β fibrils

Journal of Organic Chemistry, American Chemical Society (ACS) 2020, Vol. 85, (21) : 14174-14189

Adolfsson, Dan E.; Tyagi, Mohit; Singh, Pardeep; et al.

Dissociation between the critical role of ClpB of Francisella tularensis for the heat shock response and the DnaK interaction and its important role for efficient type VI secretion and bacterial virulence

PLoS Pathogens, Public Library of Science 2020, Vol. 16, (4) : 1-27

Alam, Athar; Golovliov, Igor; Javed, Eram; et al.

A Capped Peptide of the Aggregation Prone NAC 71-82 Amino Acid Stretch of α-Synuclein Folds into Soluble β-Sheet Oligomers at Low and Elevated Peptide Concentrations

International Journal of Molecular Sciences, MDPI 2020, Vol. 21, (5)

Näsström, Thomas; Ådén, Jörgen; Shibata, Fumina; et al.

A novel recombinant expression and purification approach for the full-length anti-apoptotic membrane protein Bcl-2

Protein Expression and Purification, Elsevier 2020, Vol. 172

Ådén, Jörgen; Ul Mushtaq, Ameeq; Dingeldein, Artur P. G.; et al.

Mitochondrial Membranes Involved in Apoptosis: the Bcl-2 Proteins

Biophysical Journal, Cell Press 2020, Vol. 118, (3) : 394A-394A

Ådén, Jörgen; Ul Mushtaq, Ameeq; Sparrman, Tobias; et al.

Mitochondrial Membrane Organization under Oxidative Stress: Insight by Solid-State NMR and Neutron Reflectometry

Biophysical Journal, CELL PRESS 2019, Vol. 116, (3) : 508A-508A

Dingeldein, Artur P. G.; Sparrman, Tobias; Ådén, Jörgen; et al.

Bax to the future: A novel, high-yielding approach for purification and expression of full-length Bax protein for structural studies

Protein Expression and Purification, Elsevier 2019, Vol. 158 : 20-26

Dingeldein, Artur Peter Günther; Lindberg, Mikael J.; Ådén, Jörgen; et al.

Viral mimetic priming enhances α-synuclein-induced degeneration: implications for Parkinson's disease

Brain, behavior, and immunity, Elsevier 2019, Vol. 80 : 525-535

Olsen, Laura K.; Cairns, Andrew G.; Ådén, Jörgen; et al.

Pyridine-Fused 2-Pyridones via Povarov and A³ Reactions: Rapid Generation of Highly Functionalized Tricyclic Heterocycles Capable of Amyloid Fibril Binding

Journal of Organic Chemistry, American Chemical Society (ACS) 2019, Vol. 84, (7) : 3887-3903

Singh, Pardeep; Adolfsson, Dan E.; Ådén, Jörgen; et al.

Synthesis of Densely Functionalized N-Alkenyl 2-Pyridones via Benzyne-Induced Ring Opening of Thiazolino-Fused 2-Pyridones

Organic Letters, American Chemical Society (ACS) 2019, Vol. 21 : 6946-6950

Singh, Pardeep; Cairns, Andrew G.; Adolfsson, Dan E.; et al.

Increased Brain Exposure of an Alpha-Synuclein Fibrillization Modulator by Utilization of an Activated Ester Prodrug Strategy

ACS Chemical Neuroscience, American Chemical Society (ACS) 2018, Vol. 9, (11) : 2542-2547

Cairns, Andrew G.; Vazquez-Romero, Ana; Mahdi-Moein, Mohammad; et al.

Helicobacter pylori Adapts to Chronic Infection and Gastric Disease via pH-Responsive BabA-Mediated Adherence

Cell Host and Microbe, CELL PRESS 2017, Vol. 21, (3) : 376-389

Bugaytsova, Jeanna A.; Björnham, Oscar; Chernov, Yevgen A.; et al.

Inhibition of curli assembly and Escherichia coli biofilm formation by the human systemic amyloid precursor transthyretin

Proceedings of the National Academy of Sciences of the United States of America, Vol. 114, (46) : 12184-12189

Jain, Neha; Ådén, Jörgen; Nagamatsu, Kanna; et al.

Copper binding triggers compaction in N-terminal tail of human copper pump ATP7B

Biochemical and Biophysical Research Communications - BBRC, Elsevier 2016, Vol. 470, (3) : 663-669

Mondol, Tanumoy; Ådén, Jörgen; Wittung-Stafshede, Pernilla

Bacterial Chaperones CsgE and CsgC Differentially Modulate Human α-Synuclein Amyloid Formation via Transient Contacts

PLOS ONE, Vol. 10, (10) : 1-11

Chorell, Erik; Andersson, Emma; Evans, Margery L.; et al.

The Bacterial Curli System Possesses a Potent and Selective Inhibitor of Amyloid Formation

Molecular Cell, Vol. 57, (3) : 445-455

Evans, Margery L.; Chorell, Erik; Taylor, Jonathan D.; et al.

Structural basis for catalytically restrictive dynamics of a high-energy enzyme state

Nature Communications, Macmillan Publishers Ltd. 2015, Vol. 6

Kovermann, Michael; Ådén, Jörgen; Grundström, Christin; et al.

Human cytoplasmic copper chaperones Atox1 and CCS exchange copper ions in vitro

Biometals, Springer 2015, Vol. 28, (3) : 577-585

Petzoldt, Svenja; Kahra, Dana; Kovermann, Michael; et al.

Synthesis of multiring fused 2‑pyridones via a nitrene insertion reaction: fluorescent modulators of α‑synuclein amyloid formation

Organic Letters, American Chemical Society (ACS) 2015, Vol. 17, (24) : 6194-6197

Singh, Pardeep; Chorell, Erik; Krishnan, K Syam; et al.

PloS Computational Biology, PLOS 2014, Vol. 10, (7) : e1003721-

Esteban-Martin, Santiago; Fenwick, Robert Bryn; Ådén, Jörgen; et al.

Macromolecular crowding effects on two homologs of ribosomal protein S16: protein-dependent structural changes and local interactions

Biophysical Journal, Vol. 107, (2) : 401-410

Mikaelsson, Therese; Ådén, Jörgen; Wittung-Stafshede, Pernilla; et al.

Folding of an unfolded protein by macromolecular crowding in vitro

Biochemistry, American Chemical Society (ACS) 2014, Vol. 53, (14) : 2271-2277

Ådén, Jörgen; Wittung-Stafshede, Pernilla

Direct Observation of Protein Unfolded State Compaction in the Presence of Macromolecular Crowding

Biophysical Journal, Cell Press 2013, Vol. 104, (3) : 694-704

Mikaelsson, Therese; Ådén, Jörgen; Johansson, Lennart B-Å; et al.

Small pH and Salt Variations Radically Alter the Thermal Stability of Metal-Binding Domains in the Copper Transporter, Wilson Disease Protein

Journal of Physical Chemistry B, American Chemical Society (ACS) 2013, Vol. 117, (42) : 13038-13050

Nilsson, Lina; Ådén, Jörgen; Niemiec, Moritz S.; et al.

Structural topology and activation of an initial adenylate kinase-substrate complex

Biochemistry, Vol. 52, (6) : 1055-1061

Ådén, Jörgen; Weise, Christoph; Brännström, Kristoffer; et al.

Modulation of a pre-existing conformational equilibrium tunes adenylate kinase activity

Journal of the American Chemical Society, Washington: American Chemical Society (ACS) 2012, Vol. 134, (40) : 16562-16570

Ådén, Jörgen; Verma, Abhinav; Schug, Alexander; et al.

Extraordinary μs-ms backbone dynamics in Arabidopsis thaliana peroxiredoxin Q

Biochimica et Biophysica Acta, Elsevier 2011, Vol. 1814, (12) : 1880-1890

Ådén, Jörgen; Wallgren, Marcus; Storm, Patrik; et al.

NMR studies of protein dynamics and structure

Umeå: Umeå universitet. Kemiska institutionen 2010

Ådén, Jörgen

Noncooperative folding of subdomains in Adenylate Kinase

Biochemistry, ACS Publications 2009, Vol. 48, (9) : 1911-1927

Rundqvist, Louise; Ådén, Jörgen; Sparrman, Tobias; et al.

Extreme temperature tolerance of a hyperthermophilic protein coupled to residual structure in the unfolded state

Journal of Molecular Biology, Vol. 379, (4) : 845-858

Wallgren, Marcus; Ådén, Jörgen; Pylypenko, Olena; et al.

NMR identification of transient complexes critical to adenylate kinase catalysis

Journal of the American Chemical Society, Vol. 129, (45) : 14003-12

Ådén, Jörgen; Wolf-Watz, Magnus

Enhanement of amyloid fibril binding by ring expansion of thiazolino fused 2-pyridone peptidomimetics

Adolfsson, Dan E.; Tyagi, Mohit; Singh, Pardeep; et al.

K₂S₂O₈-mediated aerobic oxidative coupling of 6-amino-7-(aminomethyl)-thiazolino-pyridones with aldehydes: Direct access to highly functionalized pyrimidine fused thiazolino-2-pyridones with amyloid fibril binding activity or inhibitors of Amyloid-β fibril formation

Bharate, Jaideep B.; Ådén, Jörgen; Gharibyan, Anna; et al.

Functionalization of Thiazolino fused 2-Pyridones by thiazoline ring opening and closing: Identification of new Amyloid Binding Heterocycles

Tyagi, Mohit; Adolfsson, Dan E.; Ådén, Jörgen; et al.

Arabidopsis thaliana peroxiredoxin Q is extraordinarily dynamic on the μs-ms timescale

Ådén, Jörgen; Wallgren, Marcus; Storm, Patrik; et al.

View publications in DiVA

Research groups

Group member

Fredrik Almqvist Lab

Gerhard Gröbner Lab

Research projects

1 January 2022

Design, synthesis and evaluation of novel ring-fused heterocycles targeting bacterial and human amyloid proteins

Published: 05 Jun, 2023

Neutrons provide unique insight into programmed cell death